Chromatographic column heat column box

Abstract

The utility model relates to the technical field of thermal column boxes, in particular to a chromatographic column thermal column box which comprises a box body, a box door is hinged to one side of an opening of the box body, a partition box dividing the box body into an equipment cavity and a working cavity is arranged in the box body, a plurality of placing holes used for placing chromatographic columns are formed in the top of the partition box, and the box door is hinged to the box door. Gaps are formed between the left and right side walls of the partition box and the side wall of the box body; the heating device is arranged in the equipment cavity; through the arrangement, the heating is more uniform, the temperature raising speed is higher, the working efficiency is improved, the energy loss is reduced, the three-surface heating is beneficial to keeping good column efficiency, and a positive effect is achieved on the column passing effect and the prolonging of the service life of the chromatographic column; moreover, the problems that the chromatographic column is directly grilled by a heating device to be damaged and the local temperature is relatively high are solved, and the risk that workers are scalded is avoided.

Description

Technical Field

[0001] The utility model relates to a chromatography column hot column box, belonging to the technical field of hot column boxes. Background Art

[0002] As a professional heat preservation device, the main function of the hot column oven is to maintain a constant operating temperature of the column solution in the glass chromatography column. It is used to prevent the influence of excessive high or low temperature on the column solution, ensure the concentration uniformity of the column solution, improve column efficiency, and ensure the stability of product quality. However, the current heating and heat preservation is still achieved by wrapping additional heating tape around the chromatography column. This heating method can easily damage the glass chromatography column, make it difficult to observe the status of the solution passing through the column, and has imprecise temperature control, making it unsuitable for solutions requiring high temperature stability. In addition, the heating tape is often removed and wrapped, which may cause aging and short circuit, which is very easy to cause danger. Therefore, it is of great practical significance to develop a new type of hot column oven. Utility Model Content

[0003] The utility model aims to solve the deficiencies in the prior art and provides a chromatography column hot column box.

[0004] The technical solution of the utility model for solving the above-mentioned technical problems is as follows: a chromatography column hot column box, comprising: a box body, a box door hinged on one side of the box opening, a partition box arranged inside the box body to separate the box body into an equipment chamber and a working chamber, a plurality of placement holes for placing chromatography columns are opened on the top of the partition box, and there is a gap between the left and right side walls of the partition box and the side walls of the box body; a heating device, the heating device is arranged in the equipment chamber.

[0005] Furthermore, it also includes a thermal circulation device, which includes a driving mechanism and a fan connected to the driving mechanism. The output shaft of the driving mechanism passes through the back plate of the box and is connected to the fan arranged in the equipment cavity. The air suction end of the fan is connected to the partition box through a mounting hole opened on the back plate of the partition box. The left and right side walls of the partition box are provided with regularly arranged ventilation holes.

[0006] Furthermore, the ventilation opening is a strip-shaped hole, and one side of the ventilation opening is connected to a guide plate that is inclined toward the door.

[0007] Furthermore, the heating device is a U-shaped electric heating tube, and the U-shaped electric heating tube is arranged in the gap between the left and right side walls of the compartment and the side wall of the box body.

[0008] Furthermore, the chromatography columns are grouped in pairs, the center point of the mounting hole coincides with the vertical center line of the horizontal projection of each group of chromatography columns on the back plate of the compartment box, and the center point of the mounting hole is located above the intersection of the horizontal center line of the back plate of the compartment box and the vertical center line of the horizontal projection of each group of chromatography columns on the back plate of the compartment box.

[0009] Furthermore, the vertical distance between the center point of the mounting hole and the bottom of the compartment is 0.6-0.75 times the height of the back plate of the compartment.

[0010] Furthermore, a lead-out hole for supporting and fixing the bottom of the chromatography column is provided at a position on the bottom of the box body corresponding to the placement hole.

[0011] Furthermore, the relationship among the total volume of the chromatography column, the volume of the working chamber and the internal volume of the housing satisfies the following equation: total volume of the chromatography column: volume of the working chamber: internal volume of the housing = 1: (4-6): (10-12).

