Separation and purification device suitable for separation of low-content substances

Abstract

The utility model discloses a separation and purification device suitable for separating low-content substances, which relates to the technical field of medicine separation and purification, and comprises a separation tower, and an enrichment mechanism, a separation mechanism and a detection piece which are arranged in the separation tower, the interior of the separation tower is hollow, and the opening of the separation tower is upward; the enrichment mechanism comprises a partition plate and a filter membrane which are used for vertically separating an inner cavity of the separation tower into a plurality of cavities and are fixed on the inner wall of the separation tower, and the partition plate is positioned below the filter membrane; the separation mechanism is located below the enrichment mechanism, an input port of the separation mechanism is connected with the partition plate and receives the bulk drug liquid passing through the partition plate, the detection part is arranged at the bottom of the separation tower and used for detecting separation results, and a sampling end of the detection part is communicated with an output port of the separation mechanism. And the output port of the separation mechanism is also connected with the output port of the separation tower. The method has the effect of improving separation and purification of low-content substances.

Description

Technical Field

[0001] The present application relates to the technical field of drug separation and purification, and in particular to a separation and purification device suitable for separating low-content substances. Background Art

[0002] A separation and purification device is a key device used to obtain target components from a mixture. In scientific research, industrial production, pharmaceutical manufacturing and other fields, it is often necessary to separate the target substance from a complex mixture in order to achieve the purpose of analysis, preparation or application.

[0003] When preparing various medicines, a variety of base materials are often needed. Various base materials generally do not exist independently, but are mixed in other medicinal liquids and components. Therefore, they need to be separated and purified. Most existing separation and purification devices rely on centrifugal technology, which uses centrifugal force to cause substances to produce sedimentation speed differences in the rotating field to achieve separation. However, the centrifugal separation effect of low-content target substances is not good. Therefore, the present application provides a separation and purification device suitable for the separation of low-content substances. Utility Model Content

[0004] In order to improve the separation and purification effect of low-content substances, the present application provides a separation and purification device suitable for separating low-content substances.

[0005] This application provides a separation and purification device suitable for separating low-content substances, which adopts the following technical solutions:

[0006] A separation and purification device suitable for separating low-content substances, characterized in that it includes a separation tower and an enrichment mechanism, a separation mechanism and a detection component installed in the separation tower, the interior of the separation tower is hollow and the opening is upward, a sealing cover is fixedly connected to the opening of the separation tower, and the sealing cover is penetrated by a feed inlet for inputting raw material liquid; the enrichment mechanism includes a partition and a filter membrane that vertically separates the inner cavity of the separation tower into multiple cavities and is fixed to the inner wall of the separation tower, and the partition is located below the filter membrane; the separation mechanism is located below the enrichment mechanism, the input port of the separation mechanism is connected to the partition and receives the raw material liquid passing through the partition, the detection component is located at the bottom of the separation tower and is used to detect the separation results, the sampling end of the detection component is connected to the output port of the separation mechanism, and the output port of the separation mechanism is also connected to the output port of the separation tower.

[0007] Optionally, the partition is provided with a connecting hole along the longitudinal direction, and the separation mechanism includes a connecting column, a separation column 1 and a separation column 2, the separation column 1 and the separation column 2 are hollow inside and have openings at both ends, the upper end of the connecting column is fixedly connected to the lower surface of the partition, and the connecting column is provided with a drainage channel along the longitudinal direction, the connecting hole is communicated with the drainage channel, the lower end of the connecting column is fixedly connected to the input port of the separation column 1, and the drainage channel is communicated with the inner cavity of the separation column 1, the bottom of the inner cavity of the separation tower is fixedly connected to a fixing frame, the separation column 2 is fixedly connected to the fixing frame, and the separation column 2 is located directly below the separation column 1 and the internal cavity openings are aligned, and the inner cavity of the separation tower is provided with a device for receiving waste discharged from the separation column 1. The liquid receiving component, the inner walls of the separation column 1 and the separation column 2 are respectively fixedly connected with a filter screen, the side walls of the separation column 1 and the separation column 2 are respectively fixedly connected with a connecting pipe, the other end of the connecting pipe extends out of the separation tower, the side wall of the fixed frame is fixedly connected with a four-way reversing valve, the input port of the four-way reversing valve is connected to the output port of the separation column 2 through a hose, the first interface of the four-way reversing valve is fixedly connected to the waste liquid pipe 2, the other end of the waste liquid pipe 2 extends out of the separation tower, the second interface of the four-way reversing valve is connected to the detection component through a hose, the third interface of the four-way reversing valve is re-connected to the input port of the separation column 2 through a hose, and the fourth interface of the four-way reversing valve is connected to the output port of the separation tower through a pipeline

