Cleaning disc of full-automatic single-molecule immunoassay device

Abstract

The utility model discloses a cleaning disc of a full-automatic single-molecule immunoassay device, which comprises a cleaning disc barrel, a turntable mechanism arranged in the cleaning disc barrel and a needle body lifting mechanism arranged above the cleaning disc barrel, a reaction cup is placed on a turntable of the turntable mechanism, and the needle body lifting mechanism is arranged above the cleaning disc barrel. The rotating disc can drive a reaction cup to rotate, a liquid suction needle is arranged on the needle body lifting mechanism, a liquid injection needle is fixedly arranged at the top of a cleaning disc barrel, a cleaning barrel is arranged at the top of the cleaning disc barrel and located below the needle body lifting mechanism, a water receiving barrel is further arranged on the rotating disc, and a water outlet is formed in the water receiving barrel. A drainage cylinder is arranged in the cleaning disc cylinder and located below the rotary disc. And the cleaning water after the liquid injection needle is cleaned and the cleaning water after the liquid suction needle is inserted into the cleaning barrel for cleaning are discharged out of the cleaning disc through the water receiving barrel and the water discharging barrel. When the liquid injection needle and the liquid suction needle are cleaned, the cleaning structure and steps of the liquid injection needle and the liquid suction needle are simplified.

Description

Technical Field

[0001] The utility model relates to a cleaning disk, in particular to a cleaning disk of a full-automatic single molecule immunoassay device, belonging to the technical field of medical inspection. Background Art

[0002] Since the first automated chemical analyzer was manufactured, over half a century has passed, and fully automated immunoassay analyzers have reached technological maturity. Today's fully automated immunoassay analyzers feature the following: 1. They utilize a multi-degree-of-freedom robotic arm to coordinate the movements of various modules; 2. They offer exceptional flexibility, enabling them to meet diverse analytical needs; 3. They offer rapid testing speeds and long, unattended, continuous operation times; and 4. Their integration of multiple technologies and fully automated processing yield more accurate and precise test results. Fully automated immunoassay analyzers handle all steps of the experimental testing process, including cuvette removal, sample addition, reaction solution addition, shaking, reaction initiation, measurement, analysis, and cleaning. By replacing manual labor, they not only save labor costs but, more importantly, eliminate human error and ensure data accuracy. Their advantages include speed, efficiency, high precision, and repeatability, making them widely used in processing, production, testing, and daily life assistance, and are poised to become a trend in medical testing.

[0003] During the test, nanomagnetic beads are used to bind to antibodies and antigens. After binding, the remaining liquid in the reaction cuvette must be cleaned to ensure detection results. The principle of magnetic separation and cleaning is as follows: in the enzyme-catalyzed chemiluminescent immunoassay technique, the cloned antibodies in the magnetic bead reagent react with the analyte in the sample, as well as the enzyme-labeled antibody or antigen in the reagent, through a nonspecific immune reaction, forming a magnetic immune complex that is suspended in the reaction system. In the magnetic field created by the magnet, the magnetic immune complex and unbound magnetic particles are quickly captured and attached to the area near the magnetic field. Liquid outside the magnetic particle complex is removed, separating the magnetic particle complex from the enzyme particles in the liquid. When the external magnetic field is removed and cleaning fluid is injected, the magnetic particle complex is evenly dispersed in the solution, completing the cleaning of free enzymes. The magnetic beads, acting as a reaction carrier for the antigen and antibody, have a suspending property that enables the immune reaction to occur quickly and uniformly, while also promoting the rapid separation of the immune complex from the solution.

[0004] In immunoassay analyzers, a cleaning tray is responsible for cleaning the cuvettes. During the cleaning process, the cuvettes undergo a repeated cycle of "injection, cleaning, and aspiration" before being sent to the next step for testing. Existing techniques present a problem: after a period of downtime, the injection and aspiration needles in the cleaning tray need to be cleaned. However, existing cleaning trays can only use the injection and aspiration needles to clean the magnetic beads in the cuvettes. Cleaning the injection and aspiration needles themselves requires complex steps and results in poor cleaning results.

