Allergen specificity IgE antibody detection data acquisition device

Abstract

The utility model discloses an allergen-specific IgE antibody detection data acquisition device, and particularly relates to the technical field of specific IgE. The allergen-specific IgE antibody detection data acquisition device comprises a portal frame, a plurality of reagent strip placing frames are arranged on the portal frame in a linear array; the vertical projections of the plurality of reagent strip placing racks are staggered along the width direction of the portal frame and are not overlapped with each other; a window; the camera shooting element is used for detecting the windows on the reagent strip placing frames; and a cleaning assembly. According to the allergen specificity IgE antibody detection data acquisition device, through the arrangement of the cleaning assembly, water stains or mist possibly appearing on the camera element due to water vapor evaporation or sputtering is wiped, it is guaranteed that the camera element is always clear, and due to the fact that the vertical projections of the reagent strip placing frames are arranged in the width direction of the portal frame in a staggered mode and do not overlap, the detection accuracy is improved. Therefore, all the windows are detected by the camera element, mutual shielding of the windows is avoided, and the data acquisition efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of specific IgE, in particular to an allergen specific IgE antibody detection data acquisition device. Background Art

[0002] Allergen-specific IgE testing is a test method used to determine whether an individual is allergic to a specific allergen. When entering test data, scanning is usually performed in conjunction with a scanner.

[0003] In conjunction with publication number CN207703727U, publication date 2018-08-07, an allergen-specific IgE detection platform is disclosed, including a cylindrical base and several transparent reaction hoses distributed on the surface of the base and placed along the cylindrical busbar. The base is provided with labels corresponding to each detection position.

[0004] However, the existing test data entry requires staff to use handheld cameras to acquire data, or use machine scanners. During the stacking process of test tubes, the labels may overlap with each other, resulting in unclear identification problems, which is more troublesome. Utility Model Content

[0005] The purpose of the utility model is to provide an allergen-specific IgE antibody detection data acquisition device for solving the above-mentioned problems.

[0006] To achieve the above-mentioned object, the present invention provides the following technical solution: an allergen-specific IgE antibody detection data acquisition device, comprising a gantry frame on which a plurality of reagent strip racks are arranged in a linear array, and the vertical projections of the plurality of reagent strip racks are staggered along the width direction of the gantry frame and do not overlap each other;

[0007] a window disposed on the reagent strip rack;

[0008] An imaging element, which is used to detect windows on a plurality of reagent strip racks;

[0009] a cleaning assembly including a cleaning roller driven to scrape the imaging element;

[0010] The gantry is driven to swing to oscillate multiple reagent strip racks.

[0011] Preferably, the cleaning assembly includes a transmission rod slidably arranged on the gantry, and a cleaning roller is provided on the end of the transmission rod.

[0012] Preferably, the gantry has an inclined state and a vertical state in its swinging stroke, and in the inclined state, the transmission rod loses weight and slides down.

[0013] Preferably, a plurality of pendulums are rotatably arranged inside the gantry.

[0014] Preferably, a sector gear is provided on the pendulum, and a rack meshing with the sector gear is provided on the side of the transmission rod facing the sector gear.

[0015] Preferably, a steel fork is provided on the reagent strip rack, and the steel fork is located inside the gantry and can be struck by a pendulum.

[0016] In the above technical solution, the utility model provides an allergen-specific IgE antibody detection data acquisition device, which has the following beneficial effects: through the setting of the cleaning component, water stains or mist that may appear on the camera element due to water vapor evaporation or splashing are wiped off, ensuring that the camera element is always clear, and because the vertical projections of multiple reagent strip racks are staggered and non-overlapping along the width direction of the gantry, all windows are detected by the camera element, avoiding mutual obstruction of windows and improving data acquisition efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments recorded in the present invention. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0018] Figure 1 An overall three-dimensional schematic diagram provided for an embodiment of the present utility model;

[0019] Figure 2 Schematic diagram of the light shield, gantry and reagent strip rack provided in an embodiment of the present invention;

[0020] Figure 3 A side view schematic diagram of a reagent strip rack provided in an embodiment of the present utility model;

