Chromatographic packing purification medium separation device

Abstract

The utility model provides a chromatographic packing purification medium separation device which comprises a power base and a separation mechanism, a slide rail support and a chromatographic support are installed in a combined mode, stable placement of a chromatographic glass column in the separation process is guaranteed, a better separation effect is achieved, and a bottom valve is used for adjusting setting to enable continuous flowing and closing of a glass column medium. The motor drives the gear to rotate according to a preset instruction, the rack core rod is pushed to downwards push cotton in the glass column to be immersed according to the corresponding speed, then the eluent enters the glass column, the rack core rod is pushed again, the elution time of different component gradients is shortened, the time of the separation process is shortened, and the separation efficiency is improved. The motor at the bottom rotates the receiving rotary disc at the top according to a preset instruction, separated samples of different components are poured into the separation container, separation of a purification medium is completed, the motor drives the receiving rotary disc, manual operation is reduced, long-time waiting operation of experimenters is omitted, and the labor cost is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatographic separation, in particular to a chromatographic filler purification medium separation device. Background Art

[0002] Chromatographic separation is based on the fact that different substances have different retention effects in a system composed of a stationary phase and a mobile phase, and exhibit different retention times for different substances in the mobile phase, thereby achieving separation.

[0003] According to the search announcement number: CN220918223U, a rice high fructose syrup chromatography separation device adopts a rotary structural design, and can use a rotary motor to drive the separation box to rotate, thereby improving the separation efficiency in the chromatographic column. The rice high fructose syrup chromatography separation device adopts a card seat and a protrusion slot structure to connect the chromatographic column and the bottom of the separation box, which can easily install and remove the chromatographic column and ensure the stability of the chromatographic column during rotation. The rice high fructose syrup chromatography separation device adopts an upper filter block and a lower filter block structure to connect the upper and lower shells of the chromatographic column, which can effectively prevent the loss of filler and conveniently replace and replenish filler. The rice high fructose syrup chromatography separation device adopts an L-shaped part and a T-shaped locking rod structure to connect the upper shell of the chromatographic column and the top of the separation box, which can quickly lock and unlock the chromatographic column, is simple to disassemble, and is convenient for cleaning and maintenance of the inside of the chromatographic column.

[0004] However, the following problems exist when implementing the above technical solution: the above technical solution uses a simple-structured drive separation box for chromatographic separation, and there is no good support structure to fix the chromatographic column. The separation process does not have a stable placement environment, which easily causes the re-mixing and insufficient separation of the purification media of different components inside. The separation time is long, requiring more waiting and operation time. There is no relevant separation container, the labor cost is high, and the separation work is not quick and portable. Utility Model Content

[0005] The purpose of the utility model is to provide a chromatographic filler purification medium separation device to solve the problems in the above background technology.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solutions: a chromatographic filler purification medium separation device, comprising a power base and a separation mechanism, the power base being provided with a motor inside, a bracket base being provided on the rear side of the top of the power base, a separation mechanism being provided on the top of the power base, a slide rail bracket being provided on the top central inner side of the bracket base, a chromatographic bracket being provided on the inside of the slide rail bracket, a fixing clamp being provided at the end of the chromatographic bracket, fixing screws being provided inside both sides of the fixing clamp, a fastening knob being provided on the top of the slide rail bracket, a glass column being provided on the outside of the chromatographic bracket, a bottom valve being provided at the bottom of the glass column, a support rod being provided at the top central side of the power base, a solvent funnel being provided on the top outer side of the support rod, a pushing bracket being provided on the top inner side of the support rod, a rack core rod being provided inside the pushing bracket, a gear being provided on one side of the rack core rod, a motor being provided on the outer side of the gear, a receiving turntable being provided at the bottom of the support rod, and a separation container being provided on the top of the receiving turntable.

[0007] Preferably, the power base and the motor are sleeved together, and the power base and the bracket base are bolted together.

