Fully automatic homogeneous chemiluminescence instant detection analyzer and control method thereof

Abstract

This invention provides a fully automated homogeneous chemiluminescence real-time detection analyzer and its control method. The analyzer includes: a sample compartment containing multiple sample tubes; a tip head compartment containing multiple tip heads; a reagent strip compartment containing multiple reagent strips; a reaction disk capable of being driven to rotate and having multiple placement positions; a gripper unit capable of gripping a reagent strip delivered from the reagent strip compartment and placing it on a placement position of the reaction disk; and a liquid dispensing unit assembled with a tip head delivered from the tip head compartment, which aspirates the sample from the sample tube delivered from the sample compartment and the reagent from the reagent hole of the reagent strip on the reaction disk, and places the sample and / or reagent into the detection hole of the same reagent strip. This invention greatly simplifies the real-time detection process, enables batch online loading of consumables, reagents, and samples, has a high degree of automation to meet the needs of continuous detection and batch loading, and can achieve unmanned operation, reducing labor costs.

Description

Technical Field

[0001] This invention belongs to the field of immunodiagnostic technology, specifically relating to a fully automated homogeneous chemiluminescence real-time detection and analysis instrument and its control method. Background Technology

[0002] The current disadvantages of POCT instruments in the IVD (In Vitro Diagnostics) industry on the market are as follows: 1. To save reagent waste, most instruments are packaged in single-use containers, requiring operators to place each container onto the instrument one by one, resulting in cumbersome operation; 2. Testing methods are all based on single-sample testing or round-robin testing, thus requiring dedicated personnel to operate the instruments when performing large-scale testing, increasing the hospital's labor costs; 3. Due to the single-use container design, batch setup and testing cannot be performed when encountering large-scale testing; 4. Due to the limitations of the instrument's size, batch setting of consumables, reagents, and samples is not possible, nor can online loading be achieved; 5. Because the instruments use fixed steps and fixed sequences, they cannot test items with different testing times and reagent combinations, limiting reagent development. Summary of the Invention

[0003] Therefore, the technical problem to be solved by the present invention is to provide a fully automated homogeneous chemiluminescence real-time detection and analysis instrument and its control method, which greatly simplifies the real-time detection process, enables batch online loading of consumables, reagents and samples, has a high degree of automation to meet the needs of continuous detection and batch loading, and can achieve unmanned operation, thus reducing labor costs.

[0004] To address the above problems, this invention provides a fully automated homogeneous chemiluminescence real-time detection and analysis instrument, comprising:

[0005] The sample compartment contains multiple sample tubes;

[0006] The tip head compartment contains multiple tip heads;

[0007] A reagent strip compartment containing multiple reagent strips, each of which includes at least a reagent well and a detection well.

[0008] The reaction disk is capable of being driven to rotate and has multiple placement positions extending along its diameter.

[0009] The gripper unit is capable of gripping the reagent strips delivered from the reagent strip compartment and placing them in a placement position on the reaction tray;

[0010] The liquid dispensing unit is capable of assembling with a tip head delivered from the tip head compartment, and drawing up the sample from the sample tube delivered from the sample compartment and the reagent from the reagent well of the reagent strip located at the placement position of the reaction plate, and placing the sample and / or reagent into the detection well of the same reagent strip;

[0011] The homogeneous chemiluminescence immunoassay module is capable of collecting the luminescence information of the reaction solution in the detection well of the reagent strip on the reaction plate.

[0012] In some implementations...

[0013] The sample compartment has at least one sample rack, on which multiple sample tubes are placed; or,

[0014] The tip head compartment has at least one tray, on which multiple tips are placed; or...

[0015] The reagent strip compartment has at least one reagent rack, and multiple reagent strips are placed in the reagent rack.

[0016] In some implementations...

[0017] The sample chamber includes multiple independent sample inlet channels, with multiple sample racks corresponding to each sample inlet channel. It also includes a sample inlet drive component, which can drive the sample racks to move linearly toward or away from the liquid collection unit.

[0018] In some implementations...

