Reaction device for preparing antiviral drug

Abstract

The utility model discloses a reaction device for preparing antiviral drugs, belongs to the technical field of reaction kettles, and aims to solve the problems that bubbles generated during stirring can reduce the stirring effect and the pressure in the device is increased after the bubbles are broken. The reaction device comprises a device body, a feeding pipe is arranged in the middle of the top end of the device body, the upper end of the feeding pipe is fixedly connected with a driving motor, a reaction cavity is formed in the bottom end in the device body, and a heat exchange cavity is formed in the position, above the reaction cavity, in the device body. The reaction efficiency of the device is improved, bubbles can be broken during stirring, meanwhile, heat can be recycled, medicine raw materials are preheated through the recycled heat, activation of reactant molecules is promoted, and the reaction rate and yield are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of reactors, in particular to a reaction device for preparing antiviral drugs. Background Art

[0002] Viral drugs are a class of drugs that can inhibit the growth and reproduction of viruses. They mainly work by interfering with key steps in the viral life cycle. When producing and preparing antiviral drugs, the raw materials for drug synthesis need to be added to the reactor for reaction. However, existing reactors still have certain shortcomings when used.

[0003] For example, a reactor for processing intermediate drugs with publication number CN213050567U is vertically fixedly connected to a servo motor through the middle position of the top of the top cover, and the drive shaft of the servo motor is fixedly connected to a plurality of equally spaced stirring rods. A pin is vertically fixedly connected to the middle position on the rear side of the reactor body. When the material is injected into the reactor body from the injection pipe, the PLC controller controls the servo motor to drive the stirring rod to stir the material. It is highly practical, but when the drug raw materials are stirred, a large number of bubbles will be generated. The bubbles will occupy the stirring space and reduce the effective contact area between the drug raw materials, thereby reducing the stirring effect, so that the mixing process requires longer time or higher energy input to achieve the expected effect. At the same time, a large amount of gas will be generated after the bubbles are broken, resulting in an increase in the pressure inside the device. The pressure fluctuation will affect the stability of the reaction conditions, making it difficult to accurately control the drug synthesis process, thereby affecting the quality and output of the product.

[0004] Therefore, we propose a reaction device for preparing antiviral drugs in order to solve the above problems. Utility Model Content

[0005] The purpose of the utility model is to provide a reaction device for preparing antiviral drugs, so as to solve the problem raised in the above-mentioned background technology that a large number of bubbles are generated when the drug raw materials are stirred in the current market. The bubbles occupy the stirring space, reduce the effective contact area between the drug raw materials, thereby reducing the stirring effect, so that the mixing process requires a longer time or higher energy input to achieve the desired effect. At the same time, after the bubbles are broken, a large amount of gas is generated, resulting in an increase in the pressure inside the device. The pressure fluctuation affects the stability of the reaction conditions, making it difficult to accurately control the drug synthesis process, thereby affecting the quality and output of the product.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solutions: a reaction device for preparing antiviral drugs, comprising a device body, wherein the bottom end of the device body is fixedly connected to a heating tube, and a feed pipe is provided at the middle of the top of the device body, and the upper end of the feed pipe is fixedly connected to a driving motor; it also includes: a reaction chamber is provided at the bottom end of the device body, a heat exchange chamber is provided in the device body above the reaction chamber, and a liquid chamber is provided in the device body above the heat exchange chamber, the bottom end of the feed pipe penetrates and extends into the reaction chamber, and a rotating shaft is rotatably connected in the feed pipe, a fixed rod is sleeved on the outside of the rotating shaft, and a stirring rod is sleeved on the outside of the rotating shaft below the fixed rod, and the top end of the fixed rod is fixedly connected to a vertical plate; a vibrating rod is fixedly connected to the top end of the reaction chamber, and a knocking rod is rotatably connected in the reaction chamber, a vent pipe is provided at the upper end of the reaction chamber, and the top end of the vent pipe penetrates and extends into the heat exchange chamber, an exhaust pipe is fixedly connected to the side wall of the device body, and one end of the exhaust pipe penetrates and extends into the heat exchange chamber, and a voltage stabilizing component is movably connected in one end of the exhaust pipe.

