Blending device and analyzer
By designing the power element of the mixing device to control the mixing head to suck in and discharge the magnetic bead mixture at high speed in the reagent box, the problem of long magnetic field rotation mixing time in the existing technology is solved, and rapid mixing and efficient work are achieved.
Patent Information
- Application Number
- CN202421893852.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-06
- Publication Date
- 2025-09-16
- Estimated Expiration
- 2034-08-06
AI Technical Summary
In the prior art, it takes a long time to rotate and mix the magnetic beads using a magnetic field, which affects work efficiency.
A mixing device was designed, including a driving part, a mixing head, a pipeline and a power element. The air pressure of the power element was used to control the mixing head to inhale and discharge the magnetic bead mixture in the reagent box, thereby achieving high-speed flow mixing.
The mixing efficiency of the magnetic bead mixture is improved, the waiting time is reduced, and the work efficiency is improved.
Smart Images
Figure CN223337259U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of medical devices, in particular to a mixing device and an analyzer. Background Art
[0002] The magnetic bead mixture needs to be mixed before use in the reagent bottle so that the magnetic beads are evenly distributed in the magnetic bead mixture. The traditional method is that the instrument operator uses a pipetting gun to manually pump and mix the magnetic bead mixture. The disadvantage is that the magnetic bead mixture of the same batch has poor consistency and is prone to bubbles. Alternatively, there are also methods on the market that use a magnetic field to first attract the magnetic beads from the bottom of the magnetic bead bottle to the top and then mix them through mechanical rotation. The above method takes a long time and the instrument operator needs to wait, which affects work efficiency. Utility Model Content
[0003] Based on this, it is necessary to provide a mixing device and analyzer to solve the technical problem in the current market that the magnetic beads are first attracted from the bottom of the magnetic bead bottle to the upper end by a magnetic field and then mixed by mechanical rotation. The above method takes a long time and the instrument operator needs to wait, thus affecting work efficiency.
[0004] In a first aspect, the present invention provides a mixing device, comprising a mixing assembly and a head removal assembly, wherein the mixing assembly comprises a driving member, a mixing head, a pipeline, and a power element, wherein the driving member is connected to the mixing head and is used to drive the mixing head to move to the reagent box, the mixing head is connected to the power element via the pipeline, and the driving member can also drive the mixing head to move to the head removal assembly, and the head removal assembly is used to remove the mixing head;
[0005] The power element is in a first working state, and the mixing head absorbs the magnetic bead mixture in the reagent kit;
[0006] The power element is in the second working state, and the magnetic bead mixture in the mixing head is discharged into the reagent box.
[0007] In one embodiment, the mixing assembly further includes a connecting member, and the driving member is connected to the mixing head via the connecting member. The driving member can drive the connecting member to drive the mixing head to rise and fall and rotate so as to be able to insert or detach the reagent box.
[0008] In one embodiment, the connecting member includes a first body and a second body connected to the first body, the first body is connected to the driving member, and the mixing head is detachably connected to the second body.
[0009] In one embodiment, during the process of dispensing the magnetic bead mixture in the mixing head into the reagent box, the upward movement speed of the mixing head is less than or equal to the upward movement speed of the magnetic bead mixture in the reagent box.
[0010] In one embodiment, the head removal assembly includes a frame and a head removal piece connected to the frame, the outer surface of the mixing head is provided with a protrusion, the driving member drives the mixing head to move, and the head removal piece abuts against the protrusion to separate the mixing head from the second body.
[0011] In one embodiment, the head removal piece is provided with an arc-shaped groove, and the groove wall of the arc-shaped groove abuts against the protrusion.
[0012] In one embodiment, the mixing device further includes a bracket and a placement plate connected to the bracket, wherein the placement plate is provided with a plurality of mixing heads for replacement, and the driving member drives the first body and the second body to move so that the second body is connected to the mixing head.
[0013] In one embodiment, the placement plate and the head removal component are respectively located on the movement trajectory of the mixing head.
[0014] In one embodiment, the mixing device further comprises a tray having a plurality of placement slots arranged along a circumferential direction, and the placement slots are used to place the reagent kit.
[0015] In a second aspect, the present invention further provides an analyzer, comprising an analysis module and the mixing device of any one of the above embodiments, wherein the analysis module is used to analyze the reagents in the reagent kit.
