Extraction equipment for coprophilous fungi

Abstract

The utility model relates to coprophilous fungus extraction equipment which is used for stably producing high-quality fungus liquid in the coprophilous fungus extraction process. The coprophilous fungus extraction equipment comprises a peristaltic pump, a filtrate collecting tank, a stirring tank with a flow guide net and a multi-stage filter with a flow guide net, the peristaltic pump is arranged on a pipeline between the stirring tank and the multi-stage filter, and the peristaltic pump is arranged on a pipeline between the multi-stage filter and the filtrate collecting tank. According to the technical scheme provided by the utility model, not only can the problems of low filtering efficiency and low bacteria collecting rate caused by blockage of a filtering membrane in the coprophilous bacteria liquid filtering process be solved, but also the filtering process is greatly simplified, the dependence on manpower is reduced, and the automation degree of coprophilous bacteria extracting and filling equipment is improved.

Description

Technical Field

[0001] The utility model relates to medical equipment, in particular to fecal bacteria extraction equipment. Background Art

[0002] Under normal circumstances, the intestinal flora can establish a dynamic ecological balance with the host and the external environment. Once the intestinal flora is disturbed, it will cause the host to lose multiple functions, thereby inducing disease. It is reported that 95% of diseases are related to the intestinal flora. In addition to gastrointestinal diseases, they are also closely related to metabolic system diseases, nervous system diseases, immune system diseases, tumors, etc. Flora microbiota transplantation (FMT) is a new non-restricted medical technology in the field of intestinal microecology. It is transplanted from the feces of healthy donors after matching and a series of treatments into the patient's intestines to rebuild the patient's intestinal microecology, thereby achieving intervention and treatment of various diseases.

[0003] Transplantation methods include oral (FMT-C) or enema (FMT-L). Regardless of the method, the donor's feces needs to be processed before the next step can be carried out, including testing, matching, and preparation. How to maintain a high bacterial yield and a high proportion of viable bacteria during the intestinal flora extraction process, thereby improving the effectiveness of intervention treatment, is a key goal of the intestinal fecal flora extraction process and the development of corresponding filters. The specific operation process of fecal flora extraction is as follows: First, the donor feces is transferred to a fecal collection tank and weighed, and a certain proportion of physiological saline is added and stirred to disperse; then it undergoes a coarse filtration step to remove large particles of fecal debris; the coarse filtration filtrate is then subjected to a fine filtration step to further remove small particles of debris; finally, the filtrate is further processed as necessary and made into different preparation forms, such as liquid or capsules, according to the transplantation method. The entire operation process needs to be completed in a relatively short time to ensure a high proportion of viable bacteria. In the stirring and dispersion step, if the stirring and dispersion time is not enough, the viscosity of the fecal bacteria liquid is not high, and it is relatively easy to filter, but the bacteria recovery rate is very low because a large part of the fecal bacteria remains in the large particles of residue; if the stirring and dispersion is sufficient, the viscosity of the fecal bacteria liquid will increase, and the solid content of the fecal bacteria liquid will be relatively high, which will easily clog the filter. Therefore, completing efficient extraction and separation in a short time requires relatively high requirements for the extraction process and extraction equipment. The existing technology uses a stirring tank that serves as a coarse filter tank and 5 barrel filters in series to realize the entire filtration process. Generally speaking, multi-stage series connection not only requires multiple power pumps to realize the complete filtration process, but also increases the complexity of the operation of the entire filtration process. The clogging situation of each stage is different, and the required pressure will also be different. The operation process requires manual intervention to complete the overall filtration. The high degree of dependence on manual labor limits the advancement of automated extraction and separation technology. There will also be safety issues such as the increase in filter pressure caused by the clogging of the downstream filter material, which will cause the pressure at the pipe connection to be too high and thus collapse. In addition, due to the combined use of multiple filters, the fixed volume of the system increases, the bacterial liquid recovery rate decreases, and the complex operation process prolongs the filtration time. These are not conducive to improving the viable bacteria rate and the bacterial recovery rate, resulting in low quality of the produced bacterial liquid. Utility Model Content

[0004] Based on this, a fecal bacteria extraction device is provided to solve the technical problem of how to stably produce high-quality bacterial liquid during the fecal bacteria extraction process.

[0005] The purpose of the utility model can be achieved through the following technical solutions: a fecal bacteria extraction device, including a peristaltic pump, a filtrate collection tank, a stirring tank with a diversion net and a multi-stage filter with a diversion net, wherein a peristaltic pump is provided on the pipeline between the stirring tank and the multi-stage filter, and a peristaltic pump is provided on the pipeline between the multi-stage filter and the filtrate collection tank.

