SPE small column connector with exhaust and flow velocity control functions

Abstract

The utility model discloses an SPE (Solid Phase Extraction) small column connector with exhaust and flow velocity control functions, which relates to the technical field of SPE small column connectors and comprises an SPE flow velocity regulating valve, an SPE small column connector and an exhaust component, the SPE flow velocity regulating valve consists of a valve main body, an upper connecting pipe and a lower connecting pipe, and the exhaust component is used for releasing a vacuum environment between the SPE small column connector and a solid phase extraction small column. According to the utility model, the exhaust component is arranged, and the sealing and blocking cover is unscrewed to move upwards, so that the outer air hole, the inner air hole and the circulating hole are communicated, and external air can enter the solid-phase extraction small column along the outer air hole, a gap between the outer wall of the sealing and blocking cover and the SPE small column connector and the circulating hole (or the inner air hole); in this way, the vacuum state between the SPE small column connector and the solid-phase extraction small column is eliminated, then the SPE small column connector and the solid-phase extraction small column can be separated, and compared with a traditional structure without an exhaust assembly, disassembly operation is easier and more convenient.

Description

Technical Field

[0001] The utility model relates to the technical field of SPE column connectors, in particular to an SPE column connector with exhaust and flow rate control. Background Art

[0002] The SPE technology is based on the liquid-solid chromatography theory and adopts the methods of selective adsorption and selective elution to enrich, separate and purify samples. It is a physical extraction process including liquid and solid phases. The more common method is to make a liquid sample solution pass through an adsorbent, retain the measured substance therein, then select a solvent with appropriate strength to wash away impurities, and then quickly elute the measured substance with a small amount of solvent, so as to achieve the purpose of rapid separation, purification and concentration. It can also selectively adsorb interfering impurities and let the measured substance flow out; or adsorb impurities and the measured substance at the same time, and then use a suitable solvent to selectively elute the measured substance;

[0003] The SPE column connector can be used to stack one solid phase extraction column on top of another to provide different selectivities. For example, a larger empty syringe barrel can be stacked on top of a smaller solid phase extraction column and used as a storage tank with a larger capacity, or they can be used as connectors for positive pressure methods (such as from a syringe or an air / N2 pipeline).

[0004] During the use of the existing SPE column connector, it will be used in synchronization with a flow regulating valve to control the flow rate of the solid phase extraction SPE column. During use, it is necessary to first assemble the SPE column connector and the flow regulating valve, and then assemble the upper end of the flow regulating valve and the lower end of the SPE column connector with the solid phase extraction column respectively. Moreover, during the solid phase extraction process, a vacuum will be formed between the lower end of the SPE column connector and the connected solid phase extraction column, resulting in difficult subsequent disassembly. Based on this, in order to further simplify the assembly steps and achieve convenient disassembly, an SPE column connector with exhaust and flow rate control is provided. Summary of the Utility Model

[0005] The purpose of the utility model is to provide an SPE column connector with exhaust and flow rate control to solve the problems in the above background.

[0006] To achieve the above purpose, the utility model provides the following technical solution: an SPE column connector with exhaust and flow rate control, comprising an SPE flow rate regulating valve composed of a valve body main body, an upper connecting pipe and a lower connecting pipe, and an SPE column connector. The upper connecting pipe and the lower connecting pipe are respectively fixed to the upper and lower ends of the valve body main body. The inner bottom end of the SPE column connector is fixedly connected to the outer bottom end of the lower connecting pipe, and the SPE column connector is distributed outside the lower connecting pipe;

[0007] An exhaust assembly is provided between the lower connecting pipe and the SPE column connector, and the exhaust assembly is used to relieve the vacuum environment between the SPE column connector and the solid-phase extraction column;

[0008] The exhaust assembly includes an inner air hole, a circulation hole, a plugging cover, and an outer air hole;

[0009] The inner air hole is opened on the outer side of the lower connecting pipe and is communicated with the inner side of the lower connecting pipe, and the inner air hole is distributed in the inner area of the SPE column connector;

[0010] The circulation hole is opened at the bottom of the SPE column connector and is communicated with the inner cavity of the SPE column connector;

[0011] The plugging cover is threadedly connected to the outer top of the SPE column connector and extends to the inner side of the SPE column connector. The inner ring surface of the plugging cover fits against the outer side of the lower connecting pipe and covers the inner air hole area to cut off the channel between the inner air hole and the circulation hole;

[0012] The outer air hole is opened on the upper surface of the plugging cover and penetrates to the lower surface of the first step of the plugging cover. By loosening and lifting the plugging cover, the covering of the inner air hole is released, so as to realize the connection between the inner air hole and the circulation hole and the conduction with the external space.

