Sample analyzer
By introducing a incubation device and a grab device into the blood analyzer, automatic deaggregation is achieved, and the problems of cumbersome and high cost of aggregation samples in the prior art are solved, and detection efficiency is improved.
Patent Information
- Application Number
- CN202421708257.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-18
- Publication Date
- 2025-07-25
- Estimated Expiration
- 2034-07-18
AI Technical Summary
Existing blood analyzers require manual identification and processing when processing aggregated samples, which is cumbersome and costly, affecting detection efficiency.
A sample analyzer is designed, including injection channels, incubation devices and grabbing devices, which can automatically identify aggregation samples and perform deaggregation operations through incubation processing, simplifying the processing flow.
There is no need for user manual decoupling operations, reducing processing costs and improving detection and analysis efficiency.
Smart Images

Figure CN223155028U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of blood analysis, and particularly relates to a sample analyzer. Background Art
[0002] A blood sample analyzer is an instrument used to detect parameters such as the quantity, volume, and proportion of blood cells (such as red blood cells, white blood cells, platelets, hemoglobin, etc.) in blood.
[0003] Among them, when a blood analyzer performs blood cell detection, usually blood cells are evenly distributed in the blood sample. However, when there are situations such as an increase in the content of agglutinin or too low sample temperature, the blood cells evenly suspended in the sample will aggregate into clusters due to reasons such as charge imbalance, resulting in blood cell agglutination. Directly detecting the agglutinated blood cells will cause the detected parameters to deviate from the actual values, affecting the accuracy of the measurement results of the blood analyzer.
[0004] In the process of processing a blood cell agglutination sample by the existing blood analyzer, it is necessary for the user to manually identify and process the agglutination sample. The process is cumbersome, the processing reagents are expensive, and the labor cost is high, which is not conducive to improving the analysis efficiency of the blood analyzer. Content of the Utility Model
[0005] The technical problem to be solved by the utility model is to provide a sample analyzer.
[0006] The technical solution adopted by the embodiments of the present application to solve its technical problems is:
[0007] Construct a sample analyzer, including:
[0008] An injection channel for conveying a sample rack loaded with a sample container in a first direction. The injection channel has a grasping position and a sampling position, and the sampling position is spaced from the grasping position in the first direction;
[0009] At least one sample storage space for temporarily storing the sample rack, and the sample storage space is adjacent to one side of the injection channel;
[0010] At least one incubation device for incubating an agglutination sample. The incubation device forms at least one incubation chamber for accommodating the sample container storing the agglutination sample, and the grasping position is spaced from the incubation chamber in a second direction; and
[0011] A grasping device for carrying the sample container, and the grasping device is movably arranged;
[0012] Wherein, the first direction is perpendicular to the second direction, the first direction is the length direction of the sample injection channel, and the second direction is the width direction of the sample injection channel.
[0013] In some embodiments, the grasping device, the grasping position, and the incubation chamber are at the same position in the first direction, and the incubation chamber is located behind the grasping position in the second direction. The grasping device is used to grasp the sample container from the side of the sample container in the second direction; the grasping device is movably arranged along the second direction and the third direction, and the third direction is perpendicular to the first direction and the second direction respectively, and the third direction is the height direction of the sample injection channel;
[0014] On the moving path of the grasping device, there are a first grasping and placing position and a second grasping and placing position. When the grasping device is located at the first grasping and placing position, the grasping device corresponds to the sample container located at the grasping position on the sample rack to grasp or place the sample container on the sample rack;
[0015] When the grasping device is located at the second grasping and placing position, the grasping device corresponds to the incubation chamber to grasp or place the sample container in the incubation chamber.
[0016] In some embodiments, the second grasping and placing position is lower than the first grasping and placing position in the third direction; when the grasping device is located at the first grasping and placing position, the distance between the grasping device and the bottom end of the incubation chamber in the third direction is greater than or equal to the height of the sample container.
[0017] In some embodiments, the incubation chamber is movably arranged along the third direction, and its moving path includes an avoidance position and a receiving position, and the receiving position is higher than the avoidance position; the moving path of the grasping device also includes a second grasping and placing position;
[0018] When the grasping device is located at the second grasping and placing position, the incubation chamber is located at the receiving position, and the grasping device corresponds to the incubation chamber to grasp or place the sample container in the incubation chamber; when the grasping device is located at the first grasping and placing position and the sample container is placed in the incubation chamber, the incubation chamber is located at the avoidance position; the position of the second grasping and placing position in the third direction is equal to or lower than the first grasping and placing position;
[0019] When the grasping device is located at the first grasping and placing position, the distance between the grasping device and the bottom end of the incubation chamber in the third direction is greater than or equal to the height of the sample container.
[0020] In some embodiments, the grasping device includes a grasping portion, a connecting portion, and a guide rail; the guide rail extends along the third direction and the second direction; the connecting portion is movably disposed on the guide rail, the grasping portion is connected to the connecting portion, and an avoidance space is defined between the grasping portion and the connecting portion;
[0021] When the grasping device is located at the first grasping and placing position, the avoidance space corresponds to the incubation chamber, and the distance from the top end of the avoidance space to the bottom end of the incubation chamber in the third direction is greater than or equal to the height of the sample container.
[0022] In some embodiments, the sample analyzer further includes at least one mixing device, at least one mixing chamber for accommodating the sample container is formed on the mixing device, and the mixing device is configured to mix the blood sample in the sample container in the mixing chamber;
[0023] The mixing chamber is located at the same position as the grasping position and the incubation chamber in the first direction; the mixing chamber is located between the grasping position and the incubation chamber in the second direction, or the mixing chamber is located on the side of the incubation chamber away from the grasping position in the second direction.
[0024] In some embodiments, the moving path of the grasping device further includes a second grasping and placing position and a third grasping and placing position. When the grasping device is located at the second grasping and placing position, the grasping device corresponds to the incubation chamber to grasp or place the sample container from or into the incubation chamber; when the grasping device is located at the third grasping and placing position, the grasping device corresponds to the mixing chamber to grasp or place the sample container from or into the mixing chamber; the position of the third grasping and placing position in the third direction is equal to or lower than that of the first grasping and placing position;
[0025] The mixing chamber is located between the grasping position and the incubation chamber in the second direction; the position of the second grasping and placing position in the third direction is lower than that of the third grasping and placing position;
[0026] Or, the mixing chamber is located on the side of the incubation chamber away from the grasping position in the second direction; the position of the third grasping and placing position in the third direction is equal to or lower than that of the second grasping and placing position, and the position of the second grasping and placing position in the third direction is lower than that of the first grasping and placing position.
[0027] In some embodiments, the moving path of the grasping device further includes a third grasping and placing position. When the grasping device is located at the third grasping and placing position, the grasping device corresponds to the mixing chamber to grasp or place the sample container from or into the mixing chamber; the position of the third grasping and placing position in the third direction is equal to or lower than that of the first grasping and placing position;
[0028] The incubation chamber is movably arranged along the third direction, and its moving path includes an avoidance position and a receiving position, and the receiving position is higher than the avoidance position.
[0029] The mixing chamber is located between the grasping position and the incubation chamber in the second direction; the third grasping and releasing position is equal to or lower than the first grasping and releasing position in the third direction, and the second grasping and releasing position is equal to or lower than the third grasping and releasing position in the third direction; when the grasping device is at the third grasping and releasing position and the sample container is placed in the incubation chamber, the incubation chamber is located at the avoidance position.
[0030] Or, the mixing chamber is located on the side of the incubation chamber away from the grasping position in the second direction; the second grasping and releasing position is equal to or lower than the first grasping and releasing position in the third direction, and the third grasping and releasing position is equal to or lower than the second grasping and releasing position in the third direction; when the grasping device is at the first grasping and releasing position and the sample container is placed in the incubation chamber, the incubation chamber is located at the avoidance position.
[0031] In some embodiments, the grasping device includes a grasping portion, and the grasping portion is swingably arranged along the first direction.
[0032] In some embodiments, the sample analyzer further includes a manual sampling device, and a sampling chamber for placing a sample container is arranged on the manual sampling device, and the sampling chamber is spaced from the sampling position in the second direction.
[0033] At least one incubation device is further arranged on the manual sampling device, and the incubation chamber of the incubation device is spaced from the sampling chamber and the sampling position in the second direction.
[0034] Or, at least one incubation device is further arranged on the manual sampling device, and the incubation chamber of the incubation device is the sampling chamber on the manual sampling device.
[0035] Implementing the embodiments of the present invention has at least the following beneficial effects:
[0036] By arranging the incubation device in this application, the sample analyzer constructed in this application can perform a de-aggregation operation on a blood sample determined to be an aggregated sample through the incubation treatment of the incubation device, so that it is not necessary for the user to perform a manual de-aggregation operation separately, simplifies the processing flow for the aggregated sample, reduces the processing cost, and improves the detection and analysis efficiency of the sample analyzer. BRIEF DESCRIPTION OF THE DRAWINGS
[0037] The following will further illustrate the present application in conjunction with the drawings. In the drawings:
[0038] Figure 1 It is a top view of a part of the structure of the sample analyzer in the first embodiment of the present application;
[0039] Figure 2 yes Figure 1 The module relationship diagram of the sample analyzer shown;
[0040] Figure 3 yes Figure 1 The sample analyzer shown is a side view of a part of the structure in a specific embodiment where the mixing chamber is located on the side of the incubation chamber away from the sampling position;
[0041] Figure 4 yes Figure 1 The sample analyzer shown is a side view of a part of the structure when, in a specific embodiment in which the mixing chamber is located between the incubation chamber and the sampling position, the grabbing device is located at the third grabbing and placing position, and a sample container is placed in the incubation chamber;
[0042] Figure 5 It is a side view of a part of the structure of the sample analyzer in the second embodiment of the present application, in a specific embodiment in which the mixing chamber is located on the side of the incubation chamber away from the sampling position, when the incubation chamber is located at the receiving position;
[0043] Figure 6 It is a side view of a part of the structure of the sample analyzer in the second embodiment of the present application, in a specific embodiment in which the mixing chamber is located on the side of the incubation chamber away from the sampling position, when the incubation chamber is located at the avoidance position;
[0044] Figure 7 It is a side view of a part of the structure of the sample analyzer in the second embodiment of the present application, in a specific embodiment in which the mixing chamber is located between the incubation chamber and the sampling position, when the incubation chamber is located at the receiving position;
[0045] Figure 8 It is a side view of a part of the structure of the sample analyzer in the second embodiment of the present application, in a specific embodiment in which the mixing chamber is located between the incubation chamber and the sampling position, when the incubation chamber is located at the avoidance position;
[0046] Figure 9 It is a side view of a part of the structure of the sample analyzer in the third embodiment of the present application, in a specific embodiment in which the mixing chamber is located on the side of the incubation chamber away from the sampling position;
[0047] Figure 10 It is a side view of a part of the structure of the sample analyzer in the third embodiment of the present application, in a specific embodiment in which the mixing chamber is located between the incubation chamber and the sampling position. DETAILED DESCRIPTION
[0048] In order to have a clearer understanding of the technical features, objectives, and effects of the present application, the specific embodiments of the present application will now be described in detail with reference to the accompanying drawings. In the following description, it should be understood that the orientation or positional relationships indicated by terms such as "front", "rear", "upper", "lower", "left", "right", "longitudinal", "transverse", "vertical", "horizontal", "top", "bottom", "inner", "outer", "head", "tail", etc. are based on the orientation or positional relationships shown in the accompanying drawings and are constructed and operated in a specific orientation, and are only for the convenience of describing the present technical solution, rather than indicating that the indicated device or element must have a specific orientation. Therefore, it should not be construed as a limitation to the present application.