[0019] The sample introduction drive component can selectively drive the sample holder located within one of the plurality of sample introduction channels.

[0020] In some implementations...

[0021] The tip head compartment has a consumable initial position and a platform and a consumable driving component located above the consumable initial position. The consumable driving component can drive the tray carrying the tip head to move linearly from the consumable initial position toward the liquid dispensing unit, and can drive the tray to move linearly away from the liquid dispensing unit after the tip head carried by the tray is used up, so that the tray with the used tip head is placed on the platform.

[0022] In some implementations...

[0023] The consumable initial position has a first track, and the platform has a second track. A switching element is provided between the first track and the second track. The switching element can tilt and connect the first track and the second track during the linear movement of the tray away from the liquid dispensing unit, so that the tray with the tip head used up can enter the platform. The switching element can also be lifted upward by the tray during the linear movement of the tray towards the liquid dispensing unit.

[0024] In some implementations...

[0025] The reagent strip compartment includes multiple independent reagent strip feeding channels, and multiple reagent racks are respectively located on each of the reagent strip feeding channels. It also includes a feeding drive device, which can drive the bottom reagent strip of the reagent rack to move linearly toward the gripper unit.

[0026] In some implementations...

[0027] The liquid dispensing unit includes a liquid dispensing component, a first lateral movement drive component capable of driving the liquid dispensing component to move horizontally, and a first longitudinal movement drive component capable of driving the liquid dispensing component to move vertically. The driving direction of the first lateral movement drive component coincides with a diameter direction of the reaction disk. The gripper unit includes a gripping component, a second lateral movement drive component capable of driving the gripping component to move horizontally, and a second longitudinal movement drive component capable of driving the gripping component to move vertically. The driving direction of the second lateral movement drive component is parallel to and horizontally spaced from the driving direction of the first lateral movement drive component. The length direction of the reagent strip gripped by the gripping component is perpendicular to the driving direction of the second lateral movement drive component, so as to ensure that the reagent strip placed at the placement position can be placed within the liquid dispensing operation range of the liquid dispensing unit after the reaction disk is rotated 90°.

[0028] This invention also provides a control method for a fully automated homogeneous chemiluminescence real-time detection and analysis instrument, used to control the aforementioned fully automated homogeneous chemiluminescence real-time detection and analysis instrument, comprising:

[0029] Obtain the attribute information of the reagent strip grasped by the gripper unit, and place the reagent strip in an empty placement position on the reaction plate;

[0030] The control mode corresponding to the captured reagent strip is determined based on the attribute information.

[0031] The operation of the liquid extraction unit, gripper unit, and reaction plate is controlled according to the control mode.

[0032] In some implementations...

[0033] When the attribute information is a single-step reagent mixing type, the corresponding control mode is the single-step control mode. In this mode:

[0034] The reaction disk is controlled to rotate to position the reagent strip for sample application. Then, the dispensing unit, carrying the tip, draws the sample from the corresponding sample tube and mixes the reagents from all wells of the reagent strip before injecting them into the detection wells of the reagent strip.

[0035] The reaction disk is used to incubate the reaction solution in the detection well of the reagent strip.

[0036] The system controls the rotation of the completed reagent strip in the reaction tray to the reagent strip entry / exit position, and then controls the gripper unit to remove the completed reagent strip from the reaction tray and dispose of it in the waste bin.

[0037] After a first preset incubation time, the reaction disk is rotated to the detection position to detect the reaction liquid in the detection well of the reagent strip; or,

[0038] When the attribute information is a two-step reagent mixing type, the corresponding control mode is a two-step control mode. In this mode:

[0039] The reaction disk is controlled to rotate to position the reagent strip for sample addition. Then, the dispensing unit, carrying the tip, draws the sample from the corresponding sample tube and from a portion of the reagent wells on the reagent strip, mixes the mixture, and injects it into the detection wells of the reagent strip.

[0040] The reaction disk is used to incubate the reaction solution in the detection well of the reagent strip.

[0041] The system controls the reaction disk to rotate the tested reagent strip to the reagent strip entry / exit position, and then controls the gripper unit to remove the tested reagent strip from the reaction disk and dispose of it in the waste bin.

