Ammoniation reaction device for synthesizing medical intermediates

Abstract

The utility model provides an ammoniation reaction device for synthesizing medical intermediates, and belongs to the technical field of ammoniation reaction devices. Comprising a body, a feeding hopper is fixedly assembled on the top of the body, a box body is fixedly assembled on the outer wall of the body, a first air guide pipe and a second air guide pipe penetrate through the outer wall of the body to extend into the box body, a heating pipe is arranged on the inner wall of the body, and a partition plate is fixedly assembled on the inner wall of the box body; a heat conduction pipe is arranged on the inner wall of the partition plate. Through the arrangement of the body, the feeding hopper, the box body and the first gas guide pipe structure, in the using process of the device, the heating rod is used for heating the interior of the body, so that the ammoniation reaction speed is increased, heat generated by the heating rod and the reaction after the reaction can cause the temperature and the air pressure in the body to rise rapidly, and therefore the ammoniation reaction speed is increased. Therefore, the sealing plug is pushed to move, high-temperature waste gas enters the box body, and a user is assisted in controlling the stability of air pressure and temperature in the body.

Description

Technical Field

[0001] The utility model relates to the technical field of amination reaction devices, in particular to an amination reaction device for synthesizing pharmaceutical intermediates. Background Art

[0002] In the process of treating patients, drugs are needed to control and treat the disease, and some drugs require the use of amination reactions for production during the synthesis process.

[0003] Although the existing amination reaction device can react drugs with ammonia water during use, it is not provided with a mechanism that allows the user to control the temperature and pressure environment inside the device. Therefore, excessive temperature and high pressure are likely to occur during the reaction process. At the same time, the heat generated by the reaction cannot be recovered, and a heating rod is required to reheat the inside of the device, which reduces the energy utilization rate of the existing device. Therefore, the present application provides an amination reaction device for synthesizing pharmaceutical intermediates to meet the needs. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide an amination reaction device for synthesizing pharmaceutical intermediates to solve the problems raised in the above background technology.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] An amination reaction device for synthesizing pharmaceutical intermediates comprises: a main body, a feed hopper fixedly mounted on the top of the main body, a box fixedly mounted on the outer wall of the main body, a first air duct and a second air duct respectively extending through the outer wall of the main body to the interior of the box, a heating pipe provided on the inner wall of the main body, a partition fixedly mounted on the inner wall of the box, a heat pipe provided on the inner wall of the partition, an air pump fixedly mounted on the top of the inner wall of the box, mounting grooves formed on the inner walls of the first and second air ducts, a crossbar fixedly mounted on the inner wall of the mounting groove, a spring sleeved on the outer wall of the crossbar, the outer wall of the spring abutting against a limiting ring, a connecting rod fixedly mounted on the outer wall of the limiting ring, and a sealing plug fixedly mounted on the end of the connecting rod.

[0007] Preferably, the end of the first air duct away from the main body passes through the outer wall of the box body and the partition to the inner wall of the partition, and the distance between the second air duct and the partition is 3 cm.

[0008] Preferably, the inner wall of the mounting groove is slidably connected to the outer wall of the limiting ring, the outer wall of the limiting ring is provided with a sliding hole, and the inner wall of the sliding hole is slidably connected to the outer wall of the cross bar.

[0009] Preferably, there are two sealing plugs, and the two sealing plugs are slidingly connected to the inner walls of the first air duct and the second air duct respectively.

[0010] Preferably, the interior of the box is divided into a heat recovery area and a heat conduction area by a partition, and the end of the heat conduction pipe is located inside the heat conduction area.

[0011] Preferably, the interior of the heat transfer zone is filled with cold air, and the heat recovery zone is filled with high-temperature exhaust gas.

[0012] Compared with the prior art, the present invention has at least the following beneficial effects:

[0013] 1. In the above scheme, by providing the main body, feed hopper, box body, and first air guide pipe structure, the device utilizes a heating rod to heat the interior of the main body during use, thereby accelerating the rate of the amination reaction. After the reaction, the heat generated by the heating rod and the reaction will cause the temperature and air pressure inside the main body to rise rapidly, thereby pushing the sealing plug to move and allowing high-temperature exhaust gas to enter the box body, thereby assisting the user in controlling the stability of the air pressure and temperature inside the main body.

