Preparation subpackaging device

Abstract

The utility model provides a preparation subpackaging device which comprises a main pipeline, branch pipelines, a driving pump and an exhaust pipe, the near end of the main pipeline is communicated with a stock solution bag, a plurality of branch pipelines are communicated with the main pipeline, one of the branch pipelines is communicated with the far end of the main pipeline, each branch pipeline is independently provided with a subpackaging valve and a subpackaging container, and the driving pump is communicated with the exhaust pipe. The driving pump is arranged on the main pipeline between the branch pipeline and the stock solution bag, the exhaust pipe is arranged on the main pipeline between the driving pump and the stock solution bag, a main valve is arranged on the main pipeline between the exhaust pipe and the stock solution bag, and an exhaust valve is arranged on the exhaust pipe. According to the preparation split charging device, only one exhaust pipe is arranged, contact with outside air is reduced, the risk that microorganisms pollute a pipeline is reduced, the split charging amount is controlled through the weighing sensor, the split charging uniformity and accuracy can be ensured, high-speed split charging is achieved, residual preparations in the pipeline can be emptied to be recycled, and the production efficiency is improved. And waste is reduced.

Description

Technical Field

[0001] The utility model belongs to the field of filling equipment, in particular to a preparation sub-packaging device. Background Art

[0002] In the biopharmaceutical industry, the filling and degassing of dosage forms are critical steps in the pharmaceutical production process. Accuracy, stability, and reliability are crucial for filling dosage forms. Currently, biopharmaceutical companies generally use fully automatic, multifunctional filling equipment. This type of equipment integrates multiple functions, including filling and degassing, enabling precise dosage control and automated production processes.

[0003] The invention patent with publication number CN115447861A discloses an exhaust device and an exhaust method for preparation packaging. A first exhaust port and a second exhaust port are provided at both ends of the conveying pipeline. The first exhaust port is used to exhaust the gas in the packaging bag, and the second exhaust port is used to exhaust the gas in the conveying pipeline. This solution has the following disadvantages: the two exhaust ports increase the risk of microbial contamination; the packaging efficiency is low: under high flow, the flow error of the peristaltic pump and the diaphragm pump will become larger, so the peristaltic pump and the diaphragm pump cannot achieve stable and uniform packaging; after the packaging is completed, the preparation in the storage pipeline and the conveying pipeline is not recovered, resulting in waste.

[0004] In addition, the packaging effect of existing packaging devices will be affected by the ambient temperature, which in turn affects the packaging uniformity and accuracy. This is mainly reflected in the following aspects: First, temperature changes will affect the elasticity of the pump tube. At high temperatures, the pump tube becomes soft, resulting in a smaller flow rate. Second, temperature changes will affect the viscosity and fluidity of the liquid, which in turn affects the flow rate of the peristaltic pump. As the liquid temperature rises, its viscosity decreases, and the flow rate of the diaphragm pump will increase. Third, temperature changes will also affect the material properties of the diaphragm pump, causing the pump material to deform or deform, affecting the diaphragm pump flow rate. In addition, the density of the preparation will also affect the packaging uniformity and accuracy. The reason is that as the liquid density increases, the liquid viscosity and friction increase, which will prolong the rebound time of the peristaltic pump tube and reduce the flow rate. Moreover, when the liquid density is high, the friction increases, and the diaphragm pump needs to overcome greater resistance when conveying the medium, which will reduce the flow rate.

[0005] Therefore, it is urgent to develop a pharmaceutical preparation packaging device that can improve packaging uniformity and accuracy, avoid pollution, and reduce waste. Utility Model Content

[0006] In view of this, the present invention aims to propose a preparation packaging device to reduce the risk of contamination, reduce product waste, and achieve high-speed, accurate and stable packaging of preparations.