[0006] Compared with the existing technology, the technical effect achieved by adopting this technical solution is: the use of a stirring tank with a guide net and a multi-stage filter with a guide net can reduce the blockage of the filtration path on the separation membrane by solid sticky matter during filtration, thereby accelerating the filtration efficiency. A single multi-stage filter reduces the inherent volume of the filtration system, reduces the waste of bacterial liquid, and can also reduce the number of power pumps, increase the convenience of operation, and reduce the degree of manual dependence. After the above-mentioned fecal bacteria extraction and filtration, the total number of live bacteria and the total number of colonies before and after the fecal bacteria liquid treatment are maintained at the same order of magnitude, ensuring the stable production of high-quality bacterial liquid during the fecal bacteria extraction process.

[0007] In the above-mentioned fecal bacteria extraction equipment, the stirring tank includes a stirring tank body, a coarse filtration component, and a sealing cover, and a stirring member is rotatably provided on the sealing cover. The coarse filtration component includes a separation membrane and a guide net, and the guide net is arranged on the inner side of the separation membrane.

[0008] Compared with the existing technology, the technical effect achieved by adopting this technical solution is: the use of a coarse filtration component with a guide net can avoid the formation of a dense filter cake layer in front of the separation membrane by solid sticky matter during filtration. There is no filter cake layer blocking the flow of bacterial liquid to the separation membrane, which speeds up the filtration efficiency.

[0009] In the above-mentioned fecal bacteria extraction equipment, the fecal bacteria extraction equipment also includes a stirring drive member, which drives the stirring member to rotate. The stirring drive member is arranged on the lifting drive member, and the driving end of the stirring drive member can be detachably connected to the stirring member. The lifting drive member drives the stirring drive member to approach and move away from the stirring member, so that the connection between the two is disconnected or connected.

[0010] Compared with the existing technology, the technical effect achieved by adopting this technical solution is that the driving end of the stirring drive is detachable from the stirring element. When adding feces to the stirring tank or changing the stirring tank, the stirring drive is separated from the stirring element. When stirring is required, the stirring drive is close to the stirring element and connected. This makes the fecal microorganism extraction operation more convenient and efficient.

[0011] In the above-mentioned fecal bacteria extraction equipment, the multi-stage filter includes a filter housing and a composite membrane element. The filter housing surrounds and forms a filter inner cavity. The composite membrane element divides the filter inner cavity into a liquid inlet cavity and a liquid outlet cavity. The liquid inlet cavity has a liquid inlet, and the liquid outlet cavity has a liquid outlet. The composite membrane element includes a multi-layer guide net and a multi-layer separation membrane. The filtration accuracy of the multi-layer separation membranes is arranged in order from the liquid inlet cavity to the liquid outlet cavity, and the filtration accuracy gradually increases. Each layer of the separation membrane has the guide net on the side facing the liquid inlet cavity.

[0012] Compared with the existing technology, the technical effect achieved by adopting this technical solution is that only one multi-stage filter using a composite membrane element is needed to achieve a fine filtration effect, which reduces the inherent volume of the filtration system, thereby reducing the waste of bacterial liquid, and does not require multiple peristaltic pumps to achieve multi-stage filtration, which also reduces the operational complexity of the fecal bacteria extraction process. The composite membrane element has a multi-layer guide mesh and a multi-layer separation membrane, and each separation membrane has a guide mesh on the side facing the liquid inlet cavity. This can prevent solid sticky matter from forming a dense filter cake layer in front of the separation membrane during filtration. There is no filter cake layer blocking the flow of bacterial liquid to the separation membrane, which speeds up the filtration efficiency.

[0013] In the above-mentioned fecal bacteria extraction equipment, the composite membrane element includes multiple filter layer groups, and the filter layer group includes one layer of the separation membrane and two layers of the guide nets, and the two layers of the guide nets are respectively located on both sides of the separation membrane.

[0014] In the above-mentioned fecal bacteria extraction equipment, the stirring tank is connected to the liquid inlet, and the filtrate collecting tank is connected to the liquid outlet.

[0015] In the above-mentioned fecal bacteria extraction equipment, the fecal bacteria extraction equipment also includes a filling component, which includes a filling bottle placement area, a filling liquid outlet part and an avoidance drive part. The avoidance drive part drives and connects the filling liquid outlet part, and the canned bottle placement area is arranged in the moving direction of the filling liquid outlet part.

[0016] In the above-mentioned fecal bacteria extraction equipment, the fecal bacteria extraction equipment also includes a protective agent tank, which is connected to the filling liquid outlet, and a peristaltic pump is provided on the pipeline between the protective agent tank and the filling liquid outlet.