[0042] The reaction disk is controlled to rotate so that the reagent strip is rotated back to the sample addition position. Then, the liquid dispensing unit, carrying the tip, is controlled to draw the reagent to be added a second time from the remaining reagent wells of the reagent strip and inject it into the detection well of the reagent strip.

[0043] After a second preset incubation time, the reaction disk is rotated to the detection position to detect the reaction liquid in the detection hole of the reagent strip.

[0044] This invention provides a fully automated homogeneous chemiluminescence real-time detection analyzer and its control method. It is equipped with a sample compartment containing multiple sample tubes, a tip head compartment containing multiple tip heads, and a reagent strip compartment containing multiple reagent strips. The positional changes of the sample tubes, tip heads, and reagent strips in each step of the real-time detection process are achieved through translation within the parallel plane of the liquid dispensing unit and the gripper unit, and rotation within the rotational plane of the reaction disk. This greatly simplifies the real-time detection process, enables batch online loading of consumables, reagents, and samples, and achieves a high degree of automation to meet the needs of continuous detection and batch loading. Furthermore, it enables unmanned operation, reducing labor costs. Attached Figure Description

[0045] Figure 1This is a three-dimensional structural schematic diagram of the fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to an embodiment of the present invention;

[0046] Figure 2 for Figure 1 A schematic diagram of the three-dimensional structure of the sample compartment;

[0047] Figure 3 for Figure 1 A 3D structural diagram of the Tip head compartment;

[0048] Figure 4 for Figure 1 A three-dimensional structural diagram of the reagent strip compartment;

[0049] Figure 5 for Figure 1 A three-dimensional structural diagram of the grasping unit in the image;

[0050] Figure 6 for Figure 1 A three-dimensional structural diagram of the reaction disk (disassembled);

[0051] Figure 7 for Figure 1 A three-dimensional structural diagram of the liquid extraction unit in the image;

[0052] Figure 8 for Figure 1 A three-dimensional structural diagram of the homogeneous chemiluminescence immunoassay module in the image.

[0053] The reference numerals in the attached figures are as follows:

[0054] 1. Sample compartment; 11. Sample rack; 12. Sample inlet channel; 13. Sample inlet drive unit; 2. Tip head compartment; 21. Tray; 211. Tip head; 22. Consumable drive unit; 23. Switching unit; 241. Consumable initial position; 242. Platform; 3. Reagent strip compartment; 31. Reagent rack; 32. Reagent strip feed channel; 33. Feed drive device; 4. Grip unit; 41. Grip assembly; 42. Second lateral movement drive assembly; 43. 5. Second longitudinal movement drive assembly; 6. Reaction disk; 7. Substrate; 8. Incubation plate; 9. Incubation hole; 10. Heating plate; 11. Reaction disk drive motor; 12. Liquid collection unit; 13. Liquid collection assembly; 14. First transverse movement drive assembly; 15. First longitudinal movement drive assembly; 16. Homogeneous chemiluminescence immunoassay module; 17. Detection head; 18. Light-dense element; 19. Light-dense section; 20. Receiving unit; 21. Control box. Detailed Implementation

[0055] See Figures 1 to 8As shown in the embodiment of the present invention, a fully automated homogeneous chemiluminescence instantaneous detection and analysis instrument is provided, comprising: a sample chamber 1 containing multiple sample tubes; a tip head chamber 2 containing multiple tip heads 211; a reagent strip chamber 3 containing multiple reagent strips, each reagent strip including at least a reagent hole and a detection hole; a reaction disk 5, which can be driven to rotate and has multiple placement positions extending along its diameter direction, and understandably also has an incubation mechanism; a gripper unit 4, which can grip the reagent strip delivered from the reagent strip chamber 3 and place it on one placement position of the reaction disk 5; a liquid collection unit 6, which can be assembled with one tip head 211 delivered from the tip head chamber 2, and aspirate the sample from the sample tube delivered from the sample chamber 1 and the reagent from the reagent hole of the reagent strip at the placement position of the reaction disk 5, and place the sample and / or reagent into the detection hole of the same reagent strip; and a homogeneous chemiluminescence immunoassay module 7, which can collect the luminescence information of the reaction liquid in the detection hole of the reagent strip on the reaction disk 5.

