Polypeptide synthesizer reaction kettle
By introducing a fixing and scraping mechanism into the peptide synthesizer reactor, the problems of reactor instability and cleaning were solved, and the reaction stability and cleaning efficiency were improved.
Patent Information
- Application Number
- CN202422856809.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-22
- Publication Date
- 2025-09-26
- Estimated Expiration
- 2034-11-22
AI Technical Summary
The design of traditional peptide synthesis reactors ignores the support and limit requirements, resulting in an unstable reaction process and difficulty in cleaning, especially the difficulty in removing the attachments on the inner wall of the reactor.
A peptide synthesizer reactor was designed, which included a fixing mechanism and a scraping mechanism. The fixing mechanism ensured the stability of the reactor body through components such as mounting rings, connecting rings and sliding rods. The scraping mechanism scraped off the attachments on the inner wall through a scraper, and combined with a motor drive to achieve stable support and cleaning of the reactor body.
It improves the stability and safety of the reaction process, reduces cleaning time and labor costs, and ensures that the equipment can be quickly put into the next synthesis reaction.
Smart Images
Figure CN223381616U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of polypeptide synthesis, in particular to a polypeptide synthesizer reaction kettle. Background Art
[0002] Peptide synthesis is the process of connecting multiple amino acids in a certain order into a polypeptide chain through chemical or biological methods. Peptides are widely used in biomedicine, chemistry, and materials science, such as drugs, vaccines, and research tools.
[0003] Reactors provide a stable reaction environment, including precise temperature and stirring control, as well as inert gas protection, all essential for peptide synthesis. Therefore, they are required. However, reactors are often equipped with structures such as stirring shafts or paddles. While these structures facilitate mixing and reaction of reactants, they also increase the difficulty of cleaning, making certain areas of the inner wall difficult to scrape directly. Furthermore, traditional peptide synthesis reactor designs may prioritize reaction stability and sealing, while relatively ignoring the need for support and position limiting. Their structures may be relatively simple, lacking specialized support and position limiting devices or designs. Utility Model Content
[0004] The purpose of the utility model is to provide a peptide synthesizer reactor to solve the problems raised in the above background technology.
[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solution: a peptide synthesizer reactor, comprising a base, and further comprising:
[0006] A kettle body is arranged on the top of the base, a bracket is fixedly connected to one side of the base, and a driving mechanism is arranged on the top of the kettle body;
[0007] A fixing mechanism is provided on the outside of the kettle body for supporting and fixing the kettle body, the fixing mechanism includes a mounting ring clamped on the outside of the kettle body, a connecting ring is clamped on the outside of the kettle body, a sleeve rod is provided on one side of the mounting ring, and a sliding rod is slidably connected to the inner wall of the sleeve rod;
[0008] A scraping mechanism is arranged inside the kettle body to facilitate scraping off attachments on the inner wall of the kettle body. The scraping mechanism includes a connecting plate arranged inside the kettle body, one side of the connecting plate is fixedly connected to a first scraper, one side of the connecting plate is fixedly connected to a second scraper, and one side of the second scraper is slidably connected to the inner wall of the kettle body.
[0009] Preferably, the driving mechanism includes a motor arranged on the top of the kettle body, and the output end of the motor is fixedly connected to a rotating rod.
[0010] Preferably, a connecting column is fixedly connected to the outer side of the mounting ring, and the outer side of the connecting column is fixedly connected to the inner wall of the sleeve rod.
[0011] Preferably, one end of the sliding rod is fixedly connected to a fixing block, and one side of the fixing block is fixedly connected to the inner wall of the bracket.
[0012] Preferably, a fixing bracket is fixedly connected to the outer side of the motor, and the bottom of the fixing bracket is clamped with the top of the kettle body.
[0013] Preferably, a plurality of support seats are clamped on the bottom of the kettle body, and one end of the support seat is fixedly connected to the inner wall of the base.
[0014] Preferably, a bearing is fixedly connected to the outer side of the rotating rod, and a stirring blade for mixing the raw materials is fixedly connected to the outer side of the bearing.