[0008] Optionally, the output ports of the separation column 1 and the separation column 2 are respectively fixedly connected with a collection block, the upper surface of the collection block is arranged in an arc-shaped depression, and a through hole is opened through the center position of the depression of the arc-shaped surface of the collection block.

[0009] Optionally, the receiving assembly includes a receiving plate, a motor 1, a connecting rod, a guide column and a transfer assembly, the motor 1 is fixedly connected to the bottom of the inner cavity of the separation tower and rotates in conjunction with the connecting rod, the connecting rod is vertically arranged, the receiving plate is fixedly connected to the upper end of the connecting rod, a distance is left between the separation column 1 and the separation column 2, and the receiving plate is located between the separation column 1 and the separation column 2, the guide column is fixedly penetrated by the receiving plate and aligned with the separation column 1 and the separation column 2, and a through groove is provided through the guide column along the longitudinal direction, the upper surface of the receiving plate is arranged in an arc-shaped depression, and the receiving plate is located at the lowest position of the arc-shaped depression and has a number of filter holes for filtering along the longitudinal direction, the transfer assembly is located below the receiving plate, and the input end of the transfer assembly is connected to the filter hole and the output end extends out of the separation tower.

[0010] Optionally, the transfer assembly includes a support column, a waste liquid pipe 1, a connecting pipe and a ring pipe, the lower end of the support column is fixedly connected to the bottom of the inner cavity of the separation tower, the waste liquid pipe 1 is fixedly connected to the upper end of the support column, one end of the waste liquid pipe 1 extends toward the filter hole, and the other end of the waste liquid pipe 1 extends out of the separation tower, the lower end of the ring pipe is fixedly connected to one end of the waste liquid pipe 1 facing the filter hole, and the ring pipe is vertically arranged, the upper end of the connecting pipe is fixedly connected to the lower surface of the receiving plate, and the connecting pipe is located under the filter hole, the interior of the connecting pipe is hollow and the two ends are open, a groove is provided on the upper surface of the ring pipe, the lower end of the connecting pipe is located in the groove, and the ring pipe is provided with a number of drainage holes along the longitudinal direction, and the several drainage holes are connected to the input port of the waste liquid pipe 1 and are used to drain the raw material waste liquid flowing through the connecting pipe to the waste liquid pipe 1.

[0011] Optionally, the separation tower sleeve is provided with a protective cover, and a refrigeration unit for reducing the ambient temperature of the separation tower is fixedly connected to the upper surface of the protective cover.

[0012] Optionally, a stirring mechanism extending into the inner cavity of the separation tower is provided on the top of the protective cover, and the stirring mechanism includes motor 2, a driving rod and two rotating blocks. Motor 2 is fixedly connected to the upper surface of the protective cover, and the output end of motor 2 extends into the inner cavity of the protective cover, one end of the driving rod is fixedly connected to the output end of motor 2, and the other end of the driving rod extends into the inner cavity of the separation tower, one end of the two rotating blocks is fixedly connected to the side walls on both sides of the driving rod, and the two rotating blocks are located above the filter membrane.

[0013] Optionally, the upper surface of the filter membrane is arranged to be arc-shaped and protruding, the side wall of the separation tower is connected to a waste liquid pipe three, and the connection point between the waste liquid pipe three and the separation tower is located above the filter membrane.