[0049] It should also be noted that, unless otherwise clearly specified and limited, terms such as "install", "connect", "link", "fix", "set", etc. should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two elements or the interaction relationship between two elements. When an element is referred to as being "on" or "under" another element, the element can be "directly" or "indirectly" located above the other element, or there may also be one or more intermediate elements. The terms "first", "second", "third", etc. are only for the convenience of describing the present technical solution and cannot be understood as indicating or implying relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first", "second", "third", etc. may explicitly or implicitly include one or more of such features. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.
[0050] In the following description, specific details such as specific system structures and technologies are presented for the purpose of illustration rather than limitation, so as to thoroughly understand the embodiments of the present application. However, those skilled in the art should clearly understand that the present application can also be implemented in other embodiments without these specific details. In other cases, the detailed descriptions of well-known systems, devices, circuits, and methods are omitted to avoid unnecessary details from interfering with the description of the present application.
[0051] Figures 1 to 4 The sample analyzer 1 in the first embodiment of the present application is shown. The sample analyzer 1 can detect and analyze blood samples and can also perform incubation processing on blood samples determined to be agglutinated samples.
[0052] The sample analyzer 1 includes a sample injection channel 10, a grasping device 40, and at least one incubation device 20. Among them, the sample injection channel 10 extends along a first direction and is used to convey a sample rack 2 loaded with a sample container 201 in the first direction. The incubation device 20 can incubate the agglutinated sample in the sample container 201 to achieve the effect of de-agglutination and improve the detection accuracy. The grasping device 40 is used to carry the sample container 201.
[0053] It should be understood that the sample rack 2 has a plurality of receiving cavities, and a plurality of sample containers 201 are placed in the plurality of receiving cavities one by one. The sample container 201 is used to hold a blood sample. When it is necessary to detect the blood sample in the sample container 201 on the sample rack 2, only the sample rack 2 needs to be placed on the sample injection channel 10, and through the transmission of the sample injection channel 10 and the cooperation between the other device modules of the sample analyzer 1, the collection and detection of the blood samples in each sample container 201 on the sample rack 2 can be realized.
[0054] Specifically, as Figure 1 shown, the sample injection channel 10 has a grasping position 11 and a sampling position 12, and the grasping position 11 and the sampling position 12 are spaced apart in the first direction. Among them, when a certain sample container 201 on the sample rack 2 is conveyed to the grasping position 11 of the sample injection channel 10 as the sample rack 2 moves, the grasping device 40 can take out the sample container 201 from the sample rack 2 or put the sample container 201 after the treatment back to the sample rack 2. When a certain sample container 201 on the sample rack 2 is conveyed to the sampling position 12 of the sample injection channel 10 as the sample rack 2 moves, the sample analyzer 1 can collect the blood sample from the sample container 201.
[0055] At least one incubation cavity 21 is formed on the incubation device and is used to hold the sample container 201. The incubation cavity 21 is spaced apart from the grasping position 11 in a second direction.
[0056] In this embodiment, the incubation cavity 21 is used to place the sample container 201 containing the agglutinated sample. It should be understood that, however, the incubation device 20 does not limit that the incubation cavity 21 can only place the sample container 201 containing the agglutinated sample, that is, the incubation device 20 can also incubate the non-agglutinated sample.
[0057] It should be understood that the relationship between the "blood sample" and the "agglutinated sample" mentioned is as follows: The blood sample can be divided into an agglutinated sample and a non-agglutinated sample according to whether the cells are agglutinated. The agglutinated sample includes, but is not limited to, red blood cell agglutination samples, white blood cell agglutination samples, and PLT (platelet) agglutination samples.
[0058] When blood cells agglutinate due to factors such as low temperature and abnormal agglutinins, and the volume of blood cells changes abnormally, it causes a false change in the red blood cell count when the sample analyzer 1 detects a blood sample, affecting the detection accuracy of the sample analyzer 1. Therefore, when it is detected that the blood sample is an agglutinated sample, in order to ensure the detection accuracy of the agglutinated sample, it is necessary to perform deagglutination operations such as incubating the agglutinated sample, and then perform a secondary detection on the deagglutinated sample to ensure the accuracy of the blood sample detection.
[0059] It should be noted that the judgment of the agglutinated sample can be made based on the detection results of the blood sample. For example, when the agglutinated sample is a red blood cell agglutinated sample, the detection results can include at least one of mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), hematocrit (HCT), red blood cell count (RBC), and mean corpuscular hemoglobin content (MCH). The sample analyzer 1 judges whether the blood sample is agglutinated according to the parameters of the detection results. Exemplarily, when the detection results include the MCHC parameter, it can be judged whether the blood sample is agglutinated by judging whether the MCHC is greater than a preset value. For example, the preset value can be 360 g / L or 380 g / L. When the MCHC is greater than 360 g / L or 380 g / L, it can be judged that the blood sample is an agglutinated sample. When the detection results include the MCV parameter, it can be judged whether the blood sample is agglutinated by judging whether the MCV is on the high side. When the detection results include the HCT parameter, it can be judged whether the blood sample is agglutinated by judging whether the HCT is on the low side. When the detection results include the RBC parameter, it can be judged whether the blood sample is agglutinated by judging whether the RBC is on the low side. When the detection results include the MCH parameter, it can be judged whether the blood sample is agglutinated by judging whether the MCH is on the high side. For example, whether the MCH is greater than a preset value, and the preset value can be 33 pg. If the MCH is greater than 33 pg, it can be judged that the blood sample is an agglutinated sample. When the detection results include the HGB and RBC parameters, the condition for determining whether it is an agglutinated sample is whether the ratio of HGB to RBC is greater than a preset value. For example, the preset value can be 30. It can be understood that the above-mentioned multiple judgment methods can be combined arbitrarily. For example, it can be judged whether the blood sample is agglutinated according to the ratio of HGB to RBC, MCH, and MCHC, or it can be judged whether the blood sample is agglutinated according to other parameters. The judgment method for judging whether the blood sample is agglutinated belongs to the prior art and will not be specifically limited and elaborated here.
[0060] The mentioned "incubation treatment" may refer to heating the agglutinated sample at a preset temperature for a preset time. Specifically, the "preset temperature" is preferably a temperature within the range of 35°C to 43°C. For example, the preset temperature can be set to 35°C, 36°C, 37°C, 38°C, 39°C, 40°C, 41°C, 42°C, or 43°C to be close to the human body temperature, so as to enable the agglutinated blood cells in the agglutinated sample to undergo de-agglutination at the preset temperature. The "preset time" is preferably 5 minutes to 60 minutes. For example, the preset time can be 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes, 30 minutes, 35 minutes, 40 minutes, 45 minutes, 50 minutes, 55 minutes, 60 minutes, etc.
[0061] It should be understood that the longer the preset time, the better the de-agglutination effect, but the lower the efficiency of sample analysis. Therefore, the time of the incubation treatment can be flexibly controlled according to the degree of agglutination of the agglutinated sample, sample analysis scheduling, etc. No specific limitation is made here.
[0062] The grasping device 40 is movably arranged along the second direction and the third direction. The grasping device 40 grasps the sample container from the side of the sample container in the second direction, and its position in the first direction is the same as that of the grasping position 11 and the incubation chamber 21, so that the grasping device 40 can transfer the sample container 201 between the grasping position 11 and the incubation chamber 21.
[0063] Among them, refer to together Figure 3 A first grasping and releasing position 401 is provided on the moving path of the grasping device 40. When the grasping device 40 is located at the first grasping and releasing position 401, it corresponds to the sample container 201 located at the grasping position 11 on the sample rack 2. At this time, the grasping device 40 can grasp the sample container 201 from the sample rack 2, or put back the sample container 201 that has been processed to the sample rack 2. When the grasping device 40 is located at the first grasping and releasing position 401 and the sample container 201 is placed in the incubation chamber 21, the positional relationship between the first grasping and releasing position 401 and the incubation chamber 21 can enable the grasping device 40 located at the first grasping and releasing position 401 to be spaced from the sample container 201 in the incubation chamber 21 for avoidance.
[0064] It should be understood that "when the grasping device 40 is located at the first grasping and releasing position 401, it corresponds to the sample container 201 located at the grasping position 11 on the sample rack 2" means that the grasping device 40 at the first grasping and releasing position 401 can grasp the sample container 201 at the first grasping and releasing position 401. Taking the example that the sample container 201 located at the grasping position 11 on the sample rack 2 has not been taken out, if the grasping device 40 is located at the first grasping and releasing position 401 at this time, the part of the grasping device 40 for grasping the sample container 201 can perform the grasping operation.