[0015] Compared with the prior art, the beneficial effects of the present invention are as follows:
[0016] The utility model can facilitate the support and fixation of the kettle body by arranging a fixing mechanism, can keep it stable during the reaction process, prevent the reactants from splashing out or the reaction conditions from getting out of control due to shaking or vibration, which helps to ensure the safety and accuracy of the experiment. By arranging a wall scraping mechanism, it is convenient to scrape off the attachments on the wall of the kettle body, which can significantly reduce the time and labor costs required for cleaning the reactor, and ensure that the equipment can be put into the next synthesis reaction more quickly. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] Figure 1 A schematic structural diagram of a preferred embodiment of a peptide synthesizer reactor provided by the present invention;
[0018] Figure 2 A schematic diagram of the fixing mechanism structure provided by the utility model;
[0019] Figure 3 A schematic diagram of the base and bracket structure provided by the utility model;
[0020] Figure 4 This is a schematic structural diagram of the wall scraping mechanism provided by the utility model.
[0021] In the figure: 1. Base; 2. Kettle body; 3. Bracket; 4. Fixing mechanism; 41. Mounting ring; 42. Connecting ring; 43. Sleeve rod; 44. Slide rod; 5. Driving mechanism; 51. Motor; 52. Rotating rod; 6. Scraping mechanism; 61. Connecting plate; 62. First scraper; 63. Second scraper; 7. Connecting column; 8. Fixing block; 9. Fixing frame; 10. Support seat; 11. Bearing; 12. Stirring blade. DETAILED DESCRIPTION
[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.
[0023] See also Figure 1-4 As shown, a peptide synthesizer reactor comprises a base 1. By setting the base 1, it is convenient to fix the support base 10. The top of the base 1 is provided with a kettle body 2. By setting the kettle body 2, it is convenient to perform a polypeptide synthesis reaction. It is explained here that a feeding pipe for adding raw materials is provided on the top of the kettle body 2, and a discharge pipe for discharging is connected to the outside of the kettle body 2. A bracket 3 is fixedly connected to one side of the base 1. By setting the bracket 3, it is convenient to fix the fixing block 8. A driving mechanism 5 is provided on the top of the kettle body 2; a fixing mechanism 4 is provided on the outside of the kettle body 2 for supporting and fixing the kettle body 2. The fixing mechanism 4 includes a mounting ring 41 that is clamped to the outside of the kettle body 2. By setting the mounting ring 41, it is convenient to clamp the kettle body 2. A connecting ring 42 is clamped to the outside of the kettle body 2. By setting the connecting ring 42, it is convenient to clamp the kettle body 2. One side of the mounting ring 41 is provided with The sleeve rod 43 is provided with a sleeve rod 43, which can facilitate the connection of the connecting column 7. The inner wall of the sleeve rod 43 is slidably connected to the sliding rod 44. By providing the sliding rod 44, the sleeve rod 43 can be easily reset. Here, one end of the sliding rod 44 is provided with a spring for resetting the sleeve rod 43; a scraping mechanism 6 is provided inside the kettle body 2 to facilitate scraping off the attachments on the inner wall of the kettle body 2. The scraping mechanism 6 includes a connecting plate 61 provided inside the kettle body 2. By providing the connecting plate 61, it is convenient to connect the first scraper 62. One side of the connecting plate 61 is fixedly connected to the first scraper 62. By providing the first scraper 62, it is convenient to scrape off the attachments on the inner wall of the kettle body 2. One side of the connecting plate 61 is fixedly connected to the second scraper 63. By providing the second scraper 63, it is convenient to scrape off the attachments on the inner wall of the kettle body 2, and one side of the second scraper 63 is slidably connected to the inner wall of the kettle body 2.
[0024] The driving mechanism 5 includes a motor 51 arranged on the top of the kettle body 2. By setting the motor 51, the rotating rod 52 can be rotated. The output end of the motor 51 is fixedly connected to the rotating rod 52. By setting the rotating rod 52, the bearing 11 can be rotated and the connecting plate 61 can be rotated at the same time.
[0025] The outer side of the mounting ring 41 is fixedly connected with a connecting column 7. By providing the connecting column 7, the mounting ring 41 can be connected conveniently, and the sleeve rod 43 can be connected conveniently at the same time, and the outer side of the connecting column 7 is fixedly connected to the inner wall of the sleeve rod 43; one end of the sliding rod 44 is fixedly connected with a fixing block 8. By providing the fixing block 8, the sliding rod 44 can be fixed conveniently, and one side of the fixing block 8 is fixedly connected to the inner wall of the bracket 3; the outer side of the motor 51 is fixedly connected with a fixing frame 9. By providing the fixing frame 9, the motor 51 can be fixed conveniently, and the bottom of the fixing frame 9 is clamped with the top of the kettle body 2; the bottom of the kettle body 2 is clamped with multiple groups of support seats 10. By providing the support seats 10, the kettle body 2 can be supported conveniently, and one end of the support seat 10 is fixedly connected to the inner wall of the base 1.
