Epidermal cell planting device

Abstract

The utility model discloses an epidermal cell planting device which comprises a base and a plurality of microneedle structures arranged on the base in a protruding mode, liquid injection holes are formed in the microneedle structures in a penetrating mode, a plurality of communicating holes communicated with the liquid injection holes are formed in the base, and the size of each microneedle structure ranges from 300 micrometers to 400 micrometers. According to the epidermal cell planting device disclosed by the utility model, the wound surface can be punctured through the plurality of micro-needle structures arranged on the base, a plurality of tiny wounds are formed on the wound surface, and cell suspension can enter the tiny wounds formed on the wound surface by the micro-needle structures through the communicating holes and the liquid injection holes, so that the planting process of the cell suspension is realized; due to the fact that the sizes of a plurality of small wounds formed on the wound surface by the microneedle structure are small, the wound healing time is short, and in addition, due to the fact that the cell suspension is injected into the wounds, the colonization time of the cell suspension can be prolonged by the wounds; in addition, a plurality of microneedle structures are distributed on the base, so that the cell suspension can be uniformly dispersed on the wound surface, and the healing of the wound surface is facilitated.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical devices, and in particular relates to an epidermal cell implantation device. Background Art

[0002] Burns, scalds, trauma, and chronic wounds lead to skin defects and long-term non-healing, and the damaged area must be covered and reconstructed. Typically, skin transplantation or autologous cells are used to promote wound healing after early wound debridement of large-area burns. The delivery of cytokines and growth factors can also enhance wound healing [1]. Using limited autologous skin to protect the wound is a difficult problem that the burn department has been exploring. At the same time, skin transplantation still has defects such as low area expansion ratio, postoperative scars, and intraoperative pain, which limit its clinical application. In recent years, skin transplantation technology has also gradually changed from large sheets and meshes to microparticles and cells. Cells are implanted in the wound and can exist continuously, while releasing cytokines and other factors to improve the wound microenvironment. However, existing technologies often apply epidermal stem cell suspension directly to the wound surface, which can easily cause cell loss and weaken the effect.

[0003] The information disclosed in this background technology section is only intended to increase the understanding of the overall background of the present invention, and should not be regarded as an admission or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. Utility Model Content

[0004] The purpose of the utility model is to provide an epidermal cell implantation device, which can effectively and evenly implant epidermal cells on the wound surface, increase the implantation time, and exert a long-term effect on promoting wound healing.

[0005] In order to achieve the above-mentioned purpose, the technical solution provided by a specific embodiment of the present invention is as follows: an epidermal cell implantation device, comprising a base and a plurality of microneedle structures protruding from the base, wherein the microneedle structure is provided with an injection hole, and the base is provided with a plurality of connecting holes connected to the injection hole, and the size of the microneedle structure is 300 to 400 μm.

[0006] In one or more embodiments of the present invention, the microneedle structure includes a bottom surface connected to the base, and the injection hole extends from the bottom surface along the axial direction of the microneedle structure and penetrates through it.

[0007] In one or more embodiments of the present invention, the microneedle structure includes a tip and an outer peripheral surface, and the injection hole extends from the bottom surface along the axial direction of the injection hole and penetrates the outer peripheral surface.

[0008] In one or more embodiments of the present invention, the diameter of the injection hole is 30-80 μm.

[0009] In one or more embodiments of the present invention, a plurality of the microneedle structures are distributed on the base at equal intervals.

[0010] In one or more embodiments of the present invention, the height of the microneedle structure is 50 to 1000 μm.

[0011] In one or more embodiments of the present invention, the epidermal cell implantation device further comprises a fixing seat, the base is detachably mounted on the fixing seat, and the fixing seat is provided with a liquid injection cavity connected to the communicating hole.

[0012] In one or more embodiments of the present invention, the epidermal cell implantation device includes a syringe, the fixing seat has a liquid inlet connected to the injection cavity, and the syringe is connected to the liquid inlet.

[0013] In one or more embodiments of the present invention, the epidermal cell implantation device includes a connecting hose, one end of which is connected to the syringe, and the other end of which is connected to the liquid inlet.

[0014] In one or more embodiments of the present invention, one end of the connecting hose is detachably connected to a connecting piece of different sizes, and the connecting piece is connected to the syringe.