[0056] This technical solution simultaneously configures a sample compartment 1 with multiple sample tubes, a tip head compartment 2 with multiple tip heads 211, and a reagent strip compartment 3 with multiple reagent strips. The positional changes of the sample tubes, tip heads 211, and reagent strips in each step of the point-of-care testing process are achieved by translation within the parallel plane (XZ plane) of the liquid dispensing unit 6 and the gripper unit 4, and rotation within the rotational plane (XY plane) of the reaction disk 5. This greatly simplifies the point-of-care testing process, enables batch online loading of consumables (i.e., tip heads 211), reagents, and samples, and has a high degree of automation to meet the requirements of continuous testing and batch loading. It also enables unmanned operation and reduces labor costs.

[0057] In some embodiments, the sample compartment 1 has at least one sample rack 11, on which multiple sample tubes are placed. By driving the sample rack 11, samples can be smoothly and stably injected into the corresponding position (i.e., the position corresponding to the liquid dispensing head of the liquid dispensing unit 6); or, the tip head compartment 2 has at least one tray 21, on which multiple tip heads 211 are placed. By driving the tray 21, the corresponding tip head 211 can be smoothly and stably placed in the corresponding position (i.e., the position corresponding to the liquid dispensing head of the liquid dispensing unit 6); or, the reagent strip compartment 3 has at least one reagent rack 31, on which multiple reagent strips are placed. Each reagent strip has a reagent volume for one person. Multiple reagent strips can be placed into the reagent strip compartment 3 at one time through the reagent rack 31, realizing the batch online supply of reagent strips.

[0058] The sample chamber 1 includes multiple independent sample inlet channels 12 (such as...). Figure 2As shown, the system has three sample inlet channels 12, with multiple sample holders 11 corresponding to each of the sample inlet channels 12. It also includes a sample inlet drive component 13, which can drive the sample holders 11 to move linearly toward or away from the liquid collection unit 6 (i.e., along...). Figure 1 The linear motion along the Y-axis enables batch online loading of samples. After the operator places a sample rack 11 filled with sample tubes in each sample inlet channel 12, the sample drive component 13 can control the sample rack 11 in the corresponding sample inlet channel 12 to move along the Y-axis to the position directly below the liquid collection head of the liquid collection unit 6 under the preset program of the instrument's control component (e.g., control box 9). This achieves fully automatic, batch online sample processing, saving labor costs and eliminating the need for 24 / 7 human supervision.

[0059] The sample introduction drive component 13 can selectively drive the sample holder 11 disposed within one of the plurality of sample introduction channels 12, specifically, it can move laterally along a direction perpendicular to the sample introduction direction of the sample introduction channel 12 (i.e., Figure 1 (in the X-axis direction) to achieve sample feeding drive of sample holders 11 in multiple sample feeding channels 12.

[0060] In some embodiments, the tip head compartment 2 has a consumable initial position 241, a platform 242 above the consumable initial position 241, and a consumable driving component 22. The consumable driving component 22 can drive the tray 21 carrying the tip head 211 to move linearly from the consumable initial position 241 toward the liquid dispensing unit 6, and can drive the tray 21 to move linearly away from the liquid dispensing unit 6 after the tip head 211 carried by the tray 21 is used up, so that the tray 21 with the tip head 211 used up is placed on the platform 242. In this technical solution, the tip head compartment 2 is constructed as a vertically stacked structure. This allows the tray 21 to be automatically supplied to the dispensing position of the liquid dispensing unit 6 when it is carrying tip heads 211, and to be placed on the upper platform 242 after the tip heads 211 are used up. This greatly reduces the space occupied by the instrument. At the same time, the operator only needs to place the consumable components (composed of tray 21 and tip heads 211) in the initial consumable position 241 or remove them from the platform, without having to put their hands inside, which improves the safety of the equipment and facilitates user operation.