[0017] In the above-mentioned fecal bacteria extraction equipment, the fecal bacteria extraction equipment also includes a transport arm assembly, which can move the filling bottle from the filling bottle collection tank to the filling bottle placement area, the transport arm assembly includes a twist-cap assembly, and the filling assembly also includes a filling bottle clamp, which is used to clamp the filling bottle in the filling bottle placement area, and the twist-cap assembly cooperates with the filling bottle clamp to unscrew or tighten the bottle cap of the filling bottle.

[0018] Compared with existing technologies, this solution achieves the following technical benefits: the handling arm automatically removes bottles from the bottle collection trough, moves them to the bottle storage area, unscrews the bottle caps, and tightens them again after filling. The filled bottles are then returned to the bottle collection trough and a new bottle is retrieved. This makes the entire filling process automated, eliminating the need for additional manual labor.

[0019] In the above-mentioned fecal bacteria extraction equipment, the fecal bacteria extraction equipment also includes an injection component, which includes a liquid storage tank and a cache tank. A peristaltic pump is provided on the pipeline between the liquid storage tank and the cache tank, and a peristaltic pump is provided on the pipeline between the cache tank and the stirring tank.

[0020] Compared with the existing technology, the technical effect achieved by adopting this technical solution is: physiological saline can be automatically added to the mixing tank through the liquid injection component, further improving the degree of automation of the entire fecal bacteria extraction equipment and reducing manual operations.

[0021] In the above-mentioned fecal bacteria extraction equipment, the stirring tank also includes a rotating shaft fixing seat, a rotating bearing, a fastener, an O-ring and an oil seal. The rotating shaft fixing seat and the fastener both have a central through hole. The through hole of the rotating shaft fixing seat is provided with a rotating bearing, and the through hole of the fastener is provided with an oil seal. The stirring piece is passed through the rotating bearing and the oil seal, and the O-ring is provided between the fastener and the sealing cover. The fastener is threadedly connected to the rotating shaft fixing seat, and the fastener fixes the O-ring and the rotating shaft fixing seat to the sealing cover.

[0022] Compared with the existing technology, the technical effect achieved by adopting this technical solution is: the two sealing structures of O-ring and oil seal are used to ensure that the bacterial liquid in the mixing tank will not flow out from the gap between the stirring element and the sealing cover during high-speed rotation.

[0023] The application of the technical solution of this utility model not only solves the problem of reduced filtration efficiency and low bacterial recovery caused by clogging of the filter membrane during fecal microbial liquid filtration, but also greatly simplifies the filtration process, reduces reliance on manual labor, and improves the automation level of fecal microbial extraction and perfusion equipment. In addition, it can reduce the cost of consumables, reducing the number of filtration stages from more than three to one, and the separate design of the filter screen and filter increases the feasibility of cleaning and replacement. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is the overall intention of the fecal bacteria extraction device of the embodiment of the utility model;

[0025] Figure 2 This is the local structure of the fecal bacteria extraction equipment of the utility model embodiment Figure 1 ;

[0026] Figure 3 This is the local structure of the fecal bacteria extraction equipment of the utility model embodiment Figure 2 ;

[0027] Figure 4 This is a schematic diagram of a composite membrane element according to an embodiment of the present utility model;

[0028] Figure 5 This is a schematic diagram of a coarse filter assembly according to an embodiment of the present utility model;

[0029] Figure 6 This is a schematic diagram of the liquid connection of the fecal bacteria extraction equipment according to the embodiment of the present utility model;

[0030] Figure 7 This is a cross-sectional schematic diagram of a stirring tank according to an embodiment of the present invention.

[0031] In the figure, 10, workbench; 11, support table;

[0032] 20. Mixing tank; 211. Stirring element; 212. Rotating shaft fixing seat; 213. Rotating bearing; 214. Fastener; 215. O-ring; 216. Oil seal; 22. Coarse filter assembly; 221. Inner sleeve; 222. Guide net 3; 223. Separation membrane 4; 224. Outer sleeve; 231. Sealing cover; 232. Mixing tank body; 2321. Mixing outlet; 24. Stirring drive element; 25. Lifting drive element;

[0033] 30. Multi-stage filter; 31. Composite membrane element; 311. Flow guide net 1; 312. Separation membrane 1; 313. Flow guide net 2; 314. Separation membrane 2; 315. Separation membrane 3; 32. Filter housing; 321. Upper housing; 3211. Liquid inlet; 322. Lower housing; 3221. Liquid outlet;

[0034] 40. Filtrate collection tank;

[0035] 50. Peristaltic pump; 51. Hose; 52. Catheter clamp;

[0036] 60. Filling bottle collecting tank; 61. Filling bottle;

[0037] 70. Carrying arm assembly; 71. Robotic arm; 72. Twist-cover assembly; 73. Blow rod;

