Cell sap subpackaging device

Abstract

The utility model discloses a cell sap subpackaging device which comprises a first refrigerating chamber and a second refrigerating chamber. The shaking platform is arranged in the first refrigerating chamber and is used for placing a liquid storage bag and uniformly shaking cell liquid in the liquid storage bag; the sub-packaging bag is arranged in the second refrigerating chamber, and the sub-packaging bag is communicated with the liquid storage bag through a pipeline assembly; and the exhaust assembly is used for extruding the sub-packaging bags so as to exhaust gas in the sub-packaging bags. Compared with the prior art, the cell sap subpackaging device provided by the utility model has the advantages that the subpackaging efficiency can be improved, and the activity of cells is prevented from being damaged.

Description

Technical Field

[0001] The present application relates to the technical field of cell packaging, and more specifically, to a cell fluid packaging device. Background Art

[0002] When conducting cell research and cell production for regenerative medicine cell preparations, it is necessary to package the centrally stored cell suspension into small batches. This packaging process is a key step in cell production and will have a significant impact on the quality of the cell product.

[0003] The cell aliquot bag is a functionally closed, disposable cell culture bag that provides a suitable environment for rapid cell expansion during culture while minimizing the risk of cross-contamination.

[0004] In the existing technology, packaging requires manual injection of liquid from the cell mother liquid bag through a syringe and manual squeezing to exhaust the air, which leads to low packaging efficiency and uneven exhaust. In addition, human participation challenges the sterility of cell packaging.

[0005] Therefore, there is an urgent need for a cell fluid packaging device that can improve the packaging efficiency and avoid the destruction of cell activity. Utility Model Content

[0006] In order to solve the above technical problems, the present application provides a cell fluid packaging device that can improve the packaging efficiency and avoid the destruction of cell activity.

[0007] The technical solutions provided in this application are as follows:

[0008] A cell fluid packaging device, comprising:

[0009] a first cold storage room and a second cold storage room;

[0010] A shaking platform is provided in the first cold storage chamber, the shaking platform is used to place the liquid storage bag and shake the cell fluid in the liquid storage bag evenly;

[0011] A packaging bag is provided in the second refrigerating chamber, wherein the packaging bag is connected to the liquid storage bag via a pipeline assembly;

[0012] An exhaust component is used to squeeze the packaging bag to discharge the gas in the packaging bag.

[0013] Preferably, the exhaust assembly comprises:

[0014] A fixing plate provided on one side of the dispensing bag;

[0015] A movable plate provided on a side of the dispensing bag away from the fixed plate;

[0016] a driving mechanism connected to the movable plate and configured to drive the movable plate to move toward or away from the fixed plate;

[0017] An exhaust port is communicated with the interior of the packaging bag, and a filter is provided at the exhaust port. The filter is used to allow gas to pass through and filter the gas.

[0018] Preferably, the exhaust assembly further includes:

[0019] a frame, the frame being fixedly connected to the fixing plate;

[0020] At least two fixed plates are provided, and the fixed plates are spaced apart along the first direction of the frame, and the movable plate is provided between two adjacent fixed plates.

[0021] Preferably, the driving mechanism comprises:

[0022] A moving block, wherein the moving block is connected to the movable plate via a connecting plate;

[0023] A guide rail is provided on the frame, and the moving block is slidably provided on the guide rail;

[0024] A driver is provided on the frame, and the driver is connected to the moving block, and is used for driving the moving block to move along the length direction of the guide rail.

[0025] Preferably, the exhaust assembly further includes:

[0026] The hollow areas are arranged at intervals on the fixed plate and the movable plate.

[0027] Preferably, the pipeline assembly includes:

[0028] A main pipeline connected to the liquid storage bag, wherein the main pipeline is provided with a peristaltic pump;

[0029] A branch pipe connected to the main pipe, the branch pipes are arranged in a one-to-one correspondence with the sub-packaging bags, and the liquid outlet of the branch pipe is communicated with the sub-packaging bags;

[0030] A pipe pressure valve is provided on the branch pipe, and the pipe pressure valve is provided in a one-to-one correspondence with the branch pipe.

[0031] Preferably, the pipeline assembly further includes:

[0032] A controller is connected to the pipe pressure valve and the peristaltic pump respectively.

[0033] Preferably, at least two branch pipes are provided, and the branch pipes are arranged in parallel.

[0034] Preferably, the exhaust port is provided on the main pipe, and a bubble sensor is further provided on the main pipe. The bubble sensor is provided on a side of the exhaust port close to the branch pipe.

