Precipitation equipment for research and development of micron magnetic beads
By introducing a vibrating stirring component and a separating scraping component into the sedimentation equipment, the problems of uneven stirring and filter plate clogging are solved, and efficient stirring and mixing and convenient cleaning are achieved.
Patent Information
- Application Number
- CN202422763349.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-13
- Publication Date
- 2025-09-19
- Estimated Expiration
- 2034-11-13
AI Technical Summary
Existing precipitation equipment has difficulty in effectively stirring and mixing reactants and solvents in different areas, and long-term use can easily cause the filter plate to become clogged and difficult to clean.
It adopts a vibration stirring component and a separation scraping component. The vibration stirring component realizes vibration stirring through the cooperation of the stirring plate and the triangular block. The separation scraping component uses a scraper to scrape the inclined filter plate to prevent clogging.
It achieves efficient stirring and mixing of reactants and solvents in different areas, prevents filter plate clogging, and improves the working efficiency and cleaning convenience of the equipment.
Smart Images
Figure CN223351236U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of micron magnetic beads, in particular to a precipitation device for the research and development of micron magnetic beads. Background Art
[0002] Micron magnetic beads are a type of magnetic material with a particle size between 1 and 30 microns. They have a high specific surface area, high magnetic susceptibility, and good magnetic response characteristics. These characteristics give micron magnetic beads broad application prospects in life sciences, biomedicine, materials science, and other fields. Precipitation equipment is a common device for synthesizing micron magnetic beads. Its principle is to add an appropriate amount of compound to the solution to cause a precipitation reaction in the solution, thereby obtaining micron-level magnetic bead materials.
[0003] Most existing precipitation equipment requires stirring and mixing the reactants and solvents. Due to the large internal space of the mixing box, it is difficult to stir and mix the reactants and solvents in different areas, thereby reducing the working efficiency of the device. At the same time, the solution after the precipitation reaction needs to be filtered to collect the magnetic bead material. Since most of them use filter plates for filtration, long-term use will cause it to become clogged and difficult to clean. Utility Model Content
[0004] In order to solve the problem that it is difficult to stir and mix reactants or solvents in different areas and that they will become clogged and difficult to clean after long-term use; the purpose of the utility model is to provide a precipitation device for the research and development of micron magnetic beads.
[0005] In order to solve the above technical problems, the present invention adopts the following technical solutions: a precipitation equipment for the research and development of micron magnetic beads, comprising a mixing box and a separation box, wherein the bottom end of the mixing box is fixedly connected to a valve tube, the end of the valve tube away from the mixing box is fixedly connected to the top of the separation box, the top of the mixing box is fixedly connected to a feed inlet, a vibration stirring component is provided inside the mixing box, and a separation scraping component is provided inside the separation box; the vibration stirring component comprises a stirring rod, the top of the mixing box is fixedly connected to a first motor, one end of the output shaft of the first motor is fixedly connected to the outer end of the stirring rod, the outer end of the stirring rod is rotatably connected to the inside of the mixing box, the outer surface of the stirring rod is fixedly connected to a first transmission wheel, the inside of the mixing box is rotatably connected to a fixed rod, the outer surface of the fixed rod is fixedly connected to a second transmission wheel, and the outer surface of the fixed rod is fixedly connected There is a gear, the inner side of the mixing box is slidably connected to an annular gear plate, the outer surface of the annular gear plate is fixedly connected to a plurality of evenly distributed connecting rods, the end of the connecting rod away from the annular gear plate is slidably connected to a stirring plate, the inside of the mixing box is fixedly connected to a plurality of evenly distributed triangular blocks, the inside of the mixing box is fixedly connected to a first spring, the end of the first spring away from the connecting rod is fixedly connected to the top of the stirring plate, the bottom of the stirring plate corresponds to the inclined surface of the triangular block, the inside of the mixing box is provided with an annular slide, the inside of the annular slide is slidably connected to a slider, the outer surface of the slider is fixedly connected to the outer surface of the annular gear plate, the outer surface of the second transmission wheel is provided with a transmission belt, the inner side of the transmission belt is transmission-sleeved with the outer surface of the first transmission wheel, the bottom of the mixing box is fixedly connected to a heating plate, and the inner side of the annular gear plate is meshed with the outer surface of the gear.