[0007] Preferably, the top end of the rotating shaft extends through the feed pipe and is fixedly connected to the output end of the driving motor, and the rotating shaft is fixedly connected to the fixed rod and the stirring rod, and a valve is provided at the bottom end of the feed pipe.

[0008] Preferably, the fixing rod and the vertical plate are arranged vertically, and the vertical plate corresponds to the knocking rod.

[0009] Preferably, the knocking rod is arranged at the top end of the reaction chamber, and a torsion spring providing a reset force is connected between the axial end of the knocking rod and the inner wall of the reaction chamber, and one end of the knocking rod is fitted with the vibration rod, and there are two vibration rods and knocking rods symmetrically arranged about the reaction chamber.

[0010] Preferably, two ventilation pipes are symmetrically arranged with respect to the device body, and the parts of the two ventilation pipes located in the heat exchange cavity are arranged in an arc-shaped structure.

[0011] Preferably, the voltage stabilizing assembly includes a sealing plug, an elastic telescopic rod and a support rod, the support rod is fixedly arranged in the exhaust pipe, and the side wall of the support rod is fixedly connected to the elastic telescopic rod, and the end of the elastic telescopic rod away from the support rod is fixedly connected to the sealing plug, and an opening is opened on the exhaust pipe 11 on the side of the elastic telescopic rod 1202.

[0012] Preferably, the sealing plug is slidably disposed in the exhaust pipe, and the sealing plug has a truncated cone structure, and the sealing plug and the exhaust pipe are matched in a concave-convex manner.

[0013] Compared with the prior art, the beneficial effects of the present invention are as follows: the reaction device for preparing antiviral drugs can stir the drugs, effectively improve the fluidity of the drugs, thereby improving the reaction efficiency of the device, and can break the bubbles during stirring. At the same time, heat can be recovered, and the recovered heat can be used to preheat the drug raw materials, promote the activation of reactant molecules, and improve the reaction rate and yield. The specific contents are as follows: 1. A stirring rod is provided, and the rotating shaft is driven to rotate by a driving motor, so that the rotating shaft drives the stirring rod to rotate, thereby stirring the drug stock solution in the reaction chamber and improving the mixing efficiency.

[0014] 2. A vertical plate and a vibrating rod are provided. When the rotating shaft rotates, it will synchronously drive the fixed rod to rotate, and then the fixed rod will drive the vertical plate to rotate, so that the vertical plate intermittently squeezes the knocking rod to rotate, and then the knocking rod knocks the vibrating rod driven by the torsion spring, causing the vibrating rod to vibrate, thereby using the generated vibration to realize the bursting of bubbles.

[0015] 3. A heat exchange chamber and a vent pipe are provided. After the bubbles are broken, the high-temperature gas generated will enter the heat exchange chamber through the vent pipe, thereby heating the cold water in the liquid chamber. The heated water will transfer the heat to the feed pipe, thereby preheating the medicine in the feed pipe and improving the reverse efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of the main structure of the utility model;

[0017] Figure 2 This is a schematic diagram of the side sectional structure of the utility model;

[0018] Figure 3 For this utility model Figure 2 A in the middle is an enlarged structural diagram;

[0019] Figure 4 This is a schematic diagram of the cross-sectional structure of the utility model;

[0020] Figure 5 This is a schematic diagram of the vertical plate installation structure of the utility model.

