Mixer and liquid chromatograph

Abstract

The utility model relates to the technical field of liquid chromatographs, and discloses a mixer and a liquid chromatograph. The flow guide assembly is arranged on the liquid inlet device, the flow guide assembly comprises a double-end pipe, a second pipeline, a flow dividing pipe and a buffer area, different liquids are fed into the double-end pipe in a hedging mode, preliminary mixing is conducted through hedging, the liquids are fed into the first pipeline and the flow dividing pipe through the communicating pipe, and the different liquids are further mixed through flowing in the pipelines; meanwhile, other liquid enters through the second pipeline, the split-flow liquid in the split-flow pipe makes contact with the other liquid to be premixed, the premixed liquid and the main flow liquid in the first pipeline are converged and mixed, and after the split-flow liquid and the main liquid are converged, the converged liquid is pushed by two forces in the same direction to move in an accelerated mode; the accelerated flowing liquid enters the buffer area to be buffered, the mixing time is prolonged, insufficient mixing caused by too short mixing time is avoided, and the liquid in the buffer area enters the stirring box.

Description

Technical Field

[0001] The utility model belongs to the technical field of liquid chromatographs, and in particular relates to a mixer and a liquid chromatograph. Background Art

[0002] High performance liquid chromatography is an important branch of chromatography. It uses liquid as the mobile phase and a high-pressure infusion system to pump single solvents with different polarities or mixed solvents of different proportions, buffer solutions and other mobile phases together with the sample to be tested into a chromatographic column filled with a stationary phase. After the components of the sample to be tested are separated in the chromatographic column, they enter the corresponding detector for detection, thereby achieving qualitative and quantitative analysis of the sample.

[0003] After searching, the document with publication number (CN212321534U) discloses a mixer and a liquid chromatograph, which relates to the technical field of liquid chromatographs. The mixer provided by the utility model has an inlet hole, an outlet hole and a plurality of first guide channels, one end of the plurality of first guide channels is respectively connected to the inlet fluid, and the other end of the plurality of first guide channels is respectively connected to the outlet fluid, and the extension lengths of at least two first guide channels are different.

[0004] The above-mentioned device uses a mixer with multiple first guide channels, one end of the multiple first guide channels is respectively connected to the fluid of the inlet hole, and the other end of the multiple first guide channels is respectively connected to the fluid of the outlet hole, and at least two first guide channels have different extension lengths. The mobile phase flows into the first guide channel from the inlet hole, and the mobile phases flowing through the multiple first guide channels are broken in time sequence due to the different extension lengths of the first guide channels, and are mixed and discharged through the outlet hole, thereby enhancing the mixing effect.

[0005] The guide channel used in the above device is actually a groove of a special shape. The flow time of the liquid in the groove is limited due to the size of the groove, resulting in the liquid flowing time in the groove being too short and insufficient mixing between the liquids, which affects the detection results.

[0006] In view of this, the present utility model is proposed. Utility Model Content

[0007] In order to solve the technical problem of insufficient liquid mixing, the basic concept of the technical solution adopted by the utility model is:

[0008] A mixer includes a liquid inlet with two symmetrical connection ports; a flow guide assembly, which is arranged on the liquid inlet and is used to divert and mix the liquid. The flow guide assembly includes a double-headed pipe, a second pipeline, a diverter pipe and a buffer zone. The buffer zone is fixedly connected to the liquid inlet, the second pipeline is fixedly connected to the buffer zone, the double-headed pipe is fixedly connected to the buffer zone, one end of the diverter pipe is fixedly connected to the double-headed pipe, and the other end of the diverter pipe is fixedly connected to the second pipeline; and a mixing assembly, which is arranged on the liquid inlet and fixedly connected to a connection port of the liquid inlet.

[0009] As a preferred embodiment of the present invention, the diversion assembly also includes a connecting pipe, and different pipes are fixedly connected to both ends of the double-headed pipe. One end of the connecting pipe is fixedly connected to the double-headed pipe, and the other end of the connecting pipe is fixedly connected to the diversion pipe.

[0010] As a preferred embodiment of the present invention, the diversion assembly also includes a first pipe, one end of the first pipe is fixedly connected to the connecting pipe by a fastener, the diversion pipe is fixedly connected to the first pipe, and the other end of the first pipe is connected to the buffer zone by a fastener.

