Continuous extraction device for medicine synthesis

Abstract

The utility model discloses a continuous extraction device for medicine synthesis, which comprises a bottom plate, the bottom plate is connected with an extraction box and a backflow box through a support, one side of the extraction box is connected with an extraction liquid feeding pipe and a stock solution feeding pipe, the upper side and the lower side of the extraction box are respectively connected with a U-shaped siphon and a stock solution outlet pipe, and the U-shaped siphon is connected with an electric air control valve. The end of the U-shaped siphon is connected to the upper side of the backflow box, one side of the U-shaped siphon is connected with an extraction liquid outflow pipe through a first one-way electric control valve, the upper side of the backflow box is connected with a plurality of diversion boxes, the diversion boxes are connected with a plurality of cleaning nozzles through pipelines, one side of the outer wall of the backflow box is connected with a motor, and the output end of the motor is connected with a transmission mechanism. The transmission mechanism is provided with two output ends, the first transmission rod and the second transmission rod are connected with a large-hole filter plate and a small-hole filter plate respectively, the edge of the large-hole filter plate and the edge of the small-hole filter plate are movably clamped to the inner wall of the backflow box, and the lower side of the backflow box is connected with a backflow pipe.

Description

Technical Field

[0001] The utility model belongs to the technical field of pharmaceutical synthesis, and particularly relates to a continuous extraction device for pharmaceutical synthesis. Background Art

[0002] Extraction is a method of transferring a compound from one immiscible (or slightly soluble) solvent to another by exploiting the differences in solubility or partition coefficient between the two solvents. Through repeated extractions, the majority of the compound is extracted. Extraction, also known as solvent extraction or liquid-liquid extraction (to distinguish it from solid-liquid extraction, or leaching), or extraction (commonly used in the petroleum refining industry), is a mass transfer separation process in which a liquid extractant is used to treat an immiscible binary or multicomponent solution to separate the components. It is a widely used unit operation.

[0003] In order to ensure the purity of the extract, the liquid-liquid extraction device used in the prior art for pharmaceutical synthesis generally performs a single extraction and then filters out impurities in the extract before performing another extraction. This is time-consuming and labor-intensive, and has low extraction efficiency. Therefore, a continuous extraction device for pharmaceutical synthesis is provided herein to solve the above technical problems. Utility Model Content

[0004] In view of the problems raised by the above background technology, the purpose of the present invention is to provide a continuous extraction device for pharmaceutical synthesis.

[0005] In order to achieve the above technical objectives, the technical solutions adopted by this utility model are as follows:

[0006] A continuous extraction device for pharmaceutical synthesis comprises a base plate, the base plate being connected to an extraction box and a reflux box via a bracket, an extraction liquid feed pipe and a stock liquid feed pipe being connected to one side of the extraction box, a U-shaped siphon tube and a stock liquid outlet pipe being connected to the upper and lower sides of the extraction box, respectively, the U-shaped siphon tube being connected to an electric air control valve, the end of the U-shaped siphon tube being connected to the upper side of the reflux box, one side of the U-shaped siphon tube being connected to an extraction liquid outlet pipe via a first one-way electric control valve, and the U-shaped siphon tube being connected to a second one-way electric control valve adjacent to the first one-way electric control valve;

[0007] The upper side of the reflux box is connected to multiple diversion boxes, the diversion box pipes are connected to multiple cleaning nozzles, and the pipes of multiple diversion boxes are externally connected to a water tank. A motor is connected to one side of the outer wall of the reflux box, and the output end of the motor is connected to a transmission mechanism. The transmission mechanism is provided with two output ends, and the two output ends of the transmission mechanism are respectively connected to a first transmission rod and a second transmission rod, and the first transmission rod and the second transmission rod are respectively connected to a large-pore filter plate and a small-pore filter plate, and the edges of the large-pore filter plate and the small-pore filter plate are movably clamped on the inner wall of the reflux box, and the lower side of the reflux box is connected to a reflux pipe, and the end of the reflux pipe is connected to the extraction liquid feed pipe through a water pump and a second electric valve, and the lower side of the reflux pipe is connected to a clean drain pipe through an electric-controlled valve, and the clean drain pipe is connected to a waste water tank.

[0008] It is further defined that one end of the U-shaped siphon tube is connected to a pipe adapter, and the pipe adapter is detachably connected to an extension tube. A sealed switch door is hinged on one side of the extraction box. Such a structural design can replace extension tubes of different lengths according to the height of the extraction liquid to be extracted, thereby adjusting the height position of the water inlet of the U-shaped siphon tube.