[0016] The implementation of the present invention will have the following beneficial effects:
[0017] The mixing device and analyzer of the present invention are adopted. The driving part of the mixing device is connected to the mixing head and is used to drive the mixing head to move to the reagent box. The mixing head is connected to the power element through a pipeline, so that the air pressure generated by the power element is transmitted to the mixing head through the pipeline. The driving part can also drive the mixing head to move to the head removal component, so that the head removal component can remove the current mixing head. When the power element is in a first working state, the mixing head absorbs the magnetic bead mixture in the reagent box. When the power element is in a second working state, the magnetic bead mixture in the mixing head is spit out into the reagent box, so that the magnetic bead mixture can be spit out into the reagent box under high-speed flow, thereby quickly freeing and mixing the magnetic bead mixture to improve work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.
[0019] in:
[0020] Figure 1 Schematic diagram of an axonometric mixing device in one embodiment.
[0021] Figure 2 for Figure 1 A cross-sectional view of the mixing head in the mixing device shown.
[0022] Figure 3 for Figure 1 Schematic diagram of the mixing head and the head removal piece in the mixing device shown.
[0023] Reference numerals:
[0024] 1. Mixing assembly; 11. Driving element; 12. Mixing head; 121. Protrusion; 13. Pipeline; 14. Power element; 15. Connecting element; 151. First body; 152. Second body;
[0025] 2. Head removal assembly; 21. Frame; 22. Head removal piece; 221. Arc groove;
[0026] 3. Bracket; 4. Placement plate; 5. Tray; 51. Placement slot; 100. Reagent box. DETAILED DESCRIPTION
[0027] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.
[0028] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.
[0029] In the description of the present invention, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the accompanying drawings, or is the orientation or position relationship in which the utility model product is usually placed when in use. It is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.
[0030] In addition, the terms "first", "second", etc., if used, are merely used to distinguish and describe, and should not be understood as indicating or implying relative importance.
[0031] It should be noted that, in the absence of conflict, the features in the embodiments of the present invention can be combined with each other.
[0032] Please combine Figures 1 to 3 , the mixing device provided by the present invention is now described, and the mixing device is used in an analyzer. The mixing device includes a mixing component 1 and a head removal component 2. The mixing component 1 includes a driving member 11, a mixing head 12, a pipeline 13 and a power element 14. The driving member 11 is connected to the mixing head 12 and is used to drive the mixing head 12 to move to the reagent box 100. The mixing head 12 is connected to the power element 14 through the pipeline 13. The driving member 11 can also drive the mixing head 12 to move to the head removal component 2. The head removal component 2 is used to remove the mixing head 12. By providing the head removal component 2, the currently used mixing head 12 can be removed, which is convenient for replacing the next new mixing head 12 and avoiding contamination of the next mixed liquid.
[0033] In this embodiment, the power element 14 is in the first working state, and the mixing head 12 absorbs the magnetic bead mixture in the reagent kit 100;
[0034] When the power element 14 is in the second operating state, the magnetic bead mixture in the mixing head 12 is discharged into the reagent kit 100. Specifically, the power element 14 may be a pressure pump. When the power element 14 is in the first operating state, the power element 14 draws air, allowing the mixing head 12 to absorb the magnetic bead mixture. When the power element 14 is in the second operating state, the power element 14 releases air, causing the magnetic bead mixture in the mixing head 12 to be discharged into the reagent kit 100.
[0035] It can be understood that the driving member 11 of the mixing device is connected to the mixing head 12 and is used to drive the mixing head 12 to move to the reagent box 100. The mixing head 12 is connected to the power element 14 through the pipeline 13, so that the air pressure generated by the power element 14 is transported to the mixing head 12 through the pipeline 13. The driving member 11 can also drive the mixing head 12 to move to the head removal component 2, so that the head removal component 2 can remove the current mixing head 12. The power element 14 is in the first working state, and the mixing head 12 inhales the magnetic bead mixture in the reagent box 100. The power element 14 is in the second working state, and the magnetic bead mixture in the mixing head 12 is spit out into the reagent box 100, so that the magnetic bead mixture can be spit out into the reagent box 100 under high-speed flow, thereby quickly freeing and mixing the magnetic bead mixture to improve work efficiency.
