Three-in-one equipment suitable for collecting light powdery materials

Abstract

The utility model belongs to the technical field of industrial equipment, and particularly relates to three-in-one equipment suitable for collecting light powdery materials. The first sintering net is reversely blown through the ventilation pipeline, compressed gas is introduced into the containing cavity, materials are effectively prevented from blocking the first sintering net, the materials attached to the first sintering net are reversely blown up, meanwhile, the flow guide bin is vacuumized and sucked through the second vacuum pipeline, and the sintering efficiency is improved. Therefore, it is guaranteed that the floating materials can move in the direction of the material collecting barrel subsequently, and finally all the materials are collected into the material collecting barrel. The device is simple in structural design, convenient to operate and high in practicability. According to the utility model, the condition that sterile three-in-one equipment needs to be matched with a sterile isolator and a sterile material pushing rod is effectively avoided, and the equipment cost and the later equipment maintenance cost are reduced. According to the utility model, the operation mode is optimized, the operation content is simplified, the production period is accelerated, the yield of materials is improved, and the loss of the materials is reduced.

Description

Technical Field

[0001] The utility model belongs to the technical field of industrial equipment, and particularly relates to a three-in-one device suitable for collecting light powdery materials. Background Art

[0002] Three-in-one equipment, also known as a filtration, washing, and drying machine, primarily separates solid and liquid materials through a sintered mesh at the bottom of the tank. Filtering involves multiple rinses of solid materials with a solvent, followed by the discharge of the washing liquid through the sintered mesh at the bottom of the tank. Drying involves vacuuming the tank through a vacuum line connected to the top of the tank, while hot water is circulated through the tank's interlayer to dry the material inside. Many materials require final solid-liquid separation and drying, and three-in-one equipment is used for the final steps of solid-liquid separation, rinsing, storage, and vacuum drying. The use of three-in-one equipment is already widespread. The production of sterile APIs, in particular, requires specialized design of three-in-one equipment to ensure the sterility of the production process.

[0003] After the final alcohol precipitation step, the sterile sodium hyaluronate API enters a sterile environment. The precipitate, sodium hyaluronate, is pumped into a three-in-one device for solid-liquid separation of the ethanol and sodium hyaluronate. The material is then rinsed multiple times with high-concentration ethanol and finally vacuum-dried. The dried powder is collected and packaged. Discharging from a three-in-one device typically involves counter-rotating agitators at the bottom, which discharge the material from the device's bottom outlet. However, due to the 3-5mm gap required between the agitator and the sintered mesh, the material at the bottom of the tank often cannot be fully discharged from the outlet. This necessitates the use of a sterile isolator, a sterile pusher, and the three-in-one device to ensure that any remaining material at the bottom of the tank is fully discharged from the device's bottom outlet.

[0004] The discharge method for three-in-one equipment is generally to discharge the material from the discharge port at the bottom of the three-in-one equipment by rotating the bottom stirring paddle in the opposite direction. There are generally two ways to discharge the material from three-in-one equipment. One method is to add an isolator to the discharge port of the three-in-one equipment to seal the discharge port of the three-in-one equipment as a whole. Then, inside the isolator, a sterilized scraper is used to scrape out the remaining material on the sintering mesh and collect it in a sterile bag for later use. The other method is to add an isolator on the back of the discharge port of the three-in-one equipment, open a small hole at the connection point of the three-in-one equipment with the isolator, and use a sterile pusher to push the remaining material out of the discharge port of the three-in-one equipment.

[0005] The biggest problem with the two solutions mentioned above is that the cost is too high. The reason is that the sterile three-in-one equipment needs to be equipped with a sterile isolator and a sterile push rod, which increases the cost and the subsequent operating costs of the sterile isolator are also high. Secondly, the operation is inconvenient. Because the sterile isolator needs to be sterilized separately with VHP each time it is used, and the sterile push rod needs to be sterilized separately with wet heat, etc., the process steps are cumbersome. Finally, it is easy to cause incomplete collection of materials. The reason is that whether using the scraping rod to scrape out the material or the push rod to push the material out, the operation is carried out through the small hole on the three-in-one equipment. The operating space is limited, and the materials in the dead corner cannot be touched, so it is naturally difficult to collect. Utility Model Content

[0006] The utility model is intended to overcome the defects of the prior art sterile three-in-one equipment, which requires the use of auxiliary materials such as sterile isolators and sterile push rods, significantly increases costs, has complicated process operations, and a long production cycle; large material loss and low yield. A three-in-one equipment suitable for collecting lightweight powdered materials is provided to overcome the above defects.