[0008] Preferably, the slide rail bracket is slidably connected to the bracket base, two groups of slots are provided on both sides of the slide rail bracket, the chromatogram bracket is slidably connected to the slide rail bracket via a fastening knob, the chromatogram bracket is connected to the fixing clamp via a fixing screw via a slot, and two groups of chromatogram brackets and fixing clamps are provided.

[0009] Preferably, the glass column is sleeved with the chromatographic support and the fixed clamp, and the bottom valve is fixedly connected to the chromatographic support.

[0010] Preferably, the power base is rotatably connected to the support rod, the support rod is fixedly connected to the solvent funnel, and a valve is provided at the bottom of the solvent funnel.

[0011] Preferably, the support rod and the pushing bracket are fixedly connected, the rack core rod and the pushing bracket are slidably connected, and the motor is meshed with the rack core rod via a gear.

[0012] Preferably, the receiving turntable is rotatably connected to the power base via a motor, six groups of container holders are provided on the top of the receiving turntable, the separation containers are connected to the receiving turntable via slots, and six groups of separation containers are provided.

[0013] Compared with the prior art, the beneficial effects of the present invention are:

[0014] The slide bracket is installed in combination with the chromatography bracket to ensure the stable placement of the chromatographic glass column during the separation process and achieve better separation effect. The bottom valve is used to adjust the setting of continuous flow and closure of the glass column medium to complete the separation of different media in different time periods. The motor drives the gear to rotate according to the preset instructions, pushing the rack core rod to push the cotton in the glass column downward at the corresponding speed to immerse the cotton, and then the eluent enters the glass column and pushes the rack core rod again to accelerate the elution time of the gradient of different components and reduce the time of the separation process. The bottom motor rotates the top receiving turntable according to the preset instructions, and pours the separated samples of different components into the separation container to complete the separation of the purification medium. The motor drives the receiving turntable to reduce manual operation, saves the experimenter from waiting for a long time, and reduces labor costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the overall appearance structure of the utility model;

[0016] Figure 2 This is a side view of the structure of the utility model;

[0017] Figure 3 This is a schematic diagram of the top view of the structure of the utility model;

[0018] Figure 4 This is a front view structural diagram of the utility model.

[0019] Numbers in the figure: 1. Power base; 2. Motor; 3. Bracket base; 4. Separation mechanism; 401. Slide bracket; 402. Chromatography bracket; 403. Fixing clamp; 404. Fixing screw; 405. Tightening knob; 406. Glass column; 407. Bottom valve; 408. Support rod; 409. Solvent funnel; 410. Push bracket; 411. Rack core rod; 412. Gear; 413. Motor; 5. Receiving turntable; 6. Separation container. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0021] See also Figure 1-4The utility model provides a technical solution: a chromatographic filler purification medium separation device, comprising a power base 1 and a separation mechanism 4, wherein a motor 2 is provided inside the power base 1, a support base 3 is provided on the top rear side of the power base 1, a separation mechanism 4 is provided on the top of the power base 1, a slide rail support 401 is provided on the top center of the support base 3, a chromatographic support 402 is provided inside the slide rail support 401, a fixing clamp 403 is provided at the end of the chromatographic support 402, fixing screws 404 are provided on both sides of the fixing clamp 403, and a fastening knob 405 is provided on the top of the slide rail support 401. A glass column 406 is provided on the outside of the chromatography bracket 402, and a bottom valve 407 is provided at the bottom of the glass column 406. A support rod 408 is provided in the top center of the power base 1, and a solvent funnel 409 is provided on the outside of the top of the support rod 408. A pushing bracket 410 is provided on the inside of the top of the support rod 408, and a rack core rod 411 is provided inside the pushing bracket 410. A gear 412 is provided on one side of the rack core rod 411, and a motor 413 is provided on the outside of the gear 412. A receiving turntable 5 is provided at the bottom of the support rod 408, and a separation container 6 is provided on the top of the receiving turntable 5.

[0022] Furthermore, the power base 1 and the motor 2 are sleeved, and the power base 1 and the bracket base 3 are bolted. The power base 1 is the main load-bearing part of the device, and the motor 2 drives the receiving turntable 5 on the top to rotate.