[0014] 2. In the above scheme, by providing the first air duct, the second air duct, the air pump, the partition, the heat pipe, and the mounting groove structure, after the reaction device recovers the high-temperature exhaust gas, when the temperature inside the body is not enough to accelerate the amination reaction, the temperature and pressure inside the body are lower than the temperature and pressure inside the box. This allows the sealing plug inside the second air duct to move, allowing the hot air in the heat transfer area to enter the body, thereby achieving the effect of heat energy recovery and improving the energy utilization rate of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the present disclosure and, together with the description, further serve to explain the principles of the present disclosure and to enable one skilled in the relevant art to make and use the present disclosure.

[0016] Figure 1 This is a schematic diagram of the three-dimensional structure of an amination reaction device for synthesizing pharmaceutical intermediates;

[0017] Figure 2 This is a side view schematic diagram of the structure of an amination reaction device for synthesizing pharmaceutical intermediates;

[0018] Figure 3 This is a schematic diagram of the internal structure of a side section of an amination reaction device for synthesizing pharmaceutical intermediates;

[0019] Figure 4 This is a schematic diagram of the first air duct structure of the amination reaction device for the synthesis of pharmaceutical intermediates.

[0020] [reference numerals]

[0021] 1. Main body; 2. Feed hopper; 3. Box body; 4. First air duct; 5. Second air duct; 6. Heating tube; 7. Air pump; 8. Partition; 9. Heat pipe; 10. Mounting slot; 11. Cross bar; 12. Spring; 13. Limiting ring; 14. Connecting rod; 15. Sealing plug.

[0022] As shown in the figure, in order to clearly implement the structure of the embodiment of the present invention, specific structures and devices are marked in the figure, but this is only for illustrative purposes and is not intended to limit the present invention to the specific structure, device and environment. According to specific needs, ordinary technicians in this field can adjust or modify these devices and environments, and the adjustments or modifications made are still included in the scope of the appended claims. DETAILED DESCRIPTION

[0023] The following describes in detail the amination reaction apparatus for synthesizing pharmaceutical intermediates provided by the present invention, in conjunction with the accompanying drawings and specific embodiments. It is also noted that, in order to provide a more detailed description of the embodiments, the following embodiments are listed as best and preferred embodiments, and those skilled in the art may also adopt other alternative embodiments. Furthermore, the accompanying drawings are only for the purpose of describing the embodiments in more detail and are not intended to limit the present invention in any specific manner.

[0024] It should be noted that references in the specification to "one embodiment," "an embodiment," "an exemplary embodiment," "some embodiments," etc. indicate that the described embodiments may include specific features, structures, or characteristics, but not necessarily every embodiment includes such specific features, structures, or characteristics. In addition, when specific features, structures, or characteristics are described in conjunction with an embodiment, it is within the knowledge of those skilled in the relevant art to implement such features, structures, or characteristics in conjunction with other embodiments (whether or not explicitly described).

[0025] In general, terms can be understood, at least in part, from their use in context. For example, depending at least in part on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in the singular sense, or can be used to describe a combination of features, structures, or characteristics in the plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey an exclusive set of factors, but can instead, depending at least in part on the context, allow for the presence of other factors that are not necessarily explicitly described.

[0026] It will be understood that the meanings of “on,” “over,” and “above” in this disclosure should be interpreted in the broadest manner, such that “on” means not only “directly on” something, but also includes being “on” something with intervening features or layers, and “on” or “over” means not only “on” or “above” something, but also includes being “on” or “above” something with no intervening features or layers.

[0027] Additionally, spatially relative terms such as "below," "beneath," "lower," "above," and "upper" may be used herein for descriptive convenience to describe the relationship of one element or feature to another element or features, as illustrated in the accompanying drawings. Spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the accompanying drawings. The device may be oriented in other ways, and the spatially relative descriptors used herein should be similarly interpreted accordingly.