[0035] Preferably, it also includes:

[0036] a main body, wherein the first refrigerating chamber and the second refrigerating chamber are respectively arranged in the main body, and the two second refrigerating chambers are arranged below the first refrigerating chamber;

[0037] A display screen is provided on one side of the first refrigerating chamber, and the display screen is connected to the pipeline assembly.

[0038] The cell fluid packaging device provided by the present invention is firstly provided with a first cold storage chamber, a second cold storage chamber and a pipeline assembly, wherein a shaking platform is provided in the first cold storage chamber, the shaking platform is used to place the liquid storage bag, and the cell fluid in the liquid storage bag can be shaken evenly by the shaking platform; the second cold storage chamber is used to place the packaged cell fluid, and the packaging bag is arranged in the second cold storage chamber, and the packaging bag and the liquid storage bag are connected by the pipeline assembly, and the cell fluid in the liquid storage bag is transported to the packaging bag through the pipeline assembly for packaging and storage, and the transportation process does not require the participation of outsiders and will not come into contact with the external environment, which is cleaner and more hygienic. Secondly, the cell fluid will not fill the sub-packaging bag when it is sub-packaging, but will leave a margin, which can easily cause residual gas in the sub-packaging bag, increase the fluidity of the cell fluid in the bag, and destroy the activity of the cells. In order to solve this problem, the cell sub-packaging device provided by the present invention also includes an exhaust component, which is used to squeeze the sub-packaging bag, so that the gas in the sub-packaging bag is exhausted. After the cell fluid in the liquid storage bag is transported to the sub-packaging bag through the pipeline component, it is exhausted through the exhaust component and subsequently sealed and stored. The sub-packaging efficiency of the cell fluid is better, which avoids the activity of the cells from being destroyed. It can be seen that compared with the prior art, the cell fluid sub-packaging device in the embodiment of the present invention can improve the sub-packaging efficiency and avoid the activity of the cells from being destroyed. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0040] Figure 1 A schematic structural diagram of a cell fluid packaging device provided in an embodiment of the present utility model;

[0041] Figure 2 A structural schematic diagram of a front view of a cell fluid packaging device provided in an embodiment of the present utility model;

[0042] Figure 3 A schematic structural diagram of an exhaust assembly provided in an embodiment of the present utility model;

[0043] Figure 4 A schematic structural diagram of a driving mechanism provided in an embodiment of the present utility model;

[0044] Figure 5 A structural schematic diagram of a pipeline assembly provided in an embodiment of the utility model.

[0045] Figure numerals: 1. First cold storage chamber; 2. Second cold storage chamber; 4. Exhaust assembly; 5. Bubble sensor; 6. Main body; 7. Display screen; 8. Liquid storage bag; 9. Packaging bag; 31. Main pipeline; 32. Peristaltic pump; 33. Branch pipeline; 34. Pipe pressure valve; 41. Fixed plate; 42. Movable plate; 43. Frame; 441. Moving block; 442. Connecting plate; 443. Guide rail; 444. Drive; 45. Filter element. DETAILED DESCRIPTION

[0046] In order to help those skilled in the art better understand the technical solutions in this application, the technical solutions in the embodiments of this application will be clearly and completely described below. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without making any creative efforts shall fall within the scope of protection of this application.

[0047] It should be noted that when an element is referred to as being “fixed on” or “set on” another element, it can be directly on the other element or indirectly set on the other element; when an element is referred to as being “connected to” another element, it can be directly connected to the other element or indirectly connected to the other element.

[0048] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application.

[0049] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of technical features indicated. Thus, a feature specified as "first" or "second" may explicitly or implicitly include one or more of such features. Throughout the description of this application, "plurality" or "several" means two or more, unless otherwise specifically defined.

[0050] It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the conditions under which this application can be implemented. Therefore, they have no substantive technical significance. Any structural modification, change in proportional relationship or adjustment of size should still fall within the scope of the technical content disclosed in this application without affecting the efficacy and purpose that can be achieved by this application.

[0051] The embodiments of the present invention are written in a progressive manner.

[0052] like Figures 1 to 5 As shown, an embodiment of the utility model provides a cell fluid packaging device, including: a first cold storage chamber 1 and a second cold storage chamber 2; a shaking platform arranged in the first cold storage chamber 1, the shaking platform is used to place a liquid storage bag 8 and shake the cell fluid in the liquid storage bag 8 evenly; a packaging bag 9 is arranged in the second cold storage chamber 2, and the packaging bag 9 is connected to the liquid storage bag 8 through a pipeline assembly; an exhaust assembly 4 is used to squeeze the packaging bag 9 to discharge the gas in the packaging bag 9.