[0038] 80. Filling assembly; 81. Filling clamp; 82. Filling liquid outlet; 83. Avoidance drive; 84. Canned bottle placement area;

[0039] 90. Liquid injection assembly; 91. Liquid storage tank; 92. Buffer tank; 921. Liquid level sensor; 922. Liquid filling port;

[0040] 100. Protective agent tank;

[0041] 110. Touch screen. DETAILED DESCRIPTION

[0042] To make the above-mentioned objects, features, and advantages of the present invention more clearly understood, the following detailed description of specific embodiments of the present invention is provided in conjunction with the accompanying drawings. The following description sets forth many specific details to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways than those described herein, and those skilled in the art may make similar modifications without departing from the scope of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0043] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like to indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation to the present invention.

[0044] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature specified as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of this utility model, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0045] In this utility model, unless otherwise specified or limited, the terms "installed," "connected," "connect," "fixed," etc. should be understood in a broad sense. For example, they can refer to fixed connection, detachable connection, or integration; mechanical connection, electrical connection; direct connection, or indirect connection through an intermediate medium; internal communication between two components, or interaction between two components, unless otherwise specified. Those skilled in the art will understand the specific meanings of the above terms in this utility model based on specific circumstances.

[0046] In the present invention, unless otherwise expressly specified or limited, when a first feature is "above" or "below" a second feature, it may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediary. Furthermore, when a first feature is "above," "above," or "above" a second feature, it may mean that the first feature is directly above or diagonally above the second feature, or simply means that the first feature is at a higher level than the second feature. When a first feature is "below," "below," or "below" a second feature, it may mean that the first feature is directly below or diagonally below the second feature, or simply means that the first feature is at a lower level than the second feature.

[0047] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only implementation methods.

[0048] like Figure 1 、 Figure 6 As shown, a fecal bacteria extraction device includes a workbench 10 and a stirring tank 20, a multi-stage filter 30 and a filtrate collection tank 40 arranged on the workbench 10. The stirring outlet 2321 of the stirring tank 20 is connected to the liquid inlet 3211 of the multi-stage filter 30 through a hose, and the liquid outlet 3221 of the multi-stage filter 30 is connected to the filtrate collection tank 40 through a hose. In addition, the fecal bacteria extraction device also has a protective agent tank 100 for storing a protective agent and a buffer tank 92 for storing physiological saline. The liquid in the protective agent tank 100 and the liquid in the filtrate collection tank 40 are connected to the filling component 80 through a hose. The physiological saline in the buffer tank 92 is connected to the stirring tank 20 through a hose. A peristaltic pump 50 for driving the flow of liquid is provided on these hose pipelines.

[0049] The specific structure is described in detail below with reference to the accompanying drawings.

[0050] See Figure 1 and Figure 2As shown, the mixing tank 20, the multi-stage filter 30 and the filtrate collection tank 40 are all placed on a tray, which is to facilitate the quick replacement of the three. The tray is positioned on the workbench 10, and the positions of the mixing tank body 20, the multi-stage filter 30 and the filtrate collection tank 40 can be fixed relative to the workbench 10 through positioning. The support platform 11 is fixed on the workbench 10, the lifting drive member 25 is fixed on the support platform 11, and the stirring drive member 24 is set on the lifting drive member 25. The lifting drive member 25 can drive the stirring drive member 24 to move closer to and away from the mixing tank 20. When the new mixing tank 20, the multi-stage filter 30 and the filtrate collection tank 40 are fixed on the workbench 10 through the tray, the mixing tank 20 is located at a position corresponding to the stirring drive member 24. The lifting drive member 25 drives the stirring drive member 24 to move closer to the mixing tank 20, so that the driving end of the stirring drive member 24 is connected to the stirring member 211 of the mixing tank 20, and the stirring drive member 24 drives the stirring member 211 to rotate to stir the fecal bacteria in the mixing tank 20.

[0051] Furthermore, the stirring outlet 2321 of the mixing tank 20 is connected to the liquid inlet 3211 of the multi-stage filter 30 via a hose, which passes through a peristaltic pump 50. The liquid outlet 3221 of the multi-stage filter 30 is connected to the filtrate collection tank 40 via a hose, which also passes through a peristaltic pump 50. The filling assembly 80 includes a filling outlet 82. The bacterial liquid in the filtrate collection tank 40 is connected to the filling outlet 82 via a hose, which also passes through a peristaltic pump 50. An avoidance drive 83 drives the filling outlet 82, which can be driven to move in a direction. In this direction of movement, a canned bottle placement area 84 is provided. The canned bottle placement area 84 is used to place the filling bottles 61 to be filled with bacterial liquid. The avoidance drive 83 can move the filling outlet 82 away from or above the filling bottle placement area 84. When a new filling bottle 61 is placed in the filling bottle placement area 84, the avoidance drive 83 drives the filling liquid outlet 82 to move above the filling bottle 61. The liquid in the filtrate collection tank 40 is driven by the peristaltic pump 50 to flow into the filling bottle 61. When the filtrate in the filling bottle 61 reaches the required amount, the peristaltic pump 50 stops working, and the filling liquid outlet 82 is driven by the avoidance drive 83 to move away from the top of the filling bottle 61, facilitating the transfer of the filling bottle 61. The filling liquid outlet 82 can be a section of a hose fixed to the avoidance drive 83 at the end of the hose, or it can be another component with inflow and outflow passages, which is fixed to the avoidance drive 83 and the hose is connected to the inlet of the component.