[0005] The applicant submitted an invention patent application in 2023, with publication number CN116984298A and publication date November 3, 2023. The patent document discloses a method for cleaning the injection and aspiration needles in the cleaning tray of an immunoassay analyzer, wherein a cleaning tank is arranged inside the cleaning tray below the turntable; during normal operation, the injection needle and the aspiration needle are controlled to move downward and inserted into the reaction cup on the turntable to clean the reaction cup; when the injection and aspiration needles need to be cleaned, the reaction cup is first removed, and then the injection needle and the aspiration needle are controlled to move downward so that the injection needle and the aspiration needle pass through the turntable and are inserted into the cleaning tank for cleaning the injection needle and the aspiration needle.

[0006] In this patent document, both the injection needle and the aspiration needle are installed on a needle lifting mechanism. When cleaning the injection needle and the aspiration needle, it is necessary to control the injection needle and the aspiration needle to move downward and insert them into the cleaning tank for cleaning. Therefore, the cleaning steps of the injection needle and the aspiration needle are more complicated.

[0007] Therefore, how to redesign a cleaning tray so that it can simplify the cleaning structure and steps of the injection needle and the pipette needle when the injection needle and the pipette needle are cleaned is a technical problem that needs to be solved urgently. Utility Model Content

[0008] The technical problem to be solved by the utility model is to provide a cleaning disk of a fully automatic single molecule immunoassay device in view of the defects in the prior art, which can simplify the cleaning structure and steps of the injection needle and the aspiration needle when cleaning the injection needle and the aspiration needle.

[0009] In order to solve the above technical problems, the technical solution adopted by the present invention is: a cleaning disk of a fully automatic single-molecule immunoassay device, comprising a cleaning disk cylinder, a turntable mechanism arranged inside the cleaning disk cylinder and a needle lifting mechanism arranged above the cleaning disk cylinder, a reaction cup is placed on the turntable of the turntable mechanism, and the turntable can drive the reaction cup to rotate, a pipette needle is arranged on the needle lifting mechanism, an injection needle is fixedly arranged on the top of the cleaning disk cylinder, a cleaning cylinder is arranged on the top of the cleaning disk cylinder and below the needle lifting mechanism, a water receiving cylinder is also arranged on the turntable, and a drainage cylinder is arranged inside the cleaning disk cylinder and below the turntable; the cleaning water after cleaning with the injection needle and the cleaning water after the pipette needle is inserted into the cleaning cylinder for cleaning are discharged from the cleaning disk through the water receiving cylinder and the drainage channel.

[0010] Preferably, the injection needle adopts a modular design. The modular injection needle includes a needle seat body with an internal solenoid valve and a tube body arranged at the bottom of the needle seat body. The tube body is connected to the external liquid supply system through the solenoid valve; a tube body through hole is opened on the top of the cleaning disc cylinder body. When the needle seat body of the modular injection needle is installed on the top of the cleaning disc cylinder body, the tube body is inserted into the tube body through hole.

[0011] Preferably, the inner diameter of the tube body is smaller than the diameter of the reaction cup.

[0012] Preferably, the cleaning cylinder includes a cleaning cylinder body, and a water inlet channel is provided on the side of the cleaning cylinder body, and the water inlet pipe is connected with the cylinder inner cavity of the cleaning cylinder body through the water inlet channel; a cylinder through hole is also provided on the top of the cleaning disc cylinder body, and when the cleaning cylinder body is installed on the top of the cleaning disc cylinder body, the cylinder inner cavity is connected with the cylinder through hole.

[0013] Preferably, an annular cavity is further provided in the cleaning cylinder, the water inlet channel is communicated with the annular cavity, and the annular cavity is communicated with the inner cavity of the cylinder through a spray hole.

[0014] Preferably, a plurality of the spray holes are provided.