[0053] In the existing technology, packaging requires manual injection of liquid from the cell mother liquid bag through a syringe and manual squeezing to exhaust the air, which leads to low packaging efficiency and uneven exhaust. In addition, human participation challenges the sterility of cell packaging.

[0054] The cell fluid packaging device provided by the present invention is firstly provided with a first cold storage chamber 1, a second cold storage chamber 2 and a pipeline assembly, wherein a shaking platform is provided in the first cold storage chamber 1, the shaking platform is used to place the liquid storage bag 8, and the cell fluid in the liquid storage bag 8 can be shaken evenly by the shaking platform, the second cold storage chamber 2 is used to place the packaged cell fluid, the packaging bag 9 is provided in the second cold storage chamber 2, the packaging bag 9 and the liquid storage bag 8 are connected by a pipeline assembly, and the cell fluid in the liquid storage bag 8 is transported to the packaging bag 9 through the pipeline assembly for packaging and storage. The transportation process does not require the participation of outsiders and will not come into contact with the external environment, which is cleaner and more hygienic. Secondly, the cell fluid will not fill the sub-packaging bag 9 when it is sub-packaging, but will leave a margin, which can easily cause residual gas in the sub-packaging bag 9, increase the fluidity of the cell fluid in the bag, and destroy the activity of the cells. In order to solve this problem, the cell sub-packaging device provided by the present invention also includes an exhaust component 4, which is used to squeeze the sub-packaging bag 9, so that the gas in the sub-packaging bag 9 is exhausted. After the cell fluid in the liquid storage bag 8 is transported to the sub-packaging bag 9 through the pipeline component, it is exhausted through the exhaust component 4, and then sealed and stored. The sub-packaging efficiency of the cell fluid is higher, which avoids the activity of the cells from being destroyed. It can be seen that compared with the prior art, the cell fluid sub-packaging device in the embodiment of the present invention can improve the sub-packaging efficiency and avoid the activity of the cells from being destroyed.

[0055] It should be noted that the first cold storage chamber 1 and the second cold storage chamber 2 are provided to provide a refrigerated environment for the cell fluid. A shaking platform is provided in the first cold storage chamber 1 to shake the cell fluid in the liquid storage bag 8 so that the cell fluid can be evenly transferred to each sub-packaging bag 9. The shaking platform can be any shaking platform in the prior art, and this application does not further limit the structure of the shaking platform.

[0056] The exhaust assembly 4 in this application is used to squeeze the sub-packaging bag 9 to exhaust the gas in the sub-packaging bag 9. Figure 3 and Figure 4 As shown, the exhaust component 4 in the embodiment of the present invention includes a fixed plate 41, a movable plate 42 and a driving mechanism, wherein the fixed plate 41 is arranged on one side of the packaging bag 9, and the movable plate 42 is arranged on the side of the packaging bag 9 away from the fixed plate 41, and the driving mechanism is connected to the movable plate 42, and the driving mechanism is used to drive the movable plate 42 to move toward or away from the fixed plate 41. When the driving mechanism drives the movable plate 42 to move toward the fixed plate 41, under the mutual squeezing action of the fixed plate 41 and the movable plate 42, the excess gas in the packaging bag 9 is discharged, and the packaging bag 9 is subsequently sealed. When the driving mechanism drives the movable plate 42 to move in the direction away from the fixed plate 41, the movable plate 42 is reset to facilitate the replacement of the packaging bag 9.

[0057] Furthermore, in order to facilitate the exhaust of the sub-packaging bag 9, the exhaust component 4 in the present application also includes an exhaust port, which is used to communicate with the interior of the sub-packaging bag 9. A filter is provided at the exhaust port, and the filter is used to allow gas to pass through and filter the gas. It should be noted that the filter in the present application is used to allow gas to circulate and the liquid medium cannot pass through the filter into the sub-packaging bag 9. In addition, since the filter is provided, harmful substances are prevented from entering the sub-packaging bag 9 along with the gas medium, thereby ensuring the sterility of the cell fluid during the sub-packaging process.

[0058] In the above structure, as one of the implementation modes, the exhaust port in the embodiment of the present utility model can be set on the pipeline assembly or on another exhaust pipe.

[0059] In the above structure, as one of the above methods, the exhaust assembly 4 in the embodiment of the utility model further includes a frame 43, and the fixed plate 41 is fixedly connected to the frame 43. There are at least two fixed plates 41, and the two fixed plates 41 are spaced apart along the first direction of the frame 43, and the movable plate 42 is arranged between the two adjacent fixed plates 41.

