Multi-channel concentric ring parallel segmentation ring chromatographic column

Abstract

The utility model relates to the technical field of chromatography, and discloses a multichannel concentric ring parallel segmentation ring chromatographic column, which comprises a chromatographic column tube, a sieve plate and a mounting rack, the mounting rack is mounted above the sieve plate at the bottom in the chromatographic column, a plurality of mounting grooves are arranged on the mounting rack, the mounting grooves are symmetrically arranged on four sides of the mounting rack, and the sieve plate is arranged on the mounting rack. According to the technical scheme, by arranging the rotary knobs, the multiple fixing plates can be driven to move when the rotary knobs are rotated, fixing is more convenient and faster, the inner pipe and the column core can be automatically adjusted according to needs by arranging the mounting frame with the multiple mounting grooves, and the fixing effect is better. The structures are matched with one another, time is saved, and efficiency is higher.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatography, in particular to a multi-channel concentric ring parallel split ring chromatographic column. Background Technique

[0002] Liquid chromatography technology is an efficient separation and purification technology, which has become an important separation and analysis technology in the fields of chemistry, medicine, industry, agronomy, commodity inspection and legal inspection. A liquid chromatograph consists of parts such as a liquid delivery pump, a chromatographic column, an injector, a detector, etc. Among them, the chromatographic column is the core part of liquid chromatography and also the core problem in the research of chromatography technology for many years. The target substance is separated in the chromatographic column, so the performance of the chromatographic column will affect the separation efficiency of chromatography. The radial non-uniformity of the chromatographic column leads to tailing of chromatographic peaks and loss of column efficiency, which is described as the "wall effect". Farkas observed through the use of optical fibers and on-column local fluorescence detection that in a slurry-packed column, the linear velocity of the mobile phase in the near-wall region is about 2-8% lower than that in the central region. The radial distribution of the local flow rate and local column efficiency is parabolic. In addition, a higher degree of packing non-uniformity will increase the axial width of the sample band and reduce the column efficiency of the chromatographic column. Research shows that as the efficiency of the chromatographic column increases, the influence of the radial non-uniformity of the chromatographic column increases. Therefore, the packing non-uniformity greatly reduces the efficiency of the chromatographic column, especially on high-performance chromatographic columns. According to the velocity changes of the mobile phase in the column observed by previous researchers through experiments, the loss range of column efficiency is about 10-50%. And the column efficiency loss caused by this radial non-uniformity is widespread and difficult to correct.

[0003] Most of the existing devices fix the inner tube and the column core through fixing buckles. When it is necessary to fix them, it is necessary to manually fix the fixing buckles in each installation groove in turn, and the efficiency is low. Therefore, a multi-channel concentric ring parallel split ring chromatographic column is needed. Content of the Utility Model

[0004] The purpose of the utility model is to provide a multi-channel concentric ring parallel split ring chromatographic column, which solves the problems put forward in the background technique.

[0005] The embodiment of the present application provides a multi-channel concentric ring parallel split ring chromatographic column. This device consists of a chromatographic column tube, a sieve plate, and a mounting rack. The mounting rack is installed above the sieve plate at the inner bottom of the chromatographic column. A number of installation grooves are opened on the mounting rack. The installation grooves are symmetrically arranged on the four sides of the mounting rack, and multiple groups of installation grooves are provided. A knob is rotatably installed at the lower end of the mounting rack.

[0006] In this technical solution, according to requirements such as the size of the chromatographic column tube and the separation precision, the sizes of the column core and the inner tube and the number of inner tubes can be adjusted to obtain a multi-channel parallel split-ring chromatographic column with the best peak elution effect. When it is necessary to fix the inner tube and the column core, turn the knob. The knob drives the connecting rod to rotate, thereby driving the first bevel gear mounted thereon to rotate, and then driving the second bevel gear meshing with it to rotate. When the second bevel gear rotates, it drives the threaded rod to rotate, thereby driving the fixed plate mounted thereon to move, so as to realize the fixation of the inner tube. At the same time, when the lengths of the inner tube and the column core are relatively long, there may be a situation where the fixed plate is too short and the fixing effect is not good. At this time, an extension plate can be installed in the fixing groove on the fixed plate using a threaded groove (not shown in the figure) and a bolt (not shown in the figure) so that it can adapt to the length.

