Suspension tail experiment device

Abstract

The utility model provides a tail suspension experiment device, which belongs to the technical field of tail suspension experiment devices and is characterized by comprising a base, a rear cover plate, a transparent front cover plate, a clamping mechanism, a buffer cushion and a remote controller. A buffer pad is arranged on the base, the rear cover plate is fixed on the base, the top of the transparent front cover plate is connected with the rear cover plate through a bearing, the transparent front cover plate can rotate and move to be opened and closed, the clamping mechanism is fixed in the top end of the rear cover plate, and the remote controller is an independent unit capable of freely moving. The device solves the problems that in the prior art, in the mouse hanging process, operation is tedious, consumed time is long, many man-made interference factors exist, mouse tail pressure control is difficult to quantify, too much pain is brought to a mouse, an experiment result is inaccurate, and observation is difficult to start immediately when the mouse is suspended; the modular design is adopted, the integration degree is high, the adaptability is strong, the operation is simple and easy, the use is convenient, the time of experimenters is saved, and the experiment accuracy is improved; the reaction of the mouse at the suspension moment can be observed.

Description

Technical Field

[0001] The utility model relates to the technical field of tail suspension experimental devices, in particular to a tail suspension experimental device. Background Art

[0002] The mouse tail suspension test is a common behavioral test used to assess motor coordination and endurance in mice. This test is commonly used to study neurological function, drug efficacy, genetic variation, and disease models. In the mouse tail suspension test, the mouse is suspended by its tail. This test typically lasts for a period of time, during which behavioral responses, such as attempts to rotate to avoid suspension, are observed. These responses are then used to assess motor coordination and endurance. Existing methods typically use tape to wrap the mouse's tail around a horizontal bar for suspension. This process is cumbersome, time-consuming, and painful for the mouse, often leading to significant human interference. Other existing suspension methods also often have drawbacks such as cumbersome procedures, long durations, and significant human interference. Failure to properly control the pressure of the tape or clamp on the mouse's tail can cause the tail to fall off, create excessive pressure and discomfort, or even lead to tail amputation. Prolonged tail-fixing can cause premature stress or excessive pain in the mouse, negatively impacting the final experimental results. The fixation process can also cause the mouse to become suspended prematurely, with the duration of this suspension period not observed or recorded. Summary of the Invention

[0003] The purpose of the utility model is to provide a tail suspension experimental device, which solves the problems in the prior art that the mouse suspension process is complicated, time-consuming, has many human interference factors, is difficult to quantify the control of the mouse tail pressure, causes excessive pain to the mouse, resulting in inaccurate experimental results, and is difficult to observe the mouse immediately after it is suspended in the air; at the same time, the modular design has a high degree of integration, strong adaptability, simple operation and ease of use, can save the experimenter's time and improve the accuracy of the experiment; and can also observe the mouse's reaction at the moment of suspension.

[0004] To achieve the above objectives, the present invention provides the following technical solutions:

[0005] A tail suspension experiment device is characterized by comprising a base, a rear cover, a transparent front cover, a clamping mechanism, a buffer pad and a remote controller.

[0006] A buffer pad is provided on the base, the rear cover is fixed on the base, the top of the transparent front cover is connected to the rear cover through a bearing, the transparent front cover can be rotated to switch, the clamping mechanism is fixed inside the top of the rear cover, and the remote control is an independent individual that can move freely.

[0007] Furthermore, the clamping mechanism includes a fixed bayonet, an electromagnet, a bolt, a worm gear reduction motor module, an infrared receiving module, a release button, a right clamping block, a left clamping block, a connecting rod, a knob, a platform and a fixed slider.

[0008] The fixed bayonet is arranged at the top of the clamping mechanism, and the clamping mechanism is fixed to the top inside of the rear cover through the fixed bayonet, the fixed slider is arranged at the lower part of the fixed bayonet, the electromagnet is installed in the cavity inside the fixed slider, the bolt is arranged on the central axis of the electromagnet, the worm gear reduction motor module is installed at the lower part of the fixed slider, the infrared receiving module is fixed to the outside of the worm gear reduction motor module, and the release button is installed on one side of the worm gear reduction motor module.