[0061] The consumable initial position 241 has a first track, and the platform 242 has a second track. A switching element 23 is provided between the first track and the second track. The switching element 23 can tilt and connect the first track and the second track during the linear movement of the tray 21 away from the liquid dispensing unit 6, so that the tray 21 with the tip head 211 exhausted can enter the platform 242. The switching element 23 can also be lifted upward by the tray 21 during the linear movement of the tray 21 towards the liquid dispensing unit 6. In this technical solution, the inclined connection design of the switching element 23 between the first track and the second track ensures that the tray 21 carrying the tip head 211 can move smoothly to the dispensing position of the liquid dispensing unit 6 during the consumable supply process. During this process, the tray 21 will push the switching element 23 upward (the switching element 23 and one side of the first track where the tray 21 is located form an acute angle). After the tip head on the tray 21 is used up, the consumable driving component 22 pushes the tray 21 in the opposite direction towards the consumable initial position 241 and slides along the first track. When it reaches the position of the switching element 23, the switching element 23 and one side of the first track where the tray 21 is located form an obtuse angle, and the switching element 23 cannot be pushed up. The tray 21 then enters the second track along the switching element 23 and is placed on the platform 242 above.

[0062] In some embodiments, the reagent strip compartment 3 includes multiple independent reagent strip feeding channels 32, with multiple reagent racks 31 corresponding to each reagent strip feeding channel 32. It also includes a feeding drive device 33, which can drive the reagent strip at the bottom of the reagent rack 31 to move linearly toward the gripper unit 4. The gripper unit 4 can grab the reagent strip and translate it in the XZ plane to place it in the placement position (idle placement position) of the reaction plate 5, thereby realizing the batch online supply of reagent strips.

[0063] In some embodiments, the liquid dispensing unit 6 includes a liquid dispensing component 61, a first transverse drive component 62 capable of driving the liquid dispensing component 61 to move horizontally, and a first longitudinal drive component 63 capable of driving the liquid dispensing component 61 to move vertically. The driving direction of the first transverse drive component 62 coincides with a diameter direction of the reaction disk 5. The gripper unit 4 includes a gripping component 41, a second transverse drive component 42 capable of driving the gripping component 41 to move horizontally, and a second longitudinal drive component 43 capable of driving the gripping component 41 to move vertically. The driving direction of the second transverse drive component 42 is parallel to and horizontally spaced from the driving direction of the first transverse drive component 62. The length direction of the reagent strip gripped by the gripping component 41 is perpendicular to the driving direction of the second transverse drive component 42, so as to ensure that the reagent strip placed at the placement position can be placed within the liquid dispensing operation range of the liquid dispensing unit 6 after the reaction disk 5 is rotated 90°. In this technical solution, the reaction disk 5 can realize functions such as reagent strip placement and incubation, and can also realize the displacement difference between the gripper unit 4 and the liquid taking unit 6 in the Y-axis direction by rotation, making the overall structure of the instrument simpler, more compact and reasonable.

[0064] The reaction disk 5 includes a base 511 on which a plurality of reagent strip placement positions are constructed along its radial direction. The base 511 is provided with an incubation plate 513 having an incubation hole 5131 and a heating plate 514 capable of heating the incubation plate 513. The base 511 can rotate and switch positions under the drive of the reaction disk drive motor 541.

[0065] The homogeneous chemiluminescence immunoassay module 7 includes a detection component, including a detection head 710 that can be driven to move up and down; and a light-dense component component, including a light-dense component 711, on which a light-dense section 7111 is constructed. The light-dense component 711 can switch between a first position and a second position. When the light-dense component 711 is in the first position, the light-dense component 711 enables the light-transmitting structure of the detection head 710 to achieve light-dense transmission. When the light-dense component 711 is in the second position, the light-dense structure of the reagent strip corresponding to the detection head 710 enables the light-transmitting structure of the detection head 710 to achieve light-dense transmission. In this technical solution, after the detection module completes the detection operation on the reagent strip and the light-dense structure of the reagent strip separates, the light-dense structure of the light-dense element 711 can continue the light-dense operation, greatly increasing the time the detection head is in a dark light-dense environment. The time the detection head is in contact with the outer ring light environment is only the switching time between the light-dense structure of the reagent strip and the light-dense element 711, that is, the switching time between the first position and the second position. In specific operation, the photomultiplier tube of the detection head can be disconnected from the power supply during this switching time. This reduces the possibility of damage to the photomultiplier tube caused by exposure to external ambient light, and increases the power supply time of the photomultiplier tube, making the signal more stable and effectively reducing signal fluctuations after the photomultiplier tube is re-energized, thereby improving the accuracy of the detection results.