[0007] Optionally, a connecting rod is fixedly installed on the knob, a first bevel gear is fixedly installed on the connecting rod, and the first bevel gear meshes with four second bevel gears.

[0008] By adopting the above technical solution, when the knob is rotated, the knob drives the connecting rod to rotate, thereby driving the first bevel gear mounted thereon to rotate, and then driving the second bevel gear meshing with it to rotate.

[0009] Optionally, a threaded rod is fixedly installed on the second bevel gear, and a fixed plate is threadedly installed on the threaded rod.

[0010] By adopting the above technical solution, when the second bevel gear rotates, it drives the threaded rod to rotate, thereby driving the fixed plate mounted thereon to move, so as to realize the fixation of the inner tube.

[0011] Optionally, a threaded rod and a fixed plate structure are provided on each second bevel gear.

[0012] By adopting the above technical solution, the first bevel gear can be rotated to drive the multi-directional fixed plates to move, so that the fixing effect is better.

[0013] Optionally, the fixed plate is slidably installed on the installation groove, and a protection pad is provided on the side of the fixed plate close to the center of the mounting bracket.

[0014] By adopting the above technical solution, it is prevented from damaging the inner tube and the column core during fixation.

[0015] Optionally, a column core can be installed on the mounting bracket, and an inner tube can be installed in the installation groove on the mounting bracket beside the column core.

[0016] By adopting the above technical solution, according to requirements such as the size of the chromatographic column tube and the separation precision, the sizes of the column core, the inner tube and the number of inner tubes can be adjusted to obtain a multi-channel parallel split-ring chromatographic column with the best peak elution effect.

[0017] Compared with the prior art, the beneficial effects of the technical solution of the present application are as follows:

[0018] Through the setting of the knob in the technical solution of the present application, when the knob is rotated, it can drive the movement of multiple fixing plates, making the fixing more convenient and fast. By setting the mounting frame with multiple mounting grooves, the inner tube and the column core can be adjusted according to needs. The various structures cooperate with each other, saving time and being more efficient. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Other features, objects, and advantages of the present utility model will become more apparent by reading the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0020] Figure 1 It is a schematic structural diagram of a multi-channel concentric ring parallel segmented ring chromatographic column of the present utility model;

[0021] Figure 2 It is a schematic structural diagram of a multi-channel concentric ring parallel segmented ring chromatographic column of the present utility model;

[0022] Figure 3 It is a schematic structural diagram of the bevel gear part in a multi-channel concentric ring parallel segmented ring chromatographic column of the present utility model;

[0023] Figure 4 It is a sectional view of the mounting frame in a multi-channel concentric ring parallel segmented ring chromatographic column of the present utility model.

[0024] In the figure: 1, mounting frame; 2, mounting groove; 3, knob; 4, connecting rod; 5, second bevel gear; 6, threaded rod; 7, fixing plate; 8, column core; 9, inner tube. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] Please refer to Figures 1-4 , the present utility model provides a technical solution: a multi-channel concentric ring parallel segmented ring chromatographic column. This device is composed of a chromatographic column tube, a sieve plate, and a mounting frame 1. The mounting frame 1 is installed above the sieve plate at the inner bottom of the chromatographic column. A number of mounting grooves 2 are provided on the mounting frame 1. The mounting grooves 2 are symmetrically arranged on the four sides of the mounting frame 1, and multiple groups of mounting grooves 2 are provided. A knob 3 is rotatably installed at the lower end of the mounting frame 1.

[0026] In the technical solution of the present utility model, as Figure 3 shown, a connecting rod 4 is fixedly installed on the knob 3, and a first bevel gear is fixedly installed on the connecting rod 4. The first bevel gear meshes with four second bevel gears 5. When the knob 3 is rotated, the knob 3 drives the connecting rod 4 to rotate, thereby driving the first bevel gear installed thereon to rotate, and then driving the second bevel gears 5 meshing with it to rotate.