[0012] Furthermore, it also includes a temperature control component, which includes a temperature controller, a thermometer and an over-temperature alarm device.

[0013] Furthermore, the compartment box is made of mirror-finished stainless steel.

[0014] The beneficial effects of the utility model are:

[0015] (1) Through the above arrangement, the heating surface of the working chamber can be increased to the back and left and right sides. During the heating process, the three sides are heated, making the heating more uniform and the temperature rising faster, which not only improves the work efficiency but also reduces the energy loss. In addition, the heating on the three sides also helps to maintain good column efficiency, which has a positive effect on the column flow effect and the extension of the service life of the chromatography column.

[0016] (2) By providing a partition box to separate the box body into an equipment chamber and a working chamber, the chromatography column can be separated from the heating device, which not only solves the problem of the chromatography column being damaged and having a high local temperature due to direct heating by the heating device, but also avoids the risk of workers being scalded. The heat conduction of the partition box makes the temperature rise even and stable, which can be used for solutions that are sensitive to temperature and require precise temperature control to pass through the column. Moreover, when the column solution is a Class A solvent, it can better prevent explosion and combustion, effectively improving safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic diagram of a top view of the hot column box provided in an embodiment of the present utility model;

[0018] Figure 2 A schematic diagram of the front view of the hot column box provided in an embodiment of the present utility model;

[0019] Figure 3 A schematic diagram of the three-dimensional structure of a compartment provided in an embodiment of the present utility model;

[0020] Figure 4 This is a rear view of the compartment provided in an embodiment of the present invention.

[0021] Figure numerals: 1. Box body; 2. Box door; 3. Partition box; 4. Equipment cavity; 5. Working cavity; 6. Placement hole; 7. Observation window; 8. Heating device; 9. Driving mechanism; 10. Fan; 11. Mounting hole; 12. Ventilation port; 13. Guide plate; 14. Over-temperature alarm device; 15. Bracket; 16. Universal wheel; 17. Electrostatic lead-out contact; 18. Back panel. DETAILED DESCRIPTION

[0022] The following is a detailed description of the specific embodiments of the present invention. The present invention can be implemented in many other ways than those described herein, and those skilled in the art can make similar improvements without violating the scope of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which the present invention belongs. The terms used are only for describing specific embodiments and are not intended to limit the present invention.

[0024] In the description of the present invention, it should be understood that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0025] In the description of this utility model, it should be noted that, unless otherwise expressly specified or limited, the terms "installed," "connected," "connected," and "disposed" should be understood in a broad sense. For example, they may refer to fixed connection or disposition, detachable connection or disposition, or integral connection or disposition. Those skilled in the art will understand the specific meanings of the above terms in this utility model based on specific circumstances.

[0026] like Figure 1-2As shown, the utility model provides a chromatography column hot column box, comprising: a box body 1, a box door 2 is hingedly connected to one side of the opening of the box body 1, a partition box 3 is arranged inside the box body 1 to divide the box body 1 into an equipment chamber 4 and a working chamber 5, a plurality of placement holes 6 for placing chromatography columns are opened on the top of the partition box 3, and there is a gap between the left and right side walls of the partition box 3 and the side walls of the box body 1; it should be pointed out that a heat-insulating material is sandwiched in the side walls of the box body 1, the partition box 3 is detachable or fixedly arranged in the box body 1, the partition box 3 and the box body 1 are both opened on the same side, and the number of the placement holes 6 can be increased or decreased according to the actual process requirements. In the embodiment of the utility model, four placement holes 6 are opened on the top of the partition box 3, and there is a gap between the left and right side walls of the partition box 3 and the side walls of the box body 1 The gap can be understood as a gap between the left side wall of the compartment box 3 and the left side wall of the box body 1, and a gap between the right side wall of the compartment box 3 and the right side wall of the box body 1. Preferably, in order to avoid affecting other chromatography columns during operation, the box door 2 is set to a double-door structure. In order to better observe the status of the chromatography column in the box body 1, the box door 2 is provided with an observation window 7. The observation window 7 is made of explosion-proof insulating glass or double-layer hollow glass, which is convenient for observation and can prevent staff from being scalded. In order to facilitate the removal and placement of chromatography columns and the maintenance of the hot column box, the top cover of the box body 1 is set to be movable and openable or closed, and a heat-resistant sealing ring is provided at the contact between the box door 2 and the top cover of the box body 1 and the box body 1. A heating device 8 is provided in the equipment cavity 4. The heating device 8 is an electric heater, a gas heater or a heat source heater, etc., as long as it can realize the heating function. In order to save energy and make it easier to control the temperature, the heating device 8 is preferably an electric heater.