[0023] Furthermore, the slide rail bracket 401 is slidably connected to the bracket base 3, and two groups of slots are provided on both sides of the slide rail bracket 401. The chromatographic bracket 402 is slidably connected to the slide rail bracket 401 through a fastening knob 405. The chromatographic bracket 402 is connected to the fixing clamp 403 through a fixing screw 404. There are two groups of chromatographic brackets 402 and fixing clamps 403. The slide rail bracket 401 can slide up and down in the bracket base 3 to change the height position of the chromatographic column to meet the working requirements of chromatographic columns and receiving containers of different sizes. The horizontal position of the glass column 406 is adjusted by fastening the knob 405 to adapt it to receiving containers of different sizes. The two groups of fixing clamps 403 are combined and installed with the chromatographic bracket 402 using the fixing screw 404 to ensure the stable placement of the chromatographic glass column 406 during the separation process and achieve better separation effect.

[0024] Furthermore, the glass column 406 is sleeved with the chromatographic support 402 and the fixing clamp 403, and the bottom valve 407 is fixedly connected to the chromatographic support 402. The glass column 406 is inserted downward along the circular hole where the fixing clamp 403 and the chromatographic support 402 are installed until the bottom of the glass column 406 rests against the bottom valve 407. The bottom valve 407 is used to adjust the setting of continuous flow and closure of the medium in the glass column 406 to complete the separation of different media in different time periods.

[0025] Furthermore, the power base 1 and the support rod 408 are rotatably connected, the support rod 408 and the solvent funnel 409 are fixedly connected, a valve is provided at the bottom of the solvent funnel 409, a ball of cotton is placed in the glass column 406, and the capacity of eluents of different polarities is determined according to the volume of the chromatographic filler in the glass column 406, and the eluent is poured into the solvent funnel 409. When the solvent funnel 409 is directly above the glass column 406, the valve is opened, and the eluents of each component are added in order from high to low polarity to complete the preparation part of the separation work.

[0026] Furthermore, the support rod 408 is fixedly connected to the pushing bracket 410, and the rack core rod 411 is slidably connected to the pushing bracket 410. The motor 413 is meshed with the rack core rod 411 through the gear 412. The motor 413 drives the gear 412 to rotate according to the preset instructions, pushing the rack core rod 411 downward at a corresponding speed to immerse the cotton in the glass column 406, and then the eluent enters the glass column 406, pushing the rack core rod 411 again, thereby accelerating the elution time of different component gradients and reducing the time of the separation process.

[0027] Furthermore, the receiving turntable 5 is rotatably connected to the power base 1 through the motor 2. Six groups of container holders are arranged on the top of the receiving turntable 5. The separation container 6 is connected to the receiving turntable 5 by a slot. There are six groups of separation containers 6. The motor 2 at the bottom rotates the receiving turntable 5 at the top according to the preset instructions, and the separated samples of different components are poured into the separation container 6 to complete the separation of the purification medium. The motor 2 drives the receiving turntable 5 to reduce manual operation, save the experimenter from waiting for a long time, and reduce labor costs.

[0028] The working principle is as follows: the slide bracket 401 can slide up and down in the bracket base 3 to change the height position of the chromatographic column to adapt to the working requirements of chromatographic columns and receiving containers of different sizes. The horizontal position of the glass column 406 is adjusted by tightening the knob 405 to adapt it to receiving containers of different sizes. The two sets of fixing clamps 403 are assembled with the chromatographic bracket 402 using the fixing screw 404 to ensure the stable placement of the chromatographic glass column 406 during the separation process and achieve better separation effect. The glass column 406 is inserted downward along the circular hole where the fixing clamp 403 and the chromatographic bracket 402 are installed until the bottom of the glass column 406 touches the bottom valve 407 to complete the separation of different media under different time periods. A ball of cotton is placed in the glass column 406. The capacity of eluents of different polarities is determined according to the volume of the chromatographic packing in the glass column 406. The valve is opened when the solvent funnel 409 is directly above the glass column 406. The eluents of each component are added in order from high to low polarity to complete the separation. In the preparation part of the separation work, the support rod 408 is rotated, and the rack core rod 411 is directly above the glass column 406. The motor 413 drives the gear 412 to rotate according to the preset instructions, pushing the rack core rod 411 in the bracket 410 downward at the corresponding speed to immerse the cotton in the glass column 406. Finally, different media are separated, and the eluent is poured into the solvent funnel 409, poured into the glass column 406, and the rack core rod 411 is pushed. The above steps are repeated to accelerate the elution time of different component gradients and reduce the time of the separation process. The bottom valve 407 is used to adjust the setting to continuously flow and close the medium in the glass column 406. The bottom motor 2 rotates the top receiving turntable 5 according to the preset instructions, and pours the separated samples of different components into the separation container 6 to complete the separation of the purification medium. The motor 2 drives the receiving turntable 5 to reduce manual operation, save the experimenter from waiting for a long time, and reduce labor costs. In this way, the use process of a chromatographic filler purification medium separation device is completed.