[0052] Furthermore, the workbench 10 is also provided with a transport arm assembly 70, which includes a robotic arm 71, a capping assembly 72, and a blow rod 73. The capping assembly 72 is mounted on the robotic arm 71 and can grip the filling bottles 61. The robotic arm 71 then transfers the filling bottles 61 from the filling bottle collection trough 60 to the filling bottle placement area 84. The filling assembly 80 also includes a filling clamp 81, which is driven by a pneumatic or electric cylinder to grip the filling bottles 61 placed in the filling bottle placement area 84. The capping assembly 72 then rotates the cap of the filling bottle 61, automatically unscrewing the cap before filling and tightening it after filling. The capping assembly 72 can be a rotary cylinder coupled with a gripper cylinder. The gripper cylinder drives the gripper to grip the bottle cap, and the rotary cylinder drives the gripper cylinder to rotate, thereby driving the gripper to twist the cap.

[0053] See Figure 3 and Figure 4 As shown, the multi-stage filter 30 includes a filter housing 32 and a composite membrane element 31. The space enclosed by the filter housing 32 forms a filter cavity. The composite membrane element 31 is located within the filter cavity and divides the filter cavity into two parts, namely, a liquid inlet cavity and a liquid outlet cavity. One side of the liquid inlet cavity has a liquid inlet 3211 for the inflow of unfiltered bacterial liquid, and one side of the liquid outlet cavity has a liquid outlet 3221 for the outflow of filtered bacterial liquid. The separation membranes within the composite membrane element 31 are arranged so that those with lower filtration accuracy face the liquid inlet side and those with higher filtration accuracy face the liquid outlet side. In this way, the bacterial liquid is filtered through the separation membranes with gradually increasing filtration accuracy in sequence, which can further prevent solid sticky matter from quickly clogging the separation membranes and improve the filtration effect. Using the composite membrane element 31 as the filter element solves the technical problem of sticky solids clogging the filter element, causing the filtrate to be unable to be filtered. Moreover, the multi-stage filtration effect can be achieved through only a single filter, greatly improving the filtration efficiency.

[0054] Furthermore, the filter housing 32 is divided into an upper shell 321 and a lower shell 322. The upper shell 321 and the lower shell 322 can be fixed by screws. The material of the filter housing 32 can be made of stainless steel, so that the filter can be used continuously and only the internal composite membrane element 31 needs to be replaced. The upper shell 321 has a liquid inlet 3211 and the lower shell 322 has a liquid outlet 3221. The liquid inlet 3211 and the liquid outlet 3221 can be connected to a joint for connecting to a liquid guide tube. The position where the upper shell 321 and the lower shell 322 abut against each other has a sealing ring 1. When the upper shell 321 and the lower shell 322 are fixedly connected, the upper shell 321 and the lower shell 322 squeeze the sealing ring 1, so that the sealing ring can achieve a sealing effect.

[0055] Furthermore, the composite membrane element 31 includes three filter membrane groups, each of which includes two layers of guide mesh and a layer of separation membrane. The three filter membrane groups are arranged in order as filter membrane group 1, filter membrane group 2, and filter membrane group 3. Filter membrane group 1 includes guide mesh 1 311, separation membrane 1 312, and guide mesh 2 313 stacked in sequence. Filter membrane group 2 includes guide mesh 1 311, separation membrane 2 314, and guide mesh 2 313 stacked in sequence. Filter membrane group 3 includes guide mesh 1 311, separation membrane 3 315, and guide mesh 2 313 stacked in sequence. The function of guide mesh 1 311 is to ensure that solid viscous matter first contacts guide mesh 1 311 during the filtration of the bacterial liquid. Some of the solid viscous matter enters the mesh pores of guide mesh 1 311, while others remains on the surface of guide mesh 1 311. Without the guide net 311, the bacterial liquid in front of the separation membrane would be subjected to pressure, causing the solid sticky matter in it to gradually accumulate into a layer of filter cake, which would seriously affect the filtration effect. However, the guide net 311 separates the fixed sticky matter that would otherwise easily form a filter cake layer into individual pieces, allowing the bacterial liquid to flow through the gaps in the mesh of the guide net 311, eliminating the obstruction of bacterial liquid flow caused by filter cake clogging. This improves the situation where the filtration effect of the separation membrane is significantly reduced. The superposition of the guide net 311 and the separation membrane improves the situation where sticky solids clog the separation membrane, which can cause poor bacterial liquid filtration, preventing separation membrane clogging and improving filtration efficiency.