[0013] As a further solution of the present invention: the outer wall track of the SPE column connector has a stepped structure, and the outer diameter decreases sequentially from top to bottom. The middle structure of the plugging cover has a stepped plunger structure, and the number of steps of the plugging cover is less than the number of steps of the SPE column connector;

[0014] The outer wall of the plunger at the bottom of the plugging cover has a conical structure, and the outer diameter of the plunger of the plugging cover other than the bottom corresponds to and matches the inner cavity structure of the other steps of the SPE column connector;

[0015] The inner ring diameter of the middle structure of the plugging cover matches the outer diameter of the lower connecting pipe.

[0016] As a further solution of the present invention: an annular retaining piece is integrally formed at the bottom of the plugging cover. The outer diameter of the annular retaining piece matches the inner diameter of the penultimate step of the SPE column connector, and the inner diameter of the annular retaining piece is greater than the outer diameter of the lower connecting pipe.

[0017] As a further solution of the present invention: an external thread is formed on the outer top of the SPE column connector, an internal thread matching the external thread is formed at the contact position between the plugging cover and the top of the SPE column connector, and a plurality of uniformly distributed fixing rotation blocks are integrally formed on the outer side of the plugging cover;

[0018] A limiting ring block is fixed above the sealing plug cover on the outer side of the lower connecting pipe.

[0019] As a further solution of the utility model: the height from the bottom of the limiting ring block to the top of the sealing plug cover is less than the height of the topmost stepped part of the SPE column connector, and greater than the height of the contact part between the plunger at a position other than the bottommost of the sealing plug cover and the inner cavity of the stepped inner wall of the SPE column connector.

[0020] As a further solution of the utility model: a plurality of inner air holes, circulation holes, and outer air holes are arranged along the circumferential direction, and the outer diameter of the limiting ring block is less than the distribution track diameter of the outer air holes.

[0021] Compared with the prior art, the beneficial effects of the utility model are as follows:

[0022] By arranging an exhaust assembly, by loosening the sealing plug cover to make it move upward, the outer air hole, the inner air hole, and the circulation hole are connected, so that external air can enter the inside of the solid phase extraction column along the outer air hole, the gap between the outer wall of the sealing plug cover and the SPE column connector, and the circulation hole (or the inner air hole), thus eliminating the vacuum state between the SPE column connector and the solid phase extraction column. After that, the SPE column connector and the solid phase extraction column can be separated. Compared with the traditional structure without an exhaust assembly, the disassembly operation is easier and more convenient. Description of the Drawings

[0023] Figure 1 is a schematic structural diagram of the utility model;

[0024] Figure 2 is a bottom view of the structure of the utility model;

[0025] Figure 3 is a partial part structural cross-sectional view of the utility model;

[0026] Figure 4 is a partial part cross-sectional split view of the utility model.

[0027] In the figure: 1, SPE flow rate regulating valve; 101, valve body main body; 102, upper connecting pipe; 103, lower connecting pipe; 2, SPE column connector; 3, exhaust assembly; 301, inner air hole; 302, circulation hole; 303, sealing plug cover; 304, outer air hole; 305, fixed rotating block; 306, limiting ring block; 307, annular baffle. Detailed Embodiment

[0028] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0029] Please refer to Figures 1 to 4 , in the embodiments of the present utility model, an SPE small column connector with exhaust and flow rate control includes an SPE flow rate regulating valve 1 composed of a valve body main body 101, an upper connecting pipe 102, and a lower connecting pipe 103, and an SPE small column connector 2. The upper connecting pipe 102 and the lower connecting pipe 103 are respectively fixed to the upper and lower ends of the valve body main body 101. The inner bottom end of the SPE small column connector 2 is fixedly connected to the outer bottom end of the lower connecting pipe 103, and the SPE small column connector 2 is distributed outside the lower connecting pipe 103;

[0030] An exhaust assembly 3 is provided between the lower connecting pipe 103 and the SPE small column connector 2. The exhaust assembly 3 is used to relieve the vacuum environment between the SPE small column connector 2 and the solid phase extraction small column;

[0031] The exhaust assembly 3 includes an inner air hole 301, a circulation hole 302, a plugging cover 303, and an outer air hole 304;

[0032] The inner air hole 301 is opened on the outer side of the lower connecting pipe 103 and is in communication with the inner side of the lower connecting pipe 103. The inner air hole 301 is distributed in the inner area of the SPE small column connector 2;

[0033] The circulation hole 302 is opened at the bottom of the SPE small column connector 2 and is in communication with the inner cavity of the SPE small column connector 2;

[0034] The plugging cover 303 is threadedly connected to the outer top of the SPE small column connector 2 and extends to the inner side of the SPE small column connector 2. The inner ring surface of the plugging cover 303 fits against the outer side of the lower connecting pipe 103 and forms a covering for the inner air hole 301 area, so as to cut off the channel between the inner air hole 301 and the circulation hole 302;