[0036] In one embodiment, if Figure 1 As shown, the mixing assembly 1 also includes a connector 15, and the driving member 11 is connected to the mixing head 12 through the connector 15. The driving member 11 can drive the connecting member 15 to drive the mixing head 12 to rise and fall and rotate so that it can be inserted into or removed from the reagent box 100. The driving member 11 drives the connecting member 15 to drive the mixing head 12 to descend, and the mixing head 12 extends into the bottom of the reagent box 100 by a preset distance. The power element 14 generates positive pressure, that is, suction, so that the magnetic bead mixture can be sucked into the mixing head 12. Then, the power element 14 generates negative pressure, that is, exhaust, so that the magnetic bead mixture can be spit into the reagent box 100 at a high speed to mix the magnetic bead mixture. Then, the driving member 11 drives the connecting member 15 to drive the mixing head 12 to rise and remove from the reagent box 100. The driving member 11 drives the connecting member 15 again to drive the mixing head 12 to rotate to the head removal assembly 2, so that the current mixing head 12 is removed by the head removal assembly 2.
[0037] In this embodiment, the connecting member 15 includes a first body 151 and a second body 152 connected to the first body 151. The first body 151 is connected to the driving member 11, and the mixing head 12 is detachably connected to the second body 152. The detachable connection between the mixing head 12 and the second body 152 allows the mixing head 12 to be removed by the head removal assembly 2, thereby facilitating the installation of a new mixing head 12.
[0038] Furthermore, during the process of discharging the magnetic bead mixture in the mixing head 12 into the reagent box 100, the upward movement speed of the mixing head 12 is less than or equal to the rising speed of the magnetic bead mixture in the reagent box 100. Specifically, during the process of the driving member 11 driving the connecting member 15 to drive the mixing head 12 to rise, the mixing head 12 never deviates from the height of the magnetic bead mixture discharged to the reagent box 100, thereby avoiding the generation of bubbles. Most bubbles are generated because the mixing head 12 exceeds the height of the magnetic bead mixture in the reagent box 100 during its rise, and the magnetic bead mixture discharged by the mixing head 12 collides with the magnetic bead mixture in the reagent box 100, generating bubbles.
[0039] In one embodiment, if Figures 1 to 3 As shown, the head removal assembly 2 includes a frame 21 and a head removal piece 22 connected to the frame 21. The outer surface of the mixing head 12 is provided with a protrusion 121. The driving member 11 drives the mixing head 12 to move, and the head removal piece 22 abuts against the protrusion 121 to separate the mixing head 12 from the second body 152. Specifically, the driving member 11 drives the first body 151 downward, the first body 151 drives the second body 152 downward, the second body 152 drives the mixing head 12 downward, and the mixing head 12 descends to the height of the header 22. Then, the driving member 11 drives the first body 151 to rotate, the first body 151 drives the second body 152 to rotate, and the second body 152 drives the mixing head 12 to rotate, so that the mixing head 12 approaches the header 22. Then, the driving member 11 drives the mixing head 12 upward, the protrusion 121 abuts against the header 22, so that the mixing head 12 can be separated from the second body 152, thereby removing the mixing head 12. The currently used mixing head 12 can be removed, making it easy to replace it with a new one and avoiding contamination of the next mixed liquid.
[0040] In this embodiment, the head removal member 22 is provided with an arcuate groove 221, the groove wall of which abuts against the protrusion 121. The provision of the arcuate groove 221 allows the groove wall of the arcuate groove 221 to abut against the protrusion 121, increasing the contact area with the protrusion 121, thereby making it easier to separate the mixing head 12 from the second body 152.
[0041] In one embodiment, if Figure 1As shown, the mixing device further includes a bracket 3 and a placement plate 4 connected to the bracket 3. The placement plate 4 is provided with a plurality of mixing heads 12 for replacement. The driving member 11 drives the first body 151 and the second body 152 to move so that the second body 152 is connected to the mixing head 12. Specifically, after the current mixing head 12 is removed, the driving member 11 drives the first body 151 to rotate the second body 152. The second body 152 moves to above the placement plate 4. The driving member 11 then drives the first body 151 again to lower the second body 152. The second body 152 has an interference fit with the new mixing head 12, allowing the new mixing head 12 to be tightly mounted on the second body 152.
[0042] In this embodiment, the placement plate 4 and the head removal assembly 2 are respectively located on the motion trajectory of the mixing head 12. This facilitates the removal and installation of the mixing head 12 and saves space in the mixing device. After the current mixing head 12 is removed, the driver 11 drives the first body 151 to rotate the second body 152. The second body 152 moves above the placement plate 4. The driver 11 then drives the first body 151 again to lower the second body 152. The second body 152 forms an interference fit with the new mixing head 12, allowing the new mixing head 12 to be tightly installed on the second body 152.
