Nucleic acid extractor

Abstract

The utility model provides a nucleic acid extraction instrument, and relates to the technical field of nucleic acid extraction equipment. The moving assembly comprises a first moving mechanism, a second moving mechanism and a third moving mechanism, the first moving mechanism and the second moving mechanism are arranged on the bottom plate, and the third moving mechanism is installed on the first moving mechanism; the heating assembly is arranged on the second moving mechanism; the magnetic sleeve assembly is installed on the third moving mechanism and located above the heating assembly; and the magnetic bar assembly is mounted on the third moving mechanism, and the magnetic bar assembly can be matched with the magnetic sleeve assembly. According to the embodiment of the invention, the driving mechanism of the magnetic rod assembly and the magnetic sleeve assembly can be effectively simplified, so that the purpose of simplifying the structure of the nucleic acid extractor is achieved. Meanwhile, mechanical operation can be achieved, and the probability of operation errors can be reduced.

Description

Technical Field

[0001] The present application relates to the technical field of nucleic acid extraction equipment, and in particular to a nucleic acid extraction instrument. Background Art

[0002] Magnetic rod extraction typically involves manual transfer, which is prone to operational errors, leading to contamination and impacting detection accuracy. Furthermore, the multiple washing and elution steps are time-consuming and labor-intensive, increasing the error rate. Among related technologies, mainstream nucleic acid extraction instruments on the market have either high throughput, complex operation, large product size, or complex structure, resulting in low efficiency. Utility Model Content

[0003] The present application aims to solve at least one of the technical problems existing in the prior art. To this end, the present application proposes a nucleic acid extraction instrument that can effectively simplify the structure of the nucleic acid extraction instrument.

[0004] The nucleic acid extraction instrument provided in the embodiment of the present application includes:

[0005] base plate;

[0006] A moving assembly, comprising a first moving mechanism, a second moving mechanism and a third moving mechanism, wherein the first moving mechanism and the second moving mechanism are respectively provided on the base plate, and the third moving mechanism is installed on the first moving mechanism;

[0007] a heating assembly, disposed on the second moving mechanism;

[0008] a magnetic sleeve assembly connected to the third moving mechanism and located above the heating assembly; and

[0009] a magnetic rod assembly connected to the third moving mechanism, and the magnetic rod assembly can cooperate with the magnetic sleeve assembly;

[0010] The first moving mechanism is used to drive the third moving mechanism to move along the X direction, the second moving mechanism is used to drive the heating assembly to move along the Y direction, and the third moving mechanism is used to drive the magnetic sleeve assembly and the magnetic rod assembly to move along the Z direction.

[0011] Furthermore, the heating assembly includes a mounting plate, a deep-hole plate and a heating device, the second moving mechanism includes a second slide rail, the mounting plate is slidably connected to the second slide rail, the deep-hole plate is arranged on the mounting plate, the heating device is arranged between the mounting plate and the deep-hole plate, and the heating device is used to heat the deep-hole plate.

[0012] Furthermore, the deep-well plate is provided with a plurality of workstations.

[0013] Furthermore, the heating assembly includes a limit block, which is mounted on the mounting plate and is used to provide a limit for the deep-hole plate.

[0014] Furthermore, the heating assembly further includes a push handle, which is connected to the mounting plate.

[0015] Furthermore, the third moving mechanism includes a fixed plate, a movable plate and a third driving member, the fixed plate is installed on the first moving mechanism, the movable plate is movably arranged on one side of the fixed plate, and the third driving member is installed on the fixed plate and is used to drive the movable plate to move along the Z direction; the magnetic sleeve assembly includes a vibration device, a magnetic sleeve, a first bracket and a magnetic sleeve slider, the vibration device is installed on the movable plate, the magnetic sleeve slider is connected to the vibration device, the first bracket is connected to the magnetic sleeve slider, and the magnetic sleeve is installed on the first bracket, wherein the vibration device is used to drive the magnetic sleeve slider to vibrate, so as to drive the magnetic sleeve to vibrate.