[0021] Figure 4 A schematic top view of a reagent strip rack provided in an embodiment of the present invention;

[0022] Figure 5 The embodiment of the present utility model provides Figure 2 Middle A is an enlarged schematic diagram;

[0023] Figure 6 An overall three-dimensional schematic diagram provided for an embodiment of the present utility model;

[0024] Figure 7 A schematic diagram of the structure of the gantry and camera element provided in an embodiment of the utility model;

[0025] Figure 8 A schematic diagram of the cleaning component structure provided by an embodiment of the utility model;

[0026] Figure 9 A schematic diagram of the pendulum structure within the gantry provided by an embodiment of the utility model;

[0027] Figure 10 The embodiment of the present utility model provides Figure 8 Middle B is an enlarged schematic diagram.

[0028] Description of reference numerals:

[0029] 1. Base; 2. Water tank; 3. Swing assembly; 31. Fan-shaped seat; 32. Rocker; 33. Bump; 34. Corrugated plate; 4. Gantry; 41. Sprinkler head; 42. Pendulum; 43. Fan-shaped gear; 5. Reagent strip holder; 51. Clamp; 52. Clip; 53. Window; 54. Steel fork; 6. Light shield; 7. Retraction belt; 8. Camera element; 9. Cleaning assembly; 91. Cleaning roller; 92. Drive rod; 93. Rack; 10. Air drying device; 101. Air outlet. DETAILED DESCRIPTION

[0030] In order to enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0031] like Figure 1-5 As shown, an allergen-specific IgE antibody detection auxiliary device includes a gantry 4 on which a plurality of reagent strip racks 5 are mounted in a linear array, and a light shield 6 is provided on the gantry 4;

[0032] The swing assembly 3 is used to drive the gantry 4 to swing and oscillate, and includes a fan-shaped seat 31 provided at the bottom of the gantry 4 and a swing rod 32 driven by a motor, the end of the swing rod 32 being rotatably provided on the gantry 4;

[0033] A spray head 41 is provided on the gantry 4 and points toward the reagent strip rack 5;

[0034] The air drying device 10 is disposed on the gantry 4 and is used to air dry the rinsed reagent strips.

[0035] Specifically, a water tank 2 is provided at the bottom of the base 1, and the water tank 2 contains diluted eluent, and the water tank 2 is connected to the spray head 41. A restraining belt 7 is provided on the light shield 6. When flushing the reagent strip, the light shield 6 is lowered to prevent the eluent in the spray head 41 from splashing outside the light shield 6, and the inner layer of the light shield 6 is provided with an opaque coating to avoid affecting the test results. When replacing the reagent strip, the light shield 6 is folded and fixedly stored on the gantry 4 by the restraining belt 7, and the air-drying device 10 is preset with a program for controlling the temperature within a predetermined range, including three gears: low temperature, normal temperature, and high temperature. The appropriate blowing temperature can be selected by adjusting the gear.

[0036] Furthermore, the test kit and specimens to be tested need to be taken out of the cold storage room 30 minutes to one hour in advance before the experiment and restored to room temperature of 18°C ​​to 25°C;

[0037] Prepare the cleaning solution by diluting the eluent with distilled or deionized water at a ratio of 1:25.

[0038] At the same time, the laboratory room temperature should be controlled between 18℃ and 25℃. For every 1℃ increase in room temperature, the incubation time should be reduced by 30 seconds, and vice versa.

[0039] Insert the test strip neatly and horizontally into the test strip rack 5, soak the test strip in the washing solution for 5 minutes, discard the washing solution, add 270 ml of serum, and incubate for 45 minutes;

[0040] Then the motor is started, and the motor output torque drives the rocker arm 32 to move, so that the end of the rocker arm 32 drives the gantry 4 to swing back and forth under the support of the fan-shaped seat 31. Since the bottom surface of the fan-shaped seat 31 is an arc fan, the gantry 4 is relatively stable during the swing process, thereby generating a stable vibration wave, causing the reagent strip to oscillate evenly. At the same time, the eluent is sprayed onto the window 53 through the spray head 41 to fully rinse the reagent strip. After repeated rinsing five times, the spray head 41 is turned off, and the output power of the motor is increased, so that the swing amplitude and frequency of the gantry 4 are increased, and the residual liquid in the rinsed reagent strip is thrown out.

