Purification device for production of medical intermediates
By designing a purification device for adding silo and twisting dragon conveying, vibrating silo screening, and hair dryer cleaning impurities, the problem of difficulty in cleaning impurities in the purification device of powdered pharmaceutical intermediates is solved, and convenient addition and efficient purification are achieved.
Patent Information
- Application Number
- CN202422375921.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-27
- Publication Date
- 2025-08-12
- Estimated Expiration
- 2034-09-27
AI Technical Summary
In the existing powdered pharmaceutical intermediate purification device, impurities are difficult to clean, which affects purification efficiency and has high operating risk.
A purification device including feed silo, twisted dragon, vibration silo, rough filter and fine filter are designed. The powdered pharmaceutical intermediate is conveyed through the twisted dragon, and the vibration silo is screened. The impurities are cleaned by a hair dryer and collected by a sliding plate to achieve convenient cleaning of impurities.
It realizes convenient addition and efficient purification of powdered pharmaceutical intermediates, reduces operational risks, improves purification efficiency and convenience of impurity cleaning.
Smart Images
Figure CN223209924U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of pharmaceutical intermediates, in particular to a purification device for the production of pharmaceutical intermediates. Background Art
[0002] Pharmaceutical intermediates are a critical component of the pharmaceutical industry. They serve as transitional chemicals in the drug synthesis process before producing the final active pharmaceutical ingredient (API). Simply put, pharmaceutical intermediates are compounds that have not undergone the final chemical transformation steps and lack full pharmacological activity, but they are essential precursors to the formation of therapeutically active drug molecules. Pharmaceutical intermediates can be derived from processes such as chemical synthesis, biosynthesis, or biofermentation, and range from simple organic chemicals to complex heterocyclic and fluorinated compounds. They serve as a bridge between drug development and commercial production, allowing pharmaceutical companies to construct drug molecules in a modular manner while also facilitating quality control and impurity management. In contrast to APIs, pharmaceutical intermediates are not used directly in drug formulations but serve as an intermediate step in the API production process. APIs are biologically or pharmacologically active compounds that, after undergoing all necessary chemical reactions and purification steps, can be directly formulated into tablets, capsules, or other pharmaceutical products for patient use.
[0003] In the prior art, some powdered pharmaceutical intermediates need to be purified during the production process. In the process of purifying the pharmaceutical intermediates, some powdered pharmaceutical intermediate purification devices mostly use screens to separate impurities and pharmaceutical intermediates. However, the impurities after screening are not easy to clean. The impurities retained above the filter during long-term filtration will affect the subsequent purification work and reduce the overall purification efficiency. Some purification devices used in production are generally high, making it difficult for operators to add pharmaceutical intermediates, and the process of climbing up to add is easy to cause danger to operators. Utility Model Content
[0004] The purpose of the utility model is to provide a purification device for the production of pharmaceutical intermediates, which can relatively easily clean up impurities after filtration and purification, and can relatively easily add materials.
[0005] To achieve the above-mentioned object, a purification device for producing pharmaceutical intermediates is provided, comprising a workbench, a support frame fixedly connected to the upper left side of the workbench, a feeding bin fixedly connected to the upper side of the support frame, a feeding port opened above the feeding bin, a connecting bin fixedly connected to the right side of the feeding bin, a transport pipe fixedly connected to the right side of the connecting bin, a drive motor fixedly connected to the left side of the connecting bin, and an auger fixedly connected to the output end of the drive motor;
[0006] The right side of the workbench is fixedly connected to a supporting spring, the upper end of the supporting spring is fixedly connected to the box body, the inner left side of the box body is fixedly connected to a vibration bin, the inner part of the vibration bin is fixedly connected to a fixed block, the right side of the fixed block is fixedly connected to a connecting rod, the right end of the connecting rod is fixedly connected to the vibration motor, the right middle part of the vibration bin is fixedly connected to a coarse filter screen, and the right lower part of the vibration bin is fixedly connected to a fine filter screen. A discharge chute is provided on the upper and lower sides of the right side of the box body, the inner part of the discharge chute is slidably connected with a baffle, the upper part of the baffle is fixedly connected to a sliding plate, the left side of the sliding plate is fixedly connected to a limiting spring, the upper and lower sides of the right side of the box body are fixedly connected to an impurity frame, the inner part of the impurity frame is slidably connected with an impurity box, the impurity box is provided with an impurity port above, and the right side of the impurity box is fixedly connected to a first handle.
[0007] According to the purification device for producing pharmaceutical intermediates, a fixed bracket is fixedly connected to the middle of the workbench, and the other end of the fixed bracket is fixedly connected to the transport pipe.