[0016] Furthermore, the vibration device includes a vibration drive mechanism and a vibration module, the vibration drive mechanism is installed on the movable plate, the vibration module is connected to the vibration drive mechanism, and the magnetic sleeve slider is connected to the vibration module.

[0017] Furthermore, the third moving mechanism includes a baffle, and the baffle is arranged between the magnetic sleeve assembly and the vibration module.

[0018] Furthermore, the magnetic bar assembly includes a magnetic bar slider, a second bracket, a magnetic bar and a magnetic bar driving mechanism. The magnetic sleeve slider is movably mounted on the movable plate. The second bracket is connected to the magnetic bar slider. The magnetic bar is mounted on the second bracket. The magnetic bar driving mechanism is mounted on the movable plate and is used to drive the magnetic bar slider to move along the Z direction.

[0019] Furthermore, it also includes a foot pad, which is arranged below the bottom plate.

[0020] It can be seen from the above technical solutions that the embodiments of the present application have at least the following beneficial effects:

[0021] In the nucleic acid extraction instrument provided in the embodiment of the present application, the heating component can be moved in the Y direction by the second moving mechanism, while the first moving mechanism and the third moving mechanism are used to drive the magnetic rod assembly and the magnetic sleeve assembly to move in the X direction and the Z direction respectively. There is no need to set up a driving mechanism for driving the magnetic rod assembly and the magnetic sleeve assembly to move in the Y direction. In this way, the driving mechanism of the magnetic rod assembly and the magnetic sleeve assembly can be effectively simplified, thereby achieving the purpose of simplifying the structure of the nucleic acid extraction instrument. At the same time, compared to manual operation, in the embodiment of the present application, the magnetic rod assembly and the magnetic sleeve assembly can achieve reciprocating motion in the X direction and the Z direction through the first moving mechanism and the third moving mechanism, combined with the heating component to achieve movement in the Y direction through the second moving mechanism, thereby achieving mechanized operation and reducing the probability of operational errors. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0023] Figure 1 A schematic structural diagram of a nucleic acid extraction apparatus provided in one embodiment of the present application;

[0024] Figure 2 A schematic diagram of a portion of the structure of a nucleic acid extraction instrument provided in one embodiment of the present application;

[0025] Figure 3 A schematic diagram of a portion of the structure of a nucleic acid extraction instrument provided in one embodiment of the present application;

[0026] Figure 4 A schematic diagram of the partial structure of a nucleic acid extraction instrument provided in one embodiment of the present application.

[0027] Reference numerals:

[0028] 100, bottom plate;

[0029] 210, first moving mechanism; 211, first driving member; 212, first slide rail; 213, first slider; 220, second moving mechanism; 231, fixed plate; 232, movable plate; 233, third driving member; 234, baffle;

[0030] 310, mounting plate; 320, deep hole plate; 330, heating device; 340, limit block; 350, push handle;

[0031] 400, magnetic sleeve assembly; 411, vibration module; 412, vibration drive mechanism; 420, magnetic sleeve; 430, first bracket; 440, magnetic sleeve slider;

[0032] 500, magnetic bar assembly; 510, magnetic bar slider; 520, second bracket; 530, magnetic bar; 540, magnetic bar driving mechanism;

[0033] 610. Cooling fan; 620. Foot pad. DETAILED DESCRIPTION

[0034] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0035] The nucleic acid extraction method generally includes several important steps such as cell lysis, enzyme treatment, separation of nucleic acids and other biomacromolecules, and nucleic acid purification. Each step can be achieved individually or in combination by different methods. The nucleic acid extractor automatically completes the extraction of sample nucleic acid using a matching nucleic acid extraction reagent. Traditional manual nucleic acid extraction usually uses a centrifugal clarification method, which is time-consuming and labor-intensive. In related technologies, magnetic bead separation technology can be used to extract nucleic acids. Nucleic acid extraction is based on the magnetic bead method. The cells of animals and plants are lysed by cell lysis solution, and the proteins bound to DNA are denatured. The DNA is released and the magnetic beads can specifically adsorb the DNA. By washing, impurities such as proteins and polysaccharides other than DNA are removed, and the DNA adsorbed on the magnetic beads is dissociated with an elution solution to obtain DNA with high purity and concentration.