[0015] Preferably, a tapered hole is provided at the upper end of the through hole of the cylinder, and the large end of the tapered hole is communicated with the inner cavity of the cylinder.

[0016] Preferably, the water receiving cylinder includes an upper end water receiving cylinder and a lower end water receiving cylinder connected to the upper end water receiving cylinder, the diameter of the upper end water receiving cylinder is larger than the diameter of the tube body of the modular liquid injection needle, and the diameter of the upper end water receiving cylinder is also larger than the diameter of the cylinder through hole on the top of the cleaning disc cylinder.

[0017] Preferably, the diameter of the drainage cylinder is larger than the diameter of the lower end water receiving cylinder of the water receiving cylinder.

[0018] The beneficial effects of the present invention are as follows: by providing a cleaning mechanism located at the top, a water receiving mechanism located in the middle, and a drainage mechanism located at the bottom, the present invention utilizes the cooperation of the three mechanisms to ensure the normal conduct of the detection operation and greatly simplify the cleaning structure and steps of the injection needle and the liquid aspiration needle when the injection and liquid aspiration needles are cleaned. The injection needle adopts a modular design, retaining only the needle body structure of the liquid aspiration needle, thus reducing the number of needle bodies and the requirements for the concentricity of the needle body. The modular design of the injection needle also facilitates disassembly and assembly operations. By designing the specific structure of the cleaning cylinder, it is possible to ensure normal detection operations and clean the needle body of the liquid aspiration needle. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a schematic diagram of the three-dimensional structure of the cleaning disk in the embodiment of the present utility model;

[0020] Figure 2 This is a schematic diagram of the axial cross-sectional structure of the cleaning disc in the embodiment of the present utility model;

[0021] Figure 3 This is a schematic diagram of the three-dimensional structure of the modular injection needle in an embodiment of the present utility model;

[0022] Figure 4 This is a partial axial cross-sectional structural diagram of the modular liquid injection needle in an embodiment of the present utility model after being installed on the top of the cleaning disk cylinder;

[0023] Figure 5 This is a partial axial cross-sectional structural diagram of the cleaning cylinder after it is installed on the top of the cleaning disc body in the embodiment of the present utility model;

[0024] Figure 6 A schematic diagram of a partial axial cross-sectional structure of the cleaning cylinder in an embodiment of the present invention during normal detection operation;

[0025] Figure 7 This is a schematic diagram of the three-dimensional structure of the turntable with the water collecting cylinder in the embodiment of the present utility model;

[0026] Figure 8 This is a partial three-dimensional structural diagram of the embodiment of the present invention after the drain cylinder is installed inside the washing disk body;

[0027] Figure 9 This is a schematic diagram of the principle structure when cleaning the inner wall of the injection needle in an embodiment of the present utility model;

[0028] Figure 10 This is a schematic diagram of the principle structure when cleaning the inner wall of the liquid-absorbing needle in an embodiment of the present utility model;

[0029] Figure 11This is a schematic diagram of the principle structure of cleaning the outer wall of the liquid pipette needle in the embodiment of the utility model. Figure 1 ;

[0030] Figure 12 This is a schematic diagram of the principle structure of cleaning the outer wall of the liquid pipette needle in the embodiment of the utility model. Figure 2 .

[0031] In the figure: 1. Cleaning disc cylinder, 111. Tube through hole, 112. Cylinder through hole, 1121. Conical hole, 2. Turntable mechanism, 211. Turntable, 3. Needle lifting mechanism, 4. Reaction cup, 5. Cleaning cylinder, 511. Cleaning cylinder, 512. Water inlet channel, 513. Cylinder inner cavity, 514. Annular cavity, 6. Injection needle, 611. Needle seat body, 612. Tube body, 7. Aspiration needle, 8. Water inlet pipe, 9. Water receiving cylinder, 911. Upper end water receiving cylinder, 912. Lower end water receiving cylinder, 10. Drain cylinder. DETAILED DESCRIPTION