[0008] According to the purification device for producing pharmaceutical intermediates, a first hose is fixedly connected to the top of the box, a feeding funnel is fixedly connected to the top of the first hose, a lid is rotatably connected to the rear of the feeding funnel, a sealing strip is fixedly connected to the front of the lid, and the right end of the transport pipe corresponds to the feeding funnel.
[0009] According to the purification device for the production of pharmaceutical intermediates, a second hose is fixedly connected to the bottom of the box body, the lower end of the second hose is fixedly connected to the discharge bin, a discharge port is provided above the discharge bin, the second hose corresponds to the discharge port, the inside of the discharge bin is slidably connected to the discharge box, and a second handle is fixedly connected to the front of the discharge box.
[0010] According to the purification device for producing pharmaceutical intermediates, an observation window is fixedly connected to the front of the box, a hair dryer is fixedly connected to the box, and an isolation net is fixedly connected to the output end of the hair dryer.
[0011] According to the purification device for producing pharmaceutical intermediates, the auger is located inside the transport pipe, and the auger is rotatably connected to the transport pipe.
[0012] According to the purification device for producing pharmaceutical intermediates, the coarse filter is located inside the box and is fixedly connected to the box, and the fine filter is located inside the box and is fixedly connected to the box.
[0013] According to the purification device for producing pharmaceutical intermediates, the discharge bin is located above the workbench, and the discharge bin is fixedly connected to the workbench.
[0014] The utility model has the following beneficial effects:
[0015] 1. Compared with the prior art, this purification device for the production of pharmaceutical intermediates is provided with a feeding bin and a feed port is opened above the feeding bin, so that the operator can add the pharmaceutical intermediate to be purified into the feed port. The auger is driven by a driving motor to rotate. One end of the auger is located inside the connecting bin, so that the pharmaceutical intermediates inside the feeding bin and the connecting bin are transported to the other end of the transport pipe through the cooperation of the auger and the transport pipe. The transport pipe corresponds to the feed funnel, thereby realizing the addition of the pharmaceutical intermediate, so that the operator can add the pharmaceutical intermediate more easily while avoiding the danger of climbing.
[0016] 2. Compared with the existing technology, this purification device for the production of pharmaceutical intermediates is equipped with a hair dryer. After the purification process is completed, purified impurities remain on the coarse filter and the fine filter. After a long period of filtration, a large amount of impurities remain on the two. When cleaning is required, the lid is rotated to make the sealing strip fit tightly with the feed funnel. Driven by the hair dryer, the impurities above the coarse filter and the fine filter are gathered at a lower position on the right side of the two. By sliding the sliding plate upward, the impurities above the two fall into the inside of the impurity box, thereby achieving the cleaning of the impurities.
[0017] Additional aspects and advantages of the present invention will be given in part in the following description and will become apparent from the following description or learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] The present invention will be further described below with reference to the accompanying drawings and embodiments;
[0019] Figure 1 This is a three-dimensional diagram of a purification device for producing pharmaceutical intermediates according to the utility model;
[0020] Figure 2 This is a cross-sectional view of a box of a purification device for producing pharmaceutical intermediates according to the utility model;
[0021] Figure 3 This is an exploded view of the box and discharge bin of a purification device for producing pharmaceutical intermediates in the utility model;
[0022] Figure 4 This is a cross-sectional view of a transport pipe of a purification device for producing pharmaceutical intermediates according to the utility model.
[0023] Legend:
[0024] 1. Workbench; 2. Support frame; 3. Feeding bin; 4. Feeding port; 5. Connecting bin; 6. Transport pipe; 7. Drive motor; 8. Auger; 9. Fixed bracket; 10. Support spring; 11. Box body; 12. First hose; 13. Feeding funnel; 14. Lid; 15. Sealing strip; 16. Vibration bin; 17. Fixed block; 18. Connecting rod; 19. Vibration motor; 20. Coarse filter; 21. Fine filter; 22. Discharge chute; 23. Baffle; 24. Sliding plate; 25. Limit spring; 26. Impurity frame; 27. Impurity box; 28. Impurity port; 29. First handle; 30. Second hose; 31. Discharge bin; 32. Discharge port; 33. Discharge box; 34. Second handle; 35. Observation window; 36. Blower; 37. Isolation net. DETAILED DESCRIPTION
[0025] This section will describe in detail the specific embodiments of the present invention. The preferred embodiments of the present invention are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and overall technical solution of the present invention, but it cannot be understood as a limitation on the scope of protection of the present invention.