[0036] The magnetic bead method generally uses magnetic rod and magnetic bead separation technology for nucleic acid extraction. The magnetic rod and magnetic rod sleeve are usually used to coordinate the movement to achieve the adsorption and transfer of magnetic beads. At the same time, the magnetic rod sleeve is used to repeatedly stir and fully mix the reaction liquid system. After the steps of sample lysis, nucleic acid adsorption to magnetic beads, magnetic bead washing and nucleic acid elution, the purified nucleic acid is finally obtained.

[0037] See also Figures 1 to 4 As shown, one embodiment of the present application discloses a nucleic acid extraction instrument for nucleic acid extraction, wherein the nucleic acid extraction instrument includes a base plate 100, a moving component, a heating component, a magnetic sleeve component 400 and a magnetic rod component 500.

[0038] Specifically, the moving assembly includes a first moving mechanism 210, a second moving mechanism 220, and a third moving mechanism. The first moving mechanism 210 and the second moving mechanism 220 are respectively disposed on the base plate 100, and the third moving mechanism is mounted on the first moving mechanism 210. The heating assembly is disposed on the second moving mechanism 220. The magnetic sleeve assembly 400 is connected to the third moving mechanism and is located above the heating assembly. The magnetic rod assembly 500 is connected to the third moving mechanism and can cooperate with the magnetic sleeve assembly 400. The first moving mechanism 210 is used to drive the third moving mechanism to move in the X direction, the second moving mechanism 220 is used to drive the heating assembly to move in the Y direction, and the third moving mechanism is used to drive the magnetic sleeve assembly 400 and the magnetic rod assembly 500 to move in the Z direction.

[0039] It should be noted that the magnetic bar assembly 500 can be moved relative to the magnetic sleeve assembly 400 along the Z direction, so that the magnetic bar assembly 500 can be mated with or disengaged from the magnetic sleeve assembly 400 .

[0040] In the nucleic acid extraction instrument provided by the present application, the heating component can be moved in the Y direction by the second moving mechanism 220, while the first moving mechanism 210 and the third moving mechanism are used to move the magnetic rod assembly 500 and the magnetic sleeve assembly 400 in the X direction and the Z direction respectively. There is no need to set up a driving mechanism for driving the magnetic rod assembly 500 and the magnetic sleeve assembly 400 to move in the Y direction. In this way, the driving mechanism of the magnetic rod assembly 500 and the magnetic sleeve assembly 400 can be effectively simplified, thereby achieving the purpose of simplifying the structure of the nucleic acid extraction instrument. At the same time, compared to manual operation, in the embodiment of the present application, the magnetic rod assembly 500 and the magnetic sleeve assembly 400 can be reciprocated in the X direction and the Z direction by the first moving mechanism 210 and the third moving mechanism, and combined with the heating component to move in the Y direction through the second moving mechanism 220, so that mechanized operation can be achieved, which can reduce the probability of operational errors.

[0041] In some embodiments of this application, see Figure 1 and Figure 2 As shown, the heating assembly includes a mounting plate 310, a deep-well plate 320, and a heating device 330. The second moving mechanism 220 includes a second slide rail. The mounting plate 310 is slidably connected to the second slide rail. The deep-well plate 320 is disposed on the mounting plate 310. The heating device 330 is disposed between the mounting plate 310 and the deep-well plate 320. The heating device 330 is used to heat the deep-well plate 320. The extension direction of the second slide rail is consistent with the Y direction. In this way, the mounting plate 310 can be moved along the Y direction by slidingly connecting to the second slide rail.