[0032] After research, the applicant discovered that during daily work, when cleaning the magnetic beads in the reaction cup using a cleaning tray, when using an injection needle to inject liquid into the reaction cup, since the injection needle is inserted into the liquid in the reaction cup, when cleaning the injection needle, only the inner wall of the injection needle needs to be cleaned; when using a pipette needle to aspirate liquid into the reaction cup, since the pipette needle needs to be inserted into the liquid in the reaction cup, when cleaning the pipette needle, both the inner and outer walls of the pipette needle need to be cleaned. Therefore, when cleaning the injection needle, cleaning water is actually injected from the outside using the injection needle. During the injection process, the cleaning water flowing through the injection needle is used to clean the inner wall of the injection needle. The pipette needle, on the other hand, needs to be inserted into a cleaning container, such as a cleaning tank, to absorb cleaning water, and the cleaning water in the cleaning container is used to clean the inner and outer walls of the pipette needle.

[0033] Therefore, in view of the cleaning characteristics of the above-mentioned injection needle and suction needle, the injection needle does not need to be raised or lowered together with the needle body lifting mechanism. Since the cleaning water of the injection needle comes from the outside, it only needs to consider how to discharge the cleaning water injected from the outside. The suction needle needs to be raised or lowered together with the needle body lifting mechanism and inserted into the cleaning container for cleaning, but the discharge of the cleaning water in the cleaning container also needs to be considered.

[0034] Therefore, in order to simplify the cleaning steps of the injection needle and the pipette needle, the applicant designed the injection needle and the pipette needle separately, that is, the injection needle was fixed on the top of the cleaning tray, and the pipette needle was still set on the needle body lifting mechanism; the next step is to discharge the cleaning water. In order to simplify the cleaning structure and cleaning steps, if the cleaning water for cleaning the injection needle and the cleaning water for cleaning the pipette needle can be combined and discharged together, the cleaning structure and cleaning steps can be simplified to the greatest extent. Therefore, the applicant designed three mechanisms from top to bottom of the cleaning tray, namely the cleaning mechanism located at the top, the water receiving mechanism located in the middle and the drainage mechanism located at the bottom.

[0035] The cleaning mechanism located above refers to the cleaning cylinder arranged on the top of the cleaning disk between the needle lifting mechanism and the turntable. When normal detection work is carried out, the pipette needle can be lowered as the needle lifting mechanism passes through the cleaning cylinder and inserted into the reaction cup on the turntable. When the pipette needle is cleaned, the pipette needle can be lowered as the needle lifting mechanism is inserted into the cleaning cylinder for cleaning. The injection needle is fixed on the top of the cleaning disk. When normal detection work is carried out, the injection needle can normally inject liquid into the reaction cup on the turntable. When the injection needle is cleaned, the external cleaning water can be directly drawn in and injected using the injection needle. Thus, the cleaning position of the injection needle and the pipette needle is set on the top of the cleaning disk.

[0036] The water receiving mechanism located in the middle refers to a water receiving cylinder arranged on the turntable, and the water receiving cylinder is used to receive the cleaning water discharged from the upper cleaning mechanism after cleaning the injection needle and the washing needle, and guide the cleaning water after cleaning to the drainage mechanism located below.

[0037] The drainage mechanism located below is located in the cleaning tray and below the turntable, where a drainage cylinder is provided for discharging the cleaning water directed therefrom by the water receiving cylinder to the outside of the cleaning tray.

[0038] Through the above design concept, the utility model utilizes the different cleaning characteristics of the injection needle and the aspiration needle, and greatly simplifies the cleaning steps of the injection needle and the aspiration needle when cleaning the injection needle and the aspiration needle.

