Sorting and filtering device for tumor cell clusters

Abstract

The utility model relates to a sorting and filtering device for tumor cell clusters, which comprises a filter cartridge and a collecting cartridge positioned below the filter cartridge, a filter assembly is arranged in the filter cartridge, and the filter assembly comprises a first filter plate and a second filter plate which are arranged at an interval along the axial direction of the filter cartridge; the circumferential surface of the first filter plate and the circumferential surface of the second filter plate are attached to the inner wall of the filter cartridge, the first filter plate and the second filter plate are both provided with through holes allowing tumor cell clusters to penetrate through, and the upper side of the first filter plate is provided with a first connecting part used for movably connecting the filter assembly to the filter cartridge; a second connecting part for movably connecting the second filter plate to the first filter plate is arranged on the upper side of the second filter plate. The sorting and filtering device for the tumor cell clusters not only can perform double filtration on tumor cells, but also can conveniently take out the filter plate after filtration is completed, so that thorough disinfection treatment is facilitated.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a tumor cell cluster separation and filtering device. Background Art

[0002] Oncologists often need to sort tumor cell clusters during their work and conduct a series of research operations on the biological characteristics of the sorted tumor cell clusters. This is very important for cancer research and clinical applications. Currently, sorting and filtering devices are usually used to sort tumor cell clusters. Existing sorting and filtering devices usually install a filter cylinder above the collection cylinder, and a filter plate is installed inside the filter cylinder. During filtration, tissue dispersion is poured into the filter cylinder, and the filter plate separates the larger fat tissue, membrane tissue, and connective tissue in the tissue dispersion from the tumor cell clusters, thereby achieving sorting and filtration of tumor cell clusters.

[0003] However, existing sorting and filtering devices have some shortcomings: first, they usually only use single-layer filtration, and some impurities still exist after filtration, resulting in poor filtration effect; second, the filter plate is usually fixed in the filter cartridge, which makes it difficult to thoroughly disinfect the sorting and filtering device after use. Utility Model Content

[0004] The technical problem to be solved by the present invention is to provide a tumor cell cluster sorting and filtering device in response to the above-mentioned defects, which can not only perform double filtration on tumor cells, but also facilitate the removal of the filter plate after the filtration is completed, thereby facilitating thorough disinfection.

[0005] The technical solution adopted by the utility model to solve its technical problems is: a tumor cell cluster sorting and filtering device, comprising a filter cartridge and a collecting cartridge located below the filter cartridge, a filter assembly being provided in the filter cartridge, the filter assembly comprising a first filter plate and a second filter plate spaced apart along the axial direction of the filter cartridge, the circumferential surfaces of the first filter plate and the second filter plate both being in contact with the inner wall of the filter cartridge, through holes being provided on the first filter plate and the second filter plate for tumor cell clusters to pass through, a first connecting portion being provided on the upper side of the first filter plate for movably connecting the filter assembly to the filter cartridge, and a second connecting portion being provided on the upper side of the second filter plate for movably connecting it to the first filter plate.

[0006] Compared with the existing technology, the beneficial effect of this solution is that: when screening tumor cell clusters, the tissue dispersion liquid is poured into the filter cartridge, and the tumor cell clusters pass through the first filter plate and the second filter plate into the collection cartridge, and other cell tissues in the tissue dispersion liquid are intercepted by the first filter plate and the second filter plate. The tumor cell clusters in the tissue dispersion liquid are double-filtered by the first filter plate and the second filter plate arranged in the filter cartridge, which can ensure that the obtained tumor cell cluster samples are more accurate, thereby ensuring that subsequent research results are more accurate; since the second filter plate is movably connected to the first filter plate through the second connection part, and the first filter plate is movably connected to the filter cartridge through the first connection part, after the filtration is completed, the first filter plate and the second filter plate can be more conveniently removed from the filter cartridge for disinfection. Compared with disinfecting the entire filtration device, the first filter plate and the second filter plate are removed from the filter cartridge and disinfected separately, which ensures that the disinfection is more thorough, thereby ensuring the safety of subsequent use.

[0007] As a preferred embodiment of the present invention, the first connecting portion includes a first connecting plate fixed on the upper side of the first filter plate and a first claw arranged on the outer side of the upper side of the first connecting plate. The filter assembly is fixed to the filter cartridge by clamping the first claw with the upper side of the filter cartridge.