[0006] Preferably, the separation scraping assembly includes a scraper, an open partition is fixedly connected to the inside of the separation box, an inclined filter plate is fixedly connected to the outer surface of the open partition, and one end of the inclined filter plate away from the open partition is fixedly connected to the inner side of the separation box, a first slide groove is symmetrically opened inside the separation box, a fixed block is slidably connected inside the first slide groove, the outer surface of the fixed block is fixedly connected to the outer end of the scraper, the outer surface of the separation box is fixedly connected to the second motor, one end of the output shaft of the second motor is fixedly connected to the rotating rod, and the outer surface of the rotating rod is fixed to the inner side of the open partition The outer end of the rotating rod is rotatably connected to the inner side of the separation box, and the outer surface of the rotating rod is symmetrically fixedly connected to the take-up wheel, and the inner side of the take-up wheel is fixedly connected to a pulling rope, and the end of the pulling rope away from the take-up wheel is fixedly connected to the outer surface of the fixed block, and the outer surface of the fixed block is fixedly connected to a second spring, and the end of the second spring away from the fixed block is fixedly connected to the inner side of the first slide groove, and the opening of the opening partition is rotatably connected to a baffle, and the opening of the opening partition is symmetrically fixedly connected to a clockwork spring, and the outer surface of the clockwork spring is fixedly connected to the outer surface of the baffle.
[0007] Compared with the prior art, the beneficial effects of the present invention are:
[0008] 1. By setting up a vibration stirring assembly, the bottom of the stirring plate contacts and slides with the inclined surface of the triangular block, so that the stirring plate is squeezed by the triangular block and moves toward the inside of the connecting rod. After the stirring plate passes through the triangular block, it is reset under the action of the first spring force, so that the stirring plate can move up and down inside the mixing box to form vibration stirring, so that the reactants and solvents in different areas can be stirred and mixed.
[0009] 2. By setting up a separate scraping assembly, the take-up wheel rotates to reel in the pulling rope and pull the fixed block. The fixed block slides inside the first slide groove under the tension and squeezes the second spring. At the same time, the fixed block moves to drive the scraper to scrape the surface of the inclined filter plate and push the reactants to prevent the inclined filter plate from being blocked. BRIEF DESCRIPTION OF THE DRAWINGS
[0010] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.
[0011] Figure 1 This is a schematic diagram of the overall structure proposed by the utility model;
[0012] Figure 2 This is a schematic diagram of the first angle structure proposed by the utility model;
[0013] Figure 3 for Figure 2 A schematic diagram of the structure at center A;
[0014] Figure 4 This is a schematic diagram of the second angle structure proposed by the utility model;
[0015] Figure 5 for Figure 4 A magnified schematic diagram of the structure at point B in the middle;
[0016] Figure 6 This is a schematic diagram of the internal structure of the separation box proposed by the utility model;
[0017] Figure 7 for Figure 6 A magnified schematic diagram of the structure at point C in the middle;
[0018] Figure 8 for Figure 6 Enlarged schematic diagram of the structure at point D in the middle.
[0019] In the figure: 1. mixing box; 2. separation box; 3. first motor; 4. feed port; 5. valve pipe; 6. second motor; 7. heating plate; 8. triangular block; 9. annular gear plate; 10. connecting rod; 11. stirring rod; 12. first spring; 13. stirring plate; 14. annular chute; 15. slider; 16. fixing rod; 17. first transmission wheel; 18. transmission belt; 19. gear; 20. second transmission wheel; 21. first chute; 22. rotating rod; 23. take-up wheel; 24. spring; 25. baffle; 26. opening partition; 27. pull rope; 28. inclined filter plate; 29. fixing block; 30. scraper; 31. second spring. DETAILED DESCRIPTION
[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.