[0007] In order to achieve the above-mentioned purpose of the invention, the present invention is implemented through the following technical solutions:

[0008] A three-in-one device suitable for collecting light powdery materials, including:

[0009] A tank body is provided with a holding cavity for holding materials, a drain port is provided at the bottom of the holding cavity, a first sintered mesh is provided above the drain port and at the lower part of the holding cavity, an agitator is provided in the holding cavity, the upper end of the agitator passes through the top of the tank body and extends upward, and a first vacuum pipeline for evacuating the holding cavity is also provided at the top of the tank body;

[0010] a vent line for backflushing the first sintered wire mesh and introducing gas into the accommodating cavity, one end of the vent line passing through the bottom of the tank body and communicating with the accommodating cavity, the other end of the vent line being fed with external compressed gas, and the gas outlet of the vent line being located below the first sintered wire mesh;

[0011] A material collecting device is located below the tank body and is connected to the accommodating cavity of the tank body. The material collecting device includes a material collecting barrel for collecting materials and a diversion bin for material circulation. The diversion bin is located above the material collecting barrel and is connected to the material collecting barrel. The side wall of the diversion bin is connected to a second vacuum pipeline, and a second sintered mesh is provided at the inlet position of the second vacuum pipeline.

[0012] The three-in-one device for collecting lightweight powdered materials of the present invention includes a tank body. A holding chamber for holding materials is provided within the tank body. A drain outlet is provided at the bottom of the holding chamber. A first sintered mesh is provided above the drain outlet and located at the bottom of the holding chamber. A stirrer is provided within the holding chamber for stirring the materials. The upper end of the stirrer extends upward through the top of the tank body. A first vacuum line for evacuating the holding chamber is also provided at the top of the tank body. The three-in-one device for collecting lightweight powdered materials of the present invention also includes a vent line. The vent line is used to backflush the first sintered mesh and introduce gas into the holding chamber. One end of the vent line extends through the bottom of the tank body and communicates with the holding chamber. The other end of the vent line is fed with external compressed gas. The outlet of the vent line (the outlet here refers to the end of the pipe through which the introduced compressed gas is discharged) is located below the first sintered mesh. The three-in-one device for collecting lightweight powdered materials of the present invention also includes a material collection device. The material collection device is located below the tank body and communicates with the tank's accommodating chamber. It includes a material collection bucket for collecting materials and a diversion chamber for material circulation. The diversion chamber is located above and communicates with the material collection bucket. A second vacuum line is connected to the sidewall of the diversion chamber, and a second sintered mesh is installed at the inlet of the second vacuum line (the inlet here refers to the point where the gas in the diversion chamber enters the second vacuum line during vacuum pumping).

[0013] Since the powdered sodium hyaluronate material has a low density and is very easy to be blown up, the utility model sets a ventilation line to back-blow the first sintered mesh and introduce compressed gas into the accommodating chamber, which effectively prevents the material from clogging the first sintered mesh and back-blows the material attached to the first sintered mesh. At the same time, the second vacuum line is used to vacuum the diversion bin, thereby ensuring that the floating material can subsequently move toward the receiving barrel and eventually all be collected in the receiving barrel. The utility model has a simple structural design, is easy to operate, and is highly practical. In addition, the utility model effectively avoids the need for a sterile three-in-one device to be equipped with a sterile isolator and a sterile push rod, which helps to reduce equipment costs and subsequent equipment maintenance costs. In addition, the utility model optimizes the operation method, simplifies the operation content, helps to speed up the production cycle, and at the same time helps to improve the yield of materials and reduce material loss.

[0014] Preferably, the top of the tank body is further provided with a first viewing window for observing the material in the accommodating cavity.