[0035] The outer air hole 304 is opened on the upper surface of the plugging cover 303 and penetrates to the lower surface of the first step of the plugging cover 303. By loosening and lifting the plugging cover 303, the covering of the inner air hole 301 is released, so as to realize the communication between the inner air hole 301 and the circulation hole 302 and the conduction with the external space;

[0036] The outer wall track of the SPE small column connector 2 has a stepped structure, and the outer diameter decreases sequentially from top to bottom. The middle structure of the plugging cover 303 has a stepped plunger structure, and the number of steps of the plugging cover 303 is less than the number of steps of the SPE small column connector 2;

[0037] The outer wall of the plunger at the bottommost part of the plugging and blocking cover 303 is in a conical structure, and the outer diameter of the plunger at the non-bottommost part of the plugging and blocking cover 303 corresponds to and matches the inner cavity structure of the other stepped inner walls of the SPE cartridge connector 2 one by one;

[0038] The inner ring diameter of the middle structure of the plugging and blocking cover 303 matches the outer diameter of the lower connecting pipe 103;

[0039] External threads are formed on the outer top of the SPE cartridge connector 2, internal threads matching the external threads are formed at the contact position of the plugging and blocking cover 303 with the top of the SPE cartridge connector 2, and a plurality of uniformly distributed fixing rotation blocks 305 are integrally formed on the outside of the plugging and blocking cover 303;

[0040] A limiting ring block 306 is fixedly arranged above the plugging and blocking cover 303 on the outside of the lower connecting pipe 103.

[0041] In this embodiment, it should be added that the stepped structure of the SPE cartridge connector 2 is mainly used to match solid-phase extraction cartridges with different diameters;

[0042] By integrating the SPE cartridge connector 2 with the SPE flow rate regulating valve 1, the assembly efficiency and disassembly efficiency during use can be further improved;

[0043] During disassembly, a deflecting force can be applied to the fixing rotation block 305 to loosen and move the plugging and blocking cover 303 upward (it should be added that at this time, the SPE cartridge connector 2 and the solid-phase extraction cartridge can remain relatively stationary under the action of vacuum negative pressure and friction force, that is, when the plugging and blocking cover 303 rotates, the SPE cartridge connector 2 remains stationary). As the plugging and blocking cover 303 moves upward, the bottom end of the plugging and blocking cover 303 moves upward above the inner air hole 301, and a gap appears between the outer wall of the plugging and blocking cover 303 and the SPE cartridge connector 2. At the same time, the bottom of the outer air hole 304 is released from being blocked. At this time, the outer air hole 304, the inner air hole 301, and the circulation hole 302 are connected, so that external air can enter the inside of the solid-phase extraction cartridge along the outer air hole 304, the gap between the outer wall of the plugging and blocking cover 303 and the SPE cartridge connector 2, and the circulation hole 302 (or the inner air hole 301). In this way, the vacuum state between the SPE cartridge connector 2 and the solid-phase extraction cartridge is eliminated, and then the SPE cartridge connector 2 and the solid-phase extraction cartridge can be separated. Compared with the traditional structure without an exhaust component, the disassembly operation is more relaxed and convenient;

[0044] At the same time, through the setting of the inner air hole 301, the remaining solution inside the lower connecting pipe 103 can all flow into the inside of the solid-phase extraction cartridge, realizing the full collection of the solution.

[0045] Please refer to with emphasis Figures 1 to 4, an annular baffle 307 is integrally formed at the bottom of the plugging cover 303. The outer diameter of the annular baffle 307 matches the inner diameter of the second-to-last stepped inner wall of the SPE cartridge connector 2, and the inner diameter of the annular baffle 307 is larger than the outer diameter of the lower connecting pipe 103;

[0046] The height from the bottom of the limiting ring block 306 to the top of the plugging cover 303 is less than the height of the topmost stepped part of the SPE cartridge connector 2 and greater than the height of the contact part between the plunger of the plugging cover 303 other than the bottommost part and the inner cavity of the other stepped inner walls of the SPE cartridge connector 2.

[0047] In this embodiment: the upward movement height of the plugging cover 303 can be limited by the limiting ring block 306 to prevent the plugging cover 303 from detaching from the SPE cartridge connector 2. At the same time, when the plugging cover 303 moves upward and contacts the small surface of the limiting ring block 306, it can be determined that the plugging cover 303 has released the plugging of the inner air hole 301. At this time, the position of the annular baffle 307 is aligned with the height of the inner air hole 301, so as to block the solution flowing out of the inner air hole 301 and prevent the solution from flowing upward. Moreover, the solution flowing out of the inner air hole 301 can flow out through the circulation hole 302 to avoid solution residue.