[0009] The right clamping block and the left clamping block are respectively fixed on the right rotating shaft and the left rotating shaft at the lower part of the worm gear reduction motor module. A small hole is provided on the upper part of the connecting rod. The bolt passes through the small hole to fix the connecting rod on the fixed slider. The knob is screwed into the threaded hole at the rear part of the platform through threaded fitting. The connecting rod passes through the rear part of the platform and is fixed to the platform by tightening the knob.

[0010] Furthermore, the left clamping block includes a sticky rubber pad, a pressure sensor, a pressure sensor fixing block, a left clamping block housing and a pressure sensor cover.

[0011] The pressure sensor is installed inside the pressure sensor fixing block, the sticky rubber pad is installed on the outside of the pressure sensor, the pressure sensor fixing block is installed on the left clamping block shell, and the pressure sensor cover is installed at the bottom of the pressure sensor fixing block.

[0012] Furthermore, the fixing slide block can be inserted into the fixing bayonet from front to back, and can also be removed from the fixing bayonet from back to front.

[0013] Furthermore, the connecting rod can be inserted into the rear cavity of the fixed slider and fixed in the cavity by a bolt; it can also fall off from the cavity by withdrawing the bolt.

[0014] Furthermore, the platform can be moved or removed on the connecting rod by loosening the knob.

[0015] Furthermore, the infrared receiving module is used to sense hand approach signals and receive remote control signals sent by the remote control.

[0016] Furthermore, the right clamping block and the left clamping block can be rotated toward the middle to clamp or rotated toward both sides to open under the drive of the worm gear reduction motor module.

[0017] Furthermore, the tops of the right clamping block and the left clamping block are arc-shaped structures.

[0018] Furthermore, the pressure sensor can sense pressure and send a signal to the worm gear reduction motor module when the sensed pressure reaches a set value.

[0019] Advantages of this utility model:

[0020] 1. It solves the problems in the existing technology of hanging mice, such as cumbersome operation, long time consumption, many human interference factors, difficulty in quantifying the pressure control of the mouse tail, excessive pain to the mouse, resulting in inaccurate experimental results, and difficulty in observing the mouse immediately after it is suspended.

[0021] 2. This device adopts modular design, with high integration, strong adaptability, simple operation and easy to use, which can save the time of the experimenters and improve the accuracy of the experiment.

[0022] 3. This device is innovative in that it can observe the instantaneous reaction of mice when they are suspended in the air. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a structural diagram of the utility model;

[0024] Figure 2 This is a schematic structural diagram of the clamping mechanism of the utility model;

[0025] Figure 3 This is an exploded view of the clamping mechanism of the present invention;

[0026] Figure 4 It is a cross-sectional view of the clamping mechanism of the utility model;

[0027] Figure 5 This is an exploded view of the left clamping block of the present invention;

[0028] Figure 6 This is a view of the left and right clamps of the utility model being opened and the platform falling;

[0029] In the figure: 1. Base, 2. Rear cover, 3. Transparent front cover, 4. Clamping mechanism, 5. Fixed bayonet, 6. Electromagnet, 7. Bolt, 8. Worm gear reduction motor module, 9. Infrared receiving module, 10. Release button, 11. Right clamping block, 12. Left clamping block, 13. Connecting rod, 14. Knob, 15. Platform, 16. Fixed slider, 17. Sticky rubber pad, 18. Pressure sensor, 19. Pressure sensor fixing block, 20. Left clamping block housing, 21. Pressure sensor cover, 22. Buffer pad, 23. Remote control. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. Therefore, the following detailed description of the embodiments of the present invention provided in the drawings is not intended to limit the scope of the utility model for which protection is claimed, but merely represents selected embodiments of the present invention.

[0031] like Figure 1 As shown, a tail suspension experiment device includes a base 1, a rear cover 2, a transparent front cover 3, a clamping mechanism 4, a buffer pad 22 and a remote control 23.

[0032] A buffer pad 22 is provided on the base 1, the rear cover 2 is fixed on the base 1, the top of the transparent front cover 3 is connected to the rear cover 2 through a bearing, the transparent front cover 3 can be rotated to switch, the clamping mechanism 4 is fixed inside the top of the rear cover 2, and the remote control 23 is an independent individual that can move freely.