[0015] Compared with the prior art, the epidermal cell implantation device of the present invention can puncture the wound surface through multiple microneedle structures arranged on the base, forming multiple tiny wounds on the wound surface. The cell suspension can enter the tiny wounds formed on the wound surface through the connecting holes and the injection holes on the microneedle structure, thereby realizing the implantation process of the cell suspension; since the microneedle structure itself is small in size, the size of the multiple tiny wounds formed on the wound surface is small, and the wound healing time is short. In addition, since the cell suspension is injected into the tiny wounds, the tiny wounds can play a stabilizing role for the cell suspension, that is, increase the implantation time; in addition, there are multiple microneedle structures distributed on the base, so that the cell suspension can be dispersed more evenly on the wound surface, which is beneficial to the healing of the wound. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments recorded in the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0017] Figure 1 This is a cross-sectional view of the base and microneedle structure in one embodiment of the present invention;

[0018] Figure 2This is a cross-sectional view of a base and a microneedle structure in another embodiment of the present invention;

[0019] Figure 3 This is a cross-sectional view of a base and a microneedle structure according to another embodiment of the present invention;

[0020] Figure 4 This is a partial cross-sectional view of an epidermal cell implantation device in one embodiment of the present invention;

[0021] Figure 5 Schematic diagram of an epidermal cell implantation device in one embodiment of the present invention.

[0022] Description of main reference numerals:

[0023] 1. Base; 11. Connecting hole; 12. Connecting surface; 2. Microneedle structure; 21. Injection hole; 22. Bottom surface; 23. Tip; 24. Peripheral surface; 3. Fixing seat; 31. Injection cavity; 32. Liquid inlet; 4. Syringe; 5. Connecting hose; 51. Connecting piece. DETAILED DESCRIPTION

[0024] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the following will be combined with the drawings of the embodiments of the present invention to clearly and completely describe the technical solutions of the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of the present invention.

[0025] like Figure 1 As shown, the epidermal cell implantation device in one embodiment of the present invention includes a base 1 and a plurality of microneedle structures 2 protruding from the base 1. The microneedle structure 2 is penetrated by an injection hole 21, and the base 1 is provided with a plurality of connecting holes 11 connected to the injection hole 21. The size of the microneedle structure 2 is 300-400 μm.

[0026] It can be understood that the multiple microneedle structures 2 arranged on the base 1 can puncture the wound surface, forming multiple tiny wounds on the wound surface, and the cell suspension can enter the tiny wounds formed on the wound surface through the connecting hole 11 and the injection hole 21 of the microneedle structure 2, thereby realizing the planting process of the cell suspension; since the microneedle structure 2 itself is small in size (the size of the microneedle structure 2 is 300-400 μm), the size of the multiple tiny wounds formed on the wound surface is small, and the wound healing time is short. In addition, since the cell suspension is injected into the tiny wound, the tiny wound can play a fixed role on the cell suspension, that is, increase the colonization time; in addition, there are multiple microneedle structures 2 distributed on the base 1, so that the cell suspension can be dispersed more evenly on the wound surface, which is beneficial to the healing of the tiny wounds on the wound surface. It should be noted that, in the case of Figure 1 In the embodiment shown, the cell suspension can enter the micro-wound formed on the wound surface by the microneedle structure 2 through the connecting hole 11 and the injection hole 21 under external pressure or capillary action of the connecting hole 11 and the injection hole 21. Preferably, the cell suspension can enter the micro-wound on the wound surface under external pressure, for example, through an injection device. The injection device can be part of the epidermal cell implantation device of the present invention, for example Figure 5 The syringe shown may also be a part of an epidermal cell implantation device other than the present invention, that is, the injection device may be an external device.

[0027] The microneedle structure has a size of 300-400 μm, i.e., a maximum outer diameter of the microneedle structure is 300-400 μm; preferably, the maximum outer diameter of the microneedle structure is 350 μm. The cell suspension can be considered an epidermal stem cell suspension, which is transplanted onto a skin wound to promote wound healing.

[0028] The base 1 and the microneedle structure 2 are fixedly connected. Preferably, the base 1 and the microneedle structure 2 are integrally formed. For example, the base 1 and the microneedle structure 2 can be integrally formed using a polymer polyurethane material through 3D printing.

[0029] In one embodiment, the microneedle structure 2 includes a bottom surface 22 connected to the base 1, and an injection hole 21 extends from the bottom surface 22 and is provided through the axial direction of the microneedle structure 2. That is, the bottom surface 22 of the microneedle structure 2 is connected to the base 1, and the injection hole 21 is provided to facilitate the cell suspension to enter the wound through the injection hole 21.

[0030] like Figure 1As shown, in this embodiment, the microneedle structure 2 includes a tip 23 and an outer peripheral surface 24. The injection hole 21 extends from the bottom surface 22 along the axial direction of the injection hole 21 and penetrates the outer peripheral surface 24. The injection hole 21 penetrates the middle of the outer peripheral surface 24. This arrangement can retain the tip 23, thereby ensuring that the microneedle structure 2 can better puncture the wound surface and allow the cell suspension to enter the wound, which is beneficial to the colonization effect of the cell suspension.

[0031] In another embodiment, if Figure 2 As shown, the injection hole 21 extends from the bottom surface 22 along the axial direction of the injection hole 21 and passes through the tip 23. Such a configuration allows the cell suspension to enter deeper into the wound, thereby improving the colonization effect of the cell suspension.