[0065] Specifically, the first grasping and releasing position 401 may not be limited to a specific point. At the first grasping and releasing position 401, the grasping device 40 can achieve the grasping and releasing operations of the sample container 201 by slightly horizontal movement (such as fork-lifting the sample container 201 through horizontal movement) or the self-action of the grasping device 40 (such as a jaw-type grasping device 40, by opening and tightening the jaws). However, it should be understood that in this embodiment, when the grasping device 40 is at the same position as the grasping position 11 in both the first direction and the second direction, the bottom position of the movement path of the grasping device 40 in the third direction is the first grasping and releasing position 401.
[0066] It should be understood that the first direction, the second direction, and the third direction are perpendicular to each other. The "first direction" may refer to the length direction (extension direction) of the sampling channel 10, which refers to the Figure 1 X-axis direction in this embodiment. The "second direction" may refer to the width direction of the sampling channel 10, which refers to the Figure 1 and Figure 3 Y-axis direction in this embodiment. The "third direction" may refer to the height direction of the sampling channel 10, which refers to the Figure 3 Z-axis direction in this embodiment.
[0067] By providing the incubation device 20 in this application, the sample analyzer 1 constructed in this application can not only detect blood samples, but also perform a de-agglutination operation on the blood samples judged as agglutinated samples through the incubation treatment of the incubation device 2, so that there is no need for the user to perform manual de-agglutination operations separately, simplifying the processing flow of agglutinated samples, reducing the processing cost, and improving the detection and analysis efficiency of the sample analyzer 1.
[0068] In some embodiments, the incubation device 20 further includes a heating component (not shown in the figure) for incubating the blood samples in the incubation chamber 21.
[0069] In this embodiment, the number of the incubation device 20 and the incubation chamber 21 is one, that is, there is one incubation chamber 21 on one incubation device 20. In some other optional embodiments, the number of the incubation device 20 can be set to two, three, etc. The number of the incubation chambers 21 of the incubation device 20 can also be one, two, three, etc. When one incubation device 20 is provided with multiple incubation chambers 21, the heating component of the incubation device 20 can incubate the multiple incubation chambers 21 simultaneously or separately.
[0070] Since the incubation time is relatively long, by providing multiple incubation chambers 21, the sample analyzer 1 can incubate multiple blood samples judged as agglutinated samples simultaneously. This can avoid the situation where multiple agglutinated samples need to queue up for processing.
[0071] Specifically, the heating component can be a solid heating component such as a heating resistor. In the way of solid heat conduction, the sample container 201 of the agglutinated sample is directly heated by heating the solid, so as to realize the incubation treatment of the agglutinated sample. It can also be incubated by means of water bath heating, air bath heating, etc. No specific limitation is made here.
[0072] As Figure 2 shown, in some embodiments, the sample analyzer 1 further includes a detection device 50, and the detection device 50 is used to collect the blood sample in the sample container 201 and analyze and detect the blood sample. The detection device 50 includes a sampling needle (not shown in the figure), which is movably arranged along the third direction and is used to collect the blood sample in the sample container 201 located at the sampling position 12.
[0073] In some embodiments, the detection device 50 may further include a dilution component (not shown in the figure). By diluting the blood sample by a certain multiple before detection through the dilution component, the effect of deagglutination can also be achieved. It can be used alone to dilute the agglutinated sample, or can be used in combination with the incubation device 20 and / or the mixing device 30 to perform multi-mode deagglutination treatment on the agglutinated sample.
[0074] Specifically, the dilution component can be located on the sample discharging path of the sampling needle. After the blood sample is collected by the sampling needle, it is released through the sampling needle to the dilution component for dilution by a certain multiple, and then enters the detection part of the detection device 50 through the dilution component for detection.
[0075] Among them, "a certain multiple" can preferably be in the range of 60 times to 1024 times. For example, the multiple can be 60, 120, 250, 500 or 1000. For another example, the multiple can also be 64, 128, 256, 512 or 1024, etc. It should be understood that the multiple can be flexibly selected according to the agglutination degree of the agglutinated sample, and no specific limitation is made here; in some embodiments, the diluent used for diluting the blood sample can be a heated thermal diluent to perform thermal dilution on the blood sample, and the effect of deagglutination treatment on the agglutinated sample by thermal dilution is better.
[0076] Continue to refer to Figure 2 , the sample analyzer 1 further includes a control device 60, and the control device 60 is electrically connected to the sample injection channel 10, the incubation device 20, the grasping device 40 and the detection device 50 respectively, and is used to control the operation of each device, so that the sample analyzer 1 can realize functions such as the collection and detection function and the incubation treatment function of the blood sample.
[0077] For the sample analyzer 1 constructed in this embodiment, during the specific detection process, the control device 60 controls the cooperation of other devices to sequentially collect and detect the blood samples in each sample container 201 on the sample rack 2. The control device 60 can judge whether the blood sample in the sample container 201 is an agglutinated sample according to the generated detection result. When it is judged that the blood sample in a certain sample container 201 is an agglutinated sample, the control device 60 controls the sample container 201 containing the agglutinated sample to be transported to the incubation device 20 for incubation treatment to realize the de-agglutination operation of the agglutinated sample. After the de-agglutination ends, the control device 60 then controls the sample container 201 containing the agglutinated sample to be transported to the sampling position 11, performs secondary sampling detection on the agglutinated sample after the incubation treatment, and generates a detection result again for judgment until it is judged as a non-agglutinated sample, then the detection result generated this time can be regarded as the detection result of the blood sample.
[0078] Specifically, since it takes a certain period of time (not limited here) for the blood sample to be detected from collection to obtaining the result, during the sequential collection of the blood samples on the sample rack 2, this period of time may be longer than the sampling interval of the sampling needle in adjacent two sample containers 201, or may be shorter than the interval time. Therefore, when the sample analyzer 1 detects an agglutinated sample, the control device 60 can be configured specifically according to the choices of different users.
[0079] For example, the control device 60 can be configured as follows: the sample rack 2 sequentially transports the sample containers 201 to the sampling position 12 through the sample injection channel 10 for sampling. After each sample container 201 finishes sampling at the sampling position 12, it can wait at the sampling position 12 until the control device 60 obtains the judgment on the detection result of the blood sample in the sample container 201. If it is a non-agglutinated sample, then control the sample injection channel 10 to continue transporting the sample rack 2 and transport the next adjacent sample container 201 to be sampled to the sampling position 12 for sampling. If it is an agglutinated sample, then control the sample injection channel 10 to transport the sample rack 2 and transport the sample container 201 containing the agglutinated sample to the grasping position 11, and grasp it to the incubation chamber 21 through the grasping device 40 for incubation treatment.
[0080] For example, the control device 60 can also be configured such that the sample rack 2 sequentially transports the sample containers 201 to the sampling position 12 through the sample introduction channel 10 for sampling. After the sampling of the sample container 201 is completed at the sampling position 12, the sample introduction channel 10 is continuously controlled to transport the sample rack 2, so that the sample container 201 to be sampled adjacent to the sampled sample container 201 is sampled, and so on. During this process, the control device 60 generates detection information for each of the blood samples sampled one by one. Since the detection process is carried out one by one, when it is determined that the blood sample in a certain sample container 201 is an agglutinated sample, the control device 60 can suspend the sampling and detection of the blood sample, and first determine the position of the sample container 201 containing the agglutinated sample on the sample rack 2 according to the detection sequence position of the agglutinated sample, or according to the coding information on the sample container 201, etc. At this time, the control device 60 can control the sample introduction channel 10 to transport the sample rack 2 to transport the sample container 201 containing the agglutinated sample from the sampling position 12 to the grasping position 11, and transfer it to the incubation device 20 through the grasping device 40 for incubation treatment.
[0081] For example, the control device 60 can also be configured such that the sample rack 2 sequentially transports the sample containers 201 to the sampling position 12 through the sample introduction channel 10 for sampling. After the sampling of the sample container 201 is completed at the sampling position 12, the sample introduction channel 10 is continuously controlled to transport the sample rack 2, so that the sample container 201 to be sampled adjacent to the sampled sample container 201 is sampled. And so on until all the sample containers 201 on the sample rack 2 are sampled. Then, the control device 60, according to the judgment results generated one by one (assuming there is an agglutinated sample on the sample rack 2), first determines the position of the sample container 201 containing the agglutinated sample on the sample rack 2 according to the detection sequence position of the agglutinated sample, or according to the coding information on the sample container 201, etc. At this time, the control device 60 can control the sample introduction channel 10 to transport the sample rack 2 to transport the sample container 201 containing the agglutinated sample from the sampling position 12 to the grasping position 11, and transfer it to the incubation device 20 through the grasping device 40 for incubation treatment.
[0082] It should be understood that for the transfer process and the secondary detection process after the blood sample is determined to be an agglutinated sample, there are many choices for the configuration method of the control device 60. The above are only examples of several possibilities and are not limited here. It should be understood that the configuration of the control device 60 only needs to satisfy that after the blood sample is determined to be an agglutinated sample, it can return to the sample analyzer 1 under the control of the control device 60 for deagglutination treatment such as incubation treatment and be redetected.
[0083] It should be understood that the "encoding" on the sample container 201 can be a state view of the blood sample in the sample container 201, or any form of expression such as a two-dimensional code, bar code, identification code, etc. that can represent the information of a specific sample container 201, so that the sample container 201 and the blood sample it contains are in one-to-one correspondence. No specific limitation is made here. It can be used to read and record each sample container 201 when the sample container 201 follows the sample rack 2 through the sampling channel 10 into the sample analyzer 1, so that the control device 60 can obtain various original information such as the shape, size, sample source information, and blood sample volume information of the sample container 201 according to the "encoding" information, and then perform targeted detection and processing on the blood sample in the sample container 201.
[0084] In some embodiments, an identification device (not shown in the figure) may also be provided on the sampling channel 10 for identifying the encoding on the sample container 201 to achieve a one-to-one correspondence between the blood sample in the sample container 201 and the test result.
[0085] It should be understood that the identification device may specifically be an existing image acquisition and processing device, etc. No specific limitation is made here, as long as the sample container 201 can be identified through the aforementioned encoding of the sample container 201.
[0086] In some embodiments, at least one sample temporary storage space (not shown in the figure) may also be adjacent to one side of the sampling channel 10 for temporarily storing the sample rack 2 to be tested and / or the tested sample rack 2.