[0056] Furthermore, the second guide mesh 313 can make it easier for finer solids and sticky materials to flow after filtration. It also provides increased support for the separation membrane, enhancing its ability to withstand pressurized filtrate and preventing deformation that could affect filtration performance. The combination of two layers of guide mesh and one layer of separation membrane further reduces clogging and improves the filtration performance of the entire composite membrane element 31.

[0057] Furthermore, the separation membranes are used to separate particles of different sizes on both sides of the separation membrane. Separation membrane 1 312, separation membrane 2 314, and separation membrane 3 315 have different filtration accuracies and are arranged in increasing order of filtration accuracy. The initial bacterial solution is filtered through separation membrane 1 312, separation membrane 2 314, and separation membrane 3 315 in sequence, resulting in a bacterial solution with less fixed sticky matter.

[0058] Furthermore, the first and second guide nets 311 and 313 can be made of the same material and type, or different materials and types can be selected based on actual needs. For example, the guide nets can be made of stainless steel, aluminum, Teflon, polyethylene, polypropylene, or other materials suitable for medical applications. The guide nets can be made of any type with through holes, such as a perforated plate, a mesh, a woven mesh, or a honeycomb plate.

[0059] Furthermore, the sides of the multi-layered flow-guiding mesh and the multi-layered separation membrane are aligned and bonded together by applying glue to the sides. Alternatively, ultrasonic welding is performed at selected locations around the outer circumference of the flow-guiding mesh or along the entire circumference, joining the mesh and separation membrane together. While the specific bonding and welding structures are not shown in the accompanying drawings, the above methods are readily understood by those skilled in the art. Conventional glue used in medical devices is used as the adhesive.

[0060] It should be noted that the number of filtration membrane groups in the composite membrane element 31 in the first embodiment is not necessarily three, and can be increased or decreased according to actual needs. The minimum is one, and the maximum is unlimited.

[0061] It should be noted that the style of the composite membrane element 31 is not necessarily the same as Figure 4 Such a disc shape can also be a rectangular or irregular shape, or a barrel shape, that is, the guide net and the separation membrane are like an inner and outer layer of a barrel.

[0062] See Figure 3 and Figure 5 As shown, the mixing tank 20 includes a mixing tank body 232, a coarse filter assembly 22, and a sealing cover 231. The coarse filter assembly 22 is placed inside the mixing tank body 232, and the sealing cover 231 is fixed above the mixing tank body 232 to form a sealed volume. The coarse filter assembly 22 includes an outer sleeve 224, a separation membrane 223, a guide net 222, and an inner sleeve 221. The order of these four is as follows: the outer sleeve 224 is located at the outermost side, and the separation membrane 223, the guide net 222, and the inner sleeve 221 are arranged in the order of the outer sleeve 224 being located at the outermost side, the separation membrane 223, the guide net 222, and the inner sleeve 221. The outer sleeve 224 and the inner sleeve 221 serve to support the separation membrane 223 so that the separation membrane 223 will not be deformed by the high-speed rotating bacterial solution during the filtration process. Of course, if the guide net three 222 is made of a harder material, the separation membrane four 223 and the guide net three 222 are fixed together, the guide net three 222 can directly play the role of inner sleeve 221 and outer sleeve 224 to support the separation membrane four 223, and the outer sleeve 224 or inner sleeve 221 can be omitted.

[0063] Furthermore, the function of the third guide net 222 is to ensure that solid viscous matter in the bacterial liquid is first contacted with the third guide net 222 during the filtration process. Some of the solid viscous matter enters the mesh of the third guide net 222, while others forms on the surface of the third guide net 222. Without the third guide net 222, under the influence of centrifugal force and gravity, the solid viscous matter in the bacterial liquid before the separation membrane would precipitate, squeeze each other, and gradually accumulate into a layer of filter cake, which would seriously affect the filtration effect. However, the third guide net 222 separates the solid viscous matter that would otherwise easily form a filter cake layer into individual pieces. The bacterial liquid can flow through the gaps in the mesh of the third guide net 222, eliminating the obstruction of the bacterial liquid flow caused by clogging of the filter cake. This improves the situation where the filtration effect of the separation membrane is significantly reduced. The stacking of the third guide net 222 and the separation membrane improves the situation where viscous solid matter blocks the separation membrane, resulting in poor bacterial liquid filtration, thus preventing clogging of the separation membrane and improving filtration efficiency.