[0007] In order to achieve the above-mentioned purpose, the technical solution of the utility model is achieved as follows:

[0008] A preparation packaging device comprises a main line, wherein the proximal end of the main line is connected to a stock solution bag;

[0009] A plurality of branch lines are connected to the main line, one of which is connected to the distal end of the main line. Each branch line is independently provided with a filling valve and a filling container. Each filling valve can be opened and closed independently. The preparation in the stock solution bag can enter different branch lines along the main line and be filled into different filling containers.

[0010] A driving pump is provided on the main pipeline between the branch pipeline and the raw liquid bag. The driving pump is a bidirectional pump that can transport both liquid and gas;

[0011] An exhaust pipe is provided on the main pipe between the driving pump and the raw liquid bag. A main valve is provided on the main pipe between the exhaust pipe and the raw liquid bag. An exhaust valve is provided on the exhaust pipe.

[0012] Furthermore, an air supply pipe is connected to the main line between the exhaust pipe and the main valve, and the air supply pipe is connected to a compressed air source. An air supply valve is provided on the air supply pipe, and the residual preparation in the pipeline can be emptied and recovered through the compressed air source.

[0013] Furthermore, a weighing sensor is provided at the bottom of the stock solution bag for identifying the weight of the stock solution bag, and the weight of the packaged preparation can be calculated by the change in weight before and after packaging.

[0014] Furthermore, a pressure sensor is provided on the main pipeline between the branch pipeline and the driving pump.

[0015] Furthermore, the driving pump can be selected from pumps conventionally used in the art for dispensing liquid preparations, preferably a peristaltic pump or a diaphragm pump.

[0016] Furthermore, the driving pump is a bidirectional pump, which can discharge the gas or liquid in the sub-packaging container and pump the preparation into the sub-packaging container.

[0017] Furthermore, the packaging container is a recovery container or a preparation packaging container.

[0018] Furthermore, the branch line connected to the far end of the main line is a recovery line, which is sealed and connected to the recovery container. The other branch lines are packaging lines, which are sealed and connected to the preparation packaging container. The recovery container is used to collect the gas and preparation discharged from the main line, and the preparation packaging container is used to package the preparation.

[0019] Furthermore, it also includes a controller, which is electrically connected to the driving pump, the weighing sensor and the pressure sensor.

[0020] Furthermore, the packaging container is made of a flexible material, and the gas therein can be exhausted by driving a pump.

[0021] Compared with the prior art, the preparation packaging device described in the present invention has the following advantages:

[0022] (1) The preparation packaging device described in the present invention is provided with only one exhaust pipe, which reduces contact with the outside air and reduces the risk of microbial contamination of the pipeline;

[0023] (2) The preparation dispensing device of the present invention controls the dispensing amount by means of a weighing sensor, thereby overcoming the defects of peristaltic pumps or diaphragm pumps in that the uniformity and accuracy of dispensing are affected by changes in temperature and preparation density, and can achieve high-speed dispensing;

[0024] (3) The preparation packaging device described in the present invention is connected to a compressed air source via an air supply pipe, and can empty the preparation remaining in the pipeline for recycling, thereby reducing waste. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The accompanying drawings, which constitute part of the present invention, are intended to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are intended to explain the present invention and do not constitute an improper limitation of the present invention. In the accompanying drawings:

[0026] Figure 1 This is a schematic diagram of the connection structure of the preparation packaging device described in an embodiment of the present utility model.

[0027] Description of reference numerals:

[0028] 1. Main line; 2. Original liquid bag; 3. Recovery line; 4. Recovery valve; 5. Recovery container; 6. Subpackaging line; 7. Subpackaging valve; 8. Preparation subpackaging container; 9. Peristaltic pump; 10. Exhaust pipe; 11. Exhaust port; 12. Exhaust valve; 13. Main valve; 14. Air supply pipe; 15. Air supply valve; 16. Compressed air source; 17. Weighing sensor; 18. Pressure sensor. DETAILED DESCRIPTION

[0029] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features therein can be combined with each other.