[0026] Reference Figure 1-4 The embodiment of the utility model is a purification device for the production of pharmaceutical intermediates, which includes a workbench 1, a support frame 2 is fixedly connected to the upper left side of the workbench 1, a feeding bin 3 is fixedly connected to the upper part of the support frame 2, a feeding port 4 is provided above the feeding bin 3, a connecting bin 5 is fixedly connected to the right side of the feeding bin 3, a transport pipe 6 is fixedly connected to the right side of the connecting bin 5, a driving motor 7 is fixedly connected to the left side of the connecting bin 5, an auger 8 is fixedly connected to the output end of the driving motor 7, the auger 8 is located inside the transport pipe 6, and the auger 8 is rotatably connected to the transport pipe 6.
[0027] The above structure is provided with an auger 8, one side of the auger 8 is located inside the feeding bin 3, and the other side is located inside the transport pipe 6, and the output end of the drive motor 7 is fixedly connected to the auger 8, so that the powdered pharmaceutical intermediate to be purified inside the feeding bin 3 is transported to the right side of the transport pipe 6 under the drive of the drive motor 7.
[0028] A fixed bracket 9 is fixedly connected to the middle of the workbench 1, and the other end of the fixed bracket 9 is fixedly connected to the transport pipe 6. A support spring 10 is fixedly connected to the right side of the workbench 1, and the upper end of the support spring 10 is fixedly connected to the box body 11. A first hose 12 is fixedly connected above the box body 11, and a feeding funnel 13 is fixedly connected above the first hose 12. A lid 14 is rotatably connected to the rear of the feeding funnel 13, and a sealing strip 15 is fixedly connected to the front of the lid 14. The right end of the transport pipe 6 corresponds to the feeding funnel 13, and a vibration bin 16 is fixedly connected to the inner left side of the box body 11. A fixed block 17 is fixedly connected to the inside of the vibration bin 16, and a connecting rod 18 is fixedly connected to the right side of the fixed block 17. The right end of the connecting rod 18 is fixedly connected to the vibration motor 19.
[0029] By providing a support spring 10, the support spring 10 supports the box body 11, and the box body 11 is vibrated by the drive of the vibration motor 19. Under the action of the support spring 10, the box body 11 does not cause vibration to the workbench 1 when working.
[0030] A coarse filter 20 is fixedly connected to the middle part of the right side of the vibration bin 16, and a fine filter 21 is fixedly connected to the lower right side of the vibration bin 16. The coarse filter 20 is located inside the box body 11, and the coarse filter 20 is fixedly connected to the box body 11. The fine filter 21 is located inside the box body 11, and the fine filter 21 is fixedly connected to the box body 11. A discharge chute 22 is opened on the upper and lower sides of the right side of the box body 11, and a baffle 23 is slidably connected inside the discharge chute 22. A sliding plate 24 is fixedly connected above the baffle 23, and a limiting spring 25 is fixedly connected to the left side of the sliding plate 24. An impurity frame 26 is fixedly connected to the upper and lower sides of the right side of the box body 11, and an impurity box 27 is slidably connected inside the impurity frame 26. An impurity port 28 is opened above the impurity box 27, and a first handle 29 is fixedly connected to the right side of the impurity box 27. A second hose 30 is fixedly connected to the bottom of the box body 11.
[0031] By providing the first hose 12 and the second hose 30 , when the box body 11 is in a vibrating state, the deformation of the first hose 12 and the second hose 30 can reduce the influence of the vibration on the feed hopper 13 and the discharge bin 31 .
[0032] The lower end of the second hose 30 is fixedly connected to the discharge bin 31, which is located above the workbench 1. The discharge bin 31 is fixedly connected to the workbench 1, and a discharge port 32 is provided above the discharge bin 31. The second hose 30 corresponds to the discharge port 32. The interior of the discharge bin 31 is slidably connected to a discharge box 33, and a second handle 34 is fixedly connected to the front of the discharge box 33. An observation window 35 is fixedly connected to the front of the box body 11, and a hair dryer 36 is fixedly connected to the box body 11. The output end of the hair dryer 36 is fixedly connected to an isolation net 37.
[0033] Working principle: When using the purification device for the production of pharmaceutical intermediates, the operator first adds the powdered pharmaceutical intermediate to be purified into the feeding bin 3, turns on the switch of the drive motor 7, and rotates the auger 8. Through the cooperation of the auger 8 and the transport pipe 6, the powdered pharmaceutical intermediate to be purified enters the interior of the feeding funnel 13. At this time, the switch of the vibration motor 19 is turned on to vibrate the entire box 11. Under the vibration of the box 11, the powdered pharmaceutical intermediate to be purified passes through the coarse filter 20 and the fine filter 21 faster, so that the pharmaceutical intermediate falls to the bottom of the box 11, and impurities remain above the coarse filter 20 and the fine filter 21. A second hose 30 is fixedly connected to the bottom of the box 11, and the other end of the second hose 30 is fixedly connected to the discharge bin 31. The pharmaceutical intermediates filtered inside the box 11 fall into the inside of the discharge box 33, thereby realizing the collection of the filtered pharmaceutical intermediates. By providing an observation window 35, the operator can observe the amount of impurities above the coarse filter 20 and the fine filter 21. When the amount of impurities above the two is too large, the lid 14 is closed, and after the filtered pharmaceutical intermediates are collected, the switch of the hair dryer 36 is turned on. Driven by the hair dryer 36, the impurities above the coarse filter 20 and the fine filter 21 fall into the right side of the coarse filter 20 and the fine filter 21. At this time, by sliding the sliding plate 24 upwards, some impurities fall into the inside of the impurity box 27, and the operator can use tools such as a brush to sweep the remaining impurities into the inside of the impurity box 27, thereby realizing the cleaning of impurities.