[0014] In summary, the present application includes the following beneficial technical effects: the present application can achieve the separation of low-content substances in the raw material liquid by setting up an enrichment mechanism and a filtration mechanism, detect the separation results of low-content substances by setting up a detection element, and can perform continuous separation through the filtration mechanism, thereby improving the separation and purification effect of low-content substances. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present application;

[0016] Figure 2 is a cross-sectional view of a separation tower according to an embodiment of the present application;

[0017] Figure 3 Yes Figure 2 A partial enlarged schematic diagram of part A.

[0018] Explanation of reference numerals: 1. separation tower; 11. sealing cover; 12. fixing frame; 13. waste liquid pipe 3; 14. waste liquid pipe 2; 2. enrichment mechanism; 21. partition; 211. connecting hole; 22. filter membrane; 3. separation mechanism; 31. connecting column; 311. drainage channel; 32. separation column 1; 33. separation column 2; 34. receiving assembly; 341. receiving plate; 342. motor 1; 343. connecting rod; 344. guide column; 345. through groove; 346. filter hole ; 35. Filter; 36. Connecting pipe; 37. Four-way reversing valve; 371. First interface; 372. Second interface; 373. Third interface; 374. Fourth interface; 38. Collecting block; 381. Through hole; 4. Detection part; 5. Transfer assembly; 51. Support column; 52. Waste liquid pipe 1; 53. Connecting pipe; 54. Ring pipe; 541. Groove; 6. Protective cover; 61. Refrigeration unit; 7. Stirring mechanism; 71. Motor 2; 72. Drive rod; 73. Rotating block. DETAILED DESCRIPTION

[0019] The following is combined with Figure 1-3 This application is described in further detail.

[0020] The embodiment of the present application discloses a separation and purification device suitable for separating low-content substances.

[0021] Reference Figure 1 and Figure 2 The separation and purification device suitable for separating low-content substances includes a separation tower 1 and an enrichment mechanism 2, a separation mechanism 3, and a detection element 4 installed in the separation tower 1. The interior of the separation tower 1 is hollow and the opening is upward. A sealing cover 11 is fixedly connected to the opening of the separation tower 1 by bolts, and the sealing cover 11 is provided with an inlet for inputting the raw material liquid. The enrichment mechanism 2 includes a partition 21 and a filter membrane 22. The partition 21 is fixedly connected to the inner wall of the separation tower 1 by bolts. The filter membrane 22 is fixedly connected to the inner wall of the separation tower 1 by bonding, and the filter membrane 22 is located above the partition 21. The filter membrane 22 is used to filter out low-content target substances from the raw material liquid. It can be a polytetrafluoroethylene filter membrane for separating acid and alkali solutions. The inner cavity of the separation tower 1 is divided into multiple cavities by separating the partition 21 and the filter membrane 22 to achieve filtration and enrichment of low-content target substances from the raw material liquid.

[0022] Separation mechanism 3 is located below partition 21. The input port of separation mechanism 3 is connected to partition 21 and receives the API liquid from partition 21. The output port of separation mechanism 3 is connected to the output port of separation tower 1 and is used to output the separated and purified low-content target substance from separation tower 1. Detection component 4 is fixedly connected to the bottom of separation tower 1 via bolts. The sampling end of detection component 4 is connected to the output port of separation mechanism 3. Detection component 4 is used to detect the separation results of the low-content target substance. In this embodiment, detection component 4 can be a mass spectrometer that identifies and quantifies compounds by measuring the mass-to-charge ratio of sample molecules.