[0015] By providing the first viewing window, it is easy to observe the remaining material in the accommodating chamber, thereby helping to accurately determine the end point of the production process.

[0016] Preferably, a second viewing window for observing the material in the accommodating cavity is provided on the other side wall of the tank body and located above the first sintered mesh.

[0017] By providing the second viewing window, it is helpful to directly observe the remaining material below the agitator from the side wall of the tank body, thereby helping to accurately determine the end point of the production process.

[0018] Preferably, a dust collector is provided between the top of the tank body and the first vacuum pipeline.

[0019] By setting up a dust collector, tiny dust or particulate matter that may escape during the vacuum suction process can be further captured and collected, which helps to improve filtration efficiency, meet environmental protection requirements, and at the same time protect the equipment from damage, effectively extending the service life of the equipment.

[0020] Preferably, the external compressed gas introduced into the other end of the ventilation pipeline is an inert gas.

[0021] Preferably, the inert gas is any one of nitrogen, argon and helium.

[0022] As further preferred, the inert gas is nitrogen.

[0023] Since three-in-one equipment is generally used to separate solid products from organic solvents (sodium hyaluronate production involves separating the product from 95% ethanol), inert gas provides explosion protection. Furthermore, inert gas is chemically inert and less reactive with other substances. Therefore, introducing inert gas into the vent line effectively prevents the material inside the tank from coming into contact with oxygen in the air, thereby preventing oxidation reactions. Furthermore, inert gas reduces the ingress of dust, moisture, and other impurities from the air into the tank, reducing contamination risks and improving the cleanliness and quality of the final product. Furthermore, it effectively prevents explosions from organic solvents mixed with the material inside the tank, contributing to improved production safety. Nitrogen, on the other hand, is widely used in industrial production due to its stable chemical properties, resistance to reactions with other substances, and relatively low cost. During the backflush process, nitrogen can help remove residual material from the first sintered wire, ensuring continuity and efficiency in the filtration, washing, and drying processes.

[0024] Preferably, a connecting pipe is provided on the top of the diversion bin, the lower end of the connecting pipe is connected to the diversion bin, the upper end of the connecting pipe is connected to a side wall of the tank body, and a screw valve is inserted into the upper end of the connecting pipe.

[0025] By installing a screw valve with a bellows, the containment chamber and the diversion chamber of the three-in-one device are sealed, making it suitable for steam moist heat sterilization in the diversion chamber. Furthermore, the screw valve's structural design allows for quick and easy installation and removal, enhancing the overall flexibility of the equipment. Furthermore, the screw valve can be integrated with automated control systems for remote control and automated operation, further improving production efficiency. The connecting pipe design helps reduce the possibility of material residue and scale accumulation.

[0026] Preferably, a manual valve is provided between the lower end of the diversion bin and the upper end of the material receiving barrel.

[0027] Manual valves allow operators to manually control material flow when needed, providing flexible control while preventing leakage. Manual valves also facilitate maintenance and repair of the diversion bin and receiving drum. Furthermore, in emergencies, such as equipment failures, operators can quickly close the manual valves to cut off material flow, ensuring production safety.

[0028] Therefore, the utility model has the following beneficial effects:

[0029] (1) The utility model provides a ventilation pipeline to backflush the first sintering mesh and introduce compressed gas into the accommodating chamber, thereby effectively preventing the material from clogging the first sintering mesh and backflush the material attached to the first sintering mesh. At the same time, the second vacuum pipeline is used to vacuum the guide bin, thereby ensuring that the floating material can subsequently move toward the receiving barrel and finally be collected in the receiving barrel.

[0030] (2) The utility model has a simple structural design, is easy to operate and has strong practicality;

[0031] (3) The utility model effectively avoids the need for a sterile isolator and a sterile push rod to be used with the sterile three-in-one equipment, which helps to reduce equipment costs and subsequent equipment maintenance costs;

[0032] (4) The utility model optimizes the operation mode, simplifies the operation content, helps to speed up the production cycle, and at the same time helps to improve the material yield and reduce material loss. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 This is a schematic diagram of the structure of a three-in-one device suitable for collecting light powdery materials.

