Magnetic rack for centrifugal tubes

Abstract

The utility model discloses a centrifugal tube magnetic frame which comprises a supporting seat and a magnetic component, a clamping mechanism is arranged on the supporting seat, the clamping mechanism is used for fixing a centrifugal tube and can be adjusted in the z-axis direction, and the magnetic component is arranged on the clamping mechanism; the clamping mechanism comprises an outer clamping plate and an inner clamping plate, corresponding supporting holes are formed in the outer clamping plate and the inner clamping plate respectively, the inner clamping plate is arranged in the outer clamping plate, the outer clamping plate is elastically connected with the inner clamping plate, and the inner clamping plate can move in the y-axis direction to loosen or clamp the centrifugal tube; according to the centrifugal tube fixing device, a plurality of centrifugal tubes of the same specification can be fixed at the same time, the centrifugal tube fixing device is suitable for fixing the centrifugal tubes of different specifications, the fixing position can be adjusted according to the centrifugal tubes of different specifications, the centrifugal tubes can be stably fixed, and magnetic particles in the centrifugal tubes can be fully adsorbed by a magnetic component arranged on the clamping mechanism in a matched mode; and solid-liquid separation can be synchronously carried out on batch centrifugal tubes, so that the working efficiency is improved.

Description

Technical Field

[0001] The present application relates to the technical field of centrifuge tube supports, and in particular to a centrifuge tube magnetic stand. Background Art

[0002] Magnetic bead-based nucleic acid extraction generally involves four steps: lysis, binding, washing, and elution. Magnetic bead-based nucleic acid extraction involves lysing sample cells with a cell lysis buffer. The nucleic acid molecules released from the cells are specifically adsorbed to the surface of the magnetic beads, forming a magnetic bead-nucleic acid polymer. Impurities such as proteins are not adsorbed and remain in the solution.

[0003] An electromagnetic force holder for centrifuge tubes with announcement number CN211801007U utilizes the principle of electromagnets and can control the presence or absence of magnetic force at any time to achieve control of magnetic beads (magnetic particles); however, it requires power to operate normally, and the aperture size of the magnetic holder is fixed. After use, the solution needs to be aspirated, and it is impossible to quickly separate the solution in the centrifuge tube from the magnetic beads. Because the diameter and height of centrifuge tubes of different specifications are slightly different (for example, 15mL or 50mL centrifuge tubes), when the diameter of the centrifuge tube is too large, it may not be able to be inserted. When the diameter of the centrifuge tube is too small, it is easy to loosen after being placed in the centrifuge tube holder or the height is not enough to be supported, making it difficult to use centrifuge tubes of different specifications and difficult to separate the magnetic beads from the solution. Utility Model Content

[0004] The present application provides a centrifuge tube magnetic stand to address the deficiencies of the above-mentioned prior art, and adopts the following technical solutions:

[0005] A centrifuge tube magnetic stand, comprising a support base and a magnetic component, wherein the support base is provided with a clamping mechanism, the clamping mechanism is used to fix the centrifuge tube and can be adjusted along the z-axis direction, and the magnetic component is provided on the clamping mechanism;

[0006] The clamping mechanism includes an outer clamping plate and an inner clamping plate, and the outer clamping plate and the inner clamping plate are respectively provided with corresponding support holes. The inner clamping plate is arranged inside the outer clamping plate, and the outer clamping plate and the inner clamping plate are elastically connected. The inner clamping plate can move along the y-axis direction to loosen or clamp the centrifuge tube.

[0007] Preferably, a receiving groove with an opening on one side is provided in the outer clamping plate, the inner clamping plate is arranged in the receiving groove, and at least one elastic component is provided to connect the inner clamping plate and the receiving groove along the y-axis direction.

[0008] Preferably, the support seat includes a bottom plate and side plates detachably connected to both sides of the bottom plate, and the clamping mechanism is detachably connected to the side plates and is arranged parallel to the bottom plate.

[0009] Preferably, it further comprises a plurality of buffer components, and the buffer components are respectively arranged in the supporting holes.