[0039] The technical solution of the present utility model is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0040] Example: Figure 1 and Figure 2As shown, the cleaning disk includes a cleaning disk body 1, a turntable mechanism 2 disposed within the cleaning disk body 1, and a needle lifting mechanism 3 disposed above the cleaning disk body 1. A reaction cup 4 is placed on a turntable 211 of the turntable mechanism 2, which drives the reaction cup 4 to rotate. A cleaning cylinder 5 is disposed on the top of the cleaning disk body 1 and below the needle lifting mechanism 3. An injection needle 6 is fixedly disposed on the top of the cleaning disk body 1, and a pipette needle 7 is disposed on the needle lifting mechanism 3. In this embodiment, three injection needles 6 and three pipette needles 7 are provided, for a total of six. To simplify the cleaning steps and structure, the injection needle 6 is not installed together with the pipette needle 7 on the needle lifting mechanism 3, but is installed separately. It should also be noted that in this embodiment, only the aspiration needle 7 still uses a needle-like structure as before. The injection needle 6 in this embodiment adopts a modular design and no longer uses a needle body like the aspiration needle 7. This is because when operating in the past, the needle body had to be inserted downward into the reaction cup. At this time, the more needle bodies there were, the higher the concentricity requirements for multiple needle bodies would be. Otherwise, there would be problems with some needles hitting the wall of the reaction cup during insertion. In this embodiment, the injection needle 6 adopts a modular design, retaining only the needle body structure of the aspiration needle 7. This reduces the number of needle bodies and reduces the requirements for needle body concentricity. In addition, the modular design of the injection needle 6 also facilitates disassembly and assembly. The number of cleaning cylinders 5 is the same as the number of aspiration needles 7, and there are also three of them, so that they can be used in conjunction with the aspiration needles 7 to clean the needle body.

[0041] The following describes the cleaning mechanism located at the top, the water receiving mechanism located in the middle, and the drainage mechanism located at the bottom:

[0042] 1. Cleaning mechanism located above:

[0043] 1. Explain the structure and position of the modular injection needle 6:

[0044] like Figure 3 and Figure 4As shown, the modular injection needle 6 comprises a needle holder 611 with an internal solenoid valve and a tube 612 disposed at the bottom of the needle holder 611. The tube 612 communicates with the external liquid supply system via the solenoid valve. A tube through-hole 111 is provided on the top of the cleaning disc body 1. When the modular injection needle's needle holder 611 is mounted on the top of the cleaning disc body 1, the tube 612 is inserted into the tube through-hole 111. During normal testing, the tube 612 is used to inject liquid into the cuvette on the lower turntable. At this point, a gap remains between the bottom of the tube 612 and the cuvette 4, eliminating the need for insertion into the cuvette for injection as previously required. This further reduces the risk of contamination of the modular injection needle 6. The inner diameter of the tube 612 is smaller than that of the cuvette 4, facilitating the injection of reagents from the tube 612 into the cuvette 4 without leaking elsewhere.

[0045] 2. Explain the structure and position of the cleaning cylinder 5:

[0046] like Figure 1 、 Figure 5 and Figure 6 As shown, the cleaning cylinder 5 includes a cleaning cylinder 511, and a water inlet channel 512 is provided on the side of the cleaning cylinder 511. The water inlet pipe 8 is connected to the cylinder cavity 513 of the cleaning cylinder 511 through the water inlet channel 512. A cylinder through hole 112 is also provided on the top of the cleaning disk cylinder 1. When the cleaning cylinder 511 is installed on the top of the cleaning disk cylinder 1, the cylinder cavity 513 is connected to the cylinder through hole 112. When performing normal detection operations, the aspiration needle 7 can be inserted into the reaction cup 4 at the lower position through the cylinder cavity 513 and the cylinder through hole 112. When the aspiration needle 7 is cleaned, external cleaning water is sent into the cylinder cavity 513 through the water inlet pipe 8, and then the aspiration needle 7 is controlled to be inserted into the cylinder cavity 513 for cleaning.