[0042] Furthermore, the second moving mechanism 220 includes a second slide rail and a second slider slidably connected to the second slide rail, and the mounting plate 310 is connected to the second slider.

[0043] In a possible embodiment, the heating assembly further includes a pusher 350, which is connected to the mounting plate 310. The mounting plate 310 can be pushed by the pusher 350 to move the mounting plate 310 and the deep hole plate 320 along the Y direction.

[0044] In the above embodiment, the deep hole plate 320 is provided with a plurality of workstations. In this way, different materials can be placed on the deep hole plate 320 to complete different processes or operations.

[0045] It is worth understanding that the plurality of workstations may be spaced apart along the Y direction, or may be spaced apart along the X direction, or some of the workstations may be spaced apart along the X direction and the other part along the Y direction, which is not limited here.

[0046] In some embodiments of the present application, the heating assembly includes a limiting block 340 , which is mounted on the mounting plate 310 . The limiting block 340 is used to provide a limit for the deep-well plate 320 .

[0047] In one possible implementation, see Figure 3 The first moving mechanism 210 includes a first driving member 211, a first slide rail 212 and a first slider 213 that slides with the first slide rail 212. The first slider 213 is connected to the fixed plate 231. The first driving member 211 is specifically a driving motor. The driving motor drives the first slider 213 to move along the X direction through a screw rod, thereby driving the fixed plate 231 to move along the X direction.

[0048] In some embodiments of this application, see Figure 1 、 Figure 3 and Figure 4 As shown, the third moving mechanism includes a fixed plate 231, a movable plate 232 and a third driving member 233. The fixed plate 231 is installed on the first moving mechanism 210, and the movable plate 232 is movably arranged on one side of the fixed plate 231. The third driving member 233 is installed on the fixed plate 231 and is used to drive the movable plate 232 to move along the Z direction, thereby driving the magnetic sleeve assembly 400 and the magnetic rod assembly 500 installed on the movable plate 232 to move along the Z direction together.

[0049] The magnetic sleeve assembly 400 includes a vibration device, a magnetic sleeve 420, a first bracket 430 and a magnetic sleeve slider 440. The vibration device is installed on the movable plate 232, the magnetic sleeve slider 440 is connected to the vibration device, the first bracket 430 is connected to the magnetic sleeve slider 440, and the magnetic sleeve 420 is installed on the first bracket 430. Among them, the vibration device is used to drive the magnetic sleeve slider 440 to vibrate. The third driving member 233 drives the movable plate 232 to move in the Z direction, thereby driving the magnetic sleeve assembly 400 and the magnetic rod assembly 500 to move simultaneously in the Z direction. In this way, the magnetic sleeve assembly 400 and the magnetic rod assembly 500 can penetrate into each station in the deep well plate 320, so that the magnetic rod 530 can be used to adsorb and transfer magnetic beads, and the magnetic sleeve 420 can be used to repeatedly stir the liquid in the deep well plate 320 to fully mix the reaction liquid system.

[0050] In actual applications, when the magnetic sleeve slider 440 and the magnetic sleeve 420 move along the Z direction, the vibration device drives the magnetic sleeve slider 440 to vibrate, thereby driving the magnetic sleeve 420 to vibrate.

[0051] In one possible embodiment, the third driving member 233 is a driving motor, which is connected to the movable plate 232 via a screw mechanism. The driving motor rotates by driving the screw mechanism to drive the movable plate 232 to move in the Z direction, thereby driving the magnetic sleeve assembly 400 and the magnetic rod assembly 500 to move in the Z direction simultaneously.

[0052] In some embodiments of this application, see Figure 1 、 Figure 3 and Figure 4 As shown, the magnetic bar assembly 500 includes a magnetic bar slider 510, a second bracket 520, a magnetic bar 530, and a magnetic bar drive mechanism 540. The magnetic sleeve slider 440 is movably mounted on the movable plate 232. The second bracket 520 is connected to the magnetic bar slider 510. The magnetic bar 530 is mounted on the second bracket 520. The magnetic bar drive mechanism 540 is mounted on the movable plate 232 and is used to drive the magnetic bar slider 510 to move in the Z direction. In other words, the magnetic bar 530 can move in the Y direction relative to the magnetic sleeve 420, so that the magnetic bar 530 can be extended into or removed from the magnetic sleeve 420.