[0011] As a preferred embodiment of the present invention, the diversion component further includes a valve, which is fixedly connected to the shunt pipe. The valve is a one-way valve, and the flow direction of the valve is that the liquid flows from the shunt pipe to the second pipeline.

[0012] As a preferred embodiment of the present invention, the mixing assembly includes a stirring box and a stirring rod, one side of the stirring box is fixedly connected to the buffer zone, one end of the stirring box is fixedly connected to a connecting port of the liquid inlet, and the stirring rod is rotatably connected to the inner wall of the stirring box.

[0013] As a preferred embodiment of the present invention, the mixing assembly further comprises a drive motor, the drive motor is fixedly connected to the stirring box, and the stirring rod is fixedly connected to the output shaft of the stirring box.

[0014] A liquid chromatograph comprises a chromatograph body, a connecting channel is provided on the top of the chromatograph body, all the above mixers are arranged on the connecting channel, and the connecting channel is connected to a liquid inlet through a flange.

[0015] As a preferred embodiment of the present invention, a display screen and a control template are provided on the chromatograph body, and the display screen and the control template are electrically connected to the chromatograph body. A cover plate is rotatably connected to one side of the chromatograph body, and the cover plate is clamped to the chromatograph body through a lock.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] 1. A mixer and liquid chromatograph, in which different liquids are sent into a double-headed tube by counter-balancing, are preliminarily mixed by counter-balancing, and are respectively sent into the first pipe and the diversion pipe through a connecting pipe. The different liquids are further mixed by the flow in the pipes, and at the same time, other liquids enter through the second pipe. The diversion liquid in the diversion pipe comes into contact with other liquids for pre-mixing. The pre-mixed liquid merges with the mainstream liquid in the first pipe for mixing. After the diversion liquid merges with the main liquid, the merged liquid is pushed to move faster due to two unidirectional forces. The accelerated flowing liquid enters the buffer zone for buffering, lengthening the mixing time to avoid insufficient mixing due to too short mixing time. The liquid in the buffer zone enters the stirring box.

[0018] 2. This mixer and liquid chromatograph drive the stirring rod to rotate through a driving motor. The rotation of the stirring rod generates centrifugal force to fully mix the internal liquid. Through multi-stage mixing, the problem of insufficient liquid mixing is avoided, ensuring that the test results are not affected by insufficient liquid mixing.

[0019] The specific embodiments of the present invention will be described in further detail below with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In the attached figure:

[0021] Figure 1 It is a three-dimensional schematic diagram of the utility model;

[0022] Figure 2 This is a schematic diagram of the structure between the bolt head pipe and the mixing box of the utility model;

[0023] Figure 3 This is a schematic diagram of the structure between the double-ended pipe and the diverter pipe of the utility model;

[0024] Figure 4 This is a schematic diagram of the buffer structure of the utility model;

[0025] Figure 5 This is a schematic diagram of the internal structure of the mixing box of the present utility model.

[0026] In the figure: 1. Chromatograph body; 11. Display screen; 12. Control template; 2. Liquid inlet; 3. Cover plate; 4. Double-headed pipe; 41. Connecting pipe; 42. First pipe; 5. Second pipe; 6. Stirring box; 61. Drive motor; 62. Stirring rod; 7. Diverter pipe; 71. Valve; 8. Buffer zone. DETAILED DESCRIPTION

[0027] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. The following embodiments are used to illustrate the present invention.