[0041] Add 300 ml of detection antibody (white cap) to the reagent strip and incubate for 45 minutes.

[0042] Start the motor, drive the gantry 4 to swing, and use the spray head 41 to spray the eluent on the window 53 to fully rinse the reagent strip. After repeated rinsing five times, turn off the spray head 41 and increase the motor output power to dry the residual liquid in the reagent strip.

[0043] Add 300 ml of enzyme conjugate (red cap) to the reagent strip and incubate for 20 minutes.

[0044] Start the motor, drive the gantry 4 to swing, and use the spray head 41 to spray the eluent on the window 53 to fully rinse the reagent strip. After repeated rinsing five times, turn off the spray head 41 and increase the motor output power to dry the residual liquid in the reagent strip.

[0045] Add 300 ml of substrate solution (black cap) to the reagent strip and incubate for 20 minutes.

[0046] Start the motor, drive the gantry 4 to swing, and use the spray head 41 to spray the eluent on the window 53 to fully rinse the reagent strip. After repeated rinsing five times, turn off the spray head 41 and increase the motor output power to dry the residual liquid in the reagent strip.

[0047] Finally, the air drying device 10 is started to air dry the reagent strip, and the value is read with a scanner to complete the test report.

[0048] In the above technology, the gantry 4 is driven to swing by the swing component 3, and the swing amplitude and frequency can be adjusted by adjusting the output power of the motor, so that the reagent strip can be fully oscillated, and the eluent sprayed by the spray head 41 is used to rinse the reagent strip, and then the residual liquid in the reagent strip is thrown out by the swing component 3, and finally the air-drying device 10 is started to air-dry the residual liquid, thereby reducing manpower consumption, being able to oscillate and rinse multiple reagent strips at the same time, and the reagent strip is air-dried by the setting of the air-drying device 10.

[0049] As an embodiment further provided by the present invention, the base 1 is further included for supporting the sector seat 31 , and the sector seat 31 is rotatably arranged relative to the base 1 .

[0050] Specifically, the fan-shaped seat 31 is rotatably set on the base 1. Since a wave plate 34 is provided on the base 1 and a plurality of protrusions 33 are provided on the fan-shaped seat 31, during the swinging process of the gantry 4, the fan-shaped seat 31 is driven to rotate in the wave plate 34, so that the protrusions 33 and the wave plate 34 conflict with each other, generating vibration, driving the gantry 4 to vibrate as a whole, further improving the oscillation effect on the reagent strip, and the gantry 4 can rotate along the table top of the base 1, which is convenient for the staff to adjust and take the reagent strip.

[0051] As another embodiment further provided by the present invention, the reagent strip rack 5 includes clamping plates 51 clamped on the gantry 4, and the lengths of the plurality of clamping plates 51 increase vertically from top to bottom.

[0052] Specifically, the splint 51 is equipped with a clamp 52 for clamping multiple reagent strips. Since the lengths of the multiple splints 51 increase vertically from top to bottom, the length of the bottom splint 51 is the longest. During the reciprocating swing of the gantry 4, the farther the part is from the swing axis, the greater the swing force it receives. The vertical distance between the bottom splint 51 and the swing axis is shorter. By extending the splint 51, the distance between the clamp 52 and the swing axis is extended, so that there will not be too large a difference between the oscillation amplitudes of all the reagent strips, and the vertical projections of the reagent strips can be staggered to avoid overlapping, so that the reagent strips can be fully sprayed by the spray head 41.

[0053] As another embodiment further provided by the present invention, the clip 52 is provided with an air outlet 101 which is connected to the output end of the air-drying device 10 and points to the window 53 .

[0054] Specifically, the air outlet 101 is connected to the output end of the air drying device 10 through a connecting pipe, and the air drying device 10 blows air to the air outlet 101, so that the air flows through the air outlet 101 to the window 53 and dries the wet reagent strip, thereby improving the air drying efficiency.