[0008] The beneficial effect of this solution is that the first filter plate is hung on the filter cartridge by the first claw arranged on the outer side of the upper part of the first connecting part, which makes it easy to install the filter assembly on the filter cartridge and remove it from the filter cartridge for disinfection.

[0009] As a preferred embodiment of the present invention, the second connecting part includes a second connecting plate fixedly provided on the upper side of the second filter plate and a second claw arranged on the inner side of the upper side of the second connecting plate. The lower side of the first filter plate is provided with a third connecting part for movably connecting with the second connecting part. The third connecting part includes a third connecting plate fixedly provided on the lower side of the first filter plate and a third claw arranged on the outer side of the lower part of the third connecting plate. The second filter plate is movably connected to the first filter plate by clamping the second claw with the third claw.

[0010] The beneficial effects of this solution are as follows: before installing the first filter plate and the second filter plate into the filter cartridge, the second claw arranged on the upper side of the second filter plate is engaged with the third claw arranged on the lower side of the first filter plate, thereby movably connecting the second filter plate to the bottom of the first filter plate. The first filter plate and the second filter plate are movably connected by the third claw and the second claw, which not only makes it convenient to connect them as a whole and then put them into the filter cartridge, but also allows them to be quickly separated after being taken out of the filter cartridge together and disinfected separately, thereby ensuring that disinfection is in place.

[0011] In a preferred embodiment of the present invention, a groove for engaging with the first claw is provided on the upper side of the filter cartridge along its axial direction.

[0012] The beneficial effects of this solution are: when the first filter plate is installed in the filter cartridge, the first claw is inserted into the first slot, thereby limiting the first filter plate in the horizontal direction, preventing the first filter plate from rotating around the circumferential direction of the filter cartridge when the tissue dispersion liquid is poured into the filter cartridge, thereby affecting the filtration process.

[0013] As a preferred embodiment of the present invention, a conical buffer portion is provided inside the filter cartridge, a guide cylinder is provided on the lower side of the buffer portion, and the guide cylinder is located above the first filter plate.

[0014] The beneficial effects of this solution are as follows: when pouring the tissue dispersion liquid into the filter cylinder, the tissue dispersion liquid first contacts the buffer portion provided above the first filter plate, and flows to the first filter plate through the guide cylinder, thereby preventing the tissue dispersion liquid from directly impacting the first filter plate, which may cause damage to the tumor cell clusters and affect the collection results.

[0015] As a preferred embodiment of the present invention, the upper sides of the first filter plate and the second filter plate are both provided with enclosures in the axial direction, the outer circumferential surfaces of the two enclosures are in contact with the inner wall of the filter cylinder, and the first connecting plate and the second connecting plate are both arranged on the upper side of the enclosures.

[0016] The beneficial effects of this solution are as follows: during filtration, the tumor cell clusters pass through the first filter plate and the second filter plate into the collection tube, and other cell tissues in the tissue dispersion are intercepted by the first filter plate and the second filter plate and remain thereon. The remaining tissue cells are enclosed by the barriers arranged on the upper sides of the first filter plate and the second filter plate, thereby preventing the remaining tissue cells from sliding around the first filter plate and the second filter plate and scattering on the ground after the first filter plate and the second filter plate are removed from the filter tube, thereby avoiding affecting the environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 Schematic diagram of an embodiment of the tumor cell cluster separation and filtration device of the present invention.

[0018] Figure 2 for Figure 1 Schematic diagram of the structure inside the filter cartridge.

[0019] Figure 3 for Figure 2 Schematic diagram of the structure of the first filter plate.

[0020] Figure 4 for Figure 2 Schematic diagram of the structure of the second filter plate. DETAILED DESCRIPTION

[0021] The preferred embodiments of the present invention are described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described below are only used to explain the present invention and do not limit the scope of protection of the present invention.

[0022] The terms "first", "second" and the like in the specification, claims and embodiments of this application are used to distinguish similar objects rather than to describe a specific order or sequential sequence.