[0028] like Figure 1 and Figure 2 As shown, an embodiment of the present invention provides an amination reaction device for synthesizing pharmaceutical intermediates, comprising: a body 1, a feed hopper 2 is fixedly mounted on the top of the body 1, a box 3 is fixedly mounted on the outer wall of the body 1, a first air duct 4 and a second air duct 5 are respectively passed through the outer wall of the body 1 to the interior of the box 3, a heating pipe 6 is provided on the inner wall of the body 1, a partition 8 is fixedly mounted on the inner wall of the box 3, a heat conducting pipe 9 is provided on the inner wall of the partition 8, an air pump 7 is fixedly mounted on the top of the inner wall of the box 3, the inner walls of the first air duct 4 and the second air duct 5 are both provided with mounting grooves 10, the inner wall of the mounting groove 10 is fixedly mounted with a cross bar 11, the outer wall of the cross bar 11 is sleeved with a spring 12, the outer wall of the spring 12 abuts against a limiting ring 13, the outer wall of the limiting ring 13 is fixedly mounted with a connecting rod 14, and the end of the connecting rod 14 is fixedly mounted with a sealing plug 15. By configuring the structure of the main body 1, feed hopper 2, box 3, and first air duct 4, the device utilizes the heating tube 6 to provide a stable temperature environment for the amination reaction during operation. The heat generated during the reaction is also accumulated in the main body 1, thereby causing the temperature inside the main body 1 to rise rapidly. The thermal expansion and contraction effect causes the air pressure to increase, which pushes the sealing plug 15 in the first air duct 4 to move, thereby allowing the limit ring 13 to compress the spring 12, thereby allowing the interior of the main body 1 to communicate with the interior of the box 3, allowing high-temperature exhaust gas to enter the box 3, ensuring the stability of the air pressure and temperature of the main body 1, and thus improving the safety of the reaction device.

[0029] like Figure 1 and Figure 3As shown, the end of the first air duct 4 away from the main body 1 passes through the outer wall of the box 3 and the partition 8 to the inner wall of the partition 8, and the spacing between the second air duct 5 and the partition 8 is 3 cm. Through the arrangement of the first air duct 4 and the second air duct 5 structure, during the operation of the device, the first air duct 4 can discharge the high-temperature exhaust gas into the box 3, thereby ensuring the stability of the internal air pressure of the main body 1 and avoiding damage to the equipment due to excessive air pressure. At the same time, the heat pipe 9 inside the box 3 can transfer the heat in the high-temperature exhaust gas to the cold air, thereby achieving the effect of heat recovery. When the inside of the main body 1 needs to be heated, the hot air in the heat transfer area can be directly discharged into the main body 1, reducing the operating time of the heating pipe 6 and reducing the energy loss of the device.

[0030] like Figure 1 and Figure 2 As shown, the inner wall of the mounting groove 10 is slidably connected to the outer wall of the limiting ring 13, and a sliding hole is opened on the outer wall of the limiting ring 13, and the inner wall of the sliding hole is slidably connected to the outer wall of the cross bar 11. Through the provided sliding hole and the mounting groove 10 structure, when the air pressure inside the main body 1 increases, the limiting ring 13 can compress the spring 12 in the first air duct 4 to allow high-temperature exhaust gas to enter the box body 3. When the temperature environment of the amination reaction needs to be maintained due to heat loss inside the main body 1, the air pressure is lower than the air pressure and temperature inside the box body 3, so that the limiting ring 13 inside the second air duct 5 will compress the spring 12, thereby allowing the hot air in the heat transfer area to enter the main body 1, thereby achieving the effect of heat recovery and ensuring the normal progress of the amination reaction.

[0031] like Figure 1 and Figure 4 As shown, there are two sealing plugs 15, and the two sealing plugs 15 are slidably connected to the inner walls of the first air duct 4 and the second air duct 5 respectively. By providing the two sealing plugs 15 structure, when there is no need to exhaust and heat dissipation operations inside the body 1, the sealing plug 15 inside the first air duct 4 is used to isolate the body 1 and the box 3, thereby ensuring that the rate of temperature loss inside the body 1 is reduced and the sealing performance of the device is improved. Similarly, the temperature environment and air pressure environment inside the body 1 are both sufficient to provide the high-temperature air inside the box 3 during the amination reaction without affecting the inside of the body 1.

[0032] like Figure 1 and Figure 3 As shown, the interior of the box body 3 is divided into a heat recovery area and a heat transfer area by a partition 8, and the end of the heat transfer pipe 9 is located inside the heat transfer area. The partition 8 structure is provided to isolate the high-temperature exhaust gas and the high-temperature air, thereby ensuring that the two are not mixed. In this way, when the high-temperature air is discharged into the main body 1, it will not affect the amination reaction, thereby ensuring the normal progress of the amination reaction.

[0033] like Figure 1 and Figure 4 As shown, the interior of the heat transfer area is filled with cold air, and the heat recovery area is filled with high-temperature exhaust gas. By setting the heat transfer area and the heat recovery area, the interior of the box 3 is divided into two spaces that do not interfere with each other. The cold air is heated by the heat transfer effect of the heat pipe 9, thereby achieving the effect of heat energy recovery, thereby improving the energy utilization rate of the device.