[0087] It should be understood that "adjacent" may mean connected / fixed to the sampling channel 10, or may mean spaced apart from the sampling channel 10. No specific limitation is made here.
[0088] In this embodiment, the number of the sample rack temporary storage spaces is two, both located on the front side of the sampling channel 10 (in Figure 1 the shown angle, both are on the side of the sampling channel 10 away from the incubation chamber 21), and are respectively located at both ends of the sampling channel 10. Among them, the sample rack temporary storage space in the upstream of the transmission direction can be used to place the sample rack 2 to be tested, and the sample rack temporary storage space in the downstream of the transmission direction can be used to place the tested sample rack 2.
[0089] It should be understood that the sample rack temporary storage space can be in the form of a groove, a chamber structure, etc., which is not specifically limited here, as long as it can temporarily store the sample rack 2. The size of the sample rack temporary storage space is also not specifically limited, as long as it can temporarily store a certain amount of sample racks 2, such as one, two, or more, so as to reduce the workload of the user, so that the operator can be positioned in front of the sample analyzer 1, and place the sample racks 2 to be tested in the sample rack temporary storage space on the transmission track in turn, so as to avoid the operator repeatedly taking and placing the sample racks from a distant position on the transmission track.
[0090] In some other optional embodiments, Figure 1 The angle shown is used as a reference, and the sample rack temporary storage space can also be located at both sides (or any one of the two sides) of the injection channel 10 in the X-axis direction, or can also be located at both sides (or any one of the two sides) of the injection channel 10 in the Y-axis direction. The number can be one or at least two, and the number and position can be set as long as it does not affect the cooperation between the injection channel 10 and the grabbing device 40.
[0091] In some embodiments, the sample analyzer 1 further includes a frame (not shown in the figure), and the incubation device 20, the gripping device 40, the detection device 50, etc. are all arranged in the frame to play a role of containment and protection, and can also improve the overall aesthetics of the sample analyzer 1.
[0092] In some embodiments, the grabbing device 40 can also be used to mix the blood sample to be tested to ensure the uniformity of blood cell distribution in the blood sample and improve the accuracy of blood sample testing.
[0093] It should be understood that the “mixing process” mentioned here may refer to mixing the blood sample in the sample container 201 uniformly by means of vibration and / or swinging and / or rotation and / or stirring at a certain frequency.
[0094] Specifically, before sampling and testing the blood sample to be tested, the grasping device 40 can first grasp the sample containers 201 on the sample rack 2 in turn, and the blood sample to be tested in the sample container 201 can be mixed by driving the sample container 201 to vibrate / swing / move back and forth / rotate, and then put back on the sample rack 2 to wait for transmission to the sampling position 12 for sampling and testing.
[0095] For example Figure 1 As shown, in the second direction, the incubation chamber 21 is located at the rear side of the grabbing position 11. The grabbing device 40 is installed on the side of the incubation chamber 21 away from the grabbing position 11, and can move back and forth between the incubation chamber 21 and the grabbing position 11.
[0096] It should be understood that the "rear side" here refers to the side of the sample injection channel 10 close to the inside of the frame, that is Figure 1 the side where the Y-axis points upward in the shown angle, that is, the side of the sample injection channel 10 away from the user during the use of the sample analyzer 1 (on the premise that the user is at the sample injection channel 10).
[0097] In some other alternative embodiments, the grasping device 40 and the incubation chamber 21 can also be respectively arranged on two opposite sides of the grasping position 11.
[0098] For another example Figure 3 As shown, in some embodiments, the grasping device 40 further includes a second grasping and placing position 402 on its moving path (including the part shown by the dotted line in the figure). When the grasping device 40 is located at the second grasping and placing position 402, the grasping device 40 corresponds to the incubation chamber 21. At this time, the grasping device 40 can grasp the sample container 201 from the incubation chamber 21 or place the sample container 201 into the incubation chamber 21.
[0099] It should be understood that "when the grasping device 40 is located at the second grasping and placing position 402, the grasping device 40 corresponds to the incubation chamber 21" means that the grasping device 40 at the second grasping and placing position 402 can perform a grasping operation on the sample container 201 at the second grasping and placing position 402 to grasp the first sample container 201.
[0100] Specifically, similar to the first grasping and placing position 401, the second grasping and placing position 402 may not refer to a specific point. At the second grasping and placing position 402, the grasping device 40 can also achieve the grasping and placing operations on the sample container 201 by slightly horizontal movement (such as forking the sample container 201 through horizontal movement) or the self-action of the grasping device 40 (such as a jaw-type grasping device 40, by opening and tightening the jaws). However, it should be understood that in this embodiment, when the grasping device 40 is at the same position as the incubation chamber 21 in both the first direction and the second direction, the bottom position of the moving path of the grasping device 40 in the third direction is the second grasping and placing position 402.
[0101] Further, continue to refer to Figure 3 , the moving path of the grasping device 40 (including the part shown by the dotted line in the figure) further includes a first transfer position 404 and a second transfer position 405. The first transfer position 404 is located above the first grasping and placing position 401 (grasping position 11), the second transfer position 405 is located above the second grasping and placing position 402 (incubation chamber 21), and the first transfer position 404 and the second transfer position 405 are at the same position height in the third direction.
[0102] It should be understood that the statement "the first transfer position 404 is above the first grasping and placing position 401" means that the first transfer position 404 and the first grasping and placing position 401 are in the same positions in the first direction and the second direction, and the position of the first transfer position 404 in the third direction is higher than that of the first grasping and placing position 401. The same applies to the second transfer position 405 and the second grasping and placing position 402.
[0103] In the specific process of transporting the sample container 201 by the grasping device 40, taking the transportation of the sample container 201 from the grasping position 11 to the incubation chamber 21 as an example. First, the grasping device 40 needs to be moved to the first grasping and placing position 401 so that the grasping device 40 grasps the sample container 201 on the sample rack 2. Further, the grasping device 40 is moved upward along the third direction to the first transfer position 404, then moved from the first transfer position 404 along the second direction to the second transfer position 405, and then moved downward along the third direction from the second transfer position 405 to the second grasping and placing position 402. At this time, the sample container 201 is located in the incubation chamber 21, and the grasping device 40 completes the handling operation.
[0104] Similarly, for the grasping device 40 to transport the sample container 201 from the incubation chamber 21 to the grasping position 11, the above steps can be implemented in reverse order, which will not be elaborated here.
[0105] It should be understood that the height difference in the third direction between the first grasping and placing position 401 and the first transfer position 404 is not specifically limited herein. As long as the grasping device 40 grasps the sample container 201 and the sample container 201 is placed in the incubation chamber 21, when the grasping device 40 moves between the first transfer position 404 and the second transfer position 405, the bottom end of the sample container 201 grasped by the grasping device 40 will not collide with the top end of the sample container 201 in the incubation chamber 21.
[0106] After the incubated sample container 201 is transported back from the incubation chamber 21 to the sample rack 2 at the grasping position 11, it can reach the sampling position 12 again for sampling through the transmission of the sampling channel 10. The control device 60 can make a judgment based on the secondary sampling and detection results of the detection device 50. If it is judged as a non-agglutinated sample, then the detection result this time is the final test result.
[0107] It should be understood that to ensure that the grasping device 40 can transport the sample container 201 back and forth between the first transfer position 404 and the second transfer position 405, the distance between the position of the first transfer position 404 in the third direction and the topmost position of the sample rack 2 at the grasping position 11 in the third direction should be greater than or equal to the height of the sample container 201. Similarly, the distance between the position of the second transfer position 405 in the third direction and the top position of the incubation device 20 at the incubation chamber 21 in the third direction should be greater than or equal to the height of the sample container 201.
[0108] As Figure 3 and Figure 4 shown, since the first pick-and-place position 401 is the lowest position where the picking device 40 moves along the third direction at the picking position 11, and the second pick-and-place position 402 is the lowest position where the picking device 40 moves along the third direction at the incubation chamber 21. In some embodiments, the installation position of the incubation device 20 within the frame needs to be such that the second pick-and-place position 402 is lower than the first pick-and-place position 401 in the third direction.
[0109] At this time, when the picking device 40 is located at the first pick-and-place position 401, the distance between the picking device 40 and the bottom end of the incubation chamber 21 in the third direction is greater than or equal to the height of the sample container 201.
[0110] It should be understood that since the incubation process of the agglutinated sample takes a long time, to improve the detection efficiency of the sample analyzer 1, during the incubation process, the sample analyzer 1 can synchronously detect and analyze other blood samples to be detected to ensure the continuity of the sampling and detection operations of the sample analyzer 1 and improve the detection efficiency. And since the blood sample to be detected in the sample container 201 needs to be mixed before detection. Therefore, during the incubation process of the agglutinated sample, the picking device 40 needs to move to the first pick-and-place position 401, pick up the sample container 201 to be detected, mix it, and then return the sample container 201 after the mixing process to the sample rack 2.
[0111] During the process of mixing the blood sample to be detected, the picking device 40 can be at the first transfer position 404, or at a certain position between the first pick-and-place position 401 and the first transfer position 404, or at a certain position between the first transfer position 404 and the second transfer position 405. However, when the picking device 40 is at the first pick-and-place position 401 to pick up or place the sample container 201, since the first pick-and-place position 401 is relatively close to the second pick-and-place position 402 in the third direction, and since at least part of the structure of the picking device 40 in this embodiment extends horizontally along the second direction, there may be a problem of collision between the picking device 40 and the sample container 201 undergoing incubation treatment in the incubation chamber 21.
[0112] In this embodiment, by lowering the position of the incubation chamber 21 in the third direction so that the second pick-and-place position 402 is lower than the first pick-and-place position 401 in the third direction, it is possible to avoid the sample container 201 in the incubation chamber 21, so as to ensure that during the incubation process of the agglutinated sample 20 for a preset time, the picking device 40 can smoothly and continuously mix the blood samples to be detected to ensure that the sample analyzer 1 can continuously detect the blood samples to be detected within the preset time. At the same time, it is also possible to reduce the occupation of the internal space of the frame and realize the miniaturization of the sample analyzer 1.