[0010] Preferably, the bottom plate is further provided with fixing holes, the fixing holes correspond to the supporting holes, and the diameters of the fixing holes decrease from top to bottom.

[0011] Preferably, a magnetic strip is provided inside the side panel, and an adsorption component capable of adsorbing the magnetic strip is provided on the outer clamping plate.

[0012] Preferably, the magnetic components are respectively arranged outside the support holes along the circumferential direction of the support holes.

[0013] Preferably, the magnetic component is arc-shaped.

[0014] Preferably, the support holes are distributed in an array on the inner plate and the outer plate.

[0015] The beneficial effects of this application are:

[0016] (1) The support frame is equipped with a clamping mechanism that can stably clamp and fix centrifuge tubes of different specifications to prevent the centrifuge tubes from shaking and is easy to operate. Under the premise of being able to stably clamp the centrifuge tubes, it is easy to place or take out the centrifuge tubes.

[0017] (2) The clamping mechanism can adjust its position up and down on the support frame. It is not only suitable for clamping centrifuge tubes of different specifications, but also can drive the magnetic components installed on it to move along the outer wall of the centrifuge tube, fully adsorbing the magnetic particles in the centrifuge tube to avoid waste.

[0018] (3) The clamping mechanism can stably fix multiple centrifuge tubes at the same time. After the magnetic particles are separated from the liquid, the experimenter can pour out the liquid in multiple centrifuge tubes at the same time. The magnetic particles adsorbed by the magnetic sheet are directly retained, and the centrifuge tubes will not fall. Solid-liquid separation can be achieved simply and quickly without causing the loss of magnetic particles. Batch processing is also possible to improve work efficiency and ensure the precision of experimental data. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a three-dimensional schematic diagram of this application;

[0020] Figure 2 is a top view of the present application;

[0021] Figure 3 It is a schematic diagram of the structure of the clamping mechanism of this application;

[0022] Figure 4 This is a bottom view of the clamping mechanism of the present application;

[0023] Figure 5 It is a schematic diagram of the centrifuge tube clamping of this application.

[0024] In the picture:

[0025] 1. Support frame, 11. Bottom plate, 12. Side plate;

[0026] 2. Clamping mechanism, 21. Outer splint, 22. Inner splint;

[0027] 3. Magnetic component, 4. Magnetic strip, 5. Elastic component, 6. Support hole, 7. Adsorption component, 8. Centrifuge tube, 9. Receiving slot, 10. Fixing hole. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described in this application are only some embodiments of this application, not all embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0029] See Figures 1 to 5 , further explain this application:

[0030] Combine Figure 1 , a centrifuge tube magnetic frame includes a support frame 1, a magnetic component 3 and a clamping mechanism 2, wherein the clamping mechanism 2 is used to clamp the side wall of the centrifuge tube 8 and fix the centrifuge tube 8, wherein the support frame 1 includes a bottom plate 11 and side plates 12 arranged on both sides of the bottom plate 11, and the side plates 12 are "concave" shaped; the bottom plate 11 is used to support the bottom end of the centrifuge tube 8, and the side plates 12 are detachably connected to the bottom plate 11; it is convenient for the support frame 1 to be disassembled and stored, thereby reducing the occupied space.

[0031] The clamping mechanism 2 is mounted above the support frame 1 and is arranged parallel to the base plate 11. The clamping mechanism 2 is located between the side plates 12 and is slidably connected to the side plates 12. The clamping mechanism 2 can move along the z-axis to adjust its height relative to the base plate 11. The connection between the clamping mechanism 2 and the side plates 12 is detachable for storage. The clamping mechanism 2 and the base plate 11 can support the side plates 12 on both sides, ensuring the stability of the overall structure.

[0032] In this embodiment, a "convex"-shaped card slot is provided on the side panel 12 for clamping the clamping mechanism 2 and the bottom plate 11, and protrusions corresponding to the card slot are provided on both the bottom plate 11 and the clamping mechanism 2. The protrusion moves along the card slot and is clamped in the card slot to achieve the detachability between the bottom plate 11 and the clamping mechanism 2 and the bottom plate 11, so as to ensure the overall structural stability when in use, prevent it from tipping over, and facilitate disassembly and assembly.