[0033] As a preferred embodiment of the present utility model, the clamping mechanism 4 includes a fixed bayonet 5, an electromagnet 6, a bolt 7, a worm gear reduction motor module 8, an infrared receiving module 9, a release button 10, a right clamping block 11, a left clamping block 12, a connecting rod 13, a knob 14, a platform 15 and a fixed slider 16.

[0034] The fixed bayonet 5 is arranged at the top of the clamping mechanism 4, and the clamping mechanism 4 is fixed to the top inside of the rear cover plate 2 through the fixed bayonet 5. The fixed slider 16 is arranged at the lower part of the fixed bayonet 5, and the electromagnet 6 is installed in the cavity inside the fixed slider 16. The plug 7 is arranged on the central axis of the electromagnet 6, and the plug 7 can be pulled out a short distance under the control of the electromagnet 6.

[0035] The worm gear reduction motor module 8 is mounted below the fixed slider 16 , the infrared receiving module 9 is fixed to the outside of the worm gear reduction motor module 8 , and the release button 10 is mounted on one side of the worm gear reduction motor module 8 to release the clamped rat tail.

[0036] The right clamping block 11 and the left clamping block 12 are respectively fixed on the right rotating shaft and the left rotating shaft at the lower part of the worm gear reduction motor module 8. A small hole is provided on the upper part of the connecting rod 13. The bolt 7 passes through the small hole to fix the connecting rod 13 on the fixed slider 16. The knob 14 is screwed into the threaded hole at the rear of the platform 15 through threaded fitting. The connecting rod 13 passes through the rear part of the platform 15 and is fixed to the platform 15 by tightening the knob 14.

[0037] As a preferred embodiment of the present invention, the left clamping block 12 includes a sticky rubber pad 17 , a pressure sensor 18 , a pressure sensor fixing block 19 , a left clamping block housing 20 and a pressure sensor cover 21 .

[0038] The pressure sensor 18 is installed inside the pressure sensor fixing block 19, the sticky rubber pad 17 is installed on the outside of the pressure sensor 18, the pressure sensor fixing block 19 is installed inside the left clamp block housing 20, and the pressure sensor cover 21 is installed at the bottom of the pressure sensor fixing block 19.

[0039] As a preferred embodiment of the present invention, the fixing slide block 16 can be inserted into the fixing bayonet 5 from front to back, and can also be removed from the fixing bayonet 5 from back to front.

[0040] As a preferred embodiment of the present invention, the connecting rod 13 can be inserted into the rear cavity of the fixed slider 16 and fixed in the cavity by the plug 7; it can also fall off from the cavity by withdrawing the plug 7.

[0041] As a preferred embodiment of the present invention, the platform 15 can be moved or removed on the connecting rod 13 by loosening the knob 14. The knob 14 can be tightened to fix the platform 15, or the height position of the platform 15 on the connecting rod 13 can be adjusted to adapt to the tail length of mice of different sizes.

[0042] As a preferred embodiment of the present invention, the infrared receiving module 9 is used to sense the hand approaching signal and receive the remote control signal sent by the remote controller 23.

[0043] As a preferred embodiment of the present invention, the right clamping block 11 and the left clamping block 12 can be rotated toward the middle to clamp or rotated toward both sides to open under the drive of the worm gear reduction motor module 8.

[0044] As a preferred embodiment of the present invention, the tops of the right clamping block 11 and the left clamping block 12 are arc-shaped structures.

[0045] As a preferred embodiment of the present invention, the pressure sensor 18 is capable of sensing pressure and sending a signal to the worm gear reduction motor module 8 when the sensed pressure reaches a set value.

[0046] The operating process of this utility model:

[0047] 1) Rotate and open the transparent front cover 3, place the mouse on the platform 15, lift the mouse by the tail and place it between the opened right clamping block 11 and the left clamping block 12. After the infrared receiving module 9 senses the approach of the hand, it sends a signal to the worm gear reduction motor module 8 to drive the right clamping block 11 and the left clamping block 12 to clamp. When the pressure sensor 18 senses that the pressure reaches the set value, it sends a signal to the worm gear reduction motor module 8 to stop clamping and use the worm gear self-locking effect of the worm gear reduction motor module 8 to maintain the clamping pressure. At this point, the mouse clamping operation is completed.