[0066] According to an embodiment of the present invention, a control method for a fully automated homogeneous chemiluminescence real-time detection and analysis instrument is also provided, for controlling the aforementioned fully automated homogeneous chemiluminescence real-time detection and analysis instrument, comprising:

[0067] Obtain the attribute information of the reagent strip grasped by the gripper unit 4, and place the reagent strip in the vacant placement position of the reaction plate 5;

[0068] The control mode corresponding to the captured reagent strip is determined based on the attribute information.

[0069] The operation of the liquid extraction unit 6, the gripper unit 4, and the reaction plate 5 is controlled according to the control mode.

[0070] In this technical solution, by obtaining the attribute information of the reagent strip, the control mode of the corresponding reagent strip can be obtained. Different incubation and detection programs can be run for different reagent strips. Specifically, different detection times and reaction disk 5 rotation control sequences can be used to achieve different detection items for different reagent strips.

[0071] Specifically, when the attribute information is a single-step reagent mixing type, the corresponding control mode is a single-step control mode. In this mode: the reaction disk 5 is controlled to rotate to rotate the reagent strip to the sample addition position. Then, the liquid dispensing unit 6, carrying the tip head 211, draws the sample from the corresponding sample tube and mixes the reagents from all the reagent holes of the reagent strip, injecting the mixture into the detection hole of the reagent strip. The reaction disk 5 is controlled to incubate the reaction solution in the detection hole of the reagent strip. The reagent strip that has been tested in the reaction disk 5 is controlled to rotate to the reagent strip entry / exit position. The gripper unit 4 is controlled to remove the tested reagent strip from the reaction disk 5 and discard it in the waste bin. After incubation for a first preset time, the reaction disk 5 is controlled to rotate to the detection position to detect the reaction solution in the detection hole of the reagent strip.

[0072] When the attribute information is a two-step reagent mixing type, the corresponding control mode is a two-step control mode. In this mode: the reaction disk 5 is controlled to rotate to rotate the reagent strip to the sample addition position. Then, the liquid extraction unit 6, carrying the tip 211, is controlled to extract the sample from the corresponding sample tube and extract the reagent to be added for the first time from part of the reagent holes of the reagent strip, mix them, and inject them into the detection hole of the reagent strip. The reaction disk 5 is controlled to incubate the reaction solution in the detection hole of the reagent strip. The reagent strip that has been tested by the reaction disk 5 is controlled to rotate to the reagent strip entry / exit position. The gripper unit 4 is controlled to remove the tested reagent strip from the reaction disk 5 and discard it in the waste bin. The reaction disk 5 is controlled to rotate to rotate the reagent strip to the sample addition position again. Then, the liquid extraction unit 6, carrying the tip 211, is controlled to extract the reagent to be added for the second time from the remaining reagent holes of the reagent strip and inject it into the detection hole of the reagent strip. After incubation for a second preset time, the reaction disk 5 is controlled to rotate to the detection position to detect the reaction solution in the detection hole of the reagent strip.

[0073] This design allows for full utilization of time intervals for sampling, incubation, and post-testing processing, making the testing process more time-saving and efficient.

[0074] The fully automated homogeneous chemiluminescence real-time detection and analysis instrument of the present invention will be further described below with reference to a specific embodiment:

[0075] The analyzer hardware of this invention consists of a central control touch screen (not shown in the figure), a main control circuit board (not shown in the figure, located inside the control box 9), a sample compartment 1, a tip head compartment 2, a reagent strip compartment 3, a liquid dispensing unit 6, a gripper unit 4, a homogeneous chemiluminescence immunoassay module 7, a reaction plate 5, etc. The software consists of an upper computer and a lower computer.