[0055] like Figure 6-10 As shown, an allergen-specific IgE antibody detection data acquisition device includes a gantry 4, on which a plurality of reagent strip racks 5 are arranged in a linear array, and the vertical projections of the plurality of reagent strip racks 5 are staggered along the width direction of the gantry 4 and do not overlap each other;

[0056] Window 53, which is provided on the reagent strip rack 5;

[0057] An imaging element 8 for detecting the windows 53 on the plurality of reagent strip racks 5;

[0058] a cleaning assembly 9 comprising a cleaning roller 91 driven to scrape the imaging element 8;

[0059] The gantry 4 is driven to swing so as to vibrate the plurality of reagent strip racks 5 .

[0060] Specifically, the gantry 4 is provided with a spray head 41 for spraying the reagent strips. After the reagent strip racks 5 are placed on the gantry 4, since the vertical projections of the multiple reagent strip racks 5 are staggered along the width direction of the gantry 4 and do not overlap with each other, the windows 53 on all the reagent strip racks 5 will not block each other. Therefore, the windows 53 are detected by the imaging element 8, and the detection data is entered into the control center through the preset program in the imaging element 8. After spraying, water stains or mist may appear on the imaging element 8 due to evaporation or splashing of water vapor. At this time, the imaging element 8 is wiped by the cleaning roller 91 to ensure that the imaging element 8 is always clear.

[0061] In the above technology, by setting up the cleaning component 9, water stains or mist that may appear on the camera element 8 due to evaporation or splashing of water vapor are wiped off, ensuring that the camera element 8 is always clear. In addition, since the vertical projections of the multiple reagent strip racks 5 are staggered along the width direction of the gantry 4 and do not overlap with each other, all the windows 53 are detected by the camera element 8, avoiding the windows 53 from blocking each other, thereby improving data acquisition efficiency.

[0062] As an embodiment further provided by the present invention, there are an inclined state and a vertical state in the swing stroke of the gantry 4, and in the inclined state, the transmission rod 92 loses weight and slides down.

[0063] Specifically, the transmission rod 92 is slidingly set on the gantry 4. When the gantry 4 is driven to swing, it is in a tilted state. At this time, the transmission rod 92 is tilted and is not in a horizontal state. Under the action of its own weight, the transmission rod 92 slides downward, thereby driving the cleaning roller 91 to slide relative to the camera element 8, thereby scraping and cleaning the camera element 8. The gantry 4 swings back and forth to make the transmission rod 92 slide back and forth. When the gantry 4 returns to a vertical state, the transmission rod 92 stops sliding.

[0064] As another embodiment further provided by the present invention, a plurality of pendulums 42 are rotatably arranged inside the gantry 4 .

[0065] Specifically, when the gantry 4 swings, it drives multiple pendulums 42 to swing. Since the pendulums 42 are rotatably arranged in the gantry 4, there is a speed difference between the swing of the pendulums 42 and the swing of the gantry 4, so that the pendulums 42 will collide with the inner wall of the gantry 4 and cause the gantry 4 to vibrate, thereby expanding the oscillation effect of the gantry 4 on the reagent strip. In addition, a steel fork 54 is provided on the reagent strip rack 5, and the steel fork 54 is located on the inner side of the gantry 4 and can be struck by the pendulum 42. The pendulum 42 strikes the steel fork 54 and drives the steel fork 54 to vibrate, thereby driving the reagent strip rack 5 to vibrate, thereby improving the oscillation effect on the reagent strip.

[0066] As another embodiment further provided by the present invention, a sector gear 43 is provided on the pendulum 42 , and a rack 93 meshing with the sector gear 43 is provided on the side of the transmission rod 92 facing the sector gear 43 .

[0067] Specifically, when the gantry 4 starts to swing, it drives the transmission rod 92 to move synchronously. At this time, the pendulum 42 still maintains a vertical state under the action of its own weight, so the pendulum 42 rotates relative to the transmission rod 92, and the fan gear 43 on the pendulum 42 drives the rack 93 to slide through meshing transmission, and then the pendulum 42 swings with the gantry 4, but there is a speed difference between the swing of the pendulum 42 and the swing of the gantry 4, so that the pendulum 42 always rotates relative to the transmission rod 92 during the swinging process, thereby driving the rack 93 to slide back and forth, thereby causing the transmission rod 92 to slide back and forth and wipe the camera element 8 through the cleaning roller 91 at the end. When the gantry 4 returns to the vertical state, the pendulum 42 also returns to the vertical state under the action of its own weight, and drives the rack 93 to return to the center position of the gantry 4 through the fan gear 43. At this time, the cleaning rollers 91 at both ends of the transmission rod 92 do not interfere with the camera element 8.