[0021] Example: Figure 1-8As shown, the utility model provides a precipitation equipment for the research and development of micron magnetic beads, including a mixing box 1 and a separation box 2. The bottom end of the mixing box 1 is fixedly connected to a valve tube 5, and the end of the valve tube 5 away from the mixing box 1 is fixedly connected to the top of the separation box 2. The top of the mixing box 1 is fixedly connected to a feed inlet 4, a vibration stirring component is provided inside the mixing box 1, and a separation scraping component is provided inside the separation box 2; the vibration stirring component includes a stirring rod 11, the top of the mixing box 1 is fixedly connected to a first motor 3, one end of the output shaft of the first motor 3 is fixedly connected to the outer end of the stirring rod 11, the outer end of the stirring rod 11 is rotatably connected to the inside of the mixing box 1, and the surface of the stirring rod 11 is fixedly connected to the outer end of the stirring rod 11. The surface is fixedly connected to the first transmission wheel 17, the interior of the mixing box 1 is rotatably connected to a fixed rod 16, the outer surface of the fixed rod 16 is fixedly connected to the second transmission wheel 20, the outer surface of the fixed rod 16 is fixedly connected to a gear 19, the inner side of the mixing box 1 is slidably connected to an annular gear plate 9, the outer surface of the annular gear plate 9 is fixedly connected to a plurality of evenly distributed connecting rods 10, the end of the connecting rod 10 away from the annular gear plate 9 is slidably connected to a stirring plate 13, and the interior of the mixing box 1 is fixedly connected to a plurality of evenly distributed triangular blocks 8. By setting a stirring rod 11, the bottom of the stirring plate 13 is in contact with the inclined surface of the triangular block 8 and slides, so that the stirring plate 13 is affected by the triangular block 8 The squeezing force moves toward the inside of the connecting rod 10. When the stirring plate 13 passes through the triangular block 8, it is reset under the elastic force of the first spring 12, so that the stirring plate 13 can move up and down inside the mixing box 1 to form vibration stirring, so that the reactants and solvents in different areas can be stirred and mixed. The connecting rod 10 is fixedly connected to the inside of the first spring 12. The end of the first spring 12 away from the connecting rod 10 is fixedly connected to the top of the stirring plate 13. The bottom end of the stirring plate 13 corresponds to the inclined surface of the triangular block 8, so that the stirring plate 13 can be vibrated and stirred under the action of the triangular block 8 and the first spring 12. An annular slide groove 1 is provided on the inside of the mixing box 1 4. A slider 15 is slidably connected to the inside of the annular chute 14. The outer surface of the slider 15 is fixedly connected to the outer surface of the annular gear plate 9, so that the annular gear plate 9 can rotate inside the mixing box 1. The outer surface of the second transmission wheel 20 is provided with a transmission belt 18. The inner side of the transmission belt 18 is transmission-sleeved with the outer surface of the first transmission wheel 17, so that the first transmission wheel 17 can drive the second transmission wheel 20 to rotate through the transmission belt 18. A heating plate 7 is fixedly connected to the bottom of the mixing box 1, so that the inside of the mixing box 1 can be heated to accelerate the reaction rate. The inner side of the annular gear plate 9 is meshed with the outer surface of the gear 19, so that the rotation of the gear 19 can drive the annular gear plate 9 to rotate.
[0022] The separation and scraping assembly includes a scraper 30, an open partition 26 is fixedly connected to the inside of the separation box 2, and an inclined filter plate 28 is fixedly connected to the outer surface of the open partition 26, and the end of the inclined filter plate 28 away from the open partition 26 is fixedly connected to the inner side of the separation box 2, and a first slide 21 is symmetrically provided inside the separation box 2, and a fixed block 29 is slidably connected inside the first slide 21. The outer surface of the fixed block 29 is fixedly connected to the outer end of the scraper 30, and the outer surface of the separation box 2 is fixedly connected to the second motor 6, and one end of the output shaft of the second motor 6 is fixedly connected to the rotating rod 22, and the outer surface of the rotating rod 22 is rotatably connected to the inside of the open partition 26. The outer end of the rotating rod 22 is rotatably connected to the inner side of the separation box 2, and the outer surface of the rotating rod 22 is symmetrically fixedly connected to the take-up wheel 23, and the inner side of the take-up wheel 23 is fixedly connected to the pull rope 27. The pull rope 27 is away from the end of the take-up wheel 23. The end is fixedly connected to the outer surface of the fixed block 29, and the outer surface of the fixed block 29 is fixedly connected to a second spring 31. The end of the second spring 31 away from the fixed block 29 is fixedly connected to the inner side of the first slide groove 21. The opening of the open partition 26 is rotatably connected to the baffle 25. By arranging the scraper 30, the take-up wheel 23 rotates to reel in the pulling rope 27 and pull the fixed block 29. The fixed block 29 slides inside the first slide groove 21 under the tension and squeezes the second spring 31. At the same time, the movement of the fixed block 29 drives the scraper 30 to scrape the surface of the inclined filter plate 28 and push the reactants to prevent the inclined filter plate 28 from being blocked. The opening of the open partition 26 is symmetrically fixedly connected with a clockwork spring 24. The outer surface of the clockwork spring 24 is fixedly connected to the outer surface of the baffle 25, so that the baffle 25 can close the opening of the open partition 26 under the action of the clockwork spring 24.