[0076] The application process of this analyzer is as follows:

[0077] 1. To address the issue of single-sample reagent loading, this solution incorporates eight independent reagent strip compartments 3. These eight compartments can hold the same or different reagents. Each compartment 3 can hold multiple samples, enabling batch loading. Furthermore, each of the eight independent compartments 3 can operate independently. When a compartment runs out of reagents, it can be loaded with reagents without shutting down the system, thus enabling online loading for large instruments.

[0078] 2. Tip head compartment 2 uses a whole box of tips for each test, avoiding the need to apply tips for each test and reducing user steps. In addition, the tip head compartment uses two boxes of tips for relay use, avoiding downtime caused by running out of tips and speeding up the testing process.

[0079] 3. Sample compartment 1 uses 3 independent sample racks 11, each of which can hold multiple samples. This increases the amount of samples that can be loaded at one time and avoids the inconvenience of the operator having to stay by the instrument all the time.

[0080] 4. This invention uses a central touchscreen for human-machine information exchange, making instrument operation simple and convenient.

[0081] 5. The automatic method of this invention is as follows: Reagent information and Tip head information are set via a touch screen. ① When testing a sample, the required single-use reagent strip is grabbed from the reagent strip compartment 3, and the reaction disk 5 rotates its empty channel to the reagent strip placement position. ② The gripper unit 4 moves the reagent strip to the reaction disk 5 and places the reagent strip on the empty channel of the reaction disk 5. ③ The liquid dispensing unit 6 moves to the intersection point in conjunction with the Tip head compartment 2, and the liquid dispensing unit 6 obtains the Tip head 211. ④ The sample holder 11 and the liquid dispensing unit 6 move to the intersection point simultaneously, and the liquid dispensing unit 6 obtains the sample and places the sample into the Tip head 211. ⑤ The Tip head 211 carrying the sample moves to the reaction disk 5 and removes the components of the reagent strip that were just placed into the reaction well. ⑥ Depending on the specificity of the project, if there is a second step of reagent addition, the instrument automatically performs the second step of the process. If there is no second step, after the reagent reaction is completed, the reaction disk 5 moves to the detection position, and the homogeneous chemiluminescence immunoassay module 7 reads the number of photons in the reagent, and the concentration value is calculated by the software. ⑦ The final test results are displayed on the central control touchscreen.

[0082] 6. After the test is completed, the gripper cooperates with the reaction plate 5 to grab the used reagent strip and throw it into the waste bin. The used tip head is also automatically retracted into the waste bin, reducing the number of operation steps and giving the terminal operator time to handle other matters.

[0083] 7. By coordinating the various modules of the instrument, the POCT instrument has achieved the function of large-scale chemiluminescence immunoassay.

[0084] 8. To accommodate the different time requirements of the instrument for different projects, this solution uses a time-segmented approach to avoid the problem of different time sequences not being able to be tested on the same instrument.

[0085] It will be readily understood by those skilled in the art that the aforementioned advantageous methods can be freely combined and superimposed without conflict.

[0086] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention. The above are merely preferred embodiments of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present invention, and these improvements and modifications should also be considered within the protection scope of the present invention.

Claims

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The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous chemiluminescence instant detection analyzer. The application relates to a full-automatic homogeneous The reagent strip bin (3) has at least one reagent rack (31), and multiple reagent strips are placed in the reagent rack (31).

3. The full-automatic homogeneous chemiluminescence instant detection analyzer according to claim 2, characterized in that, The sample bin (1) comprises multiple independent sample feeding channels (12), and multiple sample racks (11) are respectively and one-to-one corresponding in each sample feeding channel (12), and further comprises a sample feeding driving component (13) capable of driving the sample rack (11) to move linearly towards or away from the liquid taking unit (6).

4. The full-automatic homogeneous chemiluminescence instant detection analyzer according to claim 3, characterized in that, The sample feeding driving component (13) can selectively drive the sample rack (11) arranged in one of the multiple sample feeding channels (12).