[0113] In some other alternative embodiments, it can also be achieved by increasing the spacing distance between the grasping position 11 and the incubation chamber 21 in the second direction. At this time, when there is a sample container 201 in the incubation chamber 21 and the grasping device 40 is located at the first grasping and releasing position 401, the grasping device 40 will not collide with the sample container 201 in the incubation chamber 21.
[0114] It should be understood that if the avoidance of the sample container 201 in the incubation chamber 21 is achieved by increasing the spacing distance between the grasping position 11 and the incubation chamber 21 in the second direction, then the position of the incubation device 40 in the frame can be set more flexibly at this time (provided that it is ensured that the connection line between the incubation chamber 21 and the grasping position 11 is still parallel to the Y-axis), and the positional relationship between the first grasping and releasing position 401 and the second grasping and releasing position 402 in the third direction can be not limited. That is to say, in this embodiment, the first grasping and releasing position 401 and the second grasping and releasing position 402 can be in the same position in the third direction, or the position of the second grasping and releasing position 402 in the third direction can be higher than that of the first grasping and releasing position 401. As long as when the grasping device 40 is at the first grasping and releasing position 401, it will not collide with the sample container 201 located in the incubation chamber 21.
[0115] In some other alternative embodiments, it can also be achieved by adjusting the structure of the grasping device 40. For example, the grasping device 40 extending horizontally in the second direction is adjusted to extend vertically in the third direction (such as adjusting the fork-type claw structure extending in the horizontal direction to the grasping-type manipulator structure extending in the vertical direction, etc.) to solve the problem that the incubation chamber 21 needs to make way.
[0116] In some other alternative embodiments, the grasping device 40 can also be set to be movable along three directions: the first direction, the second direction, and the third direction, and thus can be freely moved within the movable space available in the frame, and grasp and transport the sample container 201 at each position.
[0117] Furthermore, in this embodiment, the setting positions of the grasping position 11 and the incubation chamber 21 in the first direction can be different. That is to say, the incubation chamber 21 can be set at any place within the frame that the grasping device 40 can reach, and the grasping position 11 can also be set at any place in the sample injection channel 10 that the grasping device 40 can reach. Since the grasping device 40 in this embodiment can move flexibly in the three-dimensional space, the handling operation of the sample container 201 between the two positions can still be achieved.
[0118] Meanwhile, in this embodiment, since the grasping device 40 can move flexibly in the three-dimensional space, it is not necessary to consider the setting of the positions of the incubation cavity 21 and the grasping position 11 in the third direction (i.e., the second grasping and releasing position 402 is lower than the first grasping and releasing position 401 in the third direction). That is to say, there is no need to pay attention to the problem of avoiding the sample container 201 in the incubation cavity 21. At the position where collision needs to be avoided, the grasping device 40 can avoid the sample container 201 in the incubation cavity 21 here by moving in the horizontal direction.
[0119] Thus, in this embodiment, the positional relationship between the first grasping and releasing position 401 and the second grasping and releasing position 402 in the third direction can be set flexibly. The size of the frame can also be set without reserving a large space in the third direction to ensure that the grasping device 40 avoids the sample container 201 in the incubation cavity 21 during the operation. The space reserved in the third direction at this time can enable the grasping device 40 to grasp the sample container 201 at positions such as the incubation cavity 21 and the grasping position 11. Therefore, the sample analyzer 1 in this embodiment can further reduce the occupation of the space inside the frame and realize the miniaturization of the device.
[0120] In some embodiments, the incubation device 20 can also be movably arranged in the frame along the first direction. At this time, after the incubation device 20 finishes the incubation treatment on the agglutinated sample, the incubation device 20 can move to a position corresponding to the sampling position 12 by moving along the first direction, so that the connection line between the incubation cavity 21 and the sampling position 12 is parallel to the Y-axis. The sampling needle can also be movably arranged along the second direction. By moving the sampling needle in the second direction, the sampling needle corresponds to the incubation cavity 21 at this time, and the sampling operation of the incubated agglutinated sample can also be realized.
[0121] For another example Figure 3 and Figure 4 As shown, in some embodiments, the sample analyzer 1 further includes at least one mixing device 30. The mixing device 30 is arranged in the frame and is controlled and connected to the control device 60. At least one mixing cavity 31 is formed thereon for accommodating the sample container 201. The mixing device 30 can mix the blood sample in the sample container 201 located in the mixing cavity 31.
[0122] The control device 60 can also be configured to, when it responds that the blood sample contained in the sample container 201 on the sample rack 2 is a micro blood sample, control the grasping device 40 to grasp the sample container 201 into the mixing cavity 31 and control the mixing device 30 to perform mixing treatment on it.
[0123] It should be understood that the mixing treatment of the mixing device 30 and the mixing treatment of the grasping device 40 have the same ultimate purpose, which is to ensure the uniformity of the distribution of blood cells in the blood sample to be sampled.
[0124] Specifically, the mixing device 30 may further include a driving component (not shown in the figure), which is used to drive the sample container 201 in the mixing chamber 31 to vibrate or rotate, and then through driving at a certain frequency, the mixing process of the blood sample in the sample container 201 is realized.
[0125] In this embodiment, the number of the mixing devices 30 is one, and only includes one mixing chamber 31, which is used for mixing trace blood samples. The grasping device 40 is used for mixing constant blood samples.
[0126] It should be understood that during the process of drawing blood from patients, for different patients or blood from different parts, the volume of the drawn blood sample is also different. Therefore, according to the volume of the blood sample, the blood sample can be divided into trace blood samples and constant blood samples. Among them, the blood volume of the trace blood sample is much smaller than that of the constant blood sample. And because the blood volume of the trace blood sample is small, before sampling and detecting it, the grasping device 40 is also used to mix it. For constant blood samples, the target effect can be achieved, but for trace blood samples, the target effect cannot be achieved due to the small blood volume.
[0127] The "target effect" here can be understood as the effect that sampling can be carried out and the uniformity of cells in the blood sample can ensure the accuracy of sampling and detection.
[0128] It should be noted that the trace blood sample can be an agglutinated sample or a non - agglutinated sample. The constant blood sample can be an agglutinated sample or a non - agglutinated sample.
[0129] It should be understood that in this embodiment, the mixing of the trace blood sample by the mixing device 30 does not limit that the mixing device 30 can only be used for mixing trace blood. The mixing of the constant blood sample by the grasping device 40 does not limit that the grasping device 40 can only be used for mixing constant blood samples. That is, in some other alternative embodiments, the mixing device 30 can also mix constant blood samples, and the grasping device 40 can also mix trace blood samples.
[0130] In some other alternative embodiments, the number of the mixing devices 30 can also be set to multiple, or the number of its mixing chambers 31 can also be set to multiple. When the mixing device 30 includes multiple mixing chambers 31, the driving component can act on multiple mixing chambers 31 simultaneously or separately.
[0131] Such as Figure 1 and Figure 3As shown, in this embodiment, the mixing chamber 31 is in the same position as the grasping position 11 and the incubation chamber 21 in the first direction, that is, the connection lines of the three are parallel to the Y-axis. The mixing chamber 31 is located on the side of the incubation chamber 21 away from the grasping position 11 in the second direction.
[0132] Correspondingly, the grasping device 40 further includes a third grasping and placing position 403 and a third transfer position 406 on its moving path (including the part shown by the dotted line in the figure). The third transfer position 406, the first transfer position 404, and the second transfer position 405 are at the same height position in the third direction, and the connection lines of the three positions are parallel to the Y-axis. The third transfer position 406 is in the same position as the third grasping and placing position 403 in the first and second directions, that is, the third transfer position 406 is located above the third grasping and placing position 403 (mixing chamber 31). When the grasping device 40 is at the third grasping and placing position 403, the grasping device 40 corresponds to the mixing chamber 31.
[0133] It should be understood that "when the grasping device 40 is at the third grasping and placing position 403, the grasping device 40 corresponds to the mixing chamber 31" means that the grasping device 40 at the third grasping and placing position 403 can perform a grasping operation on the sample container 201 at the third grasping and placing position 403 and grasp the first sample container 201.
[0134] Specifically, similar to the first grasping and placing position 401 and the second grasping and placing position 402, the third grasping and placing position 403 may not refer to a specific point, which will not be elaborated here. However, it should be understood that in this embodiment, when the grasping device 40 is in the same position as the mixing chamber 31 in both the first and second directions, the bottom position of the moving path of the grasping device 40 in the third direction is the third grasping and placing position 403.
[0135] In the specific operation process, when the sample container 201 is placed in the incubation chamber 21 and the incubation device 20 performs an incubation treatment on the sample container 201 for a preset time. Within the preset time, when the control device 60 determines that the sample container 201 located at the grasping position 11 on the sample rack 2 is a sample container 201 containing a trace amount of blood sample, the grasping device 40 can move to the first grasping and placing position 401, grasp the sample container 201 containing the trace amount of blood sample located at the grasping position 11, move upward along the third direction to the first transfer position 404, move from the first transfer position 404 to the third transfer position 406 through the second transfer position 405 along the second direction, and move downward from the third transfer position 406 to the third grasping and placing position 403 to place the sample container 201 containing the trace amount of blood sample into the mixing chamber 31. Further, the mixing device 30 performs a mixing process on the trace amount of blood sample.
[0136] Further, the grasping device 40 can transport the sample container 201 after the mixing process is completed back to the sample rack 2 in the reverse steps of the foregoing steps, which will not be elaborated here.
[0137] It should be understood that to ensure that the grasping device 40 can drive the sample container 201 to be transported between the three transfer positions, the distance between the position of the third transfer position 406 in the third direction and the position of the top end of the mixing device 30 at the mixing chamber 31 in the third direction also needs to be greater than or equal to the height of the sample container 201.
[0138] It should be understood that since the mixing chamber 31 is located on the side of the incubation chamber 21 away from the grasping position 11 in the second direction, and since the third grasping and placing position 403 is the lowest position where the grasping device 40 moves in the third direction at the position where the mixing chamber 31 is located, and since the second grasping and placing position 402 is the lowest position where the grasping device 40 moves in the third direction at the position where the incubation chamber 21 is located. Therefore, the mixing device 30 needs to be arranged such that the height position of the third grasping and placing position 403 in the third direction is equal to or lower than the set position of the second grasping and placing position 402 in the third direction. At this time, when the grasping device 40 places or grasps the sample container 201 at the second grasping and placing position 402, it will not collide with the mixing chamber 31 located on one side of the incubation chamber 21 to avoid the problem of collision between the two.