[0023] Working principle: Before the reaction, the staff can deliver reactants and solvents into the mixing box 1 through the feed port 4, and then start the heating plate 7, which heats the interior and starts the first motor 3 at the same time. The output shaft of the first motor 3 rotates to drive the stirring rod 11 to rotate, and the stirring rod 11 rotates to drive the first transmission wheel 17 to rotate. The first transmission wheel 17 rotates through the transmission belt 18 to rotate the second transmission wheel 20. The second transmission wheel 20 rotates to drive the fixed rod 16 to rotate. The fixed rod 16 rotates to drive the gear 19 to rotate. The gear 19 rotates to make the annular gear plate 9 rotate along the annular chute 1 inside the mixing box 1. 4 slides, the annular toothed plate 9 slides and drives the connecting rod 10 to move inside the mixing box 1, and the movement of the connecting rod 10 drives the bottom of the stirring plate 13 to contact and slide with the inclined surface of the triangular block 8, so that the stirring plate 13 is squeezed by the triangular block 8 and moves toward the inside of the connecting rod 10 and squeezes the first spring 12. The first spring 12 is forced to contract and generate elastic force. When the stirring plate 13 passes through the triangular block 8, it is reset under the elastic force of the first spring 12, so that the stirring plate 13 can move up and down inside the mixing box 1 to form vibration stirring, so that the reactants and solvents in different areas can be stirred and mixed; when the reaction is completed Afterwards, the staff opens the valve pipe 5 to allow the reactants and solvent in the mixing box 1 to enter the separation box 2. After the reactants and solvent enter the separation box 2, they will fall onto the inclined filter plate 28 for precipitation separation. The solvent will pass through the inclined filter plate 28 and enter the collection box on one side of the open partition 26. The reactants will accumulate on the inclined filter plate 28. When the precipitation separation is completed, the staff starts the second motor 6. The output shaft of the second motor 6 rotates to drive the rotating rod 22 to rotate. The rotation of the rotating rod 22 drives the take-up wheel 23 to rotate. The take-up wheel 23 rotates to reel in the pulling rope 27. The pulling rope 27 reels The roll pulls the fixed block 29, and the fixed block 29 slides inside the first slide groove 21 under the tension and squeezes the second spring 31. The second spring 31 is forced to shrink. At the same time, the fixed block 29 moves to drive the scraper 30 to scrape the surface of the inclined filter plate 28 and push the reactants to prevent the inclined filter plate 28 from being blocked. At the same time, the reactants will apply a thrust to the baffle 25 under the push of the scraper 30. The baffle 25 is forced to rotate and the clockwork spring 24 is contracted, so that the opening of the open partition 26 is no longer closed. Then the scraper 30 pushes the reactants into the collection box on the other side of the open partition 26.
[0024] Obviously, those skilled in the art may make various modifications and variations to the present invention without departing from the spirit and scope of the present invention. Thus, if such modifications and variations fall within the scope of the claims of the present invention and their equivalents, the present invention is intended to include such modifications and variations.