[0009] It is further defined that the plurality of diverter boxes are respectively connected to the two ends of the upper side of the reflux box, and each of the diverter boxes is arranged at a certain tilt angle. Such a structural design has a larger cleaning angle and improves the cleaning efficiency.

[0010] It is further defined that the transmission mechanism includes a driving gear connected to the motor output rod, the driving gear is connected to the end of the first transmission rod, the driving gear is connected to the driven gear through a transmission belt, and the driven gear is connected to the end of the second transmission rod. Such a structural design uses the motor as the power end to simultaneously drive the first transmission rod and the second transmission rod to rotate, saving energy.

[0011] It is further defined that the upper sides of the large-pore filter plate and the small-pore filter plate are connected with a conical guide block. Such a structural design can prevent the accumulation of flow and material in the middle position of the large-pore filter plate and the small-pore filter plate from affecting the filtration efficiency.

[0012] The beneficial effects of the utility model are:

[0013] 1. The utility model mainly includes an extraction box and a reflux box. The extraction box and the reflux box are connected with connection components such as a U-shaped siphon, an electric air control valve, a reflux pipe, a water pump and an electric control valve. The cooperation of each component can realize continuous and repeated extraction of the extract, and filter out impurity particles of different diameters through a large-pore filter plate and a small-pore filter plate, so as to achieve the effect of automatic continuous multiple extraction and impurity filtration, and finally extract a pharmaceutical synthetic extract with high purity, saving time and labor and having high production efficiency;

[0014] 2. In addition, the reflux box is connected with a motor, a transmission mechanism, a first transmission rod and a second transmission rod, a water tank, a diversion box, a cleaning nozzle and other related components to cooperate with each other to achieve the effect of automatically cleaning the large-pore filter plate, the small-pore filter plate and the inner wall of the reflux box, and automatically collecting wastewater and impurity residues, thereby saving cleaning efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The present invention can be further described by way of non-limiting examples given in the accompanying drawings;

[0016] Figure 1 This is a schematic cross-sectional view of the overall structure of an embodiment of a continuous extraction device for pharmaceutical synthesis according to the present invention;

[0017] Figure 2 This is an embodiment of a continuous extraction device for pharmaceutical synthesis according to the present invention. Figure 1 The structural diagram of A in FIG.

[0018] Figure 3 This is a structural diagram of related components such as a transmission mechanism in an embodiment of a continuous extraction device for pharmaceutical synthesis of the present utility model.

[0019] The main component symbols are described as follows:

[0020] Base plate 1, bracket 101;

[0021] Extraction box 2, extraction liquid feed pipe 201, raw liquid feed pipe 202, U-shaped siphon tube 203, pipe adapter 2031, extension tube 2032, raw liquid outlet pipe 204, electric air control valve 205, sealed switch door 206, first one-way electric control valve 207, extraction liquid outlet pipe 208, second one-way electric control valve 209;

[0022] Reflux box 3, diverter box 301, cleaning nozzle 302, reflux pipe 303, water pump 3031, electric control valve 304, cleaning drain pipe 305;

[0023] First transmission rod 401, second transmission rod 402, large-pore filter plate 403, small-pore filter plate 404, conical guide block 405;

[0024] Wastewater tank 5;

[0025] Driving gear 601, transmission belt 602, driven gear 603; DETAILED DESCRIPTION

[0026] In order to enable those skilled in the art to better understand the present invention, the technical solution of the present invention is further described below with reference to the accompanying drawings and embodiments.

[0027] like Figure 1-3As shown, the present invention is a continuous extraction device for pharmaceutical synthesis, comprising a base plate 1, which is connected to an extraction box 2 and a reflux box 3 via a bracket 101. An extract liquid feed pipe 201 and a stock liquid feed pipe 202 are connected to one side of the extraction box 2. A U-shaped siphon tube 203 and a stock liquid outlet pipe 204 are connected to the upper and lower sides of the extraction box 2, respectively. The U-shaped siphon tube 203 is connected to an electric air control valve 205. The end of the U-shaped siphon tube 203 is connected to the upper side of the reflux box 3. One side of the U-shaped siphon tube 203 is connected to an extract liquid outlet pipe 208 via a first one-way electric-controlled valve 207. The U-shaped siphon tube 203 is connected to a second one-way electric-controlled valve 209 next to the first one-way electric-controlled valve 207.