[0047] like Figure 5 As shown, an annular cavity 514 is also provided in the cleaning cylinder 511, and the water inlet channel 512 is connected to the annular cavity 514, and the annular cavity 514 is connected to the cylinder inner cavity 513 through the spray hole 515. In this way, when the outer wall of the liquid-absorbing needle 7 is cleaned, the spray hole 515 can be used to spray the cleaning water onto the outer wall of the liquid-absorbing needle 7, further improving the cleaning effect. A plurality of spray holes 515 can be provided. A tapered hole 1121 is provided at the upper end of the cylinder through hole 112, and the large end of the tapered hole 1121 is connected to the cylinder inner cavity 513. Here, the tapered hole 1121 is used to cooperate with the cylinder inner cavity 513 to alleviate the tendency of the cleaning water to flow downward. When the external cleaning water is continuously fed in, a certain amount of cleaning water can be retained in the cylinder inner cavity 513 during the cleaning process, thereby facilitating further cleaning of the liquid-absorbing needle 7.

[0048] 2. The water receiving mechanism in the middle:

[0049] like Figure 7 As shown, the water receiving cylinders 9 are arranged on the rotating disk 211, and their number and position correspond to the number and position of the modular liquid injection needles 6 and the liquid suction needles 7. In this embodiment, because there are three modular liquid injection needles 6 and three liquid suction needles 7, six water receiving cylinders 9 are also provided. The water receiving cylinder 9 includes an upper water receiving cylinder 911 and a lower water receiving cylinder 912 connected to the upper water receiving cylinder 911. The diameter of the upper water receiving cylinder 911 is larger than the diameter of the tubular body 612 of the modular liquid injection needle 6. This facilitates the flow of cleaning water flowing out of the tubular body 612 into the water receiving cylinder 9 when cleaning the liquid injection needle 6 and prevents it from leaking elsewhere. The diameter of the upper water receiving cylinder 911 is also larger than the diameter of the barrel through hole 112 on the top of the cleaning disk barrel body 1. This also facilitates the flow of cleaning water flowing out of the barrel through hole 112 into the water receiving cylinder 9 when cleaning the liquid suction needle 7 and prevents it from leaking elsewhere.

[0050] 3. Drainage mechanism located below:

[0051] like Figure 8 As shown, a drain cylinder 10 is installed within the wash tray body 1, below the turntable 211. The number and position of these drain cylinders 10 correspond to the number and position of the modular injection needles 6 and aspiration needles 7. Therefore, in this embodiment, six drain cylinders 10 are provided. The diameter of each drain cylinder 10 is larger than the diameter of the lower end water receiving cylinder 912 of the water receiving cylinder 9. This ensures that the wash water flowing from the lower end water receiving cylinder 912 flows into the drain cylinder 10 and does not leak elsewhere. Multiple drain cylinders 10 discharge the wash water to the exterior of the wash tray.

[0052] like Figure 4 and Figure 6 As shown, in this embodiment, when performing the liquid injection operation of normal detection, the turntable 211 is first controlled to rotate so that the reaction cup 4 on the turntable 211 is aligned with the tube 612 of the modular liquid injection needle 6, and then the solenoid valve is controlled to operate so that the external reagent is injected into the reaction cup 4 through the tube 612. After the injection is completed, the solenoid valve is controlled to operate again to stop the liquid injection from the tube 612.

[0053] When performing the normal liquid aspiration operation of the test, the turntable 211 is first controlled to rotate so that the reaction cup 4 on the turntable 211 is aligned with the barrel through hole 112 of the cleaning disk cylinder 1, and then the needle lifting mechanism 3 is controlled to move to drive the liquid aspiration needle 7 to descend, so that the liquid aspiration needle 7 passes through the barrel cavity 513 of the cleaning cylinder 5 and the barrel through hole 112 of the cleaning disk cylinder 1 in turn and is inserted into the reaction cup 4 to perform the liquid aspiration operation. After the liquid aspiration is completed, the needle lifting mechanism 3 is controlled to move again to drive the liquid aspiration needle 7 to rise and be pulled out of the reaction cup 4.