[0034] In the figure: tank body 1; accommodating chamber 2; drain port 3; first sintered mesh 4; agitator 5; first vacuum line 6; ventilation line 7; material collecting device 8; material collecting barrel 9; diversion bin 10; second vacuum line 11; second sintered mesh 12; first viewing window 13; second viewing window 14; dust collector 15; connecting pipe 16; screw valve 17; manual valve 18. DETAILED DESCRIPTION

[0035] The present invention is further described below in conjunction with the accompanying drawings and specific embodiments. Based on these descriptions, a person skilled in the art will be able to implement the present invention. Furthermore, the embodiments of the present invention described below generally represent only a portion of the present invention, rather than all of the embodiments. Therefore, all other embodiments derived by a person skilled in the art based on the embodiments of the present invention without inventive effort should fall within the scope of protection of the present invention.

[0036] Example 1

[0037] like Figure 1 As shown, the three-in-one device for collecting light powdered materials of the present invention includes a tank body 1. A holding chamber 2 for holding materials is provided inside the tank body 1, a drain port 3 is provided at the bottom of the holding chamber 2, and a first sintered mesh 4 is provided above the drain port 3 and located at the lower part of the holding chamber 2. A stirrer 5 for stirring the material is provided in the holding chamber 2, and the upper end of the stirrer 5 passes through the top of the tank body 1 and extends upward. As an embodiment, the stirrer 5 is equipped with a bellows, which is beneficial for isolating the holding chamber 2 from the outside and withstanding high-temperature steam sterilization. A first vacuum line 6 for evacuating the holding chamber 2 is also provided at the top of the tank body 1. The three-in-one device for collecting light powdered materials of the present invention also includes a ventilation line 7. The ventilation line 7 is used to back-blow the first sintered mesh 4 and introduce gas into the accommodating chamber 2. One end of the ventilation line 7 passes through the bottom of the tank body 1 and is connected to the accommodating chamber 2. The other end of the ventilation line 7 is introduced with external compressed gas. The air outlet of the ventilation line 7 is located below the first sintered mesh 4. The three-in-one device for collecting lightweight powdered materials of the present invention also includes a gathering device 8. The gathering device 8 is located below the tank body 1 and is connected to the accommodating chamber 2 of the tank body 1. The gathering device 8 includes a collecting barrel 9 for collecting materials and a diversion bin 10 for material circulation. The diversion bin 10 is located above the collecting barrel 9 and is connected to the collecting barrel 9. The side wall of the diversion bin 10 is connected to the second vacuum line 11, and a second sintered mesh 12 is provided at the inlet of the second vacuum line 11.

[0038] Since the powdered sodium hyaluronate material has a low density and is very easy to be blown up, the utility model sets a ventilation line 7 to back-blow the first sintered mesh 4 and introduce compressed gas into the accommodating chamber 2, thereby effectively preventing the material from clogging the first sintered mesh 4 and back-blow up the material attached to the first sintered mesh 4. At the same time, the second vacuum line 11 is used to vacuum and suction the guide bin 10, thereby ensuring that the floating material can subsequently move toward the receiving barrel 9 and eventually all be collected in the receiving barrel 9. The utility model has a simple structural design, is easy to operate, and is highly practical. In addition, the utility model effectively avoids the need for a sterile three-in-one device to be equipped with a sterile isolator and a sterile push rod, which helps to reduce equipment costs and subsequent equipment maintenance costs. In addition, the utility model optimizes the operation method, simplifies the operation content, helps to speed up the production cycle, and at the same time helps to improve the yield of materials and reduce material loss.

[0039] As an embodiment, a first viewing window 13 for observing the material in the accommodating chamber 2 is further provided on the top of the tank body 1 .

[0040] By providing the first viewing window 13 , it is convenient to observe the remaining material in the accommodating chamber 2 , thereby facilitating accurate determination of the end point of the production process.

[0041] As an embodiment, a second viewing window 14 for observing the material in the accommodating cavity 2 is provided on the other side wall of the tank body 1 and located above the first sintered mesh 4 .