[0028] A plurality of diversion boxes 301 are connected to the upper side of the reflux box 3, and a plurality of cleaning nozzles 302 are connected to the pipes of the diversion boxes 301. The pipes of the plurality of diversion boxes 301 are externally connected to a water tank. A motor is connected to one side of the outer wall of the reflux box 3, and the output end of the motor is connected to a transmission mechanism. The transmission mechanism has two output ends, and the two output ends of the transmission mechanism are respectively connected to a first transmission rod 401 and a second transmission rod 402. The first transmission rod 401 and the second transmission rod 402 are respectively connected to a large-pore filter plate 403 and a small-pore filter plate 404. The edges of the large-pore filter plate 403 and the small-pore filter plate 404 are movably clamped on the inner wall of the reflux box 3. A reflux pipe 303 is connected to the lower side of the reflux box 3, and the end of the reflux pipe 303 is connected to the extraction liquid feed pipe 201 through a water pump 3031 and a second electric valve. The lower side of the reflux pipe 303 is connected to a clean drain pipe 305 through an electric-controlled valve 304, and the clean drain pipe 305 is connected to the waste water tank 5.

[0029] In the embodiment of this case, the staff adds the extract and the stock solution into the extraction box 2 through the extract feed pipe 201 and the stock solution feed pipe 202 respectively, and then shakes the extraction box 2 to cause a chemical reaction between the stock solution and the extract. After the reaction is allowed to proceed for a period of time, the central controller opens the electric air control valve 205 and the second one-way electric control valve 209. The U-shaped siphon tube 203 and the electric air control valve 205 cooperate to pump the reacted extract into the reflux box 3. At the same time, the stock solution is discharged through the stock solution outlet pipe 204, and new stock solution is added to the extraction box 2 through the stock solution feed pipe 202.

[0030] At this time, the extract entering the reflux box 3 passes through the large-pore filter plate 403 and the small-pore filter plate 404 in sequence, and the impurities of different diameters are filtered out by the extract and remain on the large-pore filter plate 403 and the small-pore filter plate 404 respectively. The filtered extract remains in the reflux box 3. When all the extracts are filtered, the water pump 3031 is controlled to start, and the filtered extract is discharged into the extract feed pipe 201 through the reflux pipe 303, and then enters the extraction box 2 from the extract feed pipe 201 for re-extraction. After the extraction is completed, the first one-way electric control valve 207 is opened and the second one-way electric control valve 209 is closed by the central controller, so that the electric air control valve 205 in the U-shaped siphon tube 203 draws the extract into the extract container through the extract outlet pipe 208. Such a structural design can achieve the effect of automatic and continuous multiple extractions and filtering of impurities, and finally extract a pharmaceutical synthetic extract with higher purity, saving time and labor, and having high production efficiency.

[0031] In addition, when the device is finished using, the central controller controls to close the water pump 3031 and the second electric valve, and open the electric control valve 304, and at the same time start the motor and the water pump in the water tank. The motor drives the first transmission rod 401 and the second transmission rod 402 to rotate through the transmission mechanism. When the first transmission rod 401 and the second transmission rod 402 rotate, the large-pore filter plate 403 and the small-pore filter plate 404 rotate accordingly. The water pump in the water tank draws water into the diversion box 301 through the pipe, and then sprays it onto the large-pore filter plate 403, the small-pore filter plate 404 and the inner wall of the return box 3 through each cleaning nozzle 302 for cleaning. The clean wastewater is collected into the wastewater tank 5 through part of the return pipe 303 and the clean drain pipe 305. Such a structural design can facilitate the automatic cleaning of the large-pore filter plate 403, the small-pore filter plate 404 and the inner wall of the return box 3, and automatically collect wastewater and impurity residues.

[0032] Preferably, one end of the U-shaped siphon tube 203 is connected to a pipe adapter 2031, to which an extension tube 2032 is detachably connected. A sealed opening and closing door 206 is hingedly connected to one side of the extraction box 2. This structural design allows the extension tube 2032 of different lengths to be replaced according to the required extraction liquid height, thereby adjusting the height position of the water inlet of the U-shaped siphon tube 203. In fact, other structural shapes that facilitate adjustment of the length of one end of the U-shaped siphon tube 203 can also be considered according to specific circumstances.