[0053] Furthermore, the magnetic bar assembly 500 further includes a sliding guide rail that cooperates with the magnetic bar slider 510, and the sliding guide rail is installed on the movable plate 232. The extending direction of the sliding guide rail is consistent with the Z direction.

[0054] In a possible implementation, the magnetic rod driving mechanism 540 includes a driving motor and a screw mechanism. The magnetic rod slider 510 is connected to the screw mechanism. The driving motor drives the screw mechanism to drive the magnetic rod slider 510 to move along the Z direction.

[0055] In some embodiments of this application, see Figure 1、 Figure 3 and Figure 4 As shown, the vibration device includes a vibration drive mechanism 412 and a vibration module 411. The vibration drive mechanism 412 is mounted on the movable plate 232. The vibration module 411 is connected to the vibration drive mechanism 412. The magnetic sleeve slider 440 is connected to the vibration module 411. The vibration drive mechanism 412 is used to drive the vibration module 411 to vibrate. The vibration module 411 drives the first bracket 430 to vibrate, thereby driving the magnetic sleeve 420 to vibrate.

[0056] In a possible implementation, the vibration driving mechanism 412 includes a vibration motor, which is connected to the vibration module 411 to drive the vibration module 411 to vibrate. Specifically, the vibration module 411 may include a cam mechanism.

[0057] In some embodiments of this application, see Figure 3 and Figure 4 As shown, the third moving mechanism includes a baffle 234, which is provided between the magnetic sleeve assembly 400 and the vibration module 411. The baffle 234 can be used for shielding and preventing contamination, thereby reducing the contamination of the reagent.

[0058] In some embodiments of this application, see Figure 1 The nucleic acid extractor further includes a partition, which is mounted on the bottom plate 100 and separates the magnetic sleeve assembly 400, the magnetic rod assembly 500 and the heating assembly from the first moving mechanism 210 and the third moving mechanism.

[0059] In one possible implementation, see Figure 1 , the cross-sectional profile of the partition is U-shaped.

[0060] Furthermore, the nucleic acid extractor further includes a cooling fan 610 , which is installed on the partition.

[0061] In some embodiments of this application, see Figure 1 The nucleic acid extraction instrument further includes a foot pad 620 , which is disposed below the base plate 100 .

[0062] The following describes the nucleic acid extraction instrument of the embodiment of the present application in detail using a specific embodiment. It should be noted that the following embodiment is only an illustrative description and should not be understood as limiting the embodiment of the present application.

[0063] See also Figures 1 to 4 As shown, the nucleic acid extractor of this embodiment includes a base plate 100 , a moving assembly, a heating assembly, a magnetic sleeve assembly 400 , a magnetic rod assembly 500 , a partition, a cooling fan 610 and a foot pad 620 .

[0064] in,

[0065] The heating assembly includes an isolation cover, a mounting plate 310 , a limiting block 340 , a deep-well plate 320 , a pusher 350 and a heating device 330 . The deep-well plate 320 is used to place samples.

[0066] The magnetic sleeve assembly 400 includes a first bracket 430 and a magnetic sleeve 420 .

[0067] The magnetic bar assembly 500 includes a second bracket 520 and a magnetic bar 530 .

[0068] The heating component is installed on the plane of the base plate 100 through the second slide rail of the second moving mechanism 220. Under the push of the pusher 350, the heating component can reciprocate along the Y-axis direction. In this way, it can be used to push the sample to switch between the replacement station and the lysis and elution stations.