[0030] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0031] Example 1

[0032] like Figure 1As shown, the utility model provides a preparation filling device, including a main line, a branch line, a peristaltic pump 9, an exhaust pipe 10 and a controller. Among them, the proximal end of the main line 1 is connected to the raw liquid bag 2, and there are multiple branch lines connected to the main line 1. Each branch line is independently provided with a filling valve 7 and a filling container. Each filling valve 7 can be opened and closed independently. In this embodiment, the branch line connected to the distal end of the main line 1 is the recovery line 3, and the other branch lines are the filling lines 6. The recovery line 3 is sealed and connected to the recovery container 5 and is provided with a recovery valve 4. The recovery valve 4 is used to control the opening and closing of gas or preparation in and out of the recovery container 5. The filling line 6 is sealed and connected to the preparation filling container 8 and is provided with a filling valve 7. The filling valve 7 is used to control the opening and closing of gas or preparation in and out of the preparation filling container 8. The preparation in the raw liquid bag 2 can enter the recovery line 3 along the main line 1 and be recovered to the recovery container 5 or enter the filling line 6 along the main line 1 and be filled into the preparation filling container 8. The peristaltic pump 9 is provided on the main line between the branch line and the raw liquid bag 2. 1, the driving pump is a bidirectional pump that can transport both the preparation and the gas. The recovery container 5 and the preparation sub-packaging container 8 are made of flexible materials. The gas in the recovery container 5 and the preparation sub-packaging container 8 can be emptied by the peristaltic pump 9. A pressure sensor 18 is provided on the main line 1 between the branch line and the peristaltic pump 9 for sensing the air pressure in the main line 1. The exhaust pipe 10 is provided on the main line 1 between the peristaltic pump 9 and the stock liquid bag 2. A main valve 13 is provided on the main line 1 between the exhaust pipe 10 and the stock liquid bag 2. The main valve 13 is used to control the switch of the stock liquid bag 2 to transport the preparation outward. The free end of the exhaust pipe 10 is an exhaust port 11. The exhaust pipe 10 is provided with an exhaust valve 12. The exhaust valve 12 is used to control the switch of the exhaust pipe 10 to discharge gas outward. The controller is electrically connected to the peristaltic pump 9 and the pressure sensor 18 for controlling the switch of the peristaltic pump 9.

[0033] The method for performing preparation subpackaging by the preparation subpackaging device of this embodiment is as follows:

[0034] (1) Connect the recovery container 5 and the preparation dispensing container 8 to the recovery line 3 and the dispensing line 6, respectively. Close the main valve 13, open the recovery valve 4, the dispensing valve 7 and the exhaust valve 12, start the peristaltic pump 9 to rotate forward, and transport the gas in the recovery container 5 and the preparation dispensing container 8 along the main line 1 and the exhaust pipe 10, and finally discharge it outward from the exhaust port 11. When the pressure sensor 18 senses that the air pressure in the main line 1 reaches the negative pressure set value, close the peristaltic pump 9, the exhaust valve 12, the dispensing valve 7 and the recovery valve 4 to complete the exhaust;

[0035] (2) Open the main valve 13 and the recovery valve 4, keep the filling valve 7 closed, start the peristaltic pump 9 to reverse, and pump the preparation in the stock liquid bag 2 along the main line 1 and the recovery line 3 into the recovery container 5. The working time of the peristaltic pump 9 can be calculated based on the volume of the main line 1 between the stock liquid bag 2 and the recovery container 5 and the power of the peristaltic pump 9, or when the preparation continuously and stably enters the recovery container 5 through the recovery line 3, close the peristaltic pump 9 and the recovery valve 4 to complete the pipeline filling;

[0036] (3) Open one of the filling valves 7, start the peristaltic pump 9 to reverse, and pump the preparation in the stock liquid bag 2 along the main line 1 and the filling line 6 into the preparation filling container 8 for filling. The working time of the peristaltic pump 9 can be calculated based on the filling volume and the power of the peristaltic pump 9. Close the peristaltic pump 9 and the filling valve 7 to complete one filling.

[0037] (4) Open another dispensing valve 7 and repeat step (3) until all the preparation dispensing containers 8 are filled, and then close the peristaltic pump 9, the main valve 13 and the dispensing valve 7.