[0054] like Figure 9 As shown, in this embodiment, when cleaning the injection needle 6, the turntable 211 is first controlled to rotate so that the tube 612 of the modular injection needle 6, the water receiving cylinder 9 on the turntable 211, and the drain cylinder 10 inside the cleaning disk body 1 are vertically aligned, that is, on the same axis. Then, the solenoid valve is controlled to operate, allowing external cleaning water to be injected into the water receiving cylinder 9 through the tube 612, then flow from the water receiving cylinder 9 into the drain cylinder 10, and finally discharged (as shown by the hollow arrow in the figure). The cleaning water passing through the tube 612 is used to clean the inner wall of the modular injection needle 6.

[0055] like Figure 10 As shown, in this embodiment, when cleaning the inner wall of the liquid-absorbing needle 7, the turntable 211 is first controlled to rotate so that the cylinder through hole 112 on the top of the cleaning disc cylinder 1, the water receiving cylinder 9 on the turntable 211 and the drainage cylinder 10 inside the cleaning disc cylinder 1 are vertically aligned, that is, they are at the same axial position, and then the cleaning water is controlled to enter the cylinder inner cavity 513 of the cleaning cylinder 5 from the water inlet pipe 8, and then flow into the water receiving cylinder 9 through the cylinder inner cavity 513 and the cylinder through hole 112, and then flow from the water receiving cylinder 9 into the drainage cylinder 10, and finally be discharged (as shown by the hollow arrow in the figure). After the cleaning water enters the cleaning cylinder 5, the liquid-absorbing needle 7 inserted into the cylinder inner cavity 513 is controlled to absorb the cleaning water (as shown by the solid arrow in the figure), so that the cleaning water passing through the inner wall of the liquid-absorbing needle 7 is used to clean the inner wall of the liquid-absorbing needle 7.

[0056] like Figure 11 and Figure 12 As shown, when cleaning the outer wall of the liquid-absorbing needle 7, the turntable 211 is first controlled to rotate so that the cylinder through hole 112 on the top of the cleaning disc cylinder 1, the water receiving cylinder 9 on the turntable 211 and the drainage cylinder 10 inside the cleaning disc cylinder 1 are vertically aligned, that is, they are at the same axial position, and then the cleaning water is controlled to enter the cylinder inner cavity 513 of the cleaning cylinder 5 from the water inlet pipe 8, and then flow into the water receiving cylinder 9 through the cylinder inner cavity 513 and the cylinder through hole 112, and then flow from the water receiving cylinder 9 into the drainage cylinder 10, and finally be discharged (as shown by the hollow arrow in the figure). After the cleaning water enters the cleaning cylinder 5, the liquid-absorbing needle 7 inserted into the cylinder inner cavity 513 is controlled to move up and down in the cylinder inner cavity 513 (as shown by the solid arrow in the figure), so that the cleaning water in the cylinder inner cavity 513 is used to clean the outer wall of the liquid-absorbing needle 7.

[0057] It should be noted that, in this embodiment, the cleaning of the inner and outer walls of the aspiration needle are generally carried out separately. This is because when cleaning the outer wall of the needle body, the aspiration needle needs to be controlled to stop aspirating liquid, so as to avoid a portion of the cleaning water and air in the cylinder cavity being sucked away by the aspiration needle during the up and down movement of the aspiration needle.

[0058] When cleaning the outer wall of the pipette needle, this embodiment is carried out by controlling the pipette needle to rise and fall repeatedly in coordination with the cleaning water. In this way, the length of the outer wall of the pipette needle to be cleaned can be determined by controlling the stroke of the pipette needle to rise and fall, so that this embodiment can select the length of the outer wall of the pipette needle to be cleaned according to actual working conditions, which is more practical.