[0048] 2) All personnel evacuate, rotate and close the transparent front cover 3, turn on other external experimental recording and video equipment, and remote control 23 sends a command to infrared receiving module 9. Infrared receiving module 9 receives the command and controls electromagnet 6 to operate. Plug 7 is pulled out a short distance and then out of the small hole in connecting rod 13. Connecting rod 13 and platform 15 fall onto cushion 22. The mouse is immediately suspended in the air, and the experiment begins.

[0049] 3) After the experiment is complete, open the transparent front cover 3, press the release button 10, rotate the right and left clamps 11 and 12 open, and remove the mouse. Manually pull out the plug 7 and reinstall the connecting rod 13 onto the fixed slider 16.

[0050] The clamping mechanism 4 in the utility model can be easily placed in the mouse tail and intelligently clamp the mouse tail. During use, the process is fast and natural without any complicated and redundant steps. First, the mouse is placed on the platform 15, and the mouse tail only needs to be grasped and placed between the left and right clamping blocks 11 and 12. At this time, the infrared receiving module 9 senses the proximity of the hand and then the right clamping block 11 and the left clamping block 12 begin to automatically clamp the mouse tail. When the pressure sensor 18 senses the clamping pressure and reaches the set value, the clamping pressure is maintained. In this way, a simple step has been completed to fix the mouse tail, which is fast and convenient. Fixing the mouse tail when the mouse has all four feet on the ground can minimize the nervousness of the mouse caused by the four feet being suspended in the air before the experiment begins. The shorter operation time of the mouse can also better reduce the unsuitable nervousness of the mouse.

[0051] The pressure sensor 18 in this utility model accurately controls the pressure applied by the clamping member to the mouse's tail, thereby minimizing any adverse effects on the mouse: excessive pressure can cause discomfort, tension, and even poor blood circulation in the tail; while insufficient pressure can easily cause the mouse to fall. Therefore, by using quantified pressure measurements to precisely control clamping pressure, the clamping force is ensured to securely hold the mouse's tail while minimizing discomfort.

[0052] The infrared receiving module 9 in this utility model detects the approach of a hand and receives signals from a remote control. The former is used to automatically complete the holding process, while the latter is used to release the platform 15 after receiving the remote control signal. Therefore, a single infrared receiving sensor and an infrared receiving diode are sufficient. The former is used to receive infrared radiation emitted by the human body, and the latter is used to receive infrared signals from the remote control. This single infrared receiving sensor and infrared receiving diode are simple and commonly used, with more mature technology and lower cost.

[0053] The worm gear reduction motor module 8 in the present invention fully utilizes the self-locking effect of the worm gear to maintain the pressure of clamping the rat tail. Therefore, after completing the clamping action, the motor module no longer works and can always maintain a consistent clamping pressure without consuming energy.

[0054] The present invention can release the connecting rod 13 by remote control, thereby remotely releasing the platform 15 fixed on the connecting rod 13, so that the mouse can be instantly changed from the state of four feet on the ground to the tail hanging state. In this way, the mouse does not experience any tension and discomfort caused by the four feet hanging in the air before the experiment begins, and because the moment of the four feet hanging in the air can be controlled by human remote control, the reaction of the mouse from this moment can be fully observed. This can avoid the occurrence of the following situation: the mouse has already adapted to the tail hanging state in the process of fixing the tail and affects the subsequent observed behavior (because it is meaningless to observe the behavior of the mouse in the process of fixing the tail, and the operation interference of people is unavoidable in this process, so effective observation can only start from when the mouse is really four feet hanging in the air and there is no other interference); or it takes too long to struggle and resist and consumes too much physical strength in the process of fixing the tail, thereby affecting the subsequent observed behavior of the mouse.

[0055] The tops of the right clamping block 11 and the left clamping block 12 in the present invention are arc-shaped structures with smooth surfaces without protrusions or clinging points, thereby achieving the effect of preventing tail climbing.

