Electric magnetic frame

Abstract

The utility model provides an electric magnetic frame which comprises a main structure frame, a magnet assembly and a lifting frame unit. A perforated plate for containing a sample is placed among the four plate position angle seats at the top of the main structure frame for positioning; when magnetic force is needed, the lifting frame unit and the magnet assembly are driven to ascend through the lifting driving mechanism, all magnets of the magnet assembly are close to all hole sites of the porous plate, and magnetic beads are attracted; when the magnetic force needs to be relieved, the lifting frame unit and the magnet assembly are driven by the lifting driving mechanism to descend, all magnets of the magnet assembly are far away from all hole sites of the porous plate, and the magnetic bead adsorption force is relieved. The magnetic rack has the functions of a magnetic rack and a common test tube rack, switching between a magnetic mode and a non-magnetic mode can be completed only through control of the lifting driving mechanism, the response speed is high, the porous plate does not need to be transferred, the experiment efficiency can be remarkably improved, and space configuration is simplified.

Description

Technical Field

[0001] The utility model relates to the technical field of magnetic frames, in particular to an electric magnetic frame. Background Art

[0002] Magnetic racks play a crucial role in nucleic acid extraction and purification. They are primarily used to adsorb magnetic beads bound to nucleic acid molecules. Through the magnetic field, the beads aggregate at specific locations on the bottom or walls of a test tube, facilitating subsequent operations such as washing and elution.

[0003] Currently, in manually operated experiments, experimenters need to move test tubes between the magnetic rack and the ordinary test tube rack according to the experimental steps. For example, in the process of extracting nucleic acids by magnetic beads, experimenters may first need to place the test tubes on an ordinary test tube rack for cell lysis, mixing, and other operations. Then, when magnetic separation is required, the test tubes are moved to the magnetic rack. During the washing and elution steps, the test tubes may need to be swapped between the magnetic rack and the ordinary test tube rack multiple times to ensure that the nucleic acid molecules on the magnetic beads are fully purified and recovered. The operation of transferring test tubes is relatively cumbersome.

[0004] In some highly automated nucleic acid extraction and purification systems, robotic arms or automated transfer mechanisms are often used to precisely control the movement and positioning of test tubes between magnetic racks and ordinary test tube racks, making the system configuration more complex. Utility Model Content

[0005] In order to overcome the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide an electric magnetic frame.

[0006] In order to achieve the above-mentioned purpose, the technical solution adopted by the present invention to solve the technical problem is: an electric magnetic frame, comprising:

[0007] The main structure frame includes a base plate, support columns, a middle plate, a hollow foot seat frame and four plate angle seats. The support columns are fixedly connected between the base plate and the middle plate. The middle plate is located above the base plate. The hollow foot seat frame is fixedly installed above the middle plate. One plate angle seat is installed at each of the four corners of the top of the hollow foot seat frame.

[0008] A magnet assembly, comprising a magnet fixing seat and a plurality of magnets, wherein the plurality of magnets are fixedly mounted on an upper surface of the magnet fixing seat;

[0009] A lifting frame unit, comprising a screw connecting plate, a lower connecting plate, and a plurality of guide columns, wherein the guide columns are vertically connected between the screw connecting plate and the lower connecting plate, and the guide columns are liftably connected to and penetrate the middle plate, the screw connecting plate is located above the middle plate and connected to the magnet fixing seat, and the lower connecting plate is located below the middle plate;

[0010] The lifting drive mechanism is used to drive the lifting frame unit to move up and down.

[0011] When in use, the porous plate for holding samples is placed between the four plate angle seats on the top of the main structure frame for positioning; when magnetic force is needed, the lifting frame unit and the magnet assembly are driven up by the lifting drive mechanism, and the magnets of the magnet assembly are close to the holes of the porous plate, so as to achieve the adsorption of magnetic beads; when the magnetic force needs to be released, the lifting frame unit and the magnet assembly are driven down by the lifting drive mechanism, and the magnets of the magnet assembly are separated from the holes of the porous plate, so as to achieve the release of the adsorption force on the magnetic beads. The utility model magnetic rack has the functions of both a magnetic rack and an ordinary test tube rack. It only needs to be controlled by the lifting drive mechanism to complete the switching between the magnetic mode and the non-magnetic mode. It has a fast response speed and does not require the transfer of the porous plate. It can significantly improve the efficiency of the experiment and simplify the space configuration.