[0139] In some other alternative embodiments, the positions of the mixing device 30 and the incubation device 20 can also be controlled so that the spacing distance between the mixing chamber 31 and the incubation chamber 21 in the second direction is enlarged to achieve avoidance of the mixing device 30. At this time, when the grasping device 40 is at the second grasping and placing position 402, the grasping device 40 will not collide with the incubation device 20.
[0140] It should be understood that if the avoidance of the mixing device 30 is achieved by enlarging the spacing between the incubation chamber 21 and the mixing chamber 31 in the second direction, then the position of the mixing device 30 in the rack can be set more flexibly (provided that it is ensured that the connection line between the mixing chamber 31 and the grasping position 11 is still parallel to the Y-axis). At this time, the set position of the third grasping and placing position 403 corresponding to the mixing chamber 31 can be not specifically limited, and it can be higher than the first grasping and placing position 401, or it can be located between the first grasping and placing position 401 and the second grasping and placing position 402 in the third direction, etc.
[0141] As Figure 4 shown, in some other alternative embodiments, the position of the mixing device 30 in the rack can also be such that the mixing chamber 31 is located between the incubation chamber 21 and the grasping position 11 in the second direction.
[0142] At this time, since the first pick-and-place position 401 is the lowest position of the picking device 40 moving along the third direction at the position where the picking position 11 is located, and since the third pick-and-place position 403 is the lowest position of the picking device 40 moving along the third direction at the position where the mixing chamber 31 is located, the installation position of the mixing device 30 needs to satisfy that the height of the third pick-and-place position 403 in the third direction is equal to or lower than the height of the first pick-and-place position 401 in the third direction. At this time, it can be avoided that when the picking device 40 is at the first pick-and-place position 401 and picks up the sample container 201 on the sample rack 2 from the picking position 11 or places the sample container 201 back on the sample rack 2, the picking device 40 collides with the mixing device 30.
[0143] Similarly, since the third pick-and-place position 403 is the lowest position of the picking device 40 moving along the third direction at the position where the mixing chamber 31 is located, and since the second pick-and-place position 402 is the lowest position of the picking device 40 moving along the third direction at the position where the incubation chamber 21 is located. Therefore, the installation position of the incubation device 20 needs to satisfy that the height of the second pick-and-place position 402 in the third direction is lower than the height of the third pick-and-place position 403 in the third direction.
[0144] At this time, the height difference between the second pick-and-place position 402 and the third pick-and-place position 403 in the third direction needs to satisfy that when the picking device 40 is located at the third pick-and-place position 403 and there is a sample container 201 in the incubation chamber 21 at this time, the distance between the picking device 40 located at the third pick-and-place position 403 and the bottom end of the incubation chamber 21 in the third direction is greater than or equal to the height of the sample container 201.
[0145] By setting the height difference between the incubation chamber 21 and the mixing chamber 31 in the third direction, when there is a sample container 201 in the incubation chamber 21 and the blood sample in the sample container 201 at the picking position 11 on the sample rack 2 is a trace blood sample, during the process of the picking device 40 transporting the sample container 201 containing the trace blood sample to the mixing chamber 31 for mixing treatment, when the picking device 40 is at the third pick-and-place position 403, it can be avoided from colliding with the sample container 201 located in the incubation chamber 21.
[0146] In some other alternative embodiments, the positional relationship among the incubation chamber 21, the mixing chamber 31, and the picking position 11 can also be such that the extending direction of the connection line of the three is not parallel to the Y-axis. By increasing the moving path of the picking device 40 in the first direction, the picking device 40 can realize transporting the sample container 201 among the incubation chamber 21, the mixing chamber 31, and the picking position 11.
[0147] In some embodiments, the mixing device 30 can also perform a de-aggregation operation on the aggregated sample through mixing treatment.
[0148] It should be understood that the deagglutination treatment is used to perform deagglutination operations on the agglutinated blood cells in the agglutinated sample, so that the sample analyzer 1 can detect the blood sample after the deagglutination treatment, thereby improving the accuracy of the detection. The incubation treatment of the incubation device 20, the mixing treatment of the grasping device 40 and / or the mixing device 30, and the dilution treatment of the dilution component can all be regarded as the deagglutination treatment of the agglutinated sample. According to the different conditions of the agglutinated sample, the sample analyzer 1 can flexibly select the deagglutination treatment method, or select two or more treatment methods to be used in combination.
[0149] For example, when the agglutinated sample is a red blood cell agglutinated sample, the deagglutination treatment is at least one of the incubation treatment, the mixing treatment, and the dilution treatment, so as to disperse the agglutinated red blood cells and then perform measurement. For another example, when the agglutinated sample is a PLT agglutinated sample, the deagglutination treatment is the test channel conversion, converting the test channel to the PLT-F channel for testing, obtaining the forward scatter light and the side fluorescence of the PLT through semiconductor laser flow cytometry, forming a two-dimensional scatter plot, and then performing more accurate counting of the PLT, etc.
[0150] Therefore, in some embodiments, the incubation device 20 and the mixing device 30 can also perform the incubation treatment and the deagglutination treatment on the blood sample in the same sample container 201 at the same time. That is to say, the incubation chamber 21 and the mixing chamber 31 can be the same chamber in some embodiments. At this time, the heating component of the incubation device 20 and the driving component of the mixing device 30 both act on this chamber, so that the blood sample in the sample container 201 located in this chamber can perform the incubation treatment and the mixing treatment at the same time. At this time, when the blood sample located in this chamber is an agglutinated sample, the deagglutination operation efficiency of the agglutinated sample can be accelerated, the operation time can be shortened, and further the sampling and detection efficiency of the sample analyzer 1 can be improved.
[0151] In some embodiments, the sample analyzer 1 further includes a manual sampling device (not shown in the figure), and an injection chamber 70 (as Figure 1 shown) is provided on the manual sampling device for placing the sample container 201 containing the blood sample for which the test result is urgently needed. The injection chamber and the sampling position 12 are spaced apart in the second direction. The sampling needle of the detection device 50 can be movably provided along the second direction.
[0152] Specifically, the sampling chamber 70 is provided on the side of the sampling channel 10 away from the incubation device 20 and the mixing device 30 to facilitate user operation. When a blood sample urgently requires a test result, the operator can manually mix the urgent blood sample and place the sample container 201 after the manual mixing in the sampling chamber of the manual sampling device. At this time, the control device 60 can control the sampling needle to move in the second direction to correspond to the sampling chamber, and control the sampling needle to move downward in the third direction to collect the blood sample in the sample container 201 located in the sampling chamber.
[0153] In some embodiments, at least one incubation device 20 can also be provided on the manual sampling device to increase the number of incubation chambers 21 of the sample analyzer 1. At this time, the incubation chamber 21 on the manual sampling device needs to be spaced apart from the sampling chamber and the sampling position 12 in the second direction. Or the incubation chamber 21 can be used as the sampling chamber of the manual sampling device, so that it can be used for sampling of urgent samples and incubation treatment of agglutinated samples.
[0154] Figures 5 to 8 The sample analyzer 1 in the second embodiment of the present application is shown. The difference between this sample analyzer and the sample analyzer 1 in the first embodiment is that in this embodiment, the incubation chamber 21 of the sample analyzer 1 is movably provided in the third direction. By moving the incubation chamber 21, the movement of the sample container 201 in the incubation chamber 21 is driven, thereby achieving an avoidance effect.
[0155] Specifically, as Figure 5 and Figure 6 shown, the movement path of the incubation chamber 21 in the third direction may include an avoidance position 211 and a receiving position 212. The receiving position 212 is higher than the avoidance position 211.
[0156] As Figure 5 shown, when the grasping device 40 is located at the second grasping and placing position 402, the incubation chamber 21 is located at the receiving position 212. At this time, the grasping device 40 can perform grasping and placing operations on the sample container 201 located in the incubation chamber 21.
[0157] As Figure 6 shown, when the grasping device 40 is located at the first grasping and placing position 401 and the sample container 201 is placed in the incubation chamber 21, the incubation chamber 21 is located at the avoidance position 211. At this time, the distance between the grasping device 40 and the bottom end of the incubation chamber 21 in the third direction is greater than or equal to the height of the sample container 201, so that the grasping device 40 can avoid the sample container 201 in the incubation chamber 21.
[0158] It should be understood that when no sample container 201 is placed in the incubation chamber 21 and the grasping device 40 is not at the second grasping and releasing position 402, the incubation chamber 21 can be at the avoidance position 211 or the accommodation position 212, which is not limited herein. As long as the position is set so that it will not collide with the grasping device 40 during the normal grasping operation of the grasping device 40.
[0159] That is, since the first grasping and releasing position 401 is the lowest position where the grasping device 40 moves along the third direction at the grasping position 11, and the second grasping and releasing position 402 is the lowest position where the grasping device 40 moves along the third direction at the incubation chamber 21, the installation position of the incubation device 20 needs to meet the requirement that the position of the second grasping and releasing position 402 of the grasping device 40 in the third direction is equal to or lower than the first grasping and releasing position 401. At this time, when the grasping device 40 is at the first grasping and releasing position 401 and no sample container 201 is placed in the incubation chamber 21, regardless of whether the incubation chamber 21 is at the avoidance position 211 or the accommodation position 212, it will not collide with the incubation device 20 during the normal grasping operation of the grasping device 40.
[0160] It should be understood that the incubation chamber 21 being movably arranged along the third direction can be that the entire incubation device 20 is movably arranged along the third direction, or the wall of the incubation device 20 that defines the incubation chamber 21 is movably arranged along the third direction, or the incubation device 20 is provided with a manipulable elastic member such as a lifting member or a spring in the incubation chamber 21, so that the sample container 201 located in the incubation chamber 21 is movably arranged along the third direction, etc., which is not specifically limited herein.
[0161] Continue to refer to Figure 5 and Figure 6 , in some embodiments, when the sample analyzer 1 may further include a mixing device 30, and the mixing chamber 31 of the mixing device 30 is located on the side away from the grasping position 11 of the incubation chamber 21 in the second direction.
