Heat preservation storage device for umbilical cord mesenchymal stem cell exosome

Abstract

The utility model relates to the technical field of mesenchymal stem cell storage, and discloses an umbilical cord mesenchymal stem cell exosome heat preservation storage device which comprises a heat preservation storage box, a telescopic cabinet is embedded in one end of the heat preservation storage box, a plurality of refrigerating fluid grooves are formed in the inner side of the telescopic cabinet, supporting plates are fixed to the surfaces of the inner sides of the upper ends of the refrigerating fluid grooves, and the supporting plates are fixed to the surfaces of the inner sides of the lower ends of the refrigerating fluid grooves. A pipe placing frame is arranged at the upper end of the supporting plate, an insertion hole is formed in the outer wall of the upper end of the pipe placing frame, and a sterile storage pipe is inserted into the inner side of the insertion hole; the clamping grooves are formed in the upper surfaces of the two sides of the pipe containing frame, and the upper ends of the clamping grooves are connected with pull rods. The heat preservation storage device for the umbilical cord mesenchymal stem cell exosome is provided with a sterile storage tube, the sterile storage tube is arranged in a freezing liquid tank for cryopreserving the mesenchymal stem cell exosome through a tube placing frame, freezing storage is performed at low temperature, and when the umbilical cord mesenchymal stem cell exosome is taken and placed, a clamping block at the lower end of a pull rod is rotationally clamped in a clamping groove; workers can be prevented from being frostbitten by a low-temperature storage environment, and the use safety is better.

Description

Technical Field

[0001] The utility model relates to the technical field of mesenchymal stem cell storage, in particular to a heat preservation storage device for umbilical cord mesenchymal stem cell exosomes. Background Art

[0002] Umbilical cord mesenchymal stem cells (UCMSCs) are multipotent stem cells found in the umbilical cord tissue of newborns. They can differentiate into a variety of tissue cell types and have broad clinical application prospects. Umbilical cord MSCs are typically cryopreserved using specialized cryopreservation solutions to ensure that the cells' activity and function are maintained during long-term storage.

[0003] After searching, we found a mesenchymal stem cell exosome storage device with publication number CN221152689U, which includes a storage box with a frame connected to the lower end. This device is used to solve the problem of poor freezing effect of current storage devices. The freezing storage structure in this application does not have a safety protection structure when taking and placing the frozen exosomes. Workers are prone to frostbite when taking and placing the frozen exosomes. Therefore, we propose a heat preservation storage device for umbilical cord mesenchymal stem cell exosomes. Utility Model Content

[0004] The purpose of the present invention is to provide a heat preservation storage device for umbilical cord mesenchymal stem cell exosomes to solve the problems raised in the above background technology.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a device for heat preservation and storage of umbilical cord mesenchymal stem cell exosomes, comprising:

[0006] An insulated storage box, wherein a telescopic cabinet is embedded at one end of the insulated storage box, a plurality of freezing liquid tanks are provided inside the telescopic cabinet, a support plate is fixed to the inner surface of the upper end of the freezing liquid tank, a tube rack is placed on the upper end of the support plate, an insertion hole is opened on the outer wall of the upper end of the tube rack, and a sterile storage tube is inserted into the inner side of the insertion hole;

[0007] A card slot is opened on the upper surface of both sides of the tube placement rack, the upper end of the card slot is connected to a pull rod, a card block is fixed at the connection between the pull rod and the card slot, and an antifreeze handle is fixed to the top of the pull rod.

[0008] Furthermore, the external structure of the telescopic cabinet is consistent with that of the heat-insulating storage box, and a semi-enclosed structure is formed between the heat-insulating storage box and the telescopic cabinet. The freezing liquid tanks are evenly distributed along the inner side of the telescopic cabinet, and the tube rack forms a snap-fit ​​structure with the freezing liquid tank through the support plate, and the sterile storage tube forms a snap-fit ​​connection with the tube rack through the socket.

[0009] Furthermore, the outer structure of the clamping block is consistent with that of the upper end of the clamping slot, and the pull rod is connected to the pipe rack through the clamping block and the clamping slot.