[0032] In another embodiment, Figure 3 As shown, the base 1 has a connection surface 12 for connecting to the microneedle structure 2, and the injection hole 21 extends from the bottom surface 22 along the axial direction of the injection hole 21 and passes through the bottom of the outer peripheral surface 24. The connecting hole 11 is partially located at the connection surface 12 between the spaced microneedle structures 2. That is, the connecting hole 11 can not only deliver the cell suspension to the injection hole 21, but also directly deliver the cell suspension to the wound surface. This arrangement can increase the amount of cell suspension injected. Among them, the area of the connecting surface 12 can be determined according to the actual planting area on the wound surface. The connecting surface 12 can be rectangular, circular, elliptical, triangular, etc.

[0033] like Figure 1 As shown, the diameter of the injection hole 21 is 30-80 μm. The height of the microneedle structure 2 is 100-300 μm. The height of the microneedle structure 2 is adjustable, mainly to adapt to the thickness of the dermis of the injected object.

[0034] like Figure 1 and 5 As shown, multiple microneedle structures 2 are evenly spaced and distributed on the base 1. Such an arrangement can enhance the uniform distribution of the cell suspension on the wound surface, which is beneficial to the healing of the wound surface.

[0035] Furthermore, the epidermal cell implantation device includes a fixing base 3, to which the base 1 is detachably mounted. The fixing base 3 is provided with a liquid injection cavity 31 that communicates with the connecting hole 11. This arrangement facilitates replacement of the base 1 and the microneedle structure 2 if they become contaminated or damaged.

[0036] Furthermore, the epidermal cell implantation device includes a syringe 4. The mounting base 3 has a liquid inlet 32 connected to the injection chamber 31. The syringe 4 is connected to the liquid inlet 32. The syringe 4 can contain a cell suspension and deliver the cell suspension to the base 1 and microneedle structure 2. The syringe 4 can be a common commercially available medical syringe 4. Furthermore, the syringe can apply pressure to the cell suspension within the base 1 and microneedle structure 2, allowing it to enter the wound surface, thereby achieving epidermal cell implantation.

[0037] Preferably, the epidermal cell implantation device includes a connecting hose 5, one end of which is connected to the syringe 4 and the other end is connected to the liquid inlet 32. The connecting hose 5 can serve to connect the syringe 4 and the fixing base 3. That is, when the operating space is narrow, the connecting hose 5 can only position the fixing base 3, the base 1, and the microneedle structure 2 in the operating space, and the syringe 4 can be placed in a spacious area, thereby increasing the adaptability of the epidermal cell implantation device to various usage environments.

[0038] Preferably, one end of the connecting hose 5 is detachably connected to a connector 51 of different sizes, which is connected to the syringe 4. This arrangement allows the connector 51 to be connected to syringes 4 of different sizes (e.g., volumes), thereby increasing the adaptability of the epidermal cell implantation device to various usage environments.

[0039] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the present invention is defined by the appended claims, not the foregoing description, and all variations within the meaning and range of equivalents of the claims are intended to be encompassed within the present invention. Any reference sign in a claim should not be construed as limiting the claim to which it relates.

[0040] In addition, it should be understood that although this specification is described in terms of implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

Claims

1. An epidermal cell implantation device, characterized in that: The invention comprises a base and a plurality of microneedle structures protruding from the base, wherein the microneedle structures are provided with a liquid injection hole, and the base is provided with a plurality of connecting holes connected to the liquid injection hole, and the size of the microneedle structures is 300 to 400 μm; The microneedle structure includes a bottom surface connected to the base, and the base has a connecting surface for connecting the microneedle structure. The injection hole extends from the bottom surface along the axial direction of the injection hole and passes through the bottom of the outer peripheral surface, and part of the connecting hole is located at the connecting surface between the spaced microneedle structures.

2. The epidermal cell implantation device according to claim 1, characterized in that: The diameter of the injection hole is 30 to 80 μm.

3. The epidermal cell implantation device according to claim 1, characterized in that: The plurality of microneedle structures are distributed on the base at equal intervals.

4. The epidermal cell implantation device according to claim 1, characterized in that: The height of the microneedle structure is 50 to 1000 μm.

5. The epidermal cell implantation device according to claim 1, characterized in that: The epidermal cell implantation device further comprises a fixing seat, the base is detachably mounted on the fixing seat, and the fixing seat is provided with a liquid injection cavity connected to the communicating hole.

6. The epidermal cell implantation device according to claim 5, characterized in that: The epidermal cell implantation device comprises a syringe, the fixing seat is provided with a liquid inlet communicated with the liquid injection cavity, and the syringe is communicated with the liquid inlet.

7. The epidermal cell implantation device according to claim 6, characterized in that: The epidermal cell implantation device comprises a connecting hose, one end of which is connected to the syringe, and the other end of which is connected to the liquid inlet.

8. The epidermal cell implantation device according to claim 7, characterized in that: One end of the connecting hose is detachably connected to a connecting piece of different sizes, and the connecting piece is connected to the syringe.

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