[0033] Combine Figure 2 and Figure 5The clamping mechanism 2 includes an inner clamping plate 22 and an outer clamping plate 21. The inner clamping plate 22 is arranged inside the outer clamping plate 21 and can move inside the outer clamping plate 21 along the y-axis direction. In this way, the clamping of the centrifuge tube is more stable and will not tilt; Figure 3 The outer clamping plate 21 is provided with a receiving groove 9 with an opening on one side, and the inner clamping plate 22 is provided in the receiving groove 9. The inner clamping plate 22 and the outer clamping plate 21 are both provided with a corresponding number of supporting holes 6 (6A, 6B), which can simultaneously clamp multiple centrifuge tubes 8 of the same specifications. The supporting holes 6 (6B) on the inner clamping plate 22 are coaxially arranged with the supporting holes 6 (6A) on the outer clamping plate 21; when the inner clamping plate 22 moves, the supporting holes 6 (6A, 6B) are offset from each other, and the overlapping portion thereof becomes larger or smaller, so as to clamp centrifuge tubes 8 of different diameters, thereby being suitable for centrifuge tubes 8 of different specifications.

[0034] The supporting holes 6 (6A, 6B) are distributed in an array on the inner clamping plate 22 and the outer clamping plate 21 to facilitate the placement and removal of the centrifuge tube.

[0035] Combine Figure 2 , the inner clamping plate 22 is elastically connected to the outer clamping plate 21. In this embodiment, at least one elastic component 5 can be provided between the inner clamping plate 22 and the outer clamping plate 21 to connect them. The elastic component 5 is provided between the inner clamping plate 22 and the outer clamping plate 21 along the y-axis direction. The elastic component 5 is used to apply a y-axis thrust to the inner clamping plate 22 to push the inner clamping plate 22 to move along the Y-axis within the outer clamping plate 21, so that the overlapping portion between the support holes 6 (6A, 6B) gradually decreases to accommodate centrifuge tubes 8 of different diameters; wherein, the elastic component 5 can be a spring.

[0036] The clamping mechanism 2 applies external force to the inner clamping plate 22 from one end of the opening, so that the overlapping portion between the support holes 6 (6A, 6B) gradually increases, thereby loosening the centrifuge tube 8 to adjust the height of the clamping mechanism 2; after the adjustment is completed, the inner clamping plate 22 is pushed by the elastic component 5 to move and clamp the centrifuge tube 8, while fixing the position of the clamping mechanism 2 itself.

[0037] In this embodiment, a magnetic strip 4 is provided on the side plate 12, and adsorption members 7 are provided at both ends of the outer clamping plate 21. The adsorption members 7 are attracted to the magnetic strip 4 by magnetic force to fix the position of the clamping mechanism 2 on the support frame 1, thereby preventing the clamping mechanism 2 from falling onto the bottom plate 11.

[0038] Combine Figure 1 and Figure 3The magnetic component 3 is arranged on the clamping mechanism 2, and can also be arranged on the bottom plate 11, or the magnetic component 3 can be arranged on both the clamping mechanism 2 and the bottom plate 11; the magnetic component 3 is used to adsorb the magnetic particles in the centrifuge tube 8 on the side wall of the centrifuge tube 8, so as to pour out the liquid in the clamped centrifuge tube 8 at the same time, thereby achieving the effect of separating the magnetic particles from the liquid; the magnetic component 3 is arranged on the clamping mechanism 2, and by adjusting the movement of the clamping mechanism 2, the magnetic component 3 can be moved up and down along the outer wall of the centrifuge tube 8 to fully adsorb the magnetic particles in the centrifuge tube 8.