[0023] Reference Figure 2 The separation mechanism 3 includes a connecting column 31, a separation column 1 32 and a separation column 2 33. The upper end of the connecting column 31 is fixedly connected to the lower surface of the partition 21 by a bolt. The partition 21 and the connecting column 31 are respectively penetrated by a connecting hole 211 and a drainage channel 311 in the longitudinal direction, and the connecting hole 211 is communicated with the drainage channel 311. The lower end of the connecting column 31 is fixedly connected to the input port of the separation column 1 32 through a flange. The bottom of the inner cavity of the separation tower 1 is fixedly connected to the fixing frame 12. The separation column 2 33 is fixedly mounted on the fixing frame 12, and the separation column 2 33 is located below the separation column 1 32. The separation column 1 32 and the separation column 2 33 are hollow inside and have openings at both ends. The separation column 1 32 and the separation column 2 33 are respectively embedded with filters at the lower ends. The filter screen 35 is provided with a stationary phase, and the side walls of the separation column 1 32 and the separation column 2 33 are respectively connected to each other and provided with a connecting pipe 36 for inputting the mobile phase. When the raw material liquid flows through the separation column 1 32 or the separation column 2 33, the mobile phase is inputted into the inner cavity of the separation column 1 32 or the separation column 2 33 through the connecting pipe 36, so that the raw material liquid dissolves in the mobile phase. By taking advantage of the different physical and chemical properties of the components in the raw material liquid and the different speeds of the components passing through the stationary phase under the promotion of the mobile phase, the components are separated on the stationary phase. Among them, stationary phases with different polarities can be placed in the separation column 1 32 and the separation column 2 33. By comparing the strength of the polarity, forward and reverse separation can be achieved, thereby improving the separation effect of low-content target substances. It should be noted that the stationary phase and the mobile phase can be selected according to the different physical and chemical properties between the raw material liquid and the low-content target substance.

[0024] Reference Figure 2 The output ports of separation column 1 32 and separation column 2 33 are respectively fixedly connected with collection blocks 38 through flanges. The upper surface of the collection block 38 is arranged in an arc-shaped depression, and a through hole 381 is longitudinally penetrated through the center position of the arc-shaped depression of the collection block 38. The through hole 381 is respectively connected with the inner cavity of separation column 1 32 and separation column 2 33, and the aperture of the through hole 381 is smaller than the aperture of the inner diameter of separation column 1 32 and separation column 2 33, so that the raw material drug liquid flows out of separation column 1 32 or separation column 2 33 more smoothly, thereby reducing the leakage of the raw material drug liquid.

[0025] A receiving assembly 34 is provided within the inner chamber of separation tower 1 to discharge the waste liquid flowing out of separation column 1 32 . Receiver assembly 34 comprises a receiving tray 341 , motor 1 342 , connecting rod 343 , and guide column 344 . Motor 1 342 is fixedly connected to the bottom of the inner chamber of separation tower 1 via bolts and rotates in conjunction with connecting rod 343 . Connecting rod 343 is vertically arranged and fixedly connected to the output end of motor 342 via a bearing. A horizontal bracket is fixed to the inner wall of separation tower 1 , and the bracket end rotates through a bearing and a link with the rod body of connecting rod 343 , thereby providing increased support for connecting rod 343 . Receiver tray 341 is fixedly connected to the upper end of connecting rod 343 via bolts. Separation column 1 32 is spaced from separation column 2 33 . Receiver tray 341 is located between separation column 1 32 and separation column 2 33 . Guide column 344 is fixedly inserted through receiving tray 341 and has a through slot 345 extending through guide column 344 for the flow of the API liquid. In order to facilitate the filtration of the raw material drug waste liquid, the upper surface of the receiving plate 341 is set in an arc-shaped depression, and a number of filter holes 346 are opened through the lowest part of the arc-shaped depression of the receiving plate 341. A transfer component 5 for outputting the raw material drug waste liquid flowing through the filter holes 346 is provided under the receiving plate 341. The input end of the transfer component 5 is connected to the filter hole 346 and the output end extends out of the separation tower 1.