[0048] Please refer specifically to Figures 1 to 4 , a plurality of inner air holes 301, circulation holes 302, and outer air holes 304 are arranged along the circumferential direction, and the outer diameter of the limiting ring block 306 is smaller than the distribution track diameter of the outer air holes 304.

[0049] In this embodiment: through the structural settings of the plurality of inner air holes 301, circulation holes 302, and outer air holes 304, the air circulation is kept smooth.

[0050] The above is only the preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution of the present invention and its inventive concept, makes equivalent substitutions or changes, and should be covered by the protection scope of the present invention.

Claims

1. An SPE small column connector with exhaust and flow rate control, comprising an SPE flow rate regulating valve (1) composed of a valve body main body (101), an upper connecting pipe (102), and a lower connecting pipe (103), and an SPE small column connector (2). The upper connecting pipe (102) and the lower connecting pipe (103) are respectively fixed to the upper and lower ends of the valve body main body (101), and are characterized in that, The inner side of the bottom end of the SPE cartridge connector (2) is fixedly connected to the outer side of the bottom end of the lower connecting pipe (103), and the SPE cartridge connector (2) is distributed on the outer side of the lower connecting pipe (103); An exhaust assembly (3) is arranged between the lower connecting pipe (103) and the SPE cartridge connector (2), and the exhaust assembly (3) is used to relieve the vacuum environment between the SPE cartridge connector (2) and the solid phase extraction cartridge; The exhaust assembly (3) includes an inner air hole (301), a circulation hole (302), a plugging cover (303), and an outer air hole (304); The inner air hole (301) is opened on the outer side of the lower connecting pipe (103) and is communicated with the inner side of the lower connecting pipe (103), and the inner air hole (301) is distributed in the inner area of the SPE cartridge connector (2); The circulation hole (302) is opened at the bottom of the SPE cartridge connector (2) and is communicated with the inner cavity of the SPE cartridge connector (2); The plugging cover (303) is threadedly connected to the outer top of the SPE cartridge connector (2) and extends to the inner side of the SPE cartridge connector (2). The inner ring surface of the plugging cover (303) fits against the outer side of the lower connecting pipe (103) and forms a covering for the area of the inner air hole (301), so as to cut off the channels of the inner air hole (301) and the circulation hole (302); The outer air hole (304) is opened on the upper surface of the plugging cover (303) and penetrates to the lower surface of the first step of the plugging cover (303). By unscrewing and lifting the plugging cover (303), the covering of the inner air hole (301) is released, so as to realize the communication between the inner air hole (301) and the circulation hole (302) and the conduction with the external space.

2. The SPE small column connector with exhaust and flow rate control according to claim 1, wherein The outer wall track of the SPE cartridge connector (2) has a stepped structure, and the outer diameter decreases sequentially from top to bottom. The middle structure of the plugging cover (303) has a stepped plunger structure, and the number of steps of the plugging cover (303) is less than the number of steps of the SPE cartridge connector (2); The outer wall of the plunger at the bottommost part of the plugging cover (303) has a conical structure, and the outer diameter of the plunger of the plugging cover (303) other than the bottommost part corresponds to and matches the inner cavity structure of the other steps of the SPE cartridge connector (2); The inner ring diameter of the middle structure of the plugging cover (303) matches the outer diameter of the lower connecting pipe (103).

3. The SPE small column connector with exhaust and flow rate control according to claim 2, wherein, An annular retaining piece (307) is integrally formed at the bottom of the plugging cover (303). The outer diameter of the annular retaining piece (307) matches the inner diameter of the second-to-last step inner wall of the SPE cartridge connector (2), and the inner diameter of the annular retaining piece (307) is larger than the outer diameter of the lower connecting pipe (103).

4. The SPE cartridge connector with exhaust and flow rate control according to claim 3, characterized in that External threads are formed on the outer top of the SPE cartridge connector (2). Internal threads matching the external threads are formed at the contact position between the plugging cover (303) and the top of the SPE cartridge connector (2), and a plurality of uniformly distributed fixing rotation blocks (305) are integrally formed on the outer side of the plugging cover (303); A limiting ring block (306) is fixed on the outer side of the lower connecting pipe (103) above the plugging cover (303).

5. The SPE cartridge connector with exhaust and flow rate control according to claim 4, characterized in that, The height from the bottom of the limit ring block (306) to the top of the plugging cover (303) is less than the height of the topmost stepped part of the SPE column connector (2), and greater than the height of the contact part between the plunger of the plugging cover (303) other than the bottommost part and the inner cavity of the other stepped inner walls of the SPE column connector (2).

6. The SPE small column connector with exhaust and flow rate control according to claim 5, characterized in that, A plurality of inner air holes (301), circulation holes (302), and outer air holes (304) are provided along the circumferential direction, and the outer diameter of the limit ring block (306) is less than the diameter of the distribution locus of the outer air holes (304).

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