[0010] Furthermore, the outer walls at both ends of the telescopic cabinet are hinged with pull rings, the outer wall of one end of the telescopic cabinet close to the opening end of the thermal insulation storage box is embedded with a temperature sensor, and the outer walls of the four corners of the lower end of the thermal insulation storage box are equipped with universal wheels by bolts.

[0011] Furthermore, the pull ring and the telescopic cabinet are rotatably connected, and the telescopic cabinet forms a telescopic structure with the thermal insulation storage box through the pull ring, and the universal wheels are symmetrically arranged with respect to the central axis of the thermal insulation storage box.

[0012] Furthermore, the inner layer of the sterile storage tube is provided with an insulating liner made of hollow glass, the outer wall of the sterile storage tube is provided with a circular groove, and the groove penetrates to the outer surface of the insulating liner, and the open end of the sterile storage tube is threadedly installed with a sealing cover.

[0013] Furthermore, the grooves are symmetrically arranged about the central axis of the sterile storage tube, and the central axis of the thermal insulation liner and the sterile storage tube coincide with each other, and the sealing cover forms a sealing structure between the thermal insulation liner and the sterile storage tube.

[0014] Compared with the prior art, the beneficial effects of the present invention are:

[0015] The heat-insulating storage device for umbilical cord mesenchymal stem cell exosomes is provided with a sterile storage tube, which is placed in a freezing liquid tank for cryopreservation of mesenchymal stem cell exosomes through a tube rack and is frozen and stored at low temperatures. When taking and placing, the card block at the lower end of the pull rod is rotated and engaged in the card slot, which can prevent workers from being frostbitten by the low-temperature storage environment, and is safer to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of the main structure of the combined state of the thermal insulation storage box and the telescopic cabinet of the utility model;

[0017] Figure 2 This is a schematic diagram of the main structure of the telescopic cabinet and the pipe rack of the utility model in a partially disassembled state;

[0018] Figure 3 This is a schematic diagram of the enlarged cross-section of the pull rod and the pipe rack of the utility model;

[0019] Figure 4 This is a schematic diagram of the enlarged cross-sectional structure of the sterile storage tube part of the utility model.

[0020] In the figure: 1. Insulated storage box; 2. Telescopic cabinet; 3. Freezing liquid tank; 4. Support plate; 5. Tube rack; 6. Socket; 7. Sterile tube storage; 8. Card slot; 9. Pull rod; 10. Card block; 11. Antifreeze handle; 12. Pull ring; 13. Temperature sensor; 14. Universal wheel; 15. Insulated liner; 16. Slot; 17. Sealing cover. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0022] The utility model provides a heat preservation storage device for umbilical cord mesenchymal stem cell exosomes through improvement. Figure 1-Figure 3 , comprising: an insulated storage box 1, a telescopic cabinet 2 is embedded at one end of the insulated storage box 1, the telescopic cabinet 2 is consistent with the outer structure of the insulated storage box 1, and a semi-enclosed structure is formed between the insulated storage box 1 and the telescopic cabinet 2, and a plurality of freezing liquid tanks 3 are provided on the inner side of the telescopic cabinet 2, and the freezing liquid tanks 3 are evenly distributed at equal distances along the inner side of the telescopic cabinet 2, and the freezing liquid tanks 3 are used to freeze and seal the stored expected mesenchymal stem cell exosomes with freezing liquid; a support plate 4 is fixed to the inner surface of the upper end of the freezing liquid tank 3, and a tube rack 5 is placed on the upper end of the support plate 4, and the tube rack 5 forms a clamping structure with the support plate 4 and the freezing liquid tank 3, and an insertion hole 6 is opened on the outer wall of the upper end of the tube rack 5, and a sterile storage tube 7 is inserted into the inner side of the insertion hole 6, and the sterile storage tube 7 forms a clamping structure with the tube rack 5 through the insertion hole 6. The upper surfaces of both sides of the tube rack 5 are provided with card slots 8, and the upper ends of the card slots 8 are connected with pull rods 9. A card block 10 is fixed at the connection between the pull rod 9 and the card slot 8. The card block 10 is consistent with the external structure of the upper end of the card slot 8, and the pull rod 9 is connected to the tube rack 5 through the card block 10 and the card slot 8. The sterile storage tube 7 is placed in the freezing liquid tank 3 for cryopreserving mesenchymal stem cell exosomes through the tube rack 5 and is frozen and stored at low temperature. When taking and placing, the card block 10 at the lower end of the pull rod 9 is rotated and engaged in the card slot 8 to prevent the staff from being frostbitten by the low-temperature storage environment, and the use safety is better; the top of the pull rod 9 is fixed with an antifreeze handle 11, which is used to prevent the staff from being frostbitten by the low temperature when holding it, so as to facilitate the taking and placing of the tube rack 5.