[0012] Furthermore, the magnet fixing seat has the freedom to move up and down relative to the screw connecting plate, and a compression spring is connected between the magnet fixing seat and the screw connecting plate to provide a buffer distance to prevent the robot arm gun head from being damaged when it overshoots.

[0013] By adopting the above preferred solution, the compression spring ensures that the magnet is in full contact with the bottom of the porous plate, thereby ensuring that a stable magnetic attraction is provided to the magnetic beads in each hole of the porous plate.

[0014] Furthermore, a guide column extending downward is provided on the bottom surface of the magnet fixing seat, a guide hole sleeved on the guide column is provided on the screw connecting plate, a limit stop is provided at the lower end of the guide column, and the compression spring is sleeved on the outer periphery of the guide column.

[0015] Furthermore, a spacer block is provided between the bottom surface of the magnet fixing seat and the upper surface of the screw rod connecting plate.

[0016] By adopting the above preferred solution, the upper and lower movable spaces of the magnet fixing seat relative to the screw rod connecting plate are limited to ensure that the magnet maintains a reasonable contact pressure with the bottom of the porous plate.

[0017] Furthermore, the lifting drive mechanism is a through-type screw motor, the base of the through-type screw motor is fixedly connected to the middle plate, and the top end of the screw of the through-type screw motor is rotatably connected to the screw connecting plate.

[0018] Furthermore, the base of the through-type lead screw motor is installed below the bottom surface of the middle plate.

[0019] The adoption of the above preferred solution improves the compactness of the structural layout.

[0020] Furthermore, a linear bearing matched with the guide column is provided on the middle plate.

[0021] By adopting the above preferred solution, the lifting and lowering stability of the lifting frame unit is improved.

[0022] Furthermore, a position sensor is installed between the middle plate and the lower connecting plate, and the position sensor is used to detect the moving position of the lifting frame unit.

[0023] The above preferred solution is adopted to facilitate the detection of the moving stroke of the lifting frame unit.

[0024] Furthermore, the magnet is in the shape of a hollow cylinder, and two opposite opening slots are provided on the upper portion of the cylinder of the magnet; the directions of the opening slots of the magnet remain consistent.

[0025] By adopting the above preferred solution, the magnetic beads in each well of the multi-well plate can be easily adsorbed at positions on both sides of the opening groove, thereby preventing the magnetic beads from being adsorbed during liquid aspiration and affecting the liquid aspiration efficiency.

[0026] Furthermore, each of the plate angle seats is provided with an X-direction spring piece and a Y-direction spring piece.

[0027] By adopting the above preferred solution, the porous plate can be clamped to ensure that the position of the porous plate remains stable. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0029] Figure 1 It is a structural diagram of an implementation method of the utility model.

[0030] Figure 2 It is a cross-sectional view of an embodiment of the present invention.

[0031] Figure 3 It is a structural schematic diagram of a hidden hollow foot frame in one embodiment of the utility model.

[0032] Figure 4 It is a structural schematic diagram of an embodiment of the magnet of the utility model.

[0033] Figure 5 This is a structural schematic diagram of an embodiment of the utility model in which a porous plate is placed.

[0034] The numbers and letters in the figure represent the names of the corresponding parts:

[0035] 11-base plate; 12-support column; 13-middle plate; 131-linear bearing; 14-hollow foot frame; 15-plate angle seat; 151-X-direction spring; 152-Y-direction spring; 21-magnet fixing seat; 22-magnet; 221-opening slot; 31-screw connecting plate; 32-lower connecting plate; 33-guide column; 34-compression spring; 35-guide column; 351-limit stop; 36-spacer block; 37-position sensor; 41-through-type screw motor; 51-lower shell; 61-porous plate. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0037] like Figure 1-5 As shown, an electric magnetic frame includes:

[0038] The main structure frame includes a base plate 11, support columns 12, a middle plate 13, a hollow foot frame 14 and four plate angle seats 15. The support columns 12 are fixedly connected between the base plate 11 and the middle plate 13. The middle plate 13 is located above the base plate 11. The hollow foot frame 14 is fixedly installed above the middle plate 13. A plate angle seat 15 is installed at each of the four corners of the top of the hollow foot frame 14.