[0060] Furthermore, the movable plates 42 are arranged in a one-to-one correspondence with the number of the packaging bags 9, and the excess gas in the packaging bags 9 is discharged by driving the movable plates 42 to move. Preferably, the driving mechanism is used to drive the movable plates 42 to work together and exhaust the packaging bags 9 at the same time, which is more efficient.

[0061] As one of the embodiments, the driving mechanism in the embodiment of the utility model includes a moving block 441, a guide rail 443 and a driver 444, wherein the guide rail 443 is fixedly set on the frame 43, the moving block 441 is slidingly connected to the guide rail 443, and the moving block 441 is connected to the movable plate 42 through a connecting plate. When there are at least two movable plates 42, the movable plates 42 are connected in parallel and are both connected to the connecting plate 442. The connecting plate 442 is connected to the moving block 441. The driver 444 is used to drive the moving block 441 to move along the guide rail 443, thereby driving the movable plate 42 to move along the direction of the guide rail 443, thereby driving the movable plate 42 to squeeze the packaging bag 9 and discharge the air in the packaging bag 9.

[0062] Furthermore, as one of the implementation methods, only one moving block 441 can be provided in the embodiment of the utility model, or at least two moving blocks 441 can be provided. This application does not limit the number of moving blocks 441, which is based on convenience during use.

[0063] Furthermore, as another embodiment, the driving mechanism in the embodiment of the present invention includes a slider, a screw and a driving member, wherein the slider is connected to the movable plate 42 and the connecting plate. When there are at least two movable plates 42, the movable plates 42 are connected in parallel and are both connected to the connecting plate. The connecting plate is connected to the slider. The screw is set on the frame 43, and the screw and the frame are rotatably connected. The screw and the slider are connected by a thread. The screw extends along the first direction. The driving member is set on the frame. The driving member is used to drive the screw to rotate, so that the slider on the screw moves along the length direction of the screw, thereby driving the movable block to squeeze the packaging bag 9 and discharge the air in the packaging bag 9.

[0064] In the above structure, both ends of the lead screw in the embodiment of the present invention are connected to the frame 43 via bearing seats.

[0065] Furthermore, as one implementation mode, the exhaust assembly 4 in the embodiment of the present invention further includes hollow areas spaced apart on the fixed plate 41 and the movable plate 42 .

[0066] Furthermore, as one of the embodiments, the pipeline assembly in the embodiment of the present invention includes a main pipeline 31, a peristaltic pump 32, a branch pipeline 33 and a pipe pressure valve 34. The main pipeline 31 is used to be connected to the liquid storage bag 8, and a peristaltic pump 32 is provided on the main pipeline 31. The branch pipeline 33 is connected to the main pipeline 31, and the branch pipeline 33 is arranged in a one-to-one correspondence with the sub-packaging bag 9. The liquid outlet of the branch pipeline 33 is connected to the sub-packaging bag 9. The pipe pressure valve 34 is arranged on the branch pipeline 33, and the pipe pressure valve 34 is arranged in a one-to-one correspondence with the branch pipeline 33. The peristaltic pump 32 is used to provide power to the cell fluid so that the cell fluid flows in the main pipeline 31 and the branch pipeline 33. The pipe pressure valve 34 is arranged on the branch pipeline 33 for controlling the on and off of the branch pipeline 33. Under the action of the peristaltic pump 32 and the pipe pressure valve 34, a certain amount of cell fluid is injected into each sub-packaging bag 9, which is more convenient and more efficient.

[0067] More preferably, the pipeline assembly in the embodiment of the present invention further includes a controller, which is respectively connected to the line pressure valve 34 and the peristaltic pump 32. By controlling the on and off of the peristaltic pump 32 and the line pressure valve 34 by the controller, the whole process does not require manual intervention, which is more efficient.

[0068] Furthermore, as one implementation mode, at least two branch pipes 33 are provided in the embodiment of the present utility model, and the branch pipes 33 are provided in parallel.

[0069] In the above structure, as one preferred embodiment, the exhaust port in the embodiment of the present invention is provided on the main pipe 31, and the main pipe 31 is also provided with a bubble sensor 5, which is provided on the side of the exhaust port close to the branch pipe 33. The bubble sensor 5 monitors the bubbles in the pipe, thereby achieving the purpose of exhausting the air.