[0021] In the figure: 1. Device body; 101. Reaction chamber; 102. Heat exchange chamber; 103. Liquid chamber; 2. Feed pipe; 3. Drive motor; 4. Rotating shaft; 5. Fixed rod; 6. Stirring rod; 7. Vertical plate; 8. Vibrating rod; 9. Knocking rod; 10. Ventilation pipe; 11. Exhaust pipe; 12. Voltage stabilizing assembly; 1201. Sealing plug; 1202. Elastic telescopic rod; 1203. Support rod. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0023] Example 1: Please refer to Figure 1-Figure 5 As shown, the utility model provides a technical solution: a reaction device for preparing antiviral drugs, including a device body 1, a heating tube fixedly connected to the bottom end of the device body 1, and a feed pipe 2 is provided in the middle of the top of the device body 1, and a drive motor 3 is fixedly connected to the upper end of the feed pipe 2.

[0024] This technical solution utilizes the setting of the driving motor 3. When in use, the device is first placed on a flat ground, and then the medicine to be mixed and prepared is put into the feeding tube 2, and the valve at the bottom end of the feeding tube 2 is opened, so that the medicine in the feeding tube 2 falls into the reaction chamber 101. Through the setting of the heating tube, the medicine in the reaction chamber 101 can be heated, the reaction temperature can be increased, and the chemical reaction rate can be accelerated. Then the driving motor 3 works, which will drive the stirring rod 6 to rotate, and the medicine in the reaction chamber 101 is stirred and mixed. After the reaction is completed, it can be taken out.

[0025] Example 2: The technical content disclosed in this embodiment is an improvement made on the basis of the above-mentioned embodiment 1. When the existing drug raw materials are stirred, a large number of bubbles will be generated. The bubbles will occupy the stirring space, reduce the effective contact area between the drug raw materials, and thus reduce the stirring effect. The mixing process requires a longer time or higher energy input to achieve the desired effect. The technical solution of this invention is as follows: Figure 1 and Figure 5As shown, a defoaming component of a reactor is disclosed, wherein a reaction chamber 101 is provided at the bottom end of a device body 1, a heat exchange chamber 102 is provided in the device body 1 above the reaction chamber 101, and a liquid chamber 103 is provided in the device body 1 above the heat exchange chamber 102, a feed pipe 2 extends through the bottom end into the reaction chamber 101, and a rotating shaft 4 is rotatably connected in the feed pipe 2, a fixed rod 5 is sleeved on the outside of the rotating shaft 4, and a stirring rod 6 is sleeved on the outside of the rotating shaft 4 below the fixed rod 5, a vertical plate 7 is fixedly connected to the top of the fixed rod 5, a vibrating rod 8 is fixedly connected to the top of the reaction chamber 101, and the reaction chamber 10 1 is rotatably connected with a knocking rod 9, the top end of the rotating shaft 4 penetrates and extends out of the feeding pipe 2 and is fixedly connected to the output end of the driving motor 3, and the rotating shaft 4 is fixedly connected to the fixed rod 5 and the stirring rod 6. A valve is provided at the bottom end of the feeding pipe 2, and the fixed rod 5 and the vertical plate 7 are vertically arranged, and the vertical plate 7 corresponds to the knocking rod 9. The knocking rod 9 is arranged at the top end of the reaction chamber 101, and a torsion spring providing a reset elastic force is connected between the axial end of the knocking rod 9 and the inner wall of the reaction chamber 101, and one end of the knocking rod 9 is in contact with the vibrating rod 8, and two vibrating rods 8 and knocking rods 9 are symmetrically arranged about the reaction chamber 101.

[0026] In this technical solution, Figure 1 As shown, by utilizing the setting of the vibrating rod 8 and the knocking rod 9, the vertical plate 7 will intermittently fit with the knocking rod 9 when rotating, thereby squeezing the knocking rod 9 to rotate, and then the knocking rod 9 is driven by the torsion spring to reset and rotate, knocking the vibrating rod 8. Since the bottom end of the vibrating rod 8 is in contact with the upper surface of the solution, the vibration generated will shatter the bubbles floating on the surface, thereby accelerating the reaction rate.