[0023] The present invention is further described in detail below through preferred specific embodiments:

[0024] The figure marks in the drawings of the specification include: filter cartridge 1, slot 101, first filter plate 2, through hole 201, second filter plate 3, first connecting part 4, first connecting plate 401, first claw 402, third connecting part 5, third connecting plate 501, third claw 502, second connecting part 6, second connecting plate 601, second claw 602, buffer part 7, through hole 701, guide cartridge 8, collecting cartridge 9, support block 901, and enclosure 10.

[0025] As attached Figure 1 and attached Figure 2 As shown: The tumor cell cluster sorting and filtering device of this embodiment includes a filter cartridge 1 and a collecting cartridge 9 located below the filter cartridge 1. The inner wall of the collecting cartridge 9 is provided with a plurality of support blocks 901 for supporting the filter cartridge 1 along its circumferential direction. Only one is shown in this embodiment. A slot 101 for engaging with the first clamping claw 402 is provided on the upper side of the filter cartridge 1 along its axial direction. Two slots 101 are symmetrically arranged along the radial direction of the filter cartridge 1.

[0026] As attached Figure 2 and attached Figure 3 As shown: a filter assembly is provided in the filter cartridge 1, and the filter assembly includes a first filter plate 2 and a second filter plate 3 spaced apart along the axial direction of the filter cartridge 1. The middle parts of the first filter plate 2 and the second filter plate 3 in this embodiment are both upwardly convex arches, and the circumferential surfaces of the first filter plate 2 and the second filter plate 3 are both in contact with the inner wall of the filter cartridge 1. The upper sides of the first filter plate 2 and the second filter plate 3 are both provided with a fence 10 in the axial direction, and the outer circumferential surfaces of the two fences 10 are in contact with the inner wall of the filter cartridge 1. The first filter plate 2 and the second filter plate 3 are both provided with a through hole 201 for tumor cell clusters to pass through. In this embodiment, the diameter of the through hole 201 on the second filter plate 3 is smaller than the diameter of the through hole 201 on the first filter plate 2, which is convenient for secondary screening of tumor cell clusters.

[0027] The upper side of the first filter plate 2 is provided with a first connecting part 4 for movably connecting the filter assembly to the filter cartridge 1, the first connecting part 4 includes a first connecting plate 401 fixed on the upper side of the first filter plate 2 and a first claw 402 arranged on the outer side of the upper part of the first connecting plate 401, and the filter assembly is fixed to the filter cartridge 1 by clamping the first claw 402 with the upper side of the filter cartridge 1, and the lower side of the first filter plate 2 is provided with a third connecting part 5 for movably connecting with the second connecting part 6, the third connecting part 5 includes a third connecting plate 501 fixed on the lower side of the first filter plate 2 and a third claw 502 arranged on the outer side of the lower part of the third connecting plate 501. In this embodiment, the first connecting part 4 and the third connecting part 5 are respectively symmetrically arranged in two along the radial direction of the first filter plate 2, and the two first connecting plates 401 are both arranged on the upper side of the enclosure 10.

[0028] As attached Figure 2 and attached Figure 4 As shown: the upper side of the second filter plate 3 is provided with a second connecting part 6 for movably connecting it to the first filter plate 2, the second connecting part 6 includes a second connecting plate 601 fixed on the upper side of the second filter plate 3 and a second claw 602 arranged on the inner side of the upper part of the second connecting plate 601, and the second filter plate 3 is movably connected to the first filter plate 2 by clamping the second claw 602 with the third claw 502. In this embodiment, two second connecting parts 6 are symmetrically arranged along the radial direction of the second filter plate 3, and the two second connecting plates 601 are both arranged on the upper side of the enclosure 10.

[0029] As attached Figure 2 As shown: the interior of the filter cartridge 1 is further provided with a conical buffer portion 7, the buffer portion 7 is fixedly connected to the inner sides of the two first connecting plates 401, and a guide tube 8 is provided on the lower side of the buffer portion 7, and the guide tube 8 is located above the first filter plate 2.

[0030] Specific usage process:

[0031] When screening tumor cell clusters, the tissue dispersion liquid is poured into the filter cartridge 1. The tissue dispersion liquid first contacts the buffer portion 7 arranged above the first filter plate 2 and flows to the first filter plate 2 through the guide tube 8. The tumor cell clusters in the tissue dispersion liquid pass through the first filter plate 2 and the second filter plate 3 and enter the collection tube 9. Other cell tissues in the tissue dispersion liquid are intercepted by the first filter plate 2 and the second filter plate 3. The tumor cell clusters in the tissue dispersion liquid are double filtered by the first filter plate 2 and the second filter plate 3 arranged in the filter cartridge 1.