[0069] The magnetic sleeve assembly 400 is fixed on the magnetic sleeve slider 440. The magnetic sleeve slider 440 is equipped with a vibration module 411 and is connected to the vibration motor and installed on the movable plate 232. When the magnetic sleeve 420 moves up and down along the Z-axis direction, the vibration module 411 drives the magnetic sleeve 420 module to vibrate under the drive of the vibration motor.

[0070] The magnetic bar 530 module is fixed on the magnetic bar slider 510, and the magnetic bar slider 510 is connected to the magnetic bar 530 motor and installed on the movable plate 232. Under the drive of the magnetic bar 530 motor, the magnetic bar 530 module can reciprocate in the Z-axis direction;

[0071] The third moving mechanism includes a fixed plate 231, a movable plate 232 and a third driving member 233. The third driving member 233 is specifically a Z-axis motor. Driven by the Z-axis motor, the magnetic sleeve assembly 400 and the magnetic rod assembly 500 move up and down in the Z-axis direction.

[0072] The third moving mechanism is mounted on the first moving mechanism 210 , and the third moving mechanism can move left and right along the X-axis direction under the drive of the first moving mechanism 210 .

[0073] The nucleic acid extraction instrument of the embodiment of the present application adopts the magnetic rod method and magnetic bead separation technology, by using the magnetic rod 530 to adsorb and transfer the magnetic beads, and using the magnetic sleeve 420 to repeatedly stir the liquid to fully mix the reaction liquid system, and finally obtain the purified nucleic acid through the steps of sample lysis, nucleic acid adsorption to magnetic beads, magnetic bead washing and nucleic acid elution.

[0074] Specifically, first, a plurality of stations are provided in the deep-well plate 320, each containing a lysis solution, a washing buffer solution, an elution solution and other nucleic acid extraction reagents. The heating component is pushed under the lysis and elution station. In the first step, the sample and the lysis solution are heated by the heating device 330 to achieve mixing and sufficient reaction of the reaction solution, so that the cells are lysed and the nucleic acid is released; in the second step, the sample lysate is fully mixed with the magnetic beads, and the magnetic beads are used to adsorb nucleic acids due to their strong affinity for nucleic acids under high salt and low pH. The vibration motor drives the magnetic sleeve 420 to vibrate. At the same time, the magnetic rod driving mechanism 540 includes a magnetic rod motor, which drives the magnetic rod 530 to move relative to each other in the Z-axis direction. The magnetic rod 530 cooperates with the magnetic sleeve 420 to apply an external magnetic field, and then the third driving mechanism is used to drive the magnetic sleeve 420 and the magnetic rod 530 as a whole along the Z direction away from the lysate, so that the magnetic beads are separated from the lysate; in the third step, the first moving mechanism 210 drives the third moving mechanism to transfer the magnetic beads adsorbed with nucleic acid to a new washing buffer solution for thorough mixing and washing away impurities, and then the magnetic beads are separated from the washing buffer solution; in the fourth step, the first moving mechanism 210 drives the third moving mechanism to transfer the magnetic beads to the elution buffer solution, remove the external magnetic field, and fully mix the magnetic beads and the elution solution. The bound nucleic acid can be separated from the magnetic beads and mixed into the elution buffer solution, thereby obtaining purified nucleic acid.

[0075] In this embodiment, the entire process achieves efficient lysis, adsorption, washing, and elution, simplifies the mechanism layout, reduces production costs, improves transmission control efficiency, and accelerates nucleic acid extraction efficiency.

[0076] In the description of this application, it should be understood that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application.

[0077] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature specified as "first" or "second" may explicitly or implicitly include one or more of such features. Throughout this application, unless otherwise specified, "plurality" means two or more.

[0078] In the description of this application, it should be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" should be understood broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to direct connections, indirect connections through an intermediate medium, or internal communication between two components. Those skilled in the art will understand the specific meanings of these terms in this application based on specific circumstances.

[0079] In the description of this specification, specific features, structures, materials or characteristics may be combined in an appropriate manner in any one or more embodiments or examples.