[0028] See also Figure 1-5 , a mixer, including a liquid inlet 2, which has two connecting ports symmetrically provided on the liquid inlet 2; a guide assembly, which is arranged on the liquid inlet 2 and is used to divert and mix the liquid, and the guide assembly includes a double-headed pipe 4, a second pipe 5, a diversion pipe 7 and a buffer zone 8, the buffer zone 8 is fixedly connected to the liquid inlet 2, the second pipe 5 is fixedly connected to the buffer zone 8, the double-headed pipe 4 is fixedly connected to the buffer zone 8, one end of the diversion pipe 7 is fixedly connected to the double-headed pipe 4, and the other end of the diversion pipe 7 is fixedly connected to the second pipe 5 . The guide assembly also includes a connecting pipe 41, and the two ends of the double-headed pipe 4 are fixedly connected to different pipes, one end of the connecting pipe 41 is fixedly connected to the double-headed pipe 4, and the other end of the connecting pipe 41 is fixedly connected to the diversion pipe 7. The guide assembly also includes a first pipe 42, one end of the first pipe 42 is fixedly connected to the connecting pipe 41 by a fastener, the diversion pipe 7 is fixedly connected to the first pipe 42, and the other end of the first pipe 42 is connected to the buffer zone 8 by a fastener. The fasteners include but are not limited to bolts. The valve 71 is fixedly connected to the shunt pipe 7. The valve 71 is a one-way valve. The flow direction of the valve 71 is that the liquid flows from the shunt pipe 7 to the second pipe 5; the mixing component is arranged on the liquid inlet 2. The mixing component is fixedly connected to a connecting port of the liquid inlet 2. Different pipes are connected to both ends of the double-headed pipe 4. Different liquids are hedged and sent into the double-headed pipe 4. Preliminary mixing is performed by hedge, and the liquids are respectively sent into the first pipe 42 and the shunt pipe 7 through the connecting pipe 41. The different liquids are further mixed by the flow in the pipe. At the same time, other liquids enter through the second pipe 5. The shunt liquid in the shunt pipe 7 contacts with other liquids for pre-mixing. The pre-mixed liquid merges with the mainstream liquid in the first pipe 42 for mixing. After the shunt liquid merges with the main liquid, the two unidirectional forces push the merged liquid to accelerate the movement. The accelerated flowing liquid enters the buffer zone 8 for buffering, lengthening the mixing time to avoid insufficient mixing due to too short mixing time. The liquid in the buffer zone 8 enters the mixing box 6.

[0029] Among them, the mixing component includes a stirring box 6 and a stirring rod 62, one side of the stirring box 6 is fixedly connected to the buffer zone 8, one end of the stirring box 6 is fixedly connected to a connecting port of the liquid inlet 2, and the stirring rod 62 is rotatably connected to the inner wall of the stirring box 6. The mixing component also includes a driving motor 61, the driving motor 61 is fixedly connected to the stirring box 6, and the stirring rod 62 is fixedly connected to the output shaft of the stirring box 6. At the same time, the stirring rod 62 is driven to rotate by the driving motor 61. The rotation of the stirring rod 62 generates centrifugal force to fully mix the internal liquid. Through multi-stage mixing, the problem of insufficient liquid mixing is avoided, ensuring that the test results are not affected by insufficient liquid mixing.

[0030] A liquid chromatograph comprises: a chromatograph body 1; a connecting channel is provided on the top of the chromatograph body 1; all of the above-mentioned mixers are provided on the connecting channel; the connecting channel is connected to a liquid inlet 2 by a flange; a display screen 11 and a control template 12 are provided on the chromatograph body 1; the display screen 11 and the control template 12 are both electrically connected to the chromatograph body 1; a cover plate 3 is rotatably connected to one side of the chromatograph body 1; the cover plate 3 is snap-fitted to the chromatograph body 1 through a lock; multi-stage mixing is performed through a guide assembly and a mixing assembly, thereby avoiding the problem of insufficient liquid mixing and ensuring that the test results are not affected by insufficient liquid mixing; after sufficient mixing, the liquid enters the chromatograph body 1 through the liquid inlet 2; the other end of the liquid inlet 2 is connected to a pressure pump; the pressure pump pushes the liquid into the chromatograph body 1; and the liquid is detected by the detection assembly in the chromatograph body 1.

[0031] It is worth noting that the chromatograph body 1 can perform qualitative and quantitative analysis of the sample. The chromatograph body 1 includes an infusion system, an injector, a chromatographic column and a detector. The infusion system, the injector, the chromatographic column and the detector are connected in sequence through pipelines. The detector converts the physical or chemical properties of the sample separated by the chromatographic column into a measurable electrical signal; the chromatographic column is installed in a separate setting; the water level controller body has been disclosed in the liquid chromatograph of the prior art (CN220671349U) and will not be repeated here.