[0032] After use, first remove the filter cartridge 1 from the collecting cartridge 9, then take out the first filter plate 2 and the second filter plate 3 from the filter cartridge 1, and disinfect them separately. Since the first filter plate 2 is hung in the slot 101 on the filter cartridge 1 by the first claw 402 arranged on the outer side of the upper part of the first connecting part 4, the second filter plate 3 is engaged with the third claw 502 arranged on the outer side of the lower part of the third connecting plate 501 by the second claw 602 arranged on the inner side of the upper part of the second connecting plate 601, thereby being movably connected under the first filter plate 2. Therefore, when disinfection is required, it is only necessary to move the first claw 402 upward in the vertical direction to take the first filter plate 2 and the second filter plate 3 out of the filter cartridge 1, and then separate the first filter plate 2 and the second filter plate 3, so that the filter cartridge 1, the first filter plate 2 and the second filter plate 3 can be disinfected more thoroughly.

[0033] The preferred embodiment of the present application is described in detail above in conjunction with the accompanying drawings. The typical well-known structures and common knowledge technologies in the preferred embodiment are not described in detail here. Ordinary technicians in the relevant field can, under the inspiration given by this embodiment, improve and implement the technical solution of the present utility model in combination with their own abilities. Some typical well-known structures, well-known methods or common knowledge technologies should not become obstacles for ordinary technicians in the relevant field to implement this application.

[0034] The scope of protection required by this application shall be based on the contents of its claims, and the contents of the utility model, specific implementation methods and the contents recorded in the drawings of the specification shall be used to interpret the claims.

[0035] Within the technical concept of this application, several modifications may be made to the specific implementation methods of this application, and these modified implementation methods should also be considered to be within the scope of protection of this application.

Claims

1. A tumor cell cluster separation and filtration device, comprising a filter cartridge and a collection cartridge located below the filter cartridge, wherein a filter assembly is disposed within the filter cartridge, and characterized in that: The filter assembly includes a first filter plate and a second filter plate spaced apart along the axial direction of the filter cartridge, the circumferential surfaces of the first filter plate and the second filter plate both being in contact with the inner wall of the filter cartridge, and through holes for tumor cell clusters to pass through are provided on the first filter plate and the second filter plate, a first connecting portion for movably connecting the filter assembly to the filter cartridge is provided on the upper side of the first filter plate, and a second connecting portion for movably connecting the second filter plate to the first filter plate is provided on the upper side of the second filter plate.

2. The tumor cell cluster separation and filtration device according to claim 1, characterized in that: The first connecting portion includes a first connecting plate fixed on the upper side of the first filter plate and a first clamping claw arranged on the outer side of the upper side of the first connecting plate. The filter assembly is fixed to the filter cartridge by clamping the first clamping claw with the upper side of the filter cartridge.

3. The tumor cell cluster separation and filtration device according to claim 1, characterized in that: The second connection part includes a second connection plate fixed on the upper side of the second filter plate and a second claw arranged on the inner side of the upper side of the second connection plate. The lower side of the first filter plate is provided with a third connection part for movably connecting with the second connection part. The third connection part includes a third connection plate fixed on the lower side of the first filter plate and a third claw arranged on the outer side of the lower part of the third connection plate. The second filter plate is movably connected to the first filter plate by clamping the second claw with the third claw.

4. The tumor cell cluster separation and filtration device according to claim 2, characterized in that: A clamping groove for clamping with the first clamping claw is formed on the upper side of the filter cartridge along its axial direction.

5. The tumor cell cluster separation and filtration device according to claim 1, characterized in that: A conical buffer portion is provided inside the filter cartridge, a guide cylinder is provided on the lower side of the buffer portion, and the guide cylinder is located above the first filter plate.

6. The tumor cell cluster separation and filtration device according to claim 2, characterized in that: The upper sides of the first filter plate and the second filter plate are both provided with enclosures in the axial direction, the outer circumferential surfaces of the two enclosures are in contact with the inner wall of the filter cylinder, and the first connecting plate and the second connecting plate are both arranged on the upper sides of the enclosures.

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