[0042] The second viewing window 14 is provided to facilitate direct observation of the remaining material below the agitator 5 from the side wall of the tank body 1 , thereby facilitating accurate determination of the end point of the production process.

[0043] As an embodiment, a dust collector 15 is further provided between the top of the tank body 1 and the first vacuum pipeline 6 .

[0044] By providing the dust collector 15 , tiny dust or particles that may escape during the vacuum suction process can be further captured and collected, which helps to improve the filtration efficiency, meet environmental protection requirements, and at the same time protect the equipment from damage, effectively extending the service life of the equipment.

[0045] As an embodiment, the external compressed gas introduced into the other end of the ventilation pipe 7 is an inert gas.

[0046] As an embodiment, the inert gas is any one of nitrogen, argon, and helium.

[0047] As another embodiment, the inert gas is nitrogen.

[0048] Since three-in-one equipment is generally used to separate solid products from organic solvents (sodium hyaluronate production involves separating the product from 95% ethanol), inert gas provides an explosion-proof function. Furthermore, inert gas is chemically inactive and is less likely to react chemically with other substances. Therefore, introducing inert gas into the vent line 7 effectively prevents the material within the tank body 1 from coming into contact with oxygen in the air, thereby avoiding oxidation reactions. Furthermore, inert gas reduces the ingress of dust, moisture, and other impurities from the air into the tank body 1, reducing the risk of contamination and improving the cleanliness and quality of the final product. Furthermore, it effectively prevents explosions of organic solvents mixed with the material within the tank body 1, contributing to improved production safety. Nitrogen, due to its stable chemical properties, resistance to reaction with other substances, and relatively low cost, is widely used in industrial production. During the backflushing process, nitrogen can help remove residual material from the first sintered wire mesh 4, ensuring the continuity and production efficiency of the filtration, washing, and drying processes.

[0049] As an embodiment, a connecting pipe 16 is provided on the top of the diversion bin 10, the lower end of the connecting pipe 16 is connected to the diversion bin 10, the upper end of the connecting pipe 16 is connected to a side wall of the tank body 1, and a screw valve 17 is also inserted at the upper end of the connecting pipe 16.

[0050] By installing a screw valve 17 with a bellows, the three-in-one device seals the chamber 2 with the diversion chamber 10, making it suitable for steam moist heat sterilization of the diversion chamber 10. Furthermore, the structural design of the screw valve 17 allows for quick and easy installation and removal, enhancing the overall flexibility of the device. Furthermore, the screw valve 17 can be integrated with an automated control system, enabling remote control and automated operation, further improving production efficiency. The design of the connecting pipe 16 helps reduce the possibility of material residue and scale accumulation.

[0051] As an embodiment, a manual valve 18 is provided between the lower end of the diversion bin 10 and the upper end of the material receiving barrel 9 .

[0052] Manual valve 18 allows the operator to manually control the flow of materials when necessary, facilitating flexible material flow control while preventing material leakage. The provision of manual valve 18 also facilitates maintenance and repair of diversion bin 10 and material receiving drum 9. Furthermore, in emergency situations, such as equipment failure, the operator can quickly close manual valve 18 to cut off material flow, thereby ensuring production safety.

[0053] The specific use process of this utility model is as follows:

[0054] The sterile sodium hyaluronate bulk drug begins to enter the sterile environment after the last step of the alcohol precipitation process. After the alcohol precipitation, the precipitate, i.e., sodium hyaluronate, needs to be pumped into the three-in-one device of the utility model. The ethanol (i.e., organic solvent) and sodium hyaluronate (i.e., material) are separated into solid and liquid through the first sintered mesh 4 at the bottom of the receiving chamber 2. The material is then rinsed multiple times with high-concentration ethanol, and the washing liquid is discharged through the drain port 3 at the bottom of the receiving chamber 2. Finally, vacuum drying is performed, and the receiving chamber 2 is evacuated through the first vacuum pipeline 6 provided at the top of the tank body 1. As another embodiment, hot water can also be provided in the interlayer of the tank body 1 for heat preservation circulation ( Figure 1 This part of the structure is not drawn in the figure), and the material in the accommodating chamber 2 is further vacuum dried.