[0080] It should be understood that although the steps in the flowcharts of the accompanying drawings are shown in sequence as indicated by the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise specified herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least some of the steps in the flowcharts of the accompanying drawings may include multiple sub-steps or multiple stages, and these sub-steps or stages are not necessarily executed at the same time, but can be executed at different times, and their execution order is not necessarily sequential, but can be executed in turn or alternately with other steps or at least a portion of the sub-steps or stages of other steps.

Claims

1. A nucleic acid extraction instrument, characterized in that: include: base plate; A moving assembly, comprising a first moving mechanism, a second moving mechanism and a third moving mechanism, wherein the first moving mechanism and the second moving mechanism are respectively provided on the base plate, and the third moving mechanism is installed on the first moving mechanism; a heating assembly, disposed on the second moving mechanism; a magnetic sleeve assembly connected to the third moving mechanism and located above the heating assembly; as well as a magnetic rod assembly connected to the third moving mechanism, and the magnetic rod assembly can cooperate with the magnetic sleeve assembly; The first moving mechanism is used to drive the third moving mechanism to move along the X direction, the second moving mechanism is used to drive the heating assembly to move along the Y direction, and the third moving mechanism is used to drive the magnetic sleeve assembly and the magnetic rod assembly to move along the Z direction.

2. The nucleic acid extraction instrument according to claim 1, characterized in that The heating assembly includes a mounting plate, a deep-hole plate and a heating device. The second moving mechanism includes a second slide rail. The mounting plate is slidably connected to the second slide rail. The deep-hole plate is arranged on the mounting plate. The heating device is arranged between the mounting plate and the deep-hole plate. The heating device is used to heat the deep-hole plate.

3. The nucleic acid extraction instrument according to claim 2, characterized in that The deep hole plate is provided with a plurality of workstations.

4. The nucleic acid extraction instrument according to claim 2, characterized in that The heating assembly includes a limit block, which is installed on the mounting plate and is used to provide a limit for the deep-hole plate.

5. The nucleic acid extraction instrument according to claim 2, characterized in that The heating assembly further includes a push handle connected to the mounting plate.

6. The nucleic acid extraction instrument according to any one of claims 1 to 5, characterized in that: The third moving mechanism includes a fixed plate, a movable plate and a third driving member, the fixed plate is installed on the first moving mechanism, the movable plate is movably arranged on one side of the fixed plate, and the third driving member is installed on the fixed plate and is used to drive the movable plate to move along the Z direction; the magnetic sleeve assembly includes a vibration device, a magnetic sleeve, a first bracket and a magnetic sleeve slider, the vibration device is installed on the movable plate, the magnetic sleeve slider is connected to the vibration device, the first bracket is connected to the magnetic sleeve slider, and the magnetic sleeve is installed on the first bracket, wherein the vibration device is used to drive the magnetic sleeve slider to vibrate, so as to drive the magnetic sleeve to vibrate.

7. The nucleic acid extraction instrument according to claim 6, characterized in that: The vibration device includes a vibration driving mechanism and a vibration module. The vibration driving mechanism is installed on the movable plate. The vibration module is connected to the vibration driving mechanism. The magnetic sleeve slider is connected to the vibration module.

8. The nucleic acid extraction instrument according to claim 7, characterized in that: The third moving mechanism includes a baffle, which is arranged between the magnetic sleeve assembly and the vibration module.

9. The nucleic acid extraction instrument according to claim 6, characterized in that: The magnetic bar assembly includes a magnetic bar slider, a second bracket, a magnetic bar and a magnetic bar driving mechanism. The magnetic sleeve slider is movably installed on the movable plate. The second bracket is connected to the magnetic bar slider. The magnetic bar is installed on the second bracket. The magnetic bar driving mechanism is installed on the movable plate and is used to drive the magnetic bar slider to move along the Z direction.

10. The nucleic acid extraction instrument according to claim 1, characterized in that: It also includes a foot pad, which is arranged below the bottom plate.

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