[0027] It uses Figure 5 The technical solution shown is to first turn on the drive motor 3, which will drive the rotating shaft 4 to rotate, and then the rotating shaft 4 will drive the stirring rod 6 to rotate, thereby stirring the drug solution in the reaction chamber 101. During the stirring process, the rotating shaft 4 will drive the fixed rod 5 to rotate synchronously, and then the fixed rod 5 will drive the vertical plate 7 to rotate synchronously, so that the vertical plate 7 squeezes the knocking rod 9, and the squeezed knocking rod 9 will rotate so that its other end will move away from the vibrating rod 8. Then, when the vertical plate 7 is away from the knocking rod 9, the knocking rod 9 is driven by the torsion spring to reset and rotate, thereby knocking the vibrating rod 8, causing the vibrating rod 8 to vibrate and break the bubbles generated during stirring.

[0028] Example 3: The technical content disclosed in this embodiment is a further improvement based on the above-mentioned Example 1 and Example 2. When the bubbles are broken, a large amount of gas will be generated, resulting in an increase in the pressure inside the device. The pressure fluctuation will affect the stability of the reaction conditions, making it difficult to accurately control the drug synthesis process, thereby affecting the quality and yield of the product. In order to further solve this technical problem, the present technical solution is as follows: Figure 2-Figure 4As shown, a pressure relief assembly of a reactor is disclosed, wherein a vent pipe 10 is provided at the upper end of a reaction chamber 101, and the top end of the vent pipe 10 extends through the heat exchange chamber 102, an exhaust pipe 11 is fixedly connected to the side wall of the device body 1, and one end of the exhaust pipe 11 extends through the heat exchange chamber 102, and a pressure stabilizing assembly 12 is movably connected to the exhaust pipe 11 at one end, two vent pipes 10 are symmetrically arranged about the device body 1, and the portions of the two vent pipes 10 located in the heat exchange chamber 102 are arranged in an arc-shaped structure, and the pressure stabilizing assembly 12 includes a sealing plug 120 1. The elastic telescopic rod 1202 and the support rod 1203, the support rod 1203 is fixedly arranged in the exhaust pipe 11, and the side wall of the support rod 1203 is fixedly connected to the elastic telescopic rod 1202, and the end of the elastic telescopic rod 1202 away from the support rod 1203 is fixedly connected to the sealing plug 1201, an opening is opened on the exhaust pipe 11 on the side of the elastic telescopic rod 1202, the sealing plug 1201 is slidably arranged in the exhaust pipe 11, and the sealing plug 1201 has a truncated cone structure, and the sealing plug 1201 and the exhaust pipe 11 are matched in a concave and convex manner.

[0029] In this technical solution, Figure 2 As shown, by utilizing the setting of the sealing plug 1201 and the elastic telescopic rod 1202, when the pressure in the heat exchange chamber 102 increases, the sealing plug 1201 will move backward, thereby automatically opening the opening on the exhaust pipe 11, and discharging excess gas through the exhaust pipe 11, thereby maintaining the pressure in the heat exchange chamber 102 stable and avoiding safety hazards caused by excessive pressure.

[0030] It uses Figure 3 and Figure 4 The technical solution shown is as follows: first, cold water is added to the liquid chamber 103 through the water inlet on the top of the device body 1. After the bubbles are shattered, the generated gas enters the heat exchange chamber 102 through the vent pipe 10. Since the temperature in the reaction chamber 101 is high, the gas carries a large amount of heat. Then, after the gas enters the heat exchange chamber 102, the heat is transferred to the liquid chamber 103 through heat conduction, heating the cold water in the liquid chamber 103. Then, after the temperature of the cold water in the liquid chamber 103 increases, the heat will be transferred to the surface of the feed pipe 2, and then transferred to the medicine inside it through the feed pipe 2, thereby heating it. When the gas in the heat exchange chamber 102 increases, the pressure will increase. At this time, the sealing plug 1201 is squeezed, and slides backward along the inner wall of the exhaust pipe 11, and squeezes the elastic telescopic rod 1202 to contract, automatically opening the exhaust pipe 11 to achieve automatic pressure relief.