[0059] In summary, the present invention provides a cleaning mechanism located at the top, a water receiving mechanism located in the middle, and a drainage mechanism located at the bottom. By utilizing the cooperation of these three mechanisms, it can not only ensure the normal progress of the detection operation, but also greatly simplify the cleaning structure and steps of the injection needle and the liquid aspiration needle when the injection and liquid aspiration needles are cleaned. The injection needle adopts a modular design, and only the needle body structure of the liquid aspiration needle is retained. This reduces the number of the entire needle body and reduces the requirements for the concentricity of the needle body. The modular design of the injection needle is also convenient for disassembly and assembly. Through the specific structural design of the cleaning cylinder, it can not only ensure normal detection operation, but also perform needle body cleaning on the liquid aspiration needle.

[0060] The term "plurality" in this embodiment refers to "two or more." The above embodiments are intended only to illustrate the present invention and are not intended to limit the present invention. Persons skilled in the art may make various modifications or alterations without departing from the spirit and scope of the present invention. Therefore, all equivalent technical solutions are intended to fall within the scope of protection of the present invention, which is defined by the claims.

Claims

1. A cleaning disk for a fully automated single-molecule immunoassay device, comprising a cleaning disk body, a turntable mechanism disposed within the cleaning disk body, and a needle lift mechanism disposed above the cleaning disk body. A reaction cup is placed on a turntable of the turntable mechanism, which drives the reaction cup to rotate. A pipette needle is disposed on the needle lift mechanism. The invention is characterized in that: The injection needle is fixedly arranged on the top of the cleaning disc cylinder, and a cleaning cylinder is arranged on the top of the cleaning disc cylinder and below the needle body lifting mechanism. A water receiving cylinder is also arranged on the turntable, and a drainage cylinder is arranged inside the cleaning disc cylinder and below the turntable; the cleaning water after cleaning with the injection needle and the cleaning water after cleaning with the suction needle inserted into the cleaning cylinder are discharged from the cleaning disc through the water receiving cylinder and the drainage channel.

2. The cleaning tray according to claim 1, wherein: The injection needle adopts a modular design. The modular injection needle includes a needle seat body with an internal solenoid valve and a tube body arranged at the bottom of the needle seat body. The tube body is connected to the external liquid supply system through the solenoid valve; a tube body through hole is opened on the top of the cleaning disc cylinder body. When the needle seat body of the modular injection needle is installed on the top of the cleaning disc cylinder body, the tube body is inserted into the tube body through hole.

3. The cleaning tray according to claim 2, wherein: The inner diameter of the tube body is smaller than the diameter of the reaction cup.

4. The cleaning tray according to claim 2 or 3, characterized in that: The cleaning cylinder includes a cleaning cylinder body, a water inlet channel is provided on the side of the cleaning cylinder body, and the water inlet pipe is connected with the cylinder inner cavity of the cleaning cylinder body through the water inlet channel; a cylinder through hole is also provided on the top of the cleaning disc cylinder body, and when the cleaning cylinder body is installed on the top of the cleaning disc cylinder body, the cylinder inner cavity is connected with the cylinder through hole.

5. The cleaning tray according to claim 4, characterized in that: An annular cavity is also provided in the cleaning cylinder. The water inlet channel is communicated with the annular cavity, and the annular cavity is communicated with the inner cavity of the cylinder through a spray hole.

6. The cleaning tray according to claim 5, characterized in that: A plurality of spray holes are provided.

7. The cleaning tray according to claim 4, characterized in that: A tapered hole is provided at the upper end of the through hole of the cylinder, and the large end of the tapered hole is communicated with the inner cavity of the cylinder.

8. The cleaning tray according to claim 4, characterized in that: The water receiving cylinder includes an upper water receiving cylinder and a lower water receiving cylinder connected to the upper water receiving cylinder. The diameter of the upper water receiving cylinder is larger than the diameter of the tube body of the modular liquid injection needle, and the diameter of the upper water receiving cylinder is also larger than the diameter of the cylinder through hole on the top of the cleaning disc cylinder.

9. The cleaning tray according to claim 8, characterized in that: The diameter of the drainage cylinder is larger than the diameter of the lower end water receiving cylinder of the water receiving cylinder.

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