[0027] Through the above arrangement, the heated surface of the working chamber 5 can be increased to the back and left and right sides. During the heating process, three sides are heated, which makes the heating more uniform and the temperature rising faster, which not only improves the work efficiency but also reduces the energy loss. Moreover, the heating on three sides is also helpful to maintain a good column efficiency, which has a positive effect on the column passing effect and the extension of the service life of the chromatography column. Secondly, by setting up a partition box 3 to separate the box body 1 into the equipment chamber 4 and the working chamber 5, the chromatography column can be separated from the heating device 8, which not only solves the problem of damage and high local temperature caused by direct roasting of the chromatography column by the heating device 8, but also avoids the risk of burns to the staff. The heat conduction of the partition box 3 makes the temperature rise evenly and steadily, which can be used for solutions that are sensitive to temperature and require precise temperature control for column passing, and when the column passing solution is a Class A solvent, it can better prevent explosion and combustion, and effectively improve safety.

[0028] Specifically, such as Figure 1 and 3As shown, the hot column box of the present invention also includes a thermal cycle device, which includes a drive mechanism 9 and a fan 10 connected to the drive mechanism 9. The output shaft of the drive mechanism 9 passes through the back plate 18 of the box body 1 and is connected to the fan 10 arranged in the equipment cavity 4. The air suction end of the fan 10 is detachably connected to the compartment 3 through a mounting hole 11 provided on the back plate 18 of the compartment 3. The left and right side walls of the compartment 3 are provided with regularly arranged vents 12. It should be pointed out that the drive mechanism 9 can be electrically driven, hydraulically driven, or driven by an internal combustion engine. The embodiment of the present invention is preferably electrically driven; the fan 10 is a suction fan 10, and the vents 12 can be round holes, strip holes, holes of irregular shapes, etc., as long as they can achieve air circulation. When the heat column is working and the heat circulation device is started, the fan 10 will drive the air in the box 1 to accelerate the flow into the compartment 3. After the air contacts the chromatography column and transfers heat, it is sucked away by the fan 10 and discharged into the box 1. The heat circulation is realized through the above reciprocating flow; by opening vents 12 on the left and right side walls of the compartment 3, the hot air needs to pass through the gap between the left and right side walls of the compartment 3 and the side wall of the box 1 to enter the compartment 3. The gap narrows the flow path of the hot air, provides a certain acceleration for the flow of hot air, optimizes the flow of hot air, makes the temperature balance faster, and further improves work efficiency.

[0029] Preferably, Figure 3 As shown, the vent 12 is a strip-shaped hole, and one side of the vent 12 is connected to a guide plate 13 obliquely facing the door 2. When hot air enters the compartment 3 through the vent 12, the hot air is guided to blow toward the door 2 first. The door 2 absorbs the potential energy of the hot air during contact with the hot air, slowing down the flow of the hot air to form airflow disturbance and dissipation, and then smoothly contacts and exchanges heat with the chromatography column, which can avoid the problems of high local temperature, uneven heating, chromatography column vibration, etc. caused by the hot air accelerated by the fan 10 directly contacting the chromatography column. Through the above settings, it is possible to ensure sufficient ventilation and uniform and stable temperature increase, thereby improving the separation effect and extending the service life of the chromatography column. The guide plate 13 can also be used to block debris in the equipment cavity 4 to prevent debris from blowing into the working cavity 5 and damaging the chromatography column. Preferably, the angle between the guide plate 13 and the side wall is in the range of 40 degrees to 55 degrees. The inclination angle of the guide plate 13 determines the path of the hot air flow. If the angle is set improperly, it may cause the hot air flow to be blocked, reduce the ventilation efficiency, and even cause noise and energy consumption problems. By setting the above angle range, the disturbance and dissipation effect of the hot air inside the compartment 3 is further ensured, which is conducive to uniform heating.