[0162] At this time, since the lowest end of the grasping device 40 moving along the third direction at the mixing chamber 31 is the third grasping and releasing position 403, and since the lowest end of the grasping device 40 moving along the third direction at the incubation chamber 21 is the second grasping and releasing position. Therefore, the installation position of the mixing device 30 needs to meet the requirement that the height position of the third grasping and releasing position 403 of the grasping device 40 in the third direction is equal to or lower than the height position of the second grasping and releasing position 402 in the third direction.
[0163] By defining the positional relationship between the third grasping and releasing position 403 and the second grasping and releasing position 402 in the third direction, it can be ensured that when the grasping device 40 is at the second grasping and releasing position 402 and places or grasps the sample container 201 into the incubation chamber 21, the grasping device 40 will not collide with the mixing device 30 located on one side of the incubation device 20.
[0164] like Figure 7 and Figure 8 As shown, in some other optional embodiments, the mixing chamber 31 of the mixing device 30 can also be located between the incubation chamber 21 and the grabbing position 11 in the second direction.
[0165] At this time, since the bottom end of the gripping device 40 moving along the third direction at the gripping position 11 is the first gripping position 401, and since the bottom end of the gripping device 40 moving along the third direction at the mixing chamber 31 is the third gripping position 403, the mixing device 30 needs to be set so that the height position of the third gripping position 403 of the gripping device 40 in the third direction is equal to or lower than the height position of the first gripping position 401 in the third direction.
[0166] By limiting the positional relationship between the third grabbing and placing position 403 and the first grabbing and placing position 401 in the third direction, it can be ensured that when the grabbing device 40 is at the first grabbing and placing position 401 and placing or grabbing the sample container 201 into the sample rack 2, the grabbing device 40 will not collide with the mixing device 30.
[0167] Similarly, since the bottom end of the gripping device 40 moving along the third direction at the incubation chamber 21 is the second gripping position 402, and since the bottom end of the gripping device 40 moving along the third direction at the mixing chamber 31 is the third gripping position 403, the incubation device 20 needs to be set so that the height position of the second gripping position 402 of the gripping device 40 in the third direction is equal to or lower than the height position of the third gripping position 403 in the third direction.
[0168] At this time, when the gripping device 40 is at the third gripping position 403 and no sample container 201 is placed in the incubation chamber 21, no matter the incubation chamber 21 is at the avoidance position 211 or the receiving position 212, the gripping device 40 will not collide with the incubation device 20 during the normal gripping operation at the mixing chamber 31. Figure 8 As shown, when the gripping device 40 is at the third gripping and placing position 403, and the incubation chamber 21 contains the sample container 201, the incubation chamber 21 is at the avoidance position 211, and at this time, the distance between the gripping device 40 and the bottom of the incubation chamber 21 at the avoidance position 211 in the third direction is greater than or equal to the height of the sample container 201. In this way, the gripping device 40 can avoid the sample container 201 in the incubation chamber 21 during the normal gripping operation at the mixing chamber 31.
[0169] It should be understood that in this embodiment, when the incubation chamber 21 does not contain a sample container 201 and the gripping device 40 is not located at the third gripping position 403, the incubation chamber 21 can be located at the avoidance position 211 or the receiving position 212, which is not limited here.
[0170] Figure 9 and Figure 10 shows the sample analyzer 1 in the third embodiment of the present application. The main difference between it and the sample analyzer 1 in the first embodiment is that:
[0171] In this embodiment, the grasping device 40 includes a grasping part 41, a connecting part 42, and a guide rail (not shown in the figure). Among them, the guide rail extends along the third direction and the second direction. The connecting part 42 is movably arranged on the guide rail and is movably arranged along the guide rail in the second direction and the third direction. The grasping part 41 is connected to the connecting part 42 and is movably arranged along the second direction and the third direction under the drive of the connecting part 42. The grasping part 41 is used to grasp and transport the sample container 201 by moving in the second direction and the third direction. An avoidance space 43 is defined between the grasping part 41 and the connecting part 42.
[0172] When the grasping device 40 is located at the first grasping and placing position 401, the avoidance space 43 corresponds to the incubation chamber 21, and the distance between the top end of the avoidance space 43 and the bottom end of the incubation chamber 21 in the third direction is greater than or equal to the height of the sample container 201.
[0173] It should be understood that "when the grasping device 40 is located at the first grasping and placing position 401, the avoidance space 43 corresponds to the incubation chamber 21". In this embodiment, it can be understood that at this time, the positions of the incubation chamber 21 on the X-axis and Y-axis are located within the range defined by the avoidance space 43 on the X-axis and Y-axis.
[0174] By setting the grasping device 40 to form the avoidance space 43, the sample container 201 can be placed in the incubation chamber 21, and when the grasping device 40 is located at the first grasping and placing position 401, it is not necessary to lower the height of the incubation chamber 21 (or increase the distance between the incubation chamber 21 and the grasping position 11) to avoid the grasping device 40 from colliding with the sample container 201 in the incubation chamber 21. Furthermore, the occupation of the space inside the frame can be further reduced, the miniaturization of the device can be realized, and at the same time, the incubation treatment of the agglutinated sample and the mixing detection operation of the sample to be detected can be carried out synchronously.
[0175] Furthermore, in this embodiment, the connecting part 42 includes a vertical part 421 and a horizontal part 422. Among them, the vertical part 421 extends vertically along the third direction, the horizontal part 422 extends horizontally along the second direction, and the upper end of the vertical part 421 is connected to the front end of the horizontal part 422. The horizontal part 422 is also movably arranged on the guide rail. The grasping part 41 extends horizontally along the second direction in this embodiment, and its rear end is connected to the lower end of the vertical part 421 and extends away from the vertical part 421 along the second direction.
[0176] The structure of the connecting portion 42 is such that its projection on the plane defined by the second direction and the third direction is approximately an inverted L shape, and its projection on the plane defined by the second direction and the third direction with the grasping portion 41 is approximately an inverted Z shape. With the grasping device 40 arranged in this way, the horizontal portion 422 of the connecting portion 42 is higher than the grasping portion 41 in the third direction, and the vertical portion 421 and the horizontal portion 422 of the connecting portion 42 define the avoidance space 43 with respect to the grasping portion 41.
[0177] It should be understood that the "front end" here refers to the end of the horizontal portion 422 on the side closer to the sampling channel 10 in the second direction, that is, the left end pointed to by the Y axis in the shown angle. The "rear end" refers to the end of the grasping portion 41 on the side away from the sampling channel 10 in the second direction, that is, the right end opposite to the direction pointed to by the Y axis in the shown angle. Figure 9 In the shown angle, the left end pointed to by the Y axis. The "rear end" refers to the end of the grasping portion 41 on the side away from the sampling channel 10 in the second direction, that is, the right end opposite to the direction pointed to by the Y axis in the shown angle. Figure 9 In the shown angle, the right end opposite to the direction pointed to by the Y axis.
[0178] In some other alternative embodiments, the connecting portion 42 and the grasping portion 41 may also be arranged in other shapes such as an arc shape, an irregular structure, etc. It should be understood that for the structural forms of the grasping portion 41 and the connecting portion 42, as long as at least part of the structure of the connecting portion 42 is located behind the grasping portion 41 in the second direction, and at least part of this part of the structure is higher than the grasping portion 41 in the third direction, so that when the grasping device 40 is in the first grasping and placing position 401, the sample container 201 in the incubation chamber 21 can be avoided through the height difference (i.e., the avoidance space 43) between the grasping portion 41 and at least part of the structure of the connecting portion 42, it is acceptable.
[0179] The connecting portion 42 and the grasping portion 41 may be integrally formed, or may be connected by welding, connecting members, etc., and no specific limitation is made here.
[0180] Furthermore, in this embodiment, the distance between the grasping position 11 and the incubation chamber 21 in the second direction is greater than or equal to the length of the grasping portion 41 in the second direction. And when the grasping device 40 is in the first grasping and placing position 401, the incubation chamber 21 corresponds to the horizontal portion 422 of the connecting portion 42, and the distance from the bottom end of the horizontal portion 422 to the bottom end of the incubation chamber 21 in the third direction is greater than or equal to the height of the sample container 201.
[0181] In some embodiments, when the sample analyzer 1 may further include a mixing device 30, and the mixing chamber 31 of the mixing device 30 is located on the side of the incubation chamber 21 away from the grasping position 11 in the second direction.
[0182] The present application also constructs a sample analyzer 1 under a fourth embodiment. The main difference from the first embodiment is that in this embodiment:
[0183] The grasping device 40 includes a grasping part 41 which is movably arranged along the second direction and the third direction, and can be swingably arranged back and forth along the first direction.
[0184] It should be understood that, in this embodiment, the grasping part 41 is a jaw-type structure extending along the third direction or the second direction, and the grasping action of the jaws is used to grasp the sample container 201.
[0185] When the grasping part 41 extends vertically along the third direction, when the sample container 201 is placed in the incubation chamber 21, and the grasping device 40 is located at the first grasping and placing position 401, the problem of avoiding the position of the sample container 201 in the incubation chamber 21 does not need to be considered. At this time, the distance between the grasping position 11, the incubation chamber 21 and the mixing chamber 31 in the second direction can be further reduced, so as to further reduce the occupation of the internal space of the rack and realize the miniaturization of the equipment.
[0186] In some embodiments, when the sample analyzer 1 is provided with a mixing device 30, similarly, whether the mixing chamber 31 is located between the incubation chamber 21 and the grasping position 11 in the second direction or on the side of the incubation chamber 21 far from the grasping position 11, the problem of avoiding the position of the sample container 201 in the incubation chamber 21 does not need to be considered.
[0187] However, in some embodiments, when the sample analyzer 1 is provided with a mixing device 30 and the mixing chamber 31 is located on the side of the incubation chamber 21 far from the grasping position 11, the moving distance of the grasping part 41 in the third direction needs to be controlled.