[0038] Example 2

[0039] Based on Example 1, the preparation packaging device of this embodiment also includes an air supply pipe 14, which is connected to the main line 1 between the exhaust pipe 10 and the main valve 13. The air supply pipe 14 is connected to the compressed air source 16, and an air supply valve 15 is provided on the air supply pipe 14.

[0040] Compared with Example 1, the method for preparing a preparation by the preparation filling device of this embodiment further includes step (5): opening the air supply valve 15 and the recovery valve 4, starting the peristaltic pump 9 to reverse, and pumping the preparation remaining in the main line 1 into the recovery container 5 through the gas in the compressed air source 16. The working time of the peristaltic pump 9 can be calculated by the volume of the main line 1 between the compressed air source 16 and the recovery container 5 and the power of the peristaltic pump 9, or when no more preparation enters the recovery container 5 from the recovery line 3, the peristaltic pump 9, the air supply valve 15 and the recovery valve 4 are closed to complete the recovery of the residual preparation.

[0041] Example 3

[0042] On the basis of Example 2, the preparation packaging device of this embodiment further includes a weighing sensor 17, which is arranged at the bottom of the raw liquid bag 2. The weighing sensor 17 is electrically connected to the controller. The weighing sensor 17 senses the weight data of the raw liquid bag 2 and sends it to the controller, which controls the peristaltic pump 9 to switch on or off or adjust the power.

[0043] Compared with Example 2, the method for preparing dispensing by the preparation dispensing device of this embodiment is that, during each dispensing, 80% to 90% of the preset dispensing amount is first pumped into the preparation dispensing container 8 at high speed by the peristaltic pump 9, and then, according to the measurement value of the weighing sensor 17, the controller controls the peristaltic pump 9 to pump the remaining amount into the preparation dispensing container 8 at low speed, and then weighs again, and continues to pump in or extract the preparation of the final difference according to the final weight difference, and then turns off the peristaltic pump 9 and the dispensing pump, thereby achieving precise control of the dispensing amount and high-speed dispensing.

[0044] The embodiments described above are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative work are all within the scope of protection of the present invention.

Claims

1. A preparation packaging device, characterized in that: The preparation filling device includes a main line, the proximal end of which is connected to the stock solution bag, and a weighing sensor is provided at the bottom of the stock solution bag; a branch line, wherein a plurality of branch lines are connected to the main line, one of which is connected to the distal end of the main line, and each branch line is independently provided with a filling valve and a filling container; A driving pump, which is provided on the main pipeline between the branch pipeline and the raw liquid bag; An exhaust pipe is provided on the main pipe between the driving pump and the raw liquid bag. A main valve is provided on the main pipe between the exhaust pipe and the raw liquid bag. An exhaust valve is provided on the exhaust pipe.

2. The preparation packaging device according to claim 1, characterized in that: An air supply pipe is connected to the main pipe between the exhaust pipe and the main valve. The air supply pipe is connected to a compressed air source, and an air supply valve is provided on the air supply pipe.

3. The preparation packaging device according to claim 1, characterized in that: A pressure sensor is provided on the main pipe between the branch pipe and the driving pump.

4. The preparation packaging device according to claim 1, characterized in that: The driving pump is a peristaltic pump or a diaphragm pump.

5. The preparation packaging device according to claim 1, characterized in that: The driving pump is a bidirectional pump.

6. The preparation packaging device according to claim 1, characterized in that: The subpackaging container is a recovery container or a preparation subpackaging container.

7. The preparation packaging device according to claim 1, characterized in that: The branch line connected to the distal end of the main line is a recovery line, which is connected to a recovery container; the other branch lines are sub-packaging lines, which are connected to a preparation sub-packaging container.

8. The preparation packaging device according to claim 1, characterized in that: The preparation packaging device further includes a controller, which is electrically connected to the driving pump, the weighing sensor and the pressure sensor.

9. The preparation packaging device according to claim 1, characterized in that: The packaging container is made of flexible material.

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