[0034] The embodiments of the present invention are described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Various changes can be made within the scope of knowledge possessed by ordinary technicians in the technical field without departing from the purpose of the present invention.
Claims
1. A purification device for producing pharmaceutical intermediates, characterized in that: The invention comprises a workbench (1), wherein a support frame (2) is fixedly connected to the upper left side of the workbench (1), a feeding bin (3) is fixedly connected to the upper side of the support frame (2), a feeding port (4) is provided above the feeding bin (3), a connecting bin (5) is fixedly connected to the right side of the feeding bin (3), a transport pipe (6) is fixedly connected to the right side of the connecting bin (5), a driving motor (7) is fixedly connected to the left side of the connecting bin (5), and an auger (8) is fixedly connected to the output end of the driving motor (7); The right side of the workbench (1) is fixedly connected to a support spring (10), the upper end of the support spring (10) is fixedly connected to a box (11), the left side of the interior of the box (11) is fixedly connected to a vibration bin (16), the interior of the vibration bin (16) is fixedly connected to a fixed block (17), the right side of the fixed block (17) is fixedly connected to a connecting rod (18), the right end of the connecting rod (18) is fixedly connected to a vibration motor (19), the middle part of the right side of the vibration bin (16) is fixedly connected to a coarse filter (20), and the lower right side of the vibration bin (16) is fixedly connected to a fine filter (21). ), a discharge trough (22) is provided on the upper and lower sides of the right side of the box body (11), a baffle (23) is slidably connected inside the discharge trough (22), a sliding plate (24) is fixedly connected above the baffle (23), a limit spring (25) is fixedly connected to the left side of the sliding plate (24), an impurity frame (26) is fixedly connected to the upper and lower sides of the right side of the box body (11), an impurity box (27) is slidably connected inside the impurity frame (26), an impurity port (28) is provided above the impurity box (27), and a first handle (29) is fixedly connected to the right side of the impurity box (27).
2. A purification device for producing pharmaceutical intermediates according to claim 1, characterized in that: A fixed bracket (9) is fixedly connected to the middle of the workbench (1), and the other end of the fixed bracket (9) is fixedly connected to the transport pipe (6).
3. A purification device for producing pharmaceutical intermediates according to claim 1, characterized in that: A first hose (12) is fixedly connected to the top of the box body (11), a feeding funnel (13) is fixedly connected to the top of the first hose (12), a cover (14) is rotatably connected to the rear of the feeding funnel (13), a sealing strip (15) is fixedly connected to the front of the cover (14), and the right end of the transport pipe (6) corresponds to the feeding funnel (13).
4. A purification device for producing pharmaceutical intermediates according to claim 1, characterized in that: A second hose (30) is fixedly connected to the bottom of the box body (11), a lower end of the second hose (30) is fixedly connected to a discharge bin (31), a discharge port (32) is provided above the discharge bin (31), the second hose (30) corresponds to the discharge port (32), a discharge box (33) is slidably connected to the inside of the discharge bin (31), and a second handle (34) is fixedly connected to the front of the discharge box (33).
5. A purification device for producing pharmaceutical intermediates according to claim 1, characterized in that: An observation window (35) is fixedly connected to the front of the box (11), a blower (36) is fixedly connected to the box (11), and an isolation net (37) is fixedly connected to the output end of the blower (36).
6. A purification device for producing pharmaceutical intermediates according to claim 1, characterized in that: The auger (8) is located inside the transport pipe (6), and the auger (8) is rotatably connected to the transport pipe (6).
7. A purification device for producing pharmaceutical intermediates according to claim 1, characterized in that: The coarse filter (20) is located inside the box (11), and the coarse filter (20) is fixedly connected to the box (11); the fine filter (21) is located inside the box (11), and the fine filter (21) is fixedly connected to the box (11).
8. A purification device for producing pharmaceutical intermediates according to claim 4, characterized in that: The discharge bin (31) is located above the workbench (1), and the discharge bin (31) is fixedly connected to the workbench (1).