[0055] After drying is complete, the material is first stirred and discharged through the agitator 5 of the three-in-one device suitable for collecting light powdered materials. The screw valve 17 and manual valve 18 are opened to collect most of the product into the receiving barrel 9. The manual valve 18 is then closed. Since one end of the vent line 7 passes through the bottom of the tank body 1 and is connected to the accommodating chamber 2, and the outlet of the vent line 7 is located below the first sintered mesh 4, when the other end of the vent line 7 is pulsed with external compressed nitrogen, the second vacuum line 11 connected to the side wall of the diversion chamber 10 is opened and vacuumed, thereby ensuring that the blown material powder flows toward the receiving barrel. The compressed nitrogen and vacuum are turned off, the manual valve 18 is opened, and the intercepted material powder falls into the receiving barrel 9, and the manual valve 18 is closed. The material situation in the accommodating chamber 2 is observed through the first viewing window 13 above the three-in-one equipment (or through the second viewing window 14 provided on the other side wall of the tank body 1 and located above the first sintered mesh 4). If there is a lot of material remaining, repeat the above operation until the remaining material situation meets the requirements, and then the process operation flow can be stopped.

Claims

1. A three-in-one device suitable for collecting light powdery materials, characterized in that: include: A tank body (1) is provided with a receiving cavity (2) for receiving materials, a liquid discharge port (3) is provided at the bottom of the receiving cavity (2), a first sintered mesh (4) is provided above the liquid discharge port (3) and at the bottom of the receiving cavity (2), a stirrer (5) is provided in the receiving cavity (2), the upper end of the stirrer (5) passes through the top of the tank body (1) and extends upward, and a first vacuum pipeline (6) for evacuating the receiving cavity (2) is also provided at the top of the tank body (1); a ventilation pipe (7) for back-flushing the first sintered mesh (4) and introducing gas into the accommodating chamber (2); one end of the ventilation pipe (7) passes through the bottom of the tank body (1) and is connected to the accommodating chamber (2); the other end of the ventilation pipe (7) is introduced with external compressed gas; and the gas outlet of the ventilation pipe (7) is located below the first sintered mesh (4); A material collecting device (8) is located below the tank body (1) and is connected to the accommodating chamber (2) of the tank body (1). The material collecting device (8) includes a material collecting barrel (9) for collecting materials and a diversion chamber (10) for material circulation. The diversion chamber (10) is located above the material collecting barrel (9) and is connected to the material collecting barrel (9). The side wall of the diversion chamber (10) is connected to a second vacuum pipeline (11), and a second sintered mesh (12) is provided at the inlet of the second vacuum pipeline (11).

2. A three-in-one device suitable for collecting light powdered materials according to claim 1, characterized in that: The top of the tank body (1) is also provided with a first viewing window (13) for observing the material situation in the accommodating chamber (2).

3. The three-in-one device for collecting light powdered materials according to claim 1, characterized in that: A second viewing window (14) for observing the material in the accommodating cavity (2) is provided on the other side wall of the tank body (1) and located above the first sintered mesh (4).

4. The three-in-one device for collecting light powdered materials according to claim 1, characterized in that: A dust collector (15) is also provided between the top of the tank body (1) and the first vacuum pipeline (6).

5. The three-in-one device for collecting light powdered materials according to claim 1, characterized in that: The external compressed gas introduced into the other end of the ventilation pipeline (7) is an inert gas.

6. The three-in-one device for collecting light powdered materials according to claim 5, characterized in that: The inert gas is any one of nitrogen, argon and helium.

7. The three-in-one device for collecting light powdered materials according to claim 1, characterized in that: A connecting pipe (16) is provided on the top of the diversion chamber (10), the lower end of the connecting pipe (16) is connected to the diversion chamber (10), the upper end of the connecting pipe (16) is connected to a side wall of the tank body (1), and a screw valve (17) is inserted into the upper end of the connecting pipe (16).

8. A three-in-one device suitable for collecting light powdered materials according to claim 1 or 7, characterized in that: A manual valve (18) is provided between the lower end of the diversion bin (10) and the upper end of the material receiving barrel (9).

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