[0031] The contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0032] Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments, or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A reaction device for preparing an antiviral drug, comprising a device body (1), wherein a heating tube is fixedly connected to the bottom end of the device body (1), and a feed tube (2) is provided at the middle of the top end of the device body (1), and a drive motor (3) is fixedly connected to the upper end of the feed tube (2); characterized in that: Also includes: A reaction chamber (101) is provided at the bottom end of the device body (1), a heat exchange chamber (102) is provided in the device body (1) above the reaction chamber (101), and a liquid chamber (103) is provided in the device body (1) above the heat exchange chamber (102). The bottom end of the feed pipe (2) extends through the reaction chamber (101), and a rotating shaft (4) is rotatably connected in the feed pipe (2). A fixed rod (5) is sleeved on the outside of the rotating shaft (4), and a stirring rod (6) is sleeved on the outside of the rotating shaft (4) below the fixed rod (5). The fixed rod ( 5) A vertical plate (7) is fixedly connected to the top; a vibration rod (8) is fixedly connected to the top of the reaction chamber (101), and a knocking rod (9) is rotatably connected to the reaction chamber (101); a ventilation pipe (10) is provided at the upper end of the reaction chamber (101), and the top end of the ventilation pipe (10) extends through the heat exchange chamber (102); an exhaust pipe (11) is fixedly connected to the side wall of the device body (1), and one end of the exhaust pipe (11) extends through the heat exchange chamber (102), and a voltage stabilizing component (12) is movably connected to one end of the exhaust pipe (11).

2. The reaction device for preparing an antiviral drug according to claim 1, characterized in that: The top end of the rotating shaft (4) extends through the feed pipe (2) and is fixedly connected to the output end of the drive motor (3), and the rotating shaft (4) is fixedly connected to the fixed rod (5) and the stirring rod (6). A valve is provided at the bottom end of the feed pipe (2).

3. The reaction device for preparing an antiviral drug according to claim 2, characterized in that: The fixing rod (5) and the vertical plate (7) are arranged vertically, and the vertical plate (7) corresponds to the knocking rod (9).

4. The reaction device for preparing an antiviral drug according to claim 3, characterized in that: The knocking rod (9) is arranged at the top end of the reaction chamber (101), and a torsion spring providing a reset elastic force is connected between the axial end of the knocking rod (9) and the inner wall of the reaction chamber (101), and one end of the knocking rod (9) is fitted with the vibration rod (8), and two of the vibration rod (8) and the knocking rod (9) are symmetrically arranged with respect to the reaction chamber (101).

5. The reaction device for preparing an antiviral drug according to claim 1, characterized in that: Two ventilation pipes (10) are symmetrically arranged with respect to the device body (1), and the portions of the two ventilation pipes (10) located in the heat exchange cavity (102) are arranged in an arc-shaped structure.

6. The reaction device for preparing an antiviral drug according to claim 1, characterized in that: The voltage stabilizing assembly (12) comprises a sealing plug (1201), an elastic telescopic rod (1202) and a support rod (1203); the support rod (1203) is fixedly arranged in the exhaust pipe (11); the side wall of the support rod (1203) is fixedly connected to the elastic telescopic rod (1202); and one end of the elastic telescopic rod (1202) away from the support rod (1203) is fixedly connected to the sealing plug (1201); and an opening is provided on the exhaust pipe (11) on the side of the elastic telescopic rod (1202).

7. The reaction device for preparing an antiviral drug according to claim 6, characterized in that: The sealing plug (1201) is slidably arranged in the exhaust pipe (11), and the sealing plug (1201) has a truncated cone structure, and the sealing plug (1201) and the exhaust pipe (11) are matched in a concave-convex manner.

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