5. The full-automatic homogeneous chemiluminescence instant detection analyzer according to claim 2, characterized in that, The reagent strip bin (3) comprises multiple independent reagent strip feeding channels (32), and multiple reagent racks (31) are respectively and one-to-one corresponding on each reagent strip feeding channel (32), and further comprises a feeding driving device (33) capable of driving the reagent strip at the bottom of the reagent rack (31) to move linearly towards the gripper unit (4).

6. The full-automatic homogeneous chemiluminescence instant detection analyzer according to claim 1, characterized in that, The driving movement direction of the first horizontal movement driving assembly (62) coincides with a diameter direction of the reaction disc (5), the gripper unit (4) comprises a gripping assembly (41), a second horizontal movement driving assembly (42) capable of driving the gripping assembly (41) to move in a horizontal direction, and a second vertical movement driving assembly (43) capable of driving the gripping assembly (41) to move in a vertical direction, the driving movement direction of the second horizontal movement driving assembly (42) is parallel to the driving movement direction of the first horizontal movement driving assembly (62) and has a horizontal interval, and the length direction of the reagent strip gripped by the gripping assembly (41) is perpendicular to the driving movement direction of the second horizontal movement driving assembly (42), so as to ensure that the reagent strip placed in the placement position can be placed in the liquid taking operation range of the liquid taking unit (6) after the reaction disc (5) is rotated by 90°.

7. A control method of a fully automatic homogeneous chemiluminescence immunoassay analyzer, characterized in that, A control method for the full-automatic homogeneous chemiluminescence instant detection analyzer according to any one of claims 1 to 6, comprising: acquiring attribute information of the reagent strip gripped by the gripper unit (4) and placing the reagent strip on an idle placement position of the reaction disc (5); judging the control mode corresponding to the gripped reagent strip according to the attribute information; controlling the operation of the liquid taking unit (6), the gripper unit (4) and the reaction disc (5) according to the control mode.

8. The control method according to claim 7, characterized in that, when the attribute information is a single-step reagent mixing type, the corresponding control mode is a single-step control mode, and in this mode: controlling the reaction disc (5) to rotate to a sample adding position, and then controlling the liquid taking unit (6) to carry the Tip head (211) to suck the sample from the corresponding sample tube and to suck the reagent from the reagent holes of the reagent strip and then inject the sample and the reagent into the detection hole of the reagent strip, controlling the reaction disc (5) to incubate the reaction solution in the detection hole of the reagent strip, controlling the reaction disc (5) to rotate to a reagent strip in-out position, and then controlling the gripper unit (4) to move the reagent strip out of the reaction disc (5) and discard the reagent strip in a waste box, controlling the reaction disc (5) to rotate to a detection position after incubation for a first preset time, and then controlling the reaction disc (5) to detect the reaction solution in the detection hole of the reagent strip; or when the attribute information is of the two-step reagent mixing type, the corresponding control mode is a two-step control mode, in which mode: controlling the reaction disc (5) to rotate to a sample adding position, and then controlling the liquid taking unit (6) to carry the Tip head (211) to suck the sample from the corresponding sample tube and to suck the reagent needed to be added for the first time from part of the reagent holes of the reagent strip and then inject the sample and the reagent into the detection hole of the reagent strip, controlling the reaction disc (5) to incubate the reaction solution in the detection hole of the reagent strip, controlling the reaction disc (5) to rotate to a reagent strip in-out position, and then controlling the gripper unit (4) to move the reagent strip out of the reaction disc (5) and discard the reagent strip in a waste box, controlling the reaction disc (5) to rotate to a sample adding position, and then controlling the liquid taking unit (6) to carry the Tip head (211) to suck the reagent needed to be added for the second time from the remaining reagent holes of the reagent strip and then inject the reagent into the detection hole of the reagent strip, controlling the reaction disc (5) to rotate to a detection position after incubation for a second preset time, and then controlling the reaction disc (5) to detect the reaction solution in the detection hole of the reagent strip.

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