[0023] See also Figure 1-Figure 2, a heat preservation storage device for umbilical cord mesenchymal stem cell exosomes, comprising: pull rings 12 are hingedly connected to the outer walls of the telescopic cabinet 2 at both ends, and the pull ring 12 and the telescopic cabinet 2 form a rotational connection, and the telescopic cabinet 2 forms a telescopic structure with the heat preservation storage box 1 through the pull ring 12. The pull rings 12 set can be folded or opened at both ends of the telescopic cabinet 2, which is convenient for the staff to pull the telescopic cabinet 2 out of or push it into the heat preservation storage box 1; a temperature sensor 13 is embedded in the outer wall of one end of the telescopic cabinet 2 close to the open end of the heat preservation storage box 1, and the temperature sensor 13 is convenient for the staff to monitor the storage temperature in the freezing liquid tank 3 of the telescopic cabinet 2; universal wheels 14 are installed on the outer walls of the four corners of the lower end of the heat preservation storage box 1 by bolts, and the universal wheels 14 are symmetrically arranged about the central axis of the heat preservation storage box 1. The universal wheels 14 are convenient for the staff to move the heat preservation storage box 1, thereby improving the maneuverability of the storage device.

[0024] See also Figure 1 and Figure 4 , a heat preservation storage device for umbilical cord mesenchymal stem cell exosomes, comprising: an inner layer of a sterile storage tube 7 is provided with a heat preservation liner 15 made of a hollow glass material, and the heat preservation liner 15 coincides with the central axis of the sterile storage tube 7, the heat preservation liner 15 is used to stabilize the heat preservation effect of the sterile storage tube 7, and cooperates with the groove 16 opened on the outer wall of the sterile storage tube 7 to ensure the structural strength of the sterile storage tube 7, prevent the sterile storage tube 7 from accidentally breaking, and improve the stability of the heat preservation liner 15 in the sterile storage tube 7 under low temperature conditions; the outer wall of the sterile storage tube 7 is provided with a circular groove 16, and the groove 16 is about The central axis of the sterile storage tube 7 is symmetrically arranged, and the groove 16 extends to the outer surface of the thermal insulation liner 15. The groove 16 enables the sterile storage tube 7 to have a double-layer structure. At the same time, the external low-temperature environment is in direct contact with the thermal insulation liner 15 through the groove 16, thereby improving the temperature reduction rate of the sterile storage tube 7; the open end of the sterile storage tube 7 is threadedly installed with a sealing cover 17, and the sealing cover 17 forms a sealing structure between the thermal insulation liner 15 and the sterile storage tube 7. The sealing cover 17 is used to seal the expected mesenchymal stem cell exosomes in the sterile storage tube 7 to reduce the erosion of external impurities or pathogens.

[0025] Working principle: For this type of umbilical cord mesenchymal stem cell exosome insulation storage device, the staff first moves the insulation storage box 1 to a suitable storage position through the universal wheel 14 installed at the bottom, and then the staff rotates the pull ring 12 to conveniently pull out the telescopic cabinet 2 from the insulation storage box 1, and selects a suitable number of sterile storage tubes 7 and freezing liquid tanks 3 according to the number of exosomes to be stored. The freezing liquid tank 3 contains sufficient low-temperature freezing liquid, and the storage temperature is conveniently monitored by the temperature sensor 13, which is convenient for freezing the umbilical cord mesenchymal stem cell exosomes. Subsequently, the staff injects the umbilical cord mesenchymal stem cell exosomes to be stored into the sterile storage tube 7 and uses The sealing cover 17 is sealed, and the sterile storage tube 7 containing exosomes is inserted into the inner side of the socket 6 of the tube rack 5, and then placed on the support plate 4 fixed on the inner side of the freezing liquid tank 3. The sterile storage tube 7 with the lower end immersed in the freezing liquid tank 3 is maintained at a low temperature by the groove 16 and the heat-insulating liner 15 to ensure the stability of low-temperature storage. Finally, when taking and placing the frozen tube rack 5 and the sterile storage tube 7, the staff holds the antifreeze handle 11, inserts the block 10 at the lower end of the pull rod 9 into the slot 8 on the tube rack 5, and rotates the block 10 to engage with the upper end surface of the slot 8 to lift the storage rack and the sterile storage tube 7 placed thereon, thereby preventing the staff from being frostbitten and improving the safety of the device when in use.