[0034] The technical solution provided by the present invention is that when working, ammonia water is fed into the device through the feed hopper 2, and then the amination reaction of the medicine is started. The heating effect of the heating tube 6 is used to catalyze the progress of the amination reaction. During the amination reaction, the heat generated and the heat emitted by the heating tube 6 will cause the temperature inside the body 1 to rise rapidly, thereby increasing the air pressure inside the body 1, thereby pushing the limiting ring 13 inside the first air guide tube 4 to compress the spring 12, and then the sealing plug 15 will be separated from the first air guide tube 4, thereby allowing the inside of the body 1 and the box 3 to communicate, and the high-temperature exhaust gas will contact the heat conduction tube 9. Then, the cold air is extracted by the air pump 7 and accumulated in the heat transfer area. The cold air is heated under the heat transfer effect of the heat conduction pipe 9, thereby ensuring that the temperature inside the main body 1 will not be too high and the air pressure will not exceed the limit of the main body 1, thereby improving the safety of the device. When it is necessary to heat the inside of the main body 1, it is proved that the temperature environment and air pressure environment inside the main body 1 are both lower than the heat conduction zone. Therefore, the limit ring 13 on the inner wall of the second air conduction pipe 5 compresses the spring 12, so that the heat conduction zone is connected to the inside of the main body 1, achieving the effect of leading the hot air into the main body 1, thereby improving the energy utilization rate of the device.

[0035] This invention encompasses any alternatives, modifications, equivalents, and solutions that do not depart from the spirit and scope of this invention. While specific details are described in detail in the preferred embodiments of this invention to provide a thorough understanding, those skilled in the art will be able to fully understand this invention without these details. Furthermore, to avoid unnecessary confusion regarding the essence of this invention, well-known methods, processes, procedures, components, and circuits have not been described in detail.

[0036] Those skilled in the art will understand that all or part of the steps in the above-mentioned embodiment method can be completed by instructing the relevant hardware through a program, and the program can be stored in a computer-readable storage medium, such as ROM / RAM, a disk, an optical disk, etc.

[0037] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. An amination reaction device for synthesizing pharmaceutical intermediates, characterized in that: include: The main body (1) is fixedly provided with a feed hopper (2) on the top of the main body (1), the outer wall of the main body (1) is fixedly provided with a box (3), the outer wall of the main body (1) is respectively penetrated by a first air guide pipe (4) and a second air guide pipe (5) until the interior of the box (3), the inner wall of the main body (1) is provided with a heating pipe (6), the inner wall of the box (3) is fixedly provided with a partition (8), the inner wall of the partition (8) is provided with a heat pipe (9), the top of the inner wall of the box (3) is provided with a heat pipe (9), and the inner wall of the box (3) is provided with a heat pipe (9). The first air guide tube (4) and the second air guide tube (5) are fixedly equipped with an air pump (7), the inner walls of the first air guide tube (4) and the second air guide tube (5) are both provided with a mounting groove (10), the inner wall of the mounting groove (10) is fixedly equipped with a cross bar (11), the outer wall of the cross bar (11) is sleeved with a spring (12), the outer wall of the spring (12) abuts against a limiting ring (13), the outer wall of the limiting ring (13) is fixedly equipped with a connecting rod (14), and the end of the connecting rod (14) is fixedly equipped with a sealing plug (15).

2. The amination reaction device for synthesizing pharmaceutical intermediates according to claim 1, characterized in that: The end of the first air duct (4) away from the main body (1) passes through the outer wall of the box (3) and the partition (8) to the inner wall of the partition (8), and the distance between the second air duct (5) and the partition (8) is 3 cm.

3. The amination reaction device for synthesizing pharmaceutical intermediates according to claim 1, characterized in that: The inner wall of the mounting groove (10) is slidably connected to the outer wall of the limiting ring (13); a sliding hole is provided on the outer wall of the limiting ring (13); and the inner wall of the sliding hole is slidably connected to the outer wall of the crossbar (11).

4. The amination reaction device for synthesizing pharmaceutical intermediates according to claim 1, characterized in that: There are two sealing plugs (15), and the two sealing plugs (15) are respectively slidably connected to the inner walls of the first air duct (4) and the second air duct (5).

5. The amination reaction device for synthesizing pharmaceutical intermediates according to claim 1, characterized in that: The interior of the box (3) is divided into a heat recovery area and a heat conduction area by a partition (8), and the end of the heat conduction pipe (9) is located inside the heat conduction area.

6. The amination reaction device for synthesizing pharmaceutical intermediates according to claim 5, characterized in that: The interior of the heat transfer area is filled with cold air, and the heat recovery area is filled with high-temperature exhaust gas.

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