[0027] In the technical solution of the present utility model, as Figure 3 shown, a threaded rod 6 is fixedly installed on the second bevel gear 5, and a fixing plate 7 is threadedly installed on the threaded rod 6. When the second bevel gear 5 rotates, it will drive the threaded rod 6 to rotate, thereby driving the fixing plate 7 installed thereon to move, so as to realize the fixation of the inner tube 9.

[0028] In the technical solution of the present utility model, as Figure 3 shown, a threaded rod 6 and a fixing plate 7 structure are provided on each second bevel gear 5, and the multi-directional fixing plate 7 can be driven to move by the rotation of the first bevel gear, so that the fixing effect is better.

[0029] In the technical solution of the present utility model, as Figure 3 shown, the fixing plate 7 is slidably installed on the installation groove 2, and a protection pad is provided on the side of the fixing plate 7 close to the center of the installation frame 1 to prevent damage to the inner tube 9 and the column core 8 during fixation.

[0030] In the technical solution of the present utility model, as Figure 4 shown, the column core 8 can be installed on the installation frame 1, and the inner tube 9 can be installed in the installation groove 2 on the installation frame 1 beside the column core 8. According to the requirements such as the size of the chromatographic column tube and the separation accuracy, the size of the column core 8, the size of the inner tube 9 and the number of the inner tubes 9 can be adjusted to obtain a multi-channel parallel split ring chromatographic column with the best peak elution effect.

[0031] In this technical solution, according to the requirements such as the size of the chromatographic column tube and the separation accuracy, the size of the column core 8, the size of the inner tube 9 and the number of the inner tubes 9 can be adjusted to obtain a multi-channel parallel split ring chromatographic column with the best peak elution effect. When it is necessary to fix the inner tube 9 and the column core 8, rotate the knob 3, and the knob 3 drives the connecting rod 4 to rotate, thereby driving the first bevel gear installed thereon to rotate, and then driving the second bevel gear 5 meshing with it to rotate. When the second bevel gear 5 rotates, it will drive the threaded rod 6 to rotate, thereby driving the fixing plate 7 installed thereon to move, so as to realize the fixation of the inner tube 9. At the same time, when the lengths of the inner tube 9 and the column core 8 are relatively long, there may be a situation where the fixing plate 7 is too short and the fixing effect is not good. At this time, an extension plate can be installed in the fixing groove on the fixing plate 7 using a threaded groove (not shown in the figure) and a bolt (not shown in the figure) to make it adaptable to the length.

Claims

1. A multi-channel concentric ring parallel segmented ring chromatographic column, characterized in that: This device consists of a chromatographic column tube, a sieve plate, and a mounting rack (1). The mounting rack (1) is installed above the sieve plate at the inner bottom of the chromatographic column. A number of mounting grooves (2) are provided on the mounting rack (1). The mounting grooves (2) are symmetrically arranged on the four sides of the mounting rack (1), and multiple groups of mounting grooves (2) are provided. A knob (3) is rotatably installed at the lower end of the mounting rack (1).

2. The multi-channel concentric ring parallel segmented ring chromatographic column according to claim 1, wherein A connecting rod (4) is fixedly installed on the knob (3). A first bevel gear is fixedly installed on the connecting rod (4). The first bevel gear meshes with four second bevel gears (5).

3. The multi-channel concentric ring parallel split-ring chromatographic column according to claim 2, characterized in that, A threaded rod (6) is fixedly installed on the second bevel gear (5). A fixing plate (7) is threadedly installed on the threaded rod (6).

4. A multi-channel concentric ring parallel segmented ring chromatographic column according to claim 3, characterized in that, A threaded rod (6) and a fixing plate (7) structure are provided on each second bevel gear (5).

5. A multi-channel concentric ring parallel segmented ring chromatographic column according to claim 4, characterized in that, The fixing plate (7) is slidably installed on the mounting groove (2), and a protective pad is provided on the side of the fixing plate (7) close to the center of the mounting rack (1).

6. A multi-channel concentric ring parallel segmented ring chromatographic column according to claim 1, characterized in that, A column core (8) can be installed on the mounting rack (1), and an inner tube (9) can be installed in the mounting groove (2) on the mounting rack (1) beside the column core (8).

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