Claims
1. A precipitation device for the research and development of micron magnetic beads, comprising a mixing box (1) and a separation box (2), characterized in that: The bottom end of the mixing box (1) is fixedly connected to a valve pipe (5), the end of the valve pipe (5) away from the mixing box (1) is fixedly connected to the top end of the separation box (2), the top end of the mixing box (1) is fixedly connected to a feed port (4), a vibration stirring component is provided inside the mixing box (1), and a separation scraping component is provided inside the separation box (2); The vibration stirring assembly comprises a stirring rod (11), a first motor (3) is fixedly connected to the top of the mixing box (1), one end of the output shaft of the first motor (3) is fixedly connected to the outer end of the stirring rod (11), the outer end of the stirring rod (11) is rotatably connected to the inside of the mixing box (1), the outer surface of the stirring rod (11) is fixedly connected to a first transmission wheel (17), the inside of the mixing box (1) is rotatably connected to a fixed rod (16), the outer surface of the fixed rod (16) is fixedly connected to a second transmission wheel (20), the outer surface of the fixed rod (16) is fixedly connected to a gear (19), the inner side of the mixing box (1) is slidably connected to an annular tooth plate (9), the outer surface of the annular tooth plate (9) is fixedly connected to a plurality of evenly distributed connecting rods (10), the end of the connecting rod (10) away from the annular tooth plate (9) is slidably connected to a stirring plate (13), and the inside of the mixing box (1) is fixedly connected to a plurality of evenly distributed triangular blocks (8).
2. A precipitation device for micron magnetic bead research and development according to claim 1, characterized in that: The separation scraping assembly includes a scraper (30), an opening partition (26) is fixedly connected inside the separation box (2), an inclined filter plate (28) is fixedly connected to the outer surface of the opening partition (26), and one end of the inclined filter plate (28) away from the opening partition (26) is fixedly connected to the inner side of the separation box (2), a first chute (21) is symmetrically opened inside the separation box (2), a fixed block (29) is slidably connected inside the first chute (21), the outer surface of the fixed block (29) is fixedly connected to the outer end of the scraper (30), a second motor (6) is fixedly connected to the outer surface of the separation box (2), and one end of the output shaft of the second motor (6) is fixedly connected to the rotating rod (22 ), the outer surface of the rotating rod (22) is rotatably connected to the inside of the opening partition (26), the outer end of the rotating rod (22) is rotatably connected to the inner side of the separation box (2), the outer surface of the rotating rod (22) is symmetrically fixedly connected to the take-up wheel (23), the inner side of the take-up wheel (23) is fixedly connected to a pulling rope (27), the end of the pulling rope (27) away from the take-up wheel (23) is fixedly connected to the outer surface of the fixed block (29), the outer surface of the fixed block (29) is fixedly connected to a second spring (31), the end of the second spring (31) away from the fixed block (29) is fixedly connected to the inner side of the first sliding groove (21), and the opening of the opening partition (26) is rotatably connected to a baffle (25).
3. A precipitation device for the development of micron magnetic beads according to claim 2, characterized in that: A spring spring (24) is symmetrically fixedly connected to the opening of the opening partition (26), and the outer surface of the spring spring (24) is fixedly connected to the outer surface of the baffle (25).
4. A precipitation device for the development of micron magnetic beads according to claim 1, characterized in that: A first spring (12) is fixedly connected inside the connecting rod (10), and one end of the first spring (12) away from the connecting rod (10) is fixedly connected to the top of the stirring plate (13), and the bottom end of the stirring plate (13) corresponds to the inclined surface of the triangular block (8).
5. A precipitation device for micron magnetic bead research and development according to claim 1, characterized in that: An annular chute (14) is provided on the inner side of the mixing box (1), a slider (15) is slidably connected inside the annular chute (14), and the outer surface of the slider (15) is fixedly connected to the outer surface of the annular tooth plate (9).
6. A precipitation device for micron magnetic bead research and development according to claim 1, characterized in that: A transmission sleeve on the outer surface of the second transmission wheel (20) is provided with a transmission belt (18), and the inner side of the transmission belt (18) is transmission-connected with the outer surface sleeve of the first transmission wheel (17).
7. A precipitation device for micron magnetic bead research and development according to claim 1, characterized in that: A heating plate (7) is fixedly connected to the bottom of the mixing box (1).
8. A precipitation device for the research and development of micron magnetic beads according to claim 1, characterized in that: The inner side of the annular gear plate (9) is meshed with the outer surface of the gear (19).