[0026] The transfer assembly 5 includes a support column 51, a waste liquid pipe 52, a connecting pipe 53 and a ring pipe 54. The support column 51 is fixedly connected to the bottom of the inner cavity of the separation tower 1 by bolts, and the waste liquid pipe 52 is fixedly connected to the upper end of the support column 51 by bolts. One end of the waste liquid pipe 52 extends toward the filter hole 346, and the other end of the waste liquid pipe 52 extends out of the separation tower 1. The ring pipe 54 is fixedly connected to the end of the waste liquid pipe 52 facing the filter hole 346 by a flange. The connecting pipe 53 is welded to the lower surface of the receiving plate 341, and the connecting pipe 53 is located below the filter hole 346. The interior of the connecting pipe 53 is hollow and has openings at both ends. A groove 541 is provided on the upper surface of the ring pipe 54, and the lower end of the connecting pipe 53 is located in the groove 541. The ring pipe 54 is longitudinally penetrated with a number of drainage holes for draining the raw material waste liquid flowing through the connecting pipe 53 to the waste liquid pipe 52.

[0027] When the low-content target substance flows out from the output port of separation column 1 32, the guide column 344 is on the same axis as separation column 1 32 and separation column 2 33, and the low-content target substance flows into separation column 2 33 through the through groove 345 for separation. When the raw material drug waste liquid flows out from separation column 1 32, the output shaft of motor 1 342 rotates, driving the connecting rod 343 to drive the receiving plate 341 to rotate, and the raw material drug waste liquid flows into the receiving plate 341 and flows into the connecting pipe 53 from the filter hole 346 through the curved surface of the receiving plate 341. By providing a groove 541 on the upper surface of the annular tube 54, and a plurality of drainage holes are provided in the longitudinal direction of the annular tube 54, the lower end of the connecting pipe 53 extends into the groove 541, and the raw material drug waste liquid flowing out from the lower end of the connecting pipe 53 flows into the waste liquid pipe 1 52 through the drainage hole and is discharged from the separation tower 1. When the connecting pipe 53 rotates with the receiving plate 341, the lower end of the connecting pipe 53 is always located in the groove 541, thereby reducing the leakage of the raw material drug waste liquid.

[0028] Reference Figure 2 and Figure 3 , the fixing frame 12 is fixedly connected with a four-way reversing valve 37 by bolts, and the four-way reversing valve 37 is located below the output port of the separation column 2 33, and the output port of the separation column 2 33 is connected to the input port of the four-way reversing valve 37 through a pipeline, and the output port of the four-way reversing valve 37 has four interfaces, the first interface 371 of the four-way reversing valve 37 is connected to the waste liquid pipe 2 14, the other end of the waste liquid pipe 2 14 extends out of the separation tower 1 and is used to separate the raw material waste liquid separated by the separation column 2 33, the second interface 372 of the four-way reversing valve 37 is connected to the sampling end of the detection element 4 through a pipeline, and the sampling end can be the low-content target substance input port of the detection element 4, through the detection element To detect the separation results of the low-content target substance, the third port 373 of the four-way reversing valve 37 is connected to the side wall of the second separation column 33 via a pipeline and is used to re-input the API liquid flowing through the four-way reversing valve 37 into the second separation column 33. A hydraulic pump is fixedly connected to the bottom of the inner cavity of the separation tower 1 via bolts. The output end of the hydraulic pump is connected to the pipeline of the third port 373 of the four-way reversing valve 37, facilitating the API liquid to re-flow into the second separation column 33 for further separation. The fourth port 374 of the four-way reversing valve 37 is connected to the output port of the separation tower 1, through which the low-content target substance obtained after separation and purification is output from the separation tower 1.