[0030] Specifically, the heating device 8 is a U-shaped electric heating tube, which is arranged in the gap between the left and right side walls of the compartment 3 and the side wall of the box body 1. Taking into account the installation convenience and heating effect, the above setting is preferably set as the heating device 8 as a U-shaped electric heating tube, and it is arranged in the gap between the left and right side walls of the compartment 3 and the side wall of the box body 1. This can not only reduce the risk of continuous heat damage to the thermal cycler, but also further improve work efficiency and reduce energy loss.

[0031] Specifically, such as Figure 4 As shown, the chromatography columns are arranged in groups of two, with the center points of the mounting holes 11 coinciding with the vertical centerline Y1 of each group of chromatography columns, as projected horizontally onto the back panel 18 of the compartment 3. Furthermore, the center points of the mounting holes 11 are located above the intersection of the horizontal centerline X1 of the compartment 3 back panel 18 and the vertical centerline Y1 of each group of chromatography columns, as projected horizontally onto the back panel 18 of the compartment 3. Because hot air tends to rise, this arrangement further ensures uniform heating and helps maintain good column efficiency.

[0032] Specifically, such as Figure 4 As shown, the vertical height H1 between the center point of the mounting hole 11 and the bottom of the compartment 3 is 0.6-0.75 times the height H2 of the back plate 18 of the compartment 3. The design of the above height is very critical. If the vertical height H1 is less than 0.6 times the height H2 of the back plate 18, the hot air is not enough to heat the upper part of the chromatography column, resulting in uneven heating of the chromatography column, which in turn affects the separation effect. If the vertical height H1 is greater than 0.75 times the height H2 of the back plate 18, although the chromatography column is heated more evenly, the top of the fan 10 is too close to the top cover of the box 1, which is not conducive to the evacuation and circulation of hot air and will cause the hot air to provide a reaction force on the fan 10. In the long run, the connection strength between the fan 10 and the mounting hole 11 is affected, which may easily cause the fan 10 to vibrate and the connection between the fan 10 and the mounting hole 11 to break. Only when the vertical height H1 between the center point of the mounting hole 11 and the bottom of the box 1 is 0.6-0.75 times the height H2 of the back plate 18 of the partition box 3 can the working stability of the hot column box be coordinated, which not only ensures uniform heating, but also reduces the risk of damage to the hot column box, extends the service life, and reduces production and operation costs.

[0033] Specifically, a lead-out hole for supporting and fixing the bottom of the chromatography column is provided at a position corresponding to the placement hole 6 at the bottom of the box body 1. It should be pointed out that in order to maintain good column efficiency, the center point of the placement hole 6 coincides with the center point of the lead-out hole in the vertical direction. By providing the lead-out hole, the support for the chromatography column is strengthened, and the solution after passing through the column can be promptly led out of the box body 1, solving the problem of adverse effects of some solutions at high temperatures and improving the applicability of the hot column box described in the embodiment of the present utility model. Preferably, both the placement hole 6 and the lead-out hole are provided with an adaptive ring gasket, and the ring gasket is made of polytetrafluoroethylene or silicone, which is used to seal the box body 1 and also plays a role in reducing vibration and preventing damage to the chromatography column.

[0034] Specifically, the relationship between the total volume of the chromatography column, the volume of the working chamber 5, and the internal volume of the housing 1 satisfies the following: total volume of the chromatography column: volume of the working chamber 5: internal volume of the housing 1 = 1: (4-6): (10-12). It is understood that the total volume of the chromatography column is the sum of the volumes of the chromatography columns placed in the hot column box described in the embodiments of the present invention; through the definition of the above relationship, its role is to further coordinate and smooth the working stability of the hot column box, while ensuring uniform heating, stable thermal cycle, and the service life of the hot column box, reducing space occupation and waste of manufacturing materials.