[0039] The magnet assembly includes a magnet fixing seat 21 and a plurality of magnets 22, wherein the plurality of magnets 22 are fixedly mounted on the upper surface of the magnet fixing seat 21;

[0040] The lifting frame unit includes a screw connecting plate 31, a lower connecting plate 32, and a plurality of guide posts 33. The guide posts 33 are vertically connected between the screw connecting plate 31 and the lower connecting plate 32. The guide posts 33 are liftably connected to the middle plate 13. The screw connecting plate 31 is located above the middle plate 13 and connected to the magnet fixing seat 21. The lower connecting plate 32 is located below the middle plate 13.

[0041] The lifting drive mechanism is used to drive the lifting frame unit to move up and down.

[0042] When in use, the porous plate 61 for holding samples is placed between the four plate angle seats 15 on the top of the main structure frame for positioning; when magnetic force is needed, the lifting frame unit and the magnet assembly are driven to rise by the lifting drive mechanism, and the magnets of the magnet assembly are close to the holes of the porous plate, so as to achieve the adsorption of magnetic beads; when the magnetic force needs to be released, the lifting frame unit and the magnet assembly are driven to fall by the lifting drive mechanism, and the magnets of the magnet assembly are separated from the holes of the porous plate, so as to achieve the release of the adsorption force on the magnetic beads. The utility model magnetic rack has the functions of both a magnetic rack and an ordinary test tube rack. It only needs to be controlled by the lifting drive mechanism to complete the switching between the magnetic mode and the non-magnetic mode. It has a fast response speed and does not require the transfer of the porous plate. It can significantly improve the efficiency of the experiment and simplify the space configuration.

[0043] like Figure 2 As shown, in other embodiments of the present invention, the magnet holder 21 has the freedom to move up and down relative to the screw connecting plate 31, and a compression spring 34 is further connected between the magnet holder 21 and the screw connecting plate 31. The beneficial effect of adopting the above technical solution is that the compression spring ensures full contact between the magnet and the bottom of the porous plate, ensuring stable magnetic attraction to the magnetic beads in each hole of the porous plate.

[0044] like Figure 2 As shown, in other embodiments of the present invention, a downwardly extending guide post 35 is provided on the bottom surface of the magnet holder 21. The screw connecting plate 31 is provided with a guide hole that is sleeved onto the guide post 35. The lower end of the guide post 35 is provided with a limit stop 351, and a compression spring 34 is sleeved around the outer periphery of the guide post 35. A spacer block 36 is provided between the bottom surface of the magnet holder 21 and the upper surface of the screw connecting plate 31. This limits the vertical movement of the magnet holder relative to the screw connecting plate, ensuring that the magnet maintains a reasonable contact pressure with the bottom of the porous plate.

[0045] like Figure 2 、 3 As shown, in other embodiments of the present invention, the lifting drive mechanism is a through-type lead screw motor 41. The base of the through-type lead screw motor 41 is fixedly connected to the middle plate 13, and the top end of the lead screw of the through-type lead screw motor 41 is rotatably connected to the lead screw connecting plate 31. The base of the through-type lead screw motor 41 is mounted below the bottom surface of the middle plate 13. The beneficial effect of adopting the above technical solution is: the structural layout is improved.

[0046] like Figure 2 、 3 As shown, in some other embodiments of the present invention, a linear bearing 131 is provided on the middle plate 13 to cooperate with the guide column 33. The beneficial effect of adopting the above technical solution is to improve the lifting and moving stability of the lifting frame unit.