[0064] For further information, see Figure 7 The sealing cover 231 is provided with a rotating shaft fixing seat 212. The rotating shaft fixing seat 212 is fixed to the sealing cover 231 by a fastener 214. An O-ring 215 is provided between the fastener 214 and the sealing cover 231. When the fastener 214 locks the rotating shaft fixing seat 212 on the sealing cover 231, the fastener 214 also squeezes the O-ring 215, forming a sealed state between the fastener 214 and the sealing cover 231. The fastener 214 and the rotating shaft fixing seat 212 are connected by threads. The rotating shaft fixing seat 212 partially passes through the sealing cover 231, and the portion passing through the sealing cover 231 has a groove for mating with the fastener 214. The central through hole of the rotating shaft fixing seat 212 has a rotating bearing 213 placed inside, and the long rod portion of the stirring element 211 passes through the rotating bearing 213. The fastener 214 also has a central through hole, and the long rod of the stirring element 211 passes through the central through hole of the fastener 214. Concentrically positioned within the through-hole of the fastener 214 is a groove for an oil seal 216, which fits over the long rod of the agitator 211. An O-ring 215 seals the gap between the fastener 214 and the sealing cap 231, while the oil seal 216 seals the gap between the fastener 214 and the agitator 211. This dual-sealing arrangement prevents the bacterial solution in the mixing tank 20 from leaking out of the gap between the agitator 211 and the sealing cap 231 during high-speed rotation.

[0065] See Figure 1 and Figure 6The fecal bacteria extraction equipment also includes a liquid injection component 90 and a protective agent tank 100. The liquid injection component 90 includes a liquid storage tank 91 and a cache tank 92. The liquid storage tank 91 and the cache tank 92 are connected by a hose, and a peristaltic pump 50 is provided on the hose. A liquid level sensor 921 is also provided on the liquid storage tank 91 to remind the user to replenish the liquid. The refill port 922 is connected to the liquid storage tank 91, and the liquid in the liquid storage tank 91 can be replenished by adding liquid to the refill port 922. Physiological saline is placed in the liquid storage tank 91, and the physiological saline is input into the cache tank 92 through the peristaltic pump 50. The cache tank 92 and the stirring tank 20 are connected by a hose, and a peristaltic pump 50 is provided on the pipeline. The liquid injection component 90 can realize automatic addition of physiological saline to the stirring tank 20, further improving the degree of automation of the entire fecal bacteria extraction equipment.

[0066] Furthermore, the protective agent tank 100 is connected to the filling liquid outlet 82, and a peristaltic pump 50 is installed in the pipeline between the protective agent tank 100 and the filling liquid outlet 82. The liquid in the protective agent tank 100 also flows to the filling assembly 80 through the hose. The protective agent and the filtered bacterial solution are then poured into the filling bottle 61.

[0067] Before filling, nitrogen needs to be blown into the filling bottle 61 through the blowing rod 73. At the same time, a nitrogen outlet is also provided in the filling bottle placement area 84. This ensures that the environment in which the bacterial liquid flows from the filling liquid outlet 82 into the filling bottle 61 during filling is an oxygen-free environment.

[0068] It should be noted that in order to ensure the stability of the pipeline pressure during the entire fecal bacteria extraction process, an additional pipeline is connected to the liquid storage tank 91, the mixing tank 20, the filtrate collection tank 40 and the protective agent tank 100 respectively. The end of the pipeline is clamped by a catheter clamp 52. When it is necessary to ensure the pipeline pressure, one or more of the catheter clamps 52 can be controlled to release the clamping of the corresponding management, so that the air pressure in the tank body can flow out of the tank body.

[0069] After the fecal bacteria extraction equipment is used to extract and filter the fecal bacteria, the total number of viable bacteria and the total number of colonies in the fecal bacteria liquid before and after treatment remain at the same order of magnitude. This utility model solves the technical problem of stably producing high-quality bacterial liquid during the fecal bacteria extraction process.

[0070] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0071] The above-described embodiments merely represent several implementations of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the utility model patent. It should be noted that a person skilled in the art would be able to make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements fall within the scope of protection of the present invention. Therefore, the scope of protection of the present utility model patent shall be determined by the appended claims.

Claims

1. A fecal bacteria extraction device, comprising a peristaltic pump (50) and a filtrate collection tank (40), characterized in that: The invention also comprises a stirring tank (20) with a flow guide net and a multi-stage filter (30) with a flow guide net, wherein a peristaltic pump (50) is provided on the pipeline between the stirring tank (20) and the multi-stage filter (30), and a peristaltic pump (50) is provided on the pipeline between the multi-stage filter (30) and the filtrate collection tank (40).