[0035] Specifically, the hot column box of the present invention further includes a temperature control assembly, which includes a thermostat, a thermometer, and an over-temperature alarm device 14. It should be noted that the thermostat is used to promptly disconnect the power supply when the temperature exceeds the limit, thereby protecting the hot column box from damage; the thermometer is disposed within the working chamber 5, and since it is a conventional technical means, it will not be described in detail here; the over-temperature alarm device 14 is disposed on the door 2 or the outside of the box body 1.

[0036] Specifically, the compartment 3 is made of mirror-finished stainless steel. Through the above arrangement, the brightness in the working chamber 5 can be improved, making it easier for staff to observe the working status of the chromatography column in time, and also facilitating cleaning and disinfection during daily maintenance operations.

[0037] Specifically, such as Figure 2 As shown, a bracket 15 is provided at the bottom of the box body 1, and a universal wheel 16 is provided at the lower end of the bracket 15 for facilitating the movement of the hot column box. Furthermore, a plurality of static electricity lead-out contacts 17 are provided on the outer surface of the box body 1 and the bracket 15. The static electricity lead-out contacts 17 are connected to the lead-out wires for leading out static electricity. Through the above arrangement, static electricity can be led out in time to prevent static electricity enrichment from generating electric sparks, causing fires and explosions. When the product is a Class A solvent, it can be better explosion-proof and flame-proof, effectively improving safety and applicability.

[0038] The technical features of the above-described embodiments can be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are exhaustively listed. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0039] For ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the utility model, which all fall within the scope of protection of the utility model. The scope of protection of the utility model shall be based on the attached claims.

Claims

1. A chromatography column hot box, characterized in that, include: A box body, wherein a door is hingedly connected to one side of the box body opening, and a partition box is provided inside the box body to separate the box body into an equipment chamber and a working chamber. A plurality of placement holes for placing chromatography columns are provided on the top of the partition box, and there is a gap between the left and right side walls of the partition box and the side walls of the box body; A heating device is arranged in the equipment cavity.

2. A chromatography column hot column box according to claim 1, characterized in that, It also includes a thermal circulation device, which includes a driving mechanism and a fan connected to the driving mechanism. The output shaft of the driving mechanism passes through the back plate of the box and is connected to the fan arranged in the equipment cavity. The air suction end of the fan is connected to the partition box through a mounting hole opened on the back plate of the partition box. The left and right side walls of the partition box are provided with regularly arranged ventilation holes.

3. A chromatography column hot column box according to claim 2, characterized in that, The vent is a strip-shaped hole, and one side of the vent is connected to a guide plate that is inclined toward the door.

4. A chromatography column hot box according to claim 2, characterized in that, The heating device is a U-shaped electric heating tube, and the U-shaped electric heating tube is arranged in the gap between the left and right side walls of the compartment and the side wall of the box body.

5. A chromatography column hot box according to claim 2, characterized in that, The chromatography columns are arranged in groups of two, and the center point of the mounting hole coincides with the vertical center line of each group of chromatography columns horizontally projected on the back plate of the compartment box, and the center point of the mounting hole is located above the intersection of the horizontal center line of the back plate of the compartment box and the vertical center line of each group of chromatography columns horizontally projected on the back plate of the compartment box.

6. A chromatography column hot box according to claim 5, characterized in that, The vertical distance between the center point of the mounting hole and the bottom of the compartment is 0.6-0.75 times the height of the compartment backboard.

7. A chromatography column hot box according to claim 1, characterized in that, A lead-out hole for supporting and fixing the bottom of the chromatography column is provided at a position on the bottom of the box body corresponding to the placement hole.

8. The chromatography column hot box according to claim 1, characterized in that: The relationship between the total volume of the chromatography column, the volume of the working chamber and the internal volume of the box satisfies: the total volume of the chromatography column: the volume of the working chamber: the internal volume of the box = 1: (4-6): (10-12).

9. The chromatography column hot box according to claim 1, characterized in that: It also includes a temperature control component, which includes a temperature controller, a thermometer and an over-temperature alarm device.

10. The chromatography column hot box according to claim 1, characterized in that: The compartment box is made of mirror-finished stainless steel.

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