[0070] Furthermore, in the embodiment of the utility model, at least two bubble sensors 5 are provided, and the first bubble sensor and the second bubble sensor are respectively provided on both sides of the branch pipe, wherein the first bubble sensor is provided at one end of the main pipe close to the liquid storage bag, and the first bubble sensor is used to detect whether the gas in the liquid storage bag is emptied, and the second bubble sensor is used to detect whether the gas in the sub-packaging bag 9 is emptied. With such a setting, the monitoring effect is better.

[0071] In the above structure, as one embodiment, the cell fluid packaging device in the embodiment of the present invention further includes a main body 6, a first cold storage chamber 1 and a second cold storage chamber 2 respectively disposed within the main body 6, with the two second cold storage chambers 2 disposed below the first cold storage chamber 1; and a display screen 7 disposed on one side of the first cold storage chamber 1, the display screen 7 being connected to the pipeline assembly. Thus, by providing two second cold storage chambers 2, multiple packaging bags 9 can be packaged in a short time, achieving higher efficiency.

[0072] The above description of the disclosed embodiments will enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A cell fluid packaging device, characterized in that: include: a first refrigeration chamber (1) and a second refrigeration chamber (2); A shaking platform is provided in the first cold storage chamber (1), the shaking platform being used to place a liquid storage bag and shake the cell fluid in the liquid storage bag evenly; A sub-packaging bag is arranged in the second refrigerating chamber (2), wherein the sub-packaging bag is connected to the liquid storage bag via a pipeline assembly; An exhaust component (4) is used for squeezing the packaging bag to discharge the gas in the packaging bag.

2. The cell fluid packaging device according to claim 1, characterized in that: The exhaust assembly (4) comprises: A fixing plate (41) provided on one side of the packaging bag; A movable plate (42) provided on a side of the packaging bag away from the fixed plate (41); A driving mechanism connected to the movable plate (42) and used to drive the movable plate (42) to move toward or away from the fixed plate (41); An exhaust port is connected to the interior of the packaging bag, and a filter is provided at the exhaust port. The filter is used to allow gas to pass through and filter the gas.

3. The cell fluid packaging device according to claim 2, characterized in that: The exhaust assembly further includes: a frame (43), the frame (43) being fixedly connected to the fixing plate (41); At least two fixed plates (41) are provided, and the fixed plates (41) are spaced apart along the first direction of the frame (43), and the movable plate (42) is provided between two adjacent fixed plates (41).

4. The cell fluid packaging device according to claim 3, characterized in that: The driving mechanism comprises: A moving block (441), wherein the moving block (441) is connected to the movable plate (42) via a connecting plate (442); A guide rail (443) is provided on the frame (43), and the moving block (441) is slidably provided on the guide rail (443); A driver (444) is provided on the frame, and the driver (444) is connected to the moving block (441) and is used to drive the moving block (441) to move along the length direction of the guide rail (443).

5. The cell fluid packaging device according to claim 2, characterized in that: The exhaust assembly further includes: Hollow areas are arranged at intervals on the fixed plate (41) and the movable plate (42).

6. The cell fluid packaging device according to any one of claims 2 to 5, characterized in that: The pipeline assembly includes: a main pipeline (31) connected to the liquid storage bag, wherein a peristaltic pump (32) is provided on the main pipeline (31); a branch pipe (33) connected to the main pipe (31), the branch pipe (33) being arranged in a one-to-one correspondence with the sub-packaging bag, and the liquid outlet of the branch pipe (33) being in communication with the sub-packaging bag; A pipe pressure valve (34) is provided on the branch pipe (33), and the pipe pressure valve (34) is provided in a one-to-one correspondence with the branch pipe (33).

7. The cell fluid packaging device according to claim 6, characterized in that: The pipeline assembly further includes: A controller is connected to the pipe pressure valve and the peristaltic pump respectively.

8. The cell fluid packaging device according to claim 7, characterized in that: At least two branch pipes (33) are provided, and the branch pipes (33) are arranged in parallel.

9. The cell fluid packaging device according to claim 6, characterized in that: The exhaust port is provided on the main pipe (31), and a bubble sensor (5) is also provided on the main pipe (31). The bubble sensor (5) is provided on a side of the exhaust port close to the branch pipe (33).

10. The cell fluid packaging device according to any one of claims 1 to 5, characterized in that: Also includes: A main body (6), wherein the first refrigerating chamber (1) and the second refrigerating chamber (2) are respectively arranged in the main body, and the two second refrigerating chambers (2) are arranged below the first refrigerating chamber (1); A display screen (7) is provided on one side of the first refrigeration chamber (1), and the display screen (7) is connected to the pipeline assembly.

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