[0056] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Those skilled in the art may adjust the technical solutions described in the aforementioned embodiments or replace some of the technical features therein with equivalents. Therefore, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is intended to include such modifications and variations.

Claims

1. A tail suspension test device, characterized in that: It comprises a base (1), a rear cover (2), a transparent front cover (3), a clamping mechanism (4), a buffer pad (22) and a remote controller (23); A buffer pad (22) is provided on the base (1), the rear cover (2) is fixed on the base (1), the top of the transparent front cover (3) is connected to the rear cover (2) via a bearing, the transparent front cover (3) can be rotated to switch, the clamping mechanism (4) is fixed inside the top end of the rear cover (2), and the remote control (23) is an independent entity that can move freely.

2. The tail suspension test device according to claim 1, characterized in that: The clamping mechanism (4) comprises a fixed bayonet (5), an electromagnet (6), a bolt (7), a worm gear reduction motor module (8), an infrared receiving module (9), a release button (10), a right clamping block (11), a left clamping block (12), a connecting rod (13), a knob (14), a platform (15) and a fixed slide block (16); The fixed bayonet (5) is arranged at the top of the clamping mechanism (4), the clamping mechanism (4) is fixed to the top inner part of the rear cover (2) through the fixed bayonet (5), the fixed slider (16) is arranged at the lower part of the fixed bayonet (5), the electromagnet (6) is installed in the cavity inside the fixed slider (16), the bolt (7) is arranged on the central axis of the electromagnet (6), the worm gear reduction motor module (8) is installed at the lower part of the fixed slider (16), the infrared receiving module (9) is fixed to the outside of the worm gear reduction motor module (8), and the release button (10) is installed on one side of the worm gear reduction motor module (8); The right clamping block (11) and the left clamping block (12) are respectively fixed on the right rotating shaft and the left rotating shaft at the lower part of the worm gear reduction motor module (8); a small hole is provided on the upper part of the connecting rod (13); the bolt (7) passes through the small hole to fix the connecting rod (13) on the fixed slider (16); the knob (14) is screwed into the threaded hole at the rear part of the platform (15) through threaded engagement; the connecting rod (13) passes through the rear part of the platform (15) and is fixed to the platform (15) by tightening the knob (14).

3. A tail suspension test device according to claim 2, characterized in that: The left clamping block (12) comprises a sticky rubber pad (17), a pressure sensor (18), a pressure sensor fixing block (19), a left clamping block housing (20) and a pressure sensor cover plate (21); The pressure sensor (18) is installed inside the pressure sensor fixing block (19), the sticky rubber pad (17) is installed on the outside of the pressure sensor (18), the pressure sensor fixing block (19) is installed inside the left clamping block housing (20), and the pressure sensor cover plate (21) is installed at the bottom of the pressure sensor fixing block (19).

4. The tail suspension test apparatus according to claim 2, wherein: The fixed slide block (16) can be inserted into the fixed bayonet (5) from front to back, and can also be removed from the fixed bayonet (5) from back to front.

5. The tail suspension test device according to claim 2, characterized in that: The connecting rod (13) can be inserted into the rear cavity of the fixed slider (16) and fixed in the cavity by the bolt (7); it can also fall off from the cavity by withdrawing the bolt (7).

6. The tail suspension test device according to claim 2, characterized in that: The platform (15) can be moved or removed on the connecting rod (13) by loosening the knob (14).

7. The tail suspension test device according to claim 2, characterized in that: The infrared receiving module (9) is used to sense a hand approaching signal and receive a remote control signal sent by a remote controller (23).

8. The tail suspension test device according to claim 2, characterized in that: The right clamping block (11) and the left clamping block (12) can be rotated toward the middle to clamp or rotated toward both sides to open under the drive of the worm gear reduction motor module (8).

9. The tail suspension test device according to claim 2, characterized in that: The tops of the right clamping block (11) and the left clamping block (12) are arc-shaped structures.

10. The tail suspension experiment device according to claim 3, characterized in that: The pressure sensor (18) is capable of sensing pressure and sending a signal to the worm gear reduction motor module (8) when the sensed pressure reaches a set value.

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