[0047] like Figure 3As shown, in some other embodiments of the present invention, a position sensor 37 is installed between the middle plate 13 and the lower connecting plate 32. The position sensor 37 is used to detect the moving position of the lifting frame unit. The beneficial effect of adopting the above technical solution is that it is convenient to detect the moving stroke of the lifting frame unit.

[0048] like Figure 4 As shown, in other embodiments of the present invention, the magnet 22 is hollow cylindrical, with two opposing openings 221 defined in the upper portion of the cylinder. The openings 221 of all magnets are oriented in the same direction. This advantageously allows the magnetic beads within each well of the multi-well plate to be adsorbed to positions away from the openings, preventing them from being adsorbed during aspiration and affecting aspiration efficiency.

[0049] like Figure 1 As shown, in other embodiments of the present invention, each plate angle seat 15 is provided with an X-direction spring piece 151 and a Y-direction spring piece 152. The beneficial effect of adopting the above technical solution is that the porous plate can be clamped to ensure that the position of the porous plate remains stable.

[0050] In other embodiments of the present invention, a lower shell 51 is installed below the middle plate 13 .

[0051] The above embodiments are only for illustrating the technical concept and features of the present invention. Their purpose is to enable ordinary technicians in this field to understand the content of the present invention and implement it. They are not intended to limit the scope of protection of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the scope of protection of the present invention.

Claims

1. An electric magnetic frame, characterized in that: include: The main structure frame includes a base plate, support columns, a middle plate, a hollow foot seat frame and four plate angle seats. The support columns are fixedly connected between the base plate and the middle plate. The middle plate is located above the base plate. The hollow foot seat frame is fixedly installed above the middle plate. One plate angle seat is installed at each of the four corners of the top of the hollow foot seat frame. A magnet assembly, comprising a magnet fixing seat and a plurality of magnets, wherein the plurality of magnets are fixedly mounted on an upper surface of the magnet fixing seat; A lifting frame unit, comprising a screw connecting plate, a lower connecting plate, and a plurality of guide columns, wherein the guide columns are vertically connected between the screw connecting plate and the lower connecting plate, and the guide columns are liftably connected to and penetrate the middle plate, the screw connecting plate is located above the middle plate and connected to the magnet fixing seat, and the lower connecting plate is located below the middle plate; The lifting drive mechanism is used to drive the lifting frame unit to move up and down.

2. The electric magnetic frame according to claim 1, characterized in that: The magnet fixing seat has the freedom to move up and down relative to the screw rod connecting plate, and a compression spring is connected between the magnet fixing seat and the screw rod connecting plate.

3. The electric magnetic frame according to claim 2, characterized in that: A guide column extending downward is provided on the bottom surface of the magnet fixing seat, a guide hole sleeved on the guide column is provided on the screw rod connecting plate, a limit stop portion is provided at the lower end of the guide column, and the compression spring is sleeved on the outer periphery of the guide column.

4. The electric magnetic frame according to claim 3, characterized in that: A spacer block is provided between the bottom surface of the magnet fixing seat and the upper surface of the screw rod connecting plate.

5. The electric magnetic frame according to claim 1, characterized in that: The lifting drive mechanism is a through-type screw motor, the base of the through-type screw motor is fixedly connected to the middle plate, and the top end of the screw of the through-type screw motor is rotatably connected to the screw connecting plate.

6. The electric magnetic frame according to claim 5, characterized in that: The base of the through-type screw motor is installed below the bottom surface of the middle plate.

7. The electric magnetic frame according to claim 1, characterized in that: The middle plate is provided with a linear bearing matched with the guide column.

8. The electric magnetic frame according to claim 1, characterized in that: A position sensor is installed between the middle plate and the lower connecting plate, and the position sensor is used to detect the moving position of the lifting frame unit.

9. The electric magnetic frame according to claim 1, characterized in that: The magnet is in the shape of a hollow cylinder, and two opposite opening slots are opened on the upper part of the cylinder of the magnet; the directions of the opening slots of the magnet are kept consistent.

10. The electric magnetic frame according to claim 1, characterized in that: Each of the plate angle seats is provided with an X-direction spring piece and a Y-direction spring piece.

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