[0188] It should be understood that, in this embodiment, when the sample container 201 is placed in the incubation chamber 21, and at this time the control device 60 determines that the sample container 201 at the grasping position 11 is a micro blood sample container and needs to be grasped to the mixing chamber 31 for mixing, the grasping part 41 grasps the sample container 201 containing the micro blood sample and moves from the first transfer position 404 to the third transfer position 406. When passing through the second transfer position 405, if the moving distance of the grasping part 41 in the third direction is not controlled, the bottom end of the sample container 201 containing the micro blood sample may collide with the top end of the sample container 201 in the incubation chamber 21.
[0189] At this time, by setting that the grasping part 41 can swing along the first direction, the moving distance of the grasping part 41 in the third direction can be shortened, the space occupation can be reduced, and at the same time, the situation that the bottom end of the sample container 201 containing the micro blood sample collides with the top end of the sample container 201 in the incubation chamber 21 can be avoided.
[0190] It can be achieved through the control of the control device 60. The control device 60 can be configured to: when the grasping device 40 moves from the first transfer position 404 to the third transfer position 406 (or from the third transfer position 406 to the first transfer position 404), control the grasping part 41 to perform a yaw avoidance when passing through the second transfer position 405.
[0191] Specifically, when the grasping part 41 grasps the sample container 201 containing a trace amount of blood sample and moves along the first transfer position 404 to the third transfer position 406, when the control device 60 determines that the grasping part 41 is about to pass through the second transfer position 405, it will control the grasping part 41 to yaw along the first direction to avoid the sample container 201 in the incubation chamber 21 and prevent the two from colliding. When the control device 60 determines that the grasping part 41 has passed through the second transfer position 405, it will control the grasping part 41 to swing back along the first direction so that the sample container 201 grasped by the grasping part 41 returns to the vertically set state to ensure that it can be smoothly placed into the mixing chamber 31.
[0192] After the mixing device 30 finishes mixing the trace amount of blood sample, the movement of the grasping device 40 to move the sample container 201 containing the trace amount of blood sample from the third transfer position 406 to the first transfer position 404 is the same and will not be elaborated here.
[0193] It should be understood that "when the grasping part 41 is about to pass through the second transfer position 405" can be understood as any position before the grasping part 41 reaches the second transfer position 405, as long as starting to yaw at this position will not cause the sample container 201 grasped by the grasping part 41 to collide with other components. Similarly, "when the grasping part 41 has passed through the second transfer position 405" can be any position after the grasping part 41 passes through the second transfer position 405, as long as starting to swing back at this position will not cause the sample container 201 grasped by the grasping part 41 to collide with other components. No specific limitation is made here.
[0194] It should be understood that when the grasping part 41 passes through the second transfer position 405, the control device 60 controls the grasping part 41 to perform a yaw, which can be performed only when it is detected that there is a sample container 201 placed in the incubation chamber 21 and the grasping part 41 grasps a sample container 201. It can also not consider the placement situation of the sample container 201 in the incubation chamber 21 and / or not consider the grasping situation of the grasping part 41 on the sample container 201, and can perform deflection as long as it passes through the second transfer position 405.
[0195] In some other alternative embodiments, the grasping portion 41 may also be swingably arranged along the second direction, or swingably arranged along any direction between the second direction and the first direction, etc. It should be understood that the swinging direction of the grasping portion 41 only needs to be able to achieve the mixing of the constant blood sample and at the same time avoid the sample container 201 in the incubation chamber 21.
[0196] It can be understood that the above embodiments only represent some implementation manners of the present utility model. The description thereof is relatively specific and detailed, but it should not be construed as a limitation to the scope of the patent of the present utility model. It should be pointed out that for those of ordinary skill in the art, without departing from the concept of the present utility model, the above technical features can be freely combined, and several deformations and improvements can also be made, which all belong to the protection scope of the present utility model. Therefore, all equivalent transformations and modifications made to the scope of the claims of the present utility model shall fall within the scope covered by the claims of the present utility model.
Claims
1. A sample analyzer, characterized in that, Including: An injection channel for conveying a sample rack loaded with a sample container in a first direction. There are a grasping position and a sampling position on the injection channel, and the sampling position and the grasping position are spaced apart in the first direction. At least one sample storage space for temporarily storing the sample rack, and the sample storage space is adjacent to one side of the injection channel. At least one incubation device for incubating the agglutinated sample. The incubation device forms at least one incubation chamber for accommodating the sample container storing the agglutinated sample, and the grasping position and the incubation chamber are spaced apart in a second direction. And A grasping device for carrying the sample container, and the grasping device is movably arranged. Wherein, the first direction and the second direction are perpendicular to each other. The first direction is the length direction of the injection channel, and the second direction is the width direction of the injection channel.
2. The sample analyzer according to claim 1, characterized in that The grasping device is in the same position as the grasping position and the incubation chamber in the first direction, and the incubation chamber is located behind the grasping position in the second direction. The grasping device is used to grasp the sample container from the side of the sample container in the second direction. The grasping device is movably arranged along the second direction and a third direction. The third direction is perpendicular to the first direction and the second direction respectively, and the third direction is the height direction of the injection channel. There are a first grasping and placing position and a second grasping and placing position on the moving path of the grasping device. When the grasping device is located at the first grasping and placing position, the grasping device corresponds to the sample container located at the grasping position on the sample rack to grasp or place the sample container from / to the sample rack. When the grasping device is located at the second grasping and placing position, the grasping device corresponds to the incubation chamber to grasp or place the sample container from / to the incubation chamber.
3. The sample analyzer according to claim 2, characterized in that, The second grasping and placing position is lower than the first grasping and placing position in the third direction. When the grasping device is located at the first grasping and placing position, the distance between the grasping device and the bottom end of the incubation chamber in the third direction is greater than or equal to the height of the sample container.
4. The sample analyzer according to claim 2, wherein, The incubation chamber is movably arranged along the third direction, and its moving path includes an avoidance position and a receiving position, and the receiving position is higher than the avoidance position. There is also a second grasping and placing position on the moving path of the grasping device. When the grasping device is located at the second grasping and placing position, the incubation chamber is located at the receiving position, and the grasping device corresponds to the incubation chamber to grasp or place the sample container from / to the incubation chamber. When the grasping device is located at the first grasping and placing position and the sample container is accommodated in the incubation chamber, the incubation chamber is located at the avoidance position. The position of the second grasping and placing position in the third direction is equal to or lower than the first grasping and placing position. When the grasping device is located at the first grasping and placing position, the distance between the grasping device and the bottom end of the incubation chamber in the third direction is greater than or equal to the height of the sample container.
5. The sample analyzer according to claim 2, characterized in that, The grasping device includes a grasping part, a connecting part, and a guide rail; the guide rail extends along the third direction and the second direction; the connecting part is movably arranged on the guide rail, the grasping part is connected to the connecting part, and an avoidance space is defined between the grasping part and the connecting part; When the grasping device is at the first grasping and placing position, the avoidance space corresponds to the incubation cavity, and the distance from the top end of the avoidance space to the bottom end of the incubation cavity in the third direction is greater than or equal to the height of the sample container.
6. The sample analyzer according to claim 2, characterized in that, The sample analyzer further includes at least one mixing device, at least one mixing cavity for accommodating the sample container is formed on the mixing device, and the mixing device is used for mixing the blood sample in the sample container in the mixing cavity; The mixing cavity is in the same position as the grasping position and the incubation cavity in the first direction; the mixing cavity is located between the grasping position and the incubation cavity in the second direction, or the mixing cavity is located on the side of the incubation cavity away from the grasping position in the second direction.
7. The sample analyzer according to claim 6, characterized in that, The moving path of the grasping device further includes a second grasping and placing position and a third grasping and placing position. When the grasping device is at the second grasping and placing position, the grasping device corresponds to the incubation cavity to grasp or place the sample container from or into the incubation cavity; when the grasping device is at the third grasping and placing position, the grasping device corresponds to the mixing cavity to grasp or place the sample container from or into the mixing cavity; the position of the third grasping and placing position in the third direction is equal to or lower than that of the first grasping and placing position; The mixing cavity is located between the grasping position and the incubation cavity in the second direction; the position of the second grasping and placing position in the third direction is lower than that of the third grasping and placing position; Or, the mixing cavity is located on the side of the incubation cavity away from the grasping position in the second direction; the position of the third grasping and placing position in the third direction is equal to or lower than that of the second grasping and placing position, and the position of the second grasping and placing position in the third direction is lower than that of the first grasping and placing position.
8. The sample analyzer according to claim 6, characterized in that, The moving path of the grasping device further includes a third grasping and placing position. When the grasping device is at the third grasping and placing position, the grasping device corresponds to the mixing cavity to grasp or place the sample container from or into the mixing cavity; the position of the third grasping and placing position in the third direction is equal to or lower than that of the first grasping and placing position; The incubation cavity is movably arranged along the third direction, and its moving path includes an avoidance position and a receiving position, and the receiving position is higher than the avoidance position; The mixing cavity is located between the grasping position and the incubation cavity in the second direction; the position of the third grasping and placing position in the third direction is equal to or lower than that of the first grasping and placing position, and the position of the second grasping and placing position in the third direction is equal to or lower than that of the third grasping and placing position; when the grasping device is at the third grasping and placing position and the sample container is placed in the incubation cavity, the incubation cavity is at the avoidance position; Or, the mixing cavity is located on a side of the incubation cavity away from the grasping position in the second direction; the second grasping and releasing position is equal to or lower than the first grasping and releasing position in the third direction, and the third grasping and releasing position is equal to or lower than the second grasping and releasing position in the third direction; when the grasping device is at the first grasping and releasing position and the sample container is placed in the incubation cavity, the incubation cavity is located at the avoidance position.
9. The sample analyzer according to claim 6, wherein, The grasping device includes a grasping part, and the grasping part is swingably arranged along the first direction.
10. The sample analyzer according to claim 1, characterized in that, The sample analyzer further includes a manual sampling device, and a sampling cavity is arranged on the manual sampling device for placing a sample container, and the sampling cavity is spaced from the sampling position in the second direction; At least one incubation device is further arranged on the manual sampling device, and the incubation cavity of the incubation device is spaced from the sampling cavity and the sampling position in the second direction; Or, at least one incubation device is further arranged on the manual sampling device, and the incubation cavity of the incubation device is the sampling cavity on the manual sampling device.