[0068] Working principle: Before the experiment, the test kit and the specimen to be tested need to be taken out of the cold room 30 minutes to one hour in advance and restored to room temperature of 18℃ to 25℃;

[0069] Prepare the cleaning solution by diluting the eluent with distilled or deionized water at a ratio of 1:25.

[0070] At the same time, the laboratory room temperature should be controlled between 18℃ and 25℃. For every 1℃ increase in room temperature, the incubation time should be reduced by 30 seconds, and vice versa.

[0071] Insert the test strip neatly and horizontally into the test strip rack 5, soak the test strip in the washing solution for 5 minutes, discard the washing solution, add 270 ml of serum, and incubate for 45 minutes;

[0072] Then, the light shield 6 is lowered and the motor is started. The motor output torque drives the rocker arm 32 to move, so that the end of the rocker arm 32 drives the gantry 4 to swing back and forth under the support of the fan-shaped seat 31. Since the bottom surface of the fan-shaped seat 31 is an arc fan, the gantry 4 is relatively stable during the swinging process, thereby generating a stable vibration wave, causing the reagent strip to oscillate evenly. At the same time, the eluent is sprayed onto the window 53 through the spray head 41 to fully rinse the reagent strip. After repeated rinsing five times, the spray head 41 is turned off, and the output power of the motor is increased, so that the swing amplitude and frequency of the gantry 4 are increased, and the residual liquid in the rinsed reagent strip is thrown out.

[0073] Add 300 ml of detection antibody (white cap) to the reagent strip and incubate for 45 minutes.

[0074] Start the motor, drive the gantry 4 to swing, and use the spray head 41 to spray the eluent on the window 53 to fully rinse the reagent strip. After repeated rinsing five times, turn off the spray head 41 and increase the motor output power to dry the residual liquid in the reagent strip.

[0075] Add 300 ml of enzyme conjugate (red cap) to the reagent strip and incubate for 20 minutes.

[0076] Start the motor, drive the gantry 4 to swing, and use the spray head 41 to spray the eluent on the window 53 to fully rinse the reagent strip. After repeated rinsing five times, turn off the spray head 41 and increase the motor output power to dry the residual liquid in the reagent strip.

[0077] Add 300 ml of substrate solution (black cap) to the reagent strip and incubate for 20 minutes.

[0078] Start the motor, drive the gantry 4 to swing, and use the spray head 41 to spray the eluent on the window 53 to fully rinse the reagent strip. After repeated rinsing five times, turn off the spray head 41 and increase the motor output power to dry the residual liquid in the reagent strip.

[0079] Finally, the air drying device 10 is started to air dry the reagent strip, and the value is read with a scanner to complete the test report.

[0080] The gantry 4 is provided with a spray head 41 for spraying the reagent strips. After the reagent strip racks 5 are placed on the gantry 4, the vertical projections of the multiple reagent strip racks 5 are staggered along the width of the gantry 4 and do not overlap. At this time, the windows 53 on all the reagent strip racks 5 do not block each other. Therefore, the windows 53 are detected by the camera element 8, and the detection data is recorded into the control center through the preset program in the camera element 8.