[0033] Preferably, multiple diverter boxes 301 are connected to both ends of the upper side of the reflux box 3, and each diverter box 301 is arranged at a certain angle. This structural design has a larger cleaning angle and improves cleaning efficiency. In fact, other structural shapes that are convenient for improving cleaning efficiency can also be considered according to specific circumstances.

[0034] Preferably, the transmission mechanism includes a driving gear 601 connected to the motor output rod, the driving gear 601 being connected to the end of the first transmission rod 401, the driving gear 601 being connected to a driven gear 603 via a transmission belt 602, and the driven gear 603 being connected to the end of the second transmission rod 402. This structural design uses the motor as the power end to simultaneously drive the first transmission rod 401 and the second transmission rod 402 to rotate, saving energy. In fact, other structural shapes that can achieve the desired transmission effect while saving energy can also be considered according to specific circumstances.

[0035] Preferably, conical guide blocks 405 are connected to the upper sides of the large-pore filter plate 403 and the small-pore filter plate 404. This structural design can prevent the accumulation of fluid and material between the large-pore filter plate 403 and the small-pore filter plate 404, which can affect the filtration efficiency. In fact, other structural shapes that can prevent the filtration efficiency of the large-pore filter plate 403 and the small-pore filter plate 404 from being affected can also be considered according to specific circumstances.

[0036] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the present invention. Anyone skilled in the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by persons skilled in the art without departing from the spirit and technical principles disclosed herein shall be covered by the claims of the present invention.

Claims

1. A continuous extraction device for pharmaceutical synthesis, comprising a base plate (1), wherein the base plate (1) is connected to an extraction box (2) and a reflux box (3) via a bracket (101), and one side of the extraction box (2) is connected to an extraction liquid feed pipe (201) and a raw liquid feed pipe (202), characterized in that: The upper and lower sides of the extraction box (2) are respectively connected to a U-shaped siphon tube (203) and a raw liquid outlet pipe (204); the U-shaped siphon tube (203) is connected to an electric air control valve (205); the end of the U-shaped siphon tube (203) is connected to the upper side of the reflux box (3); one side of the U-shaped siphon tube (203) is connected to an extract outlet pipe (208) via a first one-way electric control valve (207); and the U-shaped siphon tube (203) is connected to a second one-way electric control valve (209) next to the first one-way electric control valve (207); The upper side of the reflux box (3) is connected to a plurality of diversion boxes (301), the pipelines of the diversion boxes (301) are connected to a plurality of cleaning nozzles (302), the pipelines of the plurality of diversion boxes (301) are externally connected to a water tank, a motor is connected to one side of the outer wall of the reflux box (3), the output end of the motor is connected to a transmission mechanism, the transmission mechanism is provided with two output ends, the two output ends of the transmission mechanism are respectively connected to a first transmission rod (401) and a second transmission rod (402), the first transmission rod (401) and the second transmission rod (402) are respectively connected to a large-pore filter The large-pore filter plate (403) and the small-pore filter plate (404) are both movably connected to the inner wall of the reflux box (3). The lower side of the reflux box (3) is connected to a reflux pipe (303). The end of the reflux pipe (303) is connected to the extract feed pipe (201) through a water pump (3031) and a second electric valve. The lower side of the reflux pipe (303) is connected to a clean drain pipe (305) through an electric control valve (304). The clean drain pipe (305) is connected to a wastewater tank (5).

2. A continuous extraction device for pharmaceutical synthesis according to claim 1, characterized in that: One end of the U-shaped siphon tube (203) is connected to a pipe adapter (2031), and the pipe adapter (2031) is detachably connected to an extension tube (2032). A sealed switch door (206) is hinged on one side of the extraction box (2).

3. A continuous extraction device for pharmaceutical synthesis according to claim 2, characterized in that: The plurality of diversion boxes (301) are respectively connected to the two ends of the upper side of the reflux box (3), and each of the diversion boxes (301) is arranged at a certain tilt angle.

4. A continuous extraction device for pharmaceutical synthesis according to claim 3, characterized in that: The transmission mechanism comprises a driving gear (601) connected to the motor output rod, the driving gear (601) being connected to the end of a first transmission rod (401), the driving gear (601) being connected to a driven gear (603) via a transmission belt (602), and the driven gear (603) being connected to the end of a second transmission rod (402).

5. A continuous extraction device for pharmaceutical synthesis according to claim 4, characterized in that: The upper sides of the large-pore filter plate (403) and the small-pore filter plate (404) are both connected with a conical guide block (405).

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