[0029] Although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A chromatographic packing purification medium separation device, comprising a power base (1) and a separation mechanism (4), characterized in that: The power base (1) is provided with a motor (2) inside, a bracket base (3) is provided on the rear side of the top of the power base (1), a separation mechanism (4) is provided on the top of the power base (1), a slide rail bracket (401) is provided on the top of the inner center of the bracket base (3), a chromatographic bracket (402) is provided on the inner side of the slide rail bracket (401), a fixing clamp (403) is provided at the end of the chromatographic bracket (402), fixing screws (404) are provided on both sides of the fixing clamp (403), a fastening knob (405) is provided on the top of the slide rail bracket (401), and a glass column (406) is provided on the outer side of the chromatographic bracket (402). A bottom valve (407) is provided at the bottom of the glass column (406), a support rod (408) is provided at the center of the top of the power base (1), a solvent funnel (409) is provided on the outer side of the top of the support rod (408), a pushing bracket (410) is provided on the inner side of the top of the support rod (408), a rack core rod (411) is provided inside the pushing bracket (410), a gear (412) is provided on one side of the rack core rod (411), a motor (413) is provided on the outer side of the gear (412), a receiving turntable (5) is provided at the bottom of the support rod (408), and a separation container (6) is provided on the top of the receiving turntable (5).

2. A chromatographic packing purification medium separation device according to claim 1, characterized in that: The power base (1) and the motor (2) are sleeve-connected, and the power base (1) and the bracket base (3) are bolt-connected.

3. A chromatographic packing purification medium separation device according to claim 1, characterized in that: The slide rail bracket (401) is slidably connected to the bracket base (3), two groups of slots are provided on both sides of the slide rail bracket (401), the chromatographic bracket (402) is slidably connected to the slide rail bracket (401) via a fastening knob (405), the chromatographic bracket (402) is connected to the fixed clamp (403) via a fixing screw (404), and two groups of chromatographic bracket (402) and fixed clamp (403) are provided.

4. A chromatographic packing purification medium separation device according to claim 1, characterized in that: The glass column (406) is sleeved with the chromatographic support (402) and the fixing clamp (403), and the bottom valve (407) is fixedly connected to the chromatographic support (402).

5. The chromatographic packing purification medium separation device according to claim 1, characterized in that: The power base (1) and the support rod (408) are rotatably connected, the support rod (408) and the solvent funnel (409) are fixedly connected, and a valve is provided at the bottom of the solvent funnel (409).

6. A chromatographic packing purification medium separation device according to claim 1, characterized in that: The support rod (408) is fixedly connected to the pushing bracket (410), the rack core rod (411) is slidably connected to the pushing bracket (410), and the motor (413) is meshedly connected to the rack core rod (411) via a gear (412).

7. The chromatographic packing purification medium separation device according to claim 1, characterized in that: The receiving turntable (5) is rotatably connected to the power base (1) via a motor (2); six groups of container holders are provided on the top of the receiving turntable (5); the separation containers (6) are connected to the receiving turntable (5) via a card slot; and six groups of separation containers (6) are provided.

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