[0081] The motor output torque drives the swing rod 32 to move, so that the end of the swing rod 32 drives the gantry 4 to swing back and forth under the support of the fan-shaped seat 31, and the fan-shaped seat 31 is provided with a plurality of protrusions 33. During the swinging process of the gantry 4, the fan-shaped seat 31 is driven to rotate in the wave plate 34, so that the protrusions 33 and the wave plate 34 conflict with each other, generating vibrations, driving the gantry 4 to vibrate as a whole, further improving the oscillation effect on the reagent strip, and turning on the spray head 41 to spray the reagent strip. When the gantry 4 starts to swing, it drives the transmission rod 92 to move synchronously. At this time, the pendulum 42 still maintains a vertical state under the action of its own weight. Therefore, the pendulum 42 rotates relative to the transmission rod 92, and the fan gear 43 on the pendulum 42 drives the rack 93 to slide through meshing transmission, and then the pendulum 42 swings with the gantry 4. However, there is a speed difference between the swing of the pendulum 42 and the swing of the gantry 4, so that the pendulum 42 always rotates relative to the transmission rod 92 during the swing process, thereby driving the rack 93 to slide back and forth, thereby causing the transmission rod 92 to slide back and forth and wipe the camera element 8 through the cleaning roller 91 at the end. When the pendulum 42 collides with the inner wall of the gantry 4, the pendulum 42 hits the steel fork 54 and drives the steel fork 54 to vibrate, thereby driving the reagent strip rack 5 to vibrate, thereby improving the oscillation effect on the reagent strip. When the gantry 4 returns to the vertical state, the pendulum 42 also returns to the vertical state under the action of its own weight, and drives the rack 93 to return to the center position of the gantry 4 through the fan gear 43. At this time, the cleaning rollers 91 at both ends of the transmission rod 92 do not interfere with the camera element 8, and the window is photographed again through the camera element 8 to obtain data.

[0082] At the same time, the eluent is sprayed downward through the spray head 41 to fully rinse the reagent strips. The distance between the clamp 52 and the swing axis is extended by the extended splint 51, so that there will not be too large a difference between the oscillation amplitudes of all reagent strips. After the rinsing is completed, since the air-drying device 10 is preset with a program for controlling the temperature within a predetermined range, including three gears of low temperature, normal temperature and high temperature, the appropriate blowing temperature can be selected by adjusting the gear, and the air outlet 101 is connected to the output end of the air-drying device 10 through a connecting pipe. The air outlet 101 is blown by the air-drying device 10, so that the air flow passes through the air outlet 101 to flow to the window 53 and dry the wet reagent strips, thereby improving the air-drying efficiency. Finally, the light shield 6 is folded and fixedly stored on the gantry 4 by the tightening belt 7, and the reagent strips are replaced.

[0083] The above description is merely illustrative of certain exemplary embodiments of the present invention. It goes without saying that those skilled in the art will be able to modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and description are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A device for acquiring data for detecting allergen-specific IgE antibodies, characterized in that: include: A gantry (4) is provided with a plurality of reagent strip racks (5) in a linear array, and vertical projections of the plurality of reagent strip racks (5) are staggered along the width direction of the gantry (4) and do not overlap each other; A window (53) is provided on the reagent strip rack (5); An imaging element (8) for detecting windows (53) on a plurality of reagent strip racks (5); A cleaning assembly (9) comprising a cleaning roller (91) driven to scrape the imaging element (8); The gantry (4) is driven to swing to oscillate the plurality of reagent strip racks (5).

2. The allergen-specific IgE antibody detection data acquisition device according to claim 1, characterized in that: The cleaning assembly (9) comprises a transmission rod (92) slidably arranged on the gantry (4), and a cleaning roller (91) is arranged on the end of the transmission rod (92).

3. The device for acquiring data of allergen-specific IgE antibody detection according to claim 2, characterized in that: The gantry (4) has an inclined state and a vertical state in its swinging stroke, and in the inclined state, the transmission rod (92) loses weight and slides down.

4. The device for acquiring data of allergen-specific IgE antibody detection according to claim 3, characterized in that: A plurality of pendulums (42) are rotatably arranged inside the gantry (4).

5. The device for acquiring data of allergen-specific IgE antibody detection according to claim 4, characterized in that: The pendulum (42) is provided with a sector gear (43), and a rack (93) meshing with the sector gear (43) is provided on the side of the transmission rod (92) facing the sector gear (43).

6. The device for acquiring data of allergen-specific IgE antibody detection according to claim 1, characterized in that: The reagent strip rack (5) is provided with a steel fork (54), and the steel fork (54) is located inside the gantry (4) and can be struck by the pendulum (42).

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