[0032] Working principle: Two ends of the double-ended tube 4 are connected to different pipes, and different liquids are sent into the double-ended tube 4 by counter-balancing, and are preliminarily mixed by counter-balancing, and are sent into the first pipe 42 and the diversion pipe 7 respectively through the connecting pipe 41. The different liquids are further mixed by the flow in the pipes. At the same time, other liquids enter through the second pipe 5. The diverted liquid in the diversion pipe 7 comes into contact with other liquids for pre-mixing. The pre-mixed liquid merges with the mainstream liquid in the first pipe 42 for mixing. After the diverted liquid merges with the main liquid, the two forces in the same direction push the merged liquid to accelerate its movement, and the accelerated flowing liquid enters the buffer zone 8 for Buffering prolongs the mixing time to avoid insufficient mixing due to too short mixing time. The liquid in the buffer zone 8 enters the stirring box 6. At the same time, the stirring rod 62 is driven to rotate by the driving motor 61. The rotation of the stirring rod 62 generates centrifugal force to fully mix the internal liquid. Through multi-stage mixing, the problem of insufficient liquid mixing is avoided, ensuring that the detection results are not affected by insufficient liquid mixing. After sufficient mixing, the liquid enters the chromatograph body 1 through the liquid inlet 2. The other end of the liquid inlet 2 is connected to a pressure pump. The pressure pump pushes the liquid into the chromatograph body 1, and the liquid is detected by the detection component in the chromatograph body 1.

[0033] It is understood that the present invention is described by way of certain embodiments, and those skilled in the art will appreciate that various changes or equivalent substitutions may be made to these features and embodiments without departing from the spirit and scope of the present invention. Furthermore, under the guidance of the present invention, these features and embodiments may be modified to suit specific circumstances and materials without departing from the spirit and scope of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of this application are intended to be protected by the present invention.

Claims

1. A mixer, characterized in that: include: A liquid inlet (2), wherein two connection ports are symmetrically provided on the liquid inlet (2); A flow guide assembly is provided on the liquid inlet (2), and is used for diverting and mixing the liquid. The flow guide assembly comprises a double-ended pipe (4), a second pipe (5), a diverting pipe (7), and a buffer zone (8). The buffer zone (8) is fixedly connected to the liquid inlet (2), the second pipe (5) is fixedly connected to the buffer zone (8), the double-ended pipe (4) is fixedly connected to the buffer zone (8), one end of the diverting pipe (7) is fixedly connected to the double-ended pipe (4), and the other end of the diverting pipe (7) is fixedly connected to the second pipe (5); A mixing component is provided on the liquid inlet (2), and the mixing component is fixedly connected to a connecting port of the liquid inlet (2).

2. The mixer according to claim 1, characterized in that The flow guide assembly further comprises a connecting pipe (41), and different pipelines are fixedly connected to both ends of the double-ended pipe (4), one end of the connecting pipe (41) is fixedly connected to the double-ended pipe (4), and the other end of the connecting pipe (41) is fixedly connected to the diversion pipe (7).

3. The mixer according to claim 2, characterized in that The flow guide assembly further comprises a first pipe (42), one end of the first pipe (42) being fixedly connected to the connecting pipe (41) via a fastener, the diversion pipe (7) being fixedly connected to the first pipe (42), and the other end of the first pipe (42) being connected to the buffer zone (8) via a fastener.

4. The mixer according to claim 1, characterized in that The diversion assembly further comprises a valve (71), which is fixedly connected to the diversion pipe (7). The valve (71) is a one-way valve, and the flow direction of the valve (71) is that the liquid flows from the diversion pipe (7) to the second pipeline (5).

5. The mixer according to claim 1, characterized in that The mixing assembly comprises a stirring box (6) and a stirring rod (62); one side of the stirring box (6) is fixedly connected to the buffer zone (8); one end of the stirring box (6) is fixedly connected to a connection port of the liquid inlet (2); and the stirring rod (62) is rotatably connected to the inner wall of the stirring box (6).

6. The mixer according to claim 5, characterized in that The mixing assembly further comprises a driving motor (61), the driving motor (61) is fixedly connected to the stirring box (6), and the stirring rod (62) is fixedly connected to the output shaft of the stirring box (6).

7. A liquid chromatograph, characterized in that include: A chromatograph body (1) is provided with a connecting channel on the top of the chromatograph body (1), a mixer according to any one of claims 1 to 6 is provided on the connecting channel, and the connecting channel is connected to the liquid inlet (2) through a flange.

8. The liquid chromatograph according to claim 7, characterized in that The chromatograph body (1) is provided with a display screen (11) and a control template (12), both of which are electrically connected to the chromatograph body (1). A cover plate (3) is rotatably connected to one side of the chromatograph body (1), and the cover plate (3) is snap-connected to the chromatograph body (1) via a lock.

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