2. The fecal bacteria extraction equipment according to claim 1, characterized in that: The stirring tank (20) comprises a stirring tank body (232), a coarse filter assembly (22), and a sealing cover (231). A stirring member (211) is rotatably provided on the sealing cover (231). The coarse filter assembly (22) comprises a separation membrane and a guide net, and the guide net is provided on the inner side of the separation membrane.

3. The fecal bacteria extraction device according to claim 2, characterized in that: The fecal bacteria extraction device also includes a stirring drive member (24), which drives the stirring member (211) to rotate. The stirring drive member (24) is arranged on a lifting drive member (25), and the driving end of the stirring drive member (24) can be detachably connected to the stirring member (211). The lifting drive member (25) drives the stirring drive member (24) to approach and move away from the stirring member (211), so that the connection between the two is disconnected or connected.

4. The fecal bacteria extraction device according to claim 1, characterized in that: The multi-stage filter (30) includes a filter housing (32) and a composite membrane element (31). The filter housing (32) surrounds and forms a filter inner cavity. The composite membrane element (31) divides the filter inner cavity into a liquid inlet cavity and a liquid outlet cavity. The liquid inlet cavity has a liquid inlet (3211), and the liquid outlet cavity has a liquid outlet (3221). The composite membrane element (31) includes a multi-layer guide net and a multi-layer separation membrane. The filtration accuracy of the multi-layer separation membrane is arranged in an order from the liquid inlet cavity to the liquid outlet cavity, and the filtration accuracy gradually increases. Each layer of the separation membrane has the guide net on the side facing the liquid inlet cavity.

5. The fecal bacteria extraction equipment according to claim 4, characterized in that: The composite membrane element (31) comprises a plurality of filter layer groups, wherein the filter layer group comprises a layer of the separation membrane and two layers of the guide nets, and the two layers of the guide nets are respectively located on both sides of the separation membrane.

6. The fecal bacteria extraction device according to claim 4, characterized in that: The stirring tank (20) is in communication with the liquid inlet (3211), and the filtrate collecting tank (40) is in communication with the liquid outlet (3221).

7. The fecal bacteria extraction device according to claim 1, characterized in that: The fecal bacteria extraction device also includes a filling component (80), which includes a filling bottle placement area (84), a filling liquid outlet (82) and an avoidance driving component (83), wherein the avoidance driving component (83) drives and connects the filling liquid outlet (82), and the canned bottle placement area (84) is arranged in the moving direction of the filling liquid outlet (82).

8. The fecal bacteria extraction device according to claim 7, characterized in that: The fecal bacteria extraction device further comprises a protective agent tank (100), the protective agent tank (100) is connected to the filling liquid outlet (82), and a peristaltic pump (50) is provided on the pipeline between the protective agent tank (100) and the filling liquid outlet (82).

9. The fecal bacteria extraction device according to claim 7, characterized in that: The fecal bacteria extraction equipment also includes a transport arm assembly (70), which is capable of moving the filling bottle (61) from the filling bottle collecting tank (60) to the filling bottle placement area (84), and the transport arm assembly (70) includes a twist-cap assembly (72). The filling assembly (80) also includes a filling bottle clamp (81), which is used to clamp the filling bottle (61) in the filling bottle placement area (84). The twist-cap assembly (72) cooperates with the filling bottle clamp (81) to unscrew or tighten the bottle cap of the filling bottle (61).

10. The fecal bacteria extraction device according to claim 1, characterized in that: The fecal bacteria extraction device also includes an injection component (90), which includes a liquid storage tank (91) and a cache tank (92). A peristaltic pump (50) is provided on the pipeline between the liquid storage tank (91) and the cache tank (92), and a peristaltic pump (50) is provided on the pipeline between the cache tank (92) and the stirring tank (20).

11. The fecal bacteria extraction device according to claim 2, characterized in that: The stirring tank (20) further comprises a rotating shaft fixing seat (212), a rotating bearing (213), a fastener (214), an O-ring (215) and an oil seal (216). The rotating shaft fixing seat (212) and the fastener (214) both have a central through hole. The through hole of the rotating shaft fixing seat (212) is provided with a rotating bearing (213). The through hole of the fastener (214) is provided with an oil seal (216). The stirring member (211) is provided on the rotating bearing (213) and the oil seal (216). The O-ring (215) is provided between the fastener (214) and the sealing cover (231). The fastener (214) is threadedly connected to the rotating shaft fixing seat (212). The fastener (214) fixes the O-ring (215) and the rotating shaft fixing seat (212) to the sealing cover (231).

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