[0029] When the low-content target substance flows from the output port of the separation column 2 33 to the four-way reversing valve 37, the input port of the four-way reversing valve 37 is connected to the second interface 372 of the four-way reversing valve 37, and the low-content target substance is transported to the detection component 4. The separation results of the low-content target substance are detected by the detection component 4. If the separation requirements of the low-content target substance are met, the input port of the four-way reversing valve 37 is connected to the fourth interface 374 of the four-way reversing valve 37, and the low-content target substance is output from the output end of the separation tower 1. If the detected separation results do not meet the separation requirements of the low-content target substance, the input port of the four-way reversing valve 37 is connected to the third interface 373 of the four-way reversing valve 37, and the low-content target substance is transported to the pipeline connected to the third interface 373 of the four-way reversing valve 37. The input port of the four-way reversing valve 37 is connected to the first interface 371 of the four-way reversing valve 37. After the bulk drug waste liquid is discharged from the separation tower 1 through the waste liquid pipe 2 14, the low-content target substance in the pipeline of the third interface 373 of the four-way reversing valve 37 is re-transported to the separation column 2 33 for re-separation under the action of the hydraulic pump, thereby improving the separation effect of the low-content target substance until the detection result meets the separation requirements of the low-content target substance. Through the mutual cooperation between the four-way reversing valve 37 and the detection component 4, the separation and purification effect of the low-content target substance is improved.

[0030] Reference Figure 1 and Figure 2 In order to provide a low-temperature environment for the separation and purification of low-content target substances and improve the separation effect, a protective cover 6 is arranged outside the separation tower 1, and a refrigeration unit 61 is fixedly connected above the protective cover 6 by bolts. The refrigeration unit 61 can be a refrigeration compressor. The refrigeration end of the refrigeration unit 61 is set in the inner cavity of the protective cover 6. Through the operation of the refrigeration section of the refrigeration unit 61, the temperature of the inner cavity of the protective cover 6 is reduced, thereby realizing low-temperature separation of low-content target substances and improving the separation effect of low-content target substances.

[0031] When the raw material drug liquid flows into the separation tower 1 through the feed port, in order to accelerate the enrichment effect of the enrichment mechanism 2, a stirring mechanism 7 extending into the inner cavity of the separation tower 1 is provided on the top of the protective cover 6. The stirring mechanism 7 includes a second motor 71, a drive rod 72 and two rotating blocks 73. The second motor 71 is fixedly connected to the top of the protective cover 6 by bolts. The output shaft of the second motor 71 extends into the inner cavity of the protective cover 6. One end of the drive rod 72 is connected to the output shaft of the second motor 71 and is fixed by a bearing. The drive rod 72 is vertically arranged, and the other end of the drive rod 72 extends into the inner cavity of the separation tower 1. The two rotating blocks 73 are welded to the side wall of the drive rod 72, and the two rotating blocks 73 are symmetrically arranged with the drive rod 72 as the center. The rotating blocks 73 are located above the filter membrane 22. The drive rod 72 is driven by the second motor 71 to rotate the two rotating blocks 73, thereby stirring the raw material drug liquid above the filter membrane 22 and accelerating the separation and enrichment of low-content target substances.

[0032] After enrichment by the filter membrane 22, in order to facilitate the discharge of the API waste liquid above the filter membrane 22, a waste liquid pipe three 13 is connected to the side wall of the separation tower 1, and the waste liquid pipe three 13 is located above the filter membrane 22. The upper surface of the filter membrane 22 is arranged to be an arc-shaped protrusion. After the low-content target substance passes through the filter membrane 22, the waste liquid pipe three 13 is opened to discharge the API waste liquid out of the separation tower 1.

[0033] It should be noted that in the embodiment of the present application, the connecting pipe 36 and the above-mentioned waste liquid pipes are controlled by installing solenoid valves, and the inflow of mobile phase and the discharge of bulk drug waste liquid are achieved by switching the solenoid valves.

[0034] The working principle of this embodiment is as follows: the raw material liquid is transported to the separation tower 1, and the low-content target substance is enriched by the separation effect of the filter membrane 22 and then flows into the separation column 1 32 through the connecting column 31. The connecting pipe 36 connected to the separation column 1 32 transports the mobile phase into the separation column 1 32. Under the impetus of the mobile phase, the low-content target substance passes through the stationary phase and flows to the separation column 2 33 through the guide column 344, while the target substance flows from the output port of the separation column 1 32 to the separation column 2 33. The discharged API waste liquid flows into the waste liquid pipe 52 through the receiving tray 341 and flows out of the separation tower 1. The target substance flowing through the separation column 2 33 repeats the separation process in the separation column 1 32 through the mobile phase and the stationary phase, and is then transported to the detection part 4 through the four-way reversing valve 37 to detect the separation results. If the separation requirements of the target substance are not met, the output end interface of the four-way reversing valve 37 is adjusted, and the target substance is re-transported to the separation column 2 33 for separation again until the separation requirements of the target substance are met, and the target substance is output from the separation tower 1.