[0026] The outer side of the rotating rod 52 is fixedly connected with a bearing 11. By providing the bearing 11, the stirring blade 12 can be easily connected. The outer side of the bearing 11 is fixedly connected with the stirring blade 12 for mixing the raw materials.
[0027] Working principle: When a polypeptide synthesis reaction is required, raw materials are added through the feed pipe on the top of the kettle body 2. At this time, the motor 51 is turned on, and the motor 51 rotates to drive the rotating rod 52 to rotate. When the rotating rod 52 rotates, it drives the bearing 11 to rotate. The rotation of the bearing 11 drives the stirring blade 12 to rotate, thereby mixing the raw materials. The rotation of the rotating rod 52 drives the connecting plate 61 to rotate. The rotation of the connecting plate 61 drives the first scraper 62 and the second scraper 63 to rotate, thereby scraping off the attachments on the inner wall of the kettle body 2. When the polypeptide mixing reaction is carried out, the kettle body 2 is clamped by the mounting ring 41 and the connecting ring 42, and the connecting column 7 is connected to the mounting ring 41. The sliding rod 44 resets the sleeve rod 43, thereby resetting the mounting ring 41, and then supporting the kettle body 2. After the mixing reaction, it can be discharged from the discharge pipe outside the kettle body 2.
[0028] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply the existence of any such actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article, or device comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or device. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of other identical elements in the process, method, article, or device comprising the element.
[0029] Although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A peptide synthesizer reactor, comprising a base (1), characterized in that: Also includes: A kettle body (2) is arranged on the top of a base (1), a bracket (3) is fixedly connected to one side of the base (1), and a driving mechanism (5) is arranged on the top of the kettle body (2); A fixing mechanism (4) is provided on the outside of the kettle body (2) for supporting and fixing the kettle body (2), the fixing mechanism (4) comprising a mounting ring (41) clamped on the outside of the kettle body (2), a connecting ring (42) clamped on the outside of the kettle body (2), a sleeve rod (43) provided on one side of the mounting ring (41), and a sliding rod (44) slidably connected to the inner wall of the sleeve rod (43); A scraping mechanism (6) is provided inside a kettle body (2) for conveniently scraping off attachments on the inner wall of the kettle body (2). The scraping mechanism (6) comprises a connecting plate (61) provided inside the kettle body (2), a first scraping plate (62) being fixedly connected to one side of the connecting plate (61), a second scraping plate (63) being fixedly connected to one side of the connecting plate (61), and a second scraping plate (63) being slidably connected to the inner wall of the kettle body (2).
2. A peptide synthesizer reactor according to claim 1, characterized in that: The driving mechanism (5) comprises a motor (51) arranged on the top of the kettle body (2), and the output end of the motor (51) is fixedly connected to a rotating rod (52).
3. A peptide synthesizer reactor according to claim 1, characterized in that: The outer side of the mounting ring (41) is fixedly connected to a connecting column (7), and the outer side of the connecting column (7) is fixedly connected to the inner wall of the sleeve rod (43).
4. A peptide synthesizer reactor according to claim 1, characterized in that: One end of the sliding rod (44) is fixedly connected to a fixing block (8), and one side of the fixing block (8) is fixedly connected to the inner wall of the bracket (3).
5. A peptide synthesizer reactor according to claim 2, characterized in that: The outer side of the motor (51) is fixedly connected to a fixing frame (9), and the bottom of the fixing frame (9) is clamped with the top of the kettle body (2).
6. A peptide synthesizer reactor according to claim 1, characterized in that: The bottom of the kettle body (2) is clamped with multiple groups of support seats (10), and one end of the support seat (10) is fixedly connected to the inner wall of the base (1).
7. A peptide synthesizer reactor according to claim 2, characterized in that: The outer side of the rotating rod (52) is fixedly connected to a bearing (11), and the outer side of the bearing (11) is fixedly connected to a stirring blade (12) for mixing raw materials.