[0026] Although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A device for heat preservation and storage of umbilical cord mesenchymal stem cell exosomes, characterized in that: include: A heat preservation storage box (1), wherein a telescopic cabinet (2) is embedded at one end of the heat preservation storage box (1), a plurality of freezing liquid tanks (3) are provided on the inner side of the telescopic cabinet (2), a support plate (4) is fixed to the inner surface of the upper end of the freezing liquid tank (3), a tube rack (5) is arranged on the upper end of the support plate (4), a socket (6) is provided on the outer wall of the upper end of the tube rack (5), and a sterile storage tube (7) is inserted into the inner side of the socket (6); A card slot (8) is provided on the upper surfaces of both sides of the tube placement rack (5); the upper end of the card slot (8) is connected to a pull rod (9); a card block (10) is fixed at the connection between the pull rod (9) and the card slot (8); and an antifreeze handle (11) is fixed to the top end of the pull rod (9).

2. The thermal insulation storage device for umbilical cord mesenchymal stem cell exosomes according to claim 1, characterized in that: The telescopic cabinet (2) matches the outer structure of the heat-insulating storage box (1), and a semi-enclosed structure is formed between the heat-insulating storage box (1) and the telescopic cabinet (2). The freezing liquid tank (3) is evenly distributed at equal intervals along the inner side of the telescopic cabinet (2), and the tube rack (5) forms a snap-fit ​​structure with the freezing liquid tank (3) through the support plate (4), and the sterile storage tube (7) forms a snap-fit ​​connection with the tube rack (5) through the insertion hole (6).

3. The thermal insulation storage device for umbilical cord mesenchymal stem cell exosomes according to claim 1, characterized in that: The block (10) matches the outer structure of the upper end of the slot (8), and the pull rod (9) is connected to the tube rack (5) through the block (10) and the slot (8).

4. The thermal insulation storage device for umbilical cord mesenchymal stem cell exosomes according to claim 1, characterized in that: The outer walls at both ends of the telescopic cabinet (2) are hinged with pull rings (12), the outer wall of one end of the telescopic cabinet (2) close to the open end of the thermal insulation storage box (1) is embedded with a temperature sensor (13), and the outer walls at the four corners of the lower end of the thermal insulation storage box (1) are equipped with universal wheels (14) through bolts.

5. The thermal insulation storage device for umbilical cord mesenchymal stem cell exosomes according to claim 4, characterized in that: The pull ring (12) and the telescopic cabinet (2) form a rotational connection, and the telescopic cabinet (2) forms a telescopic structure with the heat-insulating storage box (1) through the pull ring (12), and the universal wheels (14) are symmetrically arranged with respect to the central axis of the heat-insulating storage box (1).

6. The thermal insulation storage device for umbilical cord mesenchymal stem cell exosomes according to claim 1, characterized in that: The inner layer of the sterile storage tube (7) is provided with a heat-insulating inner liner (15) made of hollow glass, the outer wall of the sterile storage tube (7) is provided with a circular groove (16), and the groove (16) penetrates the outer surface of the heat-insulating inner liner (15), and the open end of the sterile storage tube (7) is threadedly mounted with a sealing cover (17).

7. The thermal insulation storage device for umbilical cord mesenchymal stem cell exosomes according to claim 6, characterized in that: The slots (16) are symmetrically arranged about the central axis of the sterile storage tube (7), and the central axis of the heat-insulating liner (15) and the sterile storage tube (7) coincide with each other, and the sealing cover (17) forms a sealing structure between the heat-insulating liner (15) and the sterile storage tube (7).

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