[0035] The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application.

Claims

1. A separation and purification device suitable for separating low-content substances, characterized by: The invention comprises a separation tower (1) and an enrichment mechanism (2), a separation mechanism (3) and a detection element (4) installed in the separation tower (1); the separation tower (1) is hollow inside and opens upward; a sealing cover (11) is fixedly connected to the opening of the separation tower (1), and the sealing cover (11) is penetrated by a feed port for inputting a raw material liquid; the enrichment mechanism (2) comprises a partition (21) and a filter membrane fixed to the inner wall of the separation tower (1) to vertically divide the inner cavity of the separation tower (1) into multiple cavities (22), the partition (21) is located below the filter membrane (22); the separation mechanism (3) is located below the enrichment mechanism (2), the input port of the separation mechanism (3) is connected to the partition (21) and receives the raw material liquid passing through the partition (21), the detection element (4) is located at the bottom of the separation tower (1) and is used to detect the separation results, the sampling end of the detection element (4) is connected to the output port of the separation mechanism (3), and the output port of the separation mechanism (3) is also connected to the output port of the separation tower (1).

2. The separation and purification device suitable for separating low-content substances according to claim 1, characterized in that: The partition (21) is provided with a connecting hole (211) along the longitudinal direction. The separation mechanism (3) includes a connecting column (31), a separation column 1 (32) and a separation column 2 (33). The separation column 1 (32) and the separation column 2 (33) are hollow inside and have openings at both ends. The upper end of the connecting column (31) is fixedly connected to the lower surface of the partition (21), and the connecting column (31) is provided with a drainage channel (311) along the longitudinal direction. The connecting hole (211) is connected to the drainage channel (311). The lower end of the connecting column (31) is fixedly connected to the input port of the separation column 1 (32), and the drainage channel (311) is connected to the inner cavity of the separation column 1 (32). The bottom of the inner cavity of the separation tower (1) is fixedly connected to a fixing frame (12). The separation column 2 (33) is fixedly connected to the fixing frame (12), and the separation column 2 (33) is located directly below the separation column 1 (32) and the internal cavity openings are aligned. The inner cavity of the separation tower (1) is provided with a receiving portion for receiving the waste liquid discharged from the separation column 1 (32). The connecting assembly (34) is fixedly connected to the inner walls of the separation column 1 (32) and the separation column 2 (33) respectively with a filter screen (35), the side walls of the separation column 1 (32) and the separation column 2 (33) respectively with a connecting pipe (36), the other end of the connecting pipe (36) extends out of the separation tower (1), the side wall of the fixed frame (12) is fixedly connected to a four-way reversing valve (37), the input port of the four-way reversing valve (37) is connected to the output port of the separation column 2 (33) through a hose, and the four-way reversing valve (37) is connected to the output port of the separation column 2 (33) through a hose. The first interface (371) of the four-way reversing valve (37) is fixedly connected to the second waste liquid pipe (14), the other end of the second waste liquid pipe (14) extends out of the separation tower (1), the second interface (372) of the four-way reversing valve (37) is connected to the detection component (4) through a hose, the third interface (373) of the four-way reversing valve (37) is reconnected to the input port of the second separation column (33) through a hose, and the fourth interface (374) of the four-way reversing valve (37) is connected to the output port of the separation tower (1) through a pipeline.

3. The separation and purification device suitable for separating low-content substances according to claim 2, characterized in that: The output ports of the separation column 1 (32) and the separation column 2 (33) are respectively fixedly connected with a collection block (38), the upper surface of the collection block (38) is arranged in an arc-shaped depression, and a through hole (381) is provided through the center position of the arc-shaped depression of the collection block (38).