[0043] In one embodiment, continue as Figure 1 As shown, the mixing device further comprises a tray 5 having a plurality of placement slots 51 arranged along the circumferential direction, the placement slots 51 being used to place the reagent kit 100. By providing a plurality of placement slots 51, a plurality of reagent kits 100 can be placed at a time, thereby improving work efficiency.
[0044] The present invention further provides an analyzer, which includes an analysis module and the mixing device of any one of the above embodiments. The analysis module is used to analyze the reagents in the reagent kit 100 .
[0045] It can be understood that the analyzer in this embodiment uses the above-mentioned mixing device, so that the driving member 11 of the mixing device is connected to the mixing head 12, and is used to drive the mixing head 12 to move to the reagent box 100. The mixing head 12 is connected to the power element 14 through the pipeline 13, so that the air pressure generated by the power element 14 is transmitted to the mixing head 12 through the pipeline 13. The driving member 11 can also drive the mixing head 12 to move to the head removal component 2, so that the head removal component 2 can remove the current mixing head 12. The power element 14 is in the first working state, and the mixing head 12 inhales the magnetic bead mixture in the reagent box 100. The power element 14 is in the second working state, and the magnetic bead mixture in the mixing head 12 is spit out into the reagent box 100, so that the magnetic bead mixture can be spit out of the reagent box 100 at a high speed, thereby quickly freeing and mixing the magnetic bead mixture to improve work efficiency.
[0046] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.
[0047] The above disclosure is only a preferred embodiment of the present invention, and certainly cannot be used to limit the scope of rights of the present invention. Therefore, equivalent changes made according to the claims of the present invention are still within the scope covered by the present invention.
Claims
1. A mixing device, characterized in that: The mixing device includes a mixing component and a head removal component. The mixing component includes a driving member, a mixing head, a pipeline and a power element. The driving member is connected to the mixing head and is used to drive the mixing head to move to the reagent box. The mixing head is connected to the power element through the pipeline. The driving member can also drive the mixing head to the head removal component, and the head removal component is used to remove the mixing head. The power element is in a first working state, and the mixing head absorbs the magnetic bead mixture in the reagent kit; The power element is in the second working state, and the magnetic bead mixture in the mixing head is discharged into the reagent box.
2. The mixing device according to claim 1, characterized in that The mixing assembly further includes a connecting member, through which the driving member is connected to the mixing head. The driving member can drive the connecting member to drive the mixing head to rise and fall and rotate so as to be inserted into or out of the reagent box.
3. The mixing device according to claim 2, characterized in that: The connecting member includes a first body and a second body connected to the first body. The first body is connected to the driving member, and the mixing head is detachably connected to the second body.
4. The mixing device according to claim 2, characterized in that: During the process of dispensing the magnetic bead mixture in the mixing head into the reagent box, the upward movement speed of the mixing head is less than or equal to the upward movement speed of the magnetic bead mixture in the reagent box.
5. The mixing device according to claim 3, characterized in that: The head removal assembly includes a frame and a head removal piece connected to the frame. A protrusion is provided on the outer surface of the mixing head. The driving piece drives the mixing head to move. The head removal piece abuts against the protrusion to separate the mixing head from the second body.
6. The mixing device according to claim 5, characterized in that: The head removal piece is provided with an arc-shaped groove, and the groove wall of the arc-shaped groove abuts against the protrusion.
7. The mixing device according to claim 3, characterized in that: The mixing device also includes a bracket and a placement plate connected to the bracket, wherein a plurality of mixing heads for replacement are placed on the placement plate, and the driving member drives the first body and the second body to move so that the second body is connected to the mixing head.
8. The mixing device according to claim 7, characterized in that: The placement plate and the head removal component are respectively located on the motion track of the mixing head.
9. The mixing device according to claim 1, characterized in that: The mixing device further comprises a tray having a plurality of placement slots arranged along a circumferential direction, wherein the placement slots are used for placing the reagent kit.
10. An analyzer, characterized in that: The analyzer comprises an analysis module and the mixing device according to any one of claims 1 to 9, wherein the analysis module is used to analyze the reagents in the kit.