[0039] In the centrifuge tube rack of the prior art, the same support frame 1 is difficult to adapt to centrifuge tubes 8 of different specifications. Corresponding support frames 1 are required for centrifuge tubes 8 of different specifications to be stably placed. When separating the magnetic particles and the solution in the centrifuge tube 8, direct dumping will cause the centrifuge tube 8 to fall out of the support frame 1. The present application is provided with a clamping mechanism 2 that can clamp the centrifuge tube 8 thereon, and the liquid in the centrifuge tube 8 can be directly dumped out without the risk of the centrifuge tube 8 falling. Before dumping, the height of the clamping mechanism 2 can be adjusted to drive the magnetic component 3 to move up and down along the outer wall of the centrifuge tube 8, so that the magnetic particles in the centrifuge tube 8 can be fully adsorbed, thereby realizing solid-liquid separation and reducing the loss of magnetic particles.

[0040] Combine Figure 3 , the magnetic components 3 are respectively arranged on the outside of the support hole 6 along the circumferential direction of the support hole 6. Wherein, the magnetic components 3 are arranged at the front end of the support hole 6 along the moving direction of the inner clamping plate 22 ( Figure 4 This ensures that the magnetic component 3 can cling tightly to the outer wall of the centrifuge tube 8 regardless of its specifications (diameter), thereby improving the adsorption efficiency of the magnetic particles in the centrifuge tube 8; the magnetic component 3 is arc-shaped and can be a magnet.

[0041] In some embodiments, a buffer component may be provided in each of the support holes 6. The buffer component is mounted on the sidewall of the support hole 6 to provide a buffer for the centrifuge tube 8 and prevent damage to the centrifuge tube 8. The buffer component may be a rubber ring.

[0042] The bottom plate 11 may be provided with fixing holes 10. The bottom plate can be fine-tuned along the y-axis according to the position of the centrifuge tube to be clamped, so that the bottom end of the centrifuge tube can be placed. The fixing holes 10 are arranged corresponding to the support holes 6 and are used to place the bottom end of the centrifuge tube 8, providing stable support for the centrifuge tube 8 and keeping the centrifuge tube 8 in a vertical position, so that the clamping mechanism 2 can clamp it. The diameter of the fixing holes 10 decreases from top to bottom, that is, the fixing holes 10 are trumpet-shaped to accommodate the bottom ends of centrifuge tubes of different specifications.

Claims

1. A centrifuge tube magnetic stand, comprising a support base and a magnetic component, characterized in that: The support seat is provided with a clamping mechanism, which is used to fix the centrifuge tube and can be adjusted along the z-axis direction, and the magnetic component is provided on the clamping mechanism; The clamping mechanism includes an outer clamping plate and an inner clamping plate, and the outer clamping plate and the inner clamping plate are respectively provided with corresponding support holes. The inner clamping plate is arranged inside the outer clamping plate, and the outer clamping plate and the inner clamping plate are elastically connected. The inner clamping plate can move along the y-axis direction to loosen or clamp the centrifuge tube.

2. The centrifuge tube magnetic stand according to claim 1, wherein: The outer clamping plate is provided with a receiving groove with one side open, the inner clamping plate is arranged in the receiving groove, and at least one elastic component is provided to connect the inner clamping plate and the receiving groove along the y-axis direction.

3. The centrifuge tube magnetic stand according to claim 2, wherein: The support seat includes a bottom plate and side plates detachably connected to both sides of the bottom plate. The clamping mechanism is detachably connected to the side plates and is arranged parallel to the bottom plate.

4. The centrifuge tube magnetic stand according to claim 1, wherein: It also includes a plurality of buffer components, which are respectively arranged in the supporting holes.

5. The centrifuge tube magnetic stand according to claim 3, wherein: The bottom plate is further provided with fixing holes, which correspond to the supporting holes, and the diameters of the fixing holes decrease from top to bottom.

6. The centrifuge tube magnetic stand according to claim 3, wherein: A magnetic strip is provided inside the side plate, and an adsorption component capable of adsorbing the magnetic strip is provided on the outer clamping plate.

7. The centrifuge tube magnetic stand according to claim 1, wherein: The magnetic components are respectively arranged outside the support holes along the circumferential direction of the support holes.

8. The centrifuge tube magnetic stand according to claim 7, characterized in that: The magnetic component is arc-shaped.

9. The centrifuge tube magnetic stand according to claim 1, wherein: The support holes are distributed in an array on the inner plate and the outer plate.

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