4. The separation and purification device suitable for separating low-content substances according to claim 2, characterized in that: The receiving assembly (34) includes a receiving plate (341), a motor (342), a connecting rod (343), a guide column (344) and a transfer assembly (5). The motor (342) is fixedly connected to the bottom of the inner cavity of the separation tower (1) and rotates in conjunction with the connecting rod (343). The connecting rod (343) is vertically arranged. The receiving plate (341) is fixedly connected to the upper end of the connecting rod (343). A distance is left between the separation column (32) and the separation column (33), and the receiving plate (341) is located between the separation column (32) and the separation column (33). The guide column (344) is fixedly installed on the receiving plate (341) and aligned with the separation column 1 (32) and the separation column 2 (33), and the guide column (344) is provided with a through groove (345) along the longitudinal direction. The upper surface of the receiving plate (341) is provided with an arc-shaped depression, and the receiving plate (341) is located at the lowest position of the arc-shaped depression and is provided with a plurality of filter holes (346) for filtering along the longitudinal direction. The transfer component (5) is located below the receiving plate (341), and the input end of the transfer component (5) is connected to the filter hole (346) and the output end extends out of the separation tower (1).

5. The separation and purification device suitable for separating low-content substances according to claim 4, characterized in that: The transfer assembly (5) includes a support column (51), a waste liquid pipe (52), a connecting pipe (53) and a ring pipe (54). The lower end of the support column (51) is fixedly connected to the bottom of the inner cavity of the separation tower (1). The waste liquid pipe (52) is fixedly connected to the upper end of the support column (51). One end of the waste liquid pipe (52) extends toward the filter hole (346), and the other end of the waste liquid pipe (52) extends out of the separation tower (1). The lower end of the ring pipe (54) is fixedly connected to one end of the waste liquid pipe (52) toward the filter hole (346), and the ring pipe (54) is vertically arranged. The upper end of the connecting tube (53) is fixedly connected to the lower surface of the receiving plate (341), and the connecting tube (53) is located below the filter hole (346). The interior of the connecting tube (53) is hollow and both ends are open. A groove (541) is provided on the upper surface of the annular tube (54), and the lower end of the connecting tube (53) is located in the groove (541). The annular tube (54) is provided with a plurality of drainage holes along the longitudinal direction. The plurality of drainage holes are connected to the input port of the waste liquid pipe (52) and are used to drain the raw material waste liquid flowing through the connecting tube (53) to the waste liquid pipe (52).

6. The separation and purification device suitable for separating low-content substances according to claim 1, characterized in that: The separation tower (1) is provided with a protective cover (6), and a refrigeration unit (61) for reducing the ambient temperature of the separation tower (1) is fixedly connected to the upper surface of the protective cover (6).

7. The separation and purification device suitable for separating low-content substances according to claim 6, characterized in that: The top of the protective cover (6) is provided with a stirring mechanism (7) extending into the inner cavity of the separation tower (1), and the stirring mechanism (7) includes a second motor (71), a driving rod (72) and two rotating blocks (73). The second motor (71) is fixedly connected to the upper surface of the protective cover (6), and the output end of the second motor (71) extends into the inner cavity of the protective cover (6). One end of the driving rod (72) is fixedly connected to the output end of the second motor (71), and the other end of the driving rod (72) extends into the inner cavity of the separation tower (1). One end of the two rotating blocks (73) is fixedly connected to the side walls on both sides of the driving rod (72), and the two rotating blocks (73) are located above the filter membrane (22).

8. The separation and purification device suitable for separating low-content substances according to claim 1, characterized in that: The upper surface of the filter membrane (22) is arranged to be arc-shaped and protruding. The side wall of the separation tower (1) is connected to a waste liquid pipe three (13). The connection point between the waste liquid pipe three (13) and the separation tower (1) is located above the filter membrane (22).

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