Continuous hyaluronic acid production system
By adding primary filters and high-temperature steam sterilization to the hyaluronic acid production system, the problems of membrane filter clogging and fermentation tank contamination were solved, and efficient continuous production of hyaluronic acid was achieved.
Patent Information
- Application Number
- CN202422622616.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-29
- Publication Date
- 2025-10-10
- Estimated Expiration
- 2034-10-29
AI Technical Summary
The existing hyaluronic acid production equipment has a high membrane filter blockage rate and fermentation tank contamination risk during continuous production in the workshop, and the existing equipment fails to effectively sterilize after sampling, affecting production progress and safety.
A primary filter is added upstream of the membrane filter and backwashed through the return pipe to reduce the impurity clogging rate; a high-temperature steam pipe is set at the sampling port for sterilization to prevent contamination of the fermentation tank.
It significantly reduces the clogging rate of membrane filters, improves filtration efficiency, effectively prevents contamination of fermentation tanks, and improves production continuity and safety.
Smart Images
Figure CN223422667U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to hyaluronic acid production technical field, concretely is hyaluronic acid continuous production system. BACKGROUND
[0002] Hyaluronic acid, also known as hyaluronic acid, is a linear macromolecular acidic mucopolysaccharide, and its composition structure is glucuronic acid and N-acetylglucosamine, and the two alternately form disaccharide units, and the disaccharide units are connected with each other through beta-1, 3 glycosidic bond and beta-1, 4 glycosidic bond. Its appearance is white amorphous solid, odorless and tasteless, soluble in water, has strong hygroscopicity, and is insoluble in organic solvents such as alcohol, ketone and ether.
[0003] In actual production, generally including raw material preparation, fermentation culture, temperature control, filtration purification, neutralization concentration, freeze drying and the like. And in the workshop continuous production, the existing device is only provided with the membrane filter, and the product after fermentation has more impurities, and then frequent shutdown is caused to clean the membrane filter, which seriously affects the production progress. Moreover, in the continuous production, the most feared thing is that the foreign bacteria enter the fermentation tank, and after sampling is completed, the existing device often only closes the valve, and does not treat the residual liquid, which causes great hidden danger. UTILITY MODEL CONTENT
[0004] According to the deficiencies in the above prior art, the utility model aims at providing a kind of hyaluronic acid continuous production system, by the setting of primary filter and return pipeline, increase primary filter on the upstream of membrane filter, carry out early removal to the impurity in fermentation broth, greatly reduce the plugging rate of membrane filter, and by return pipeline, backflush primary filter, greatly improve the overall filtration efficiency;By the setting of high-temperature steam pipeline, after sampling is completed, the sampling port is sterilized by high-temperature steam, greatly reduces the possibility of fermentation tank being contaminated.
[0005] The utility model is realized by the following technical solutions:
[0006] The hyaluronic acid continuous production system, including fermentation tank, fermentation tank is connected with membrane filter by primary filter, the lower portion of fermentation tank is equipped with sampling port, high-temperature steam pipeline is connected on sampling port, the inside of primary filter is equipped with filter plate, the lower portion of filter plate is equipped with rotary scraping plate, the inside of membrane filter is equipped with U-shaped filter membrane.
[0007] The upper edge of rotary scraping plate is tangent to the lower edge of filter plate. U-shaped filter membrane is equipped with support on both sides, and will not be deformed due to the change of water pressure.
[0008] The inside of the fermentation tank is equipped with agitator, and the lower portion of the fermentation tank is equipped with obtuse angle discharger, which is connected with the primary filter through the primary filter pipeline.
[0009] The sampling port is arranged obliquely downward, a valve is provided on the sampling port, and the connection between the high-temperature steam pipeline and the sampling port is located below the valve.
[0010] A primary filter outlet is provided on the vertical wall of the primary filter, the primary filter outlet is located above the filter plate, and the connection between the primary filter inlet pipe and the primary filter is located below the filter plate.
[0011] A support plate is provided inside the membrane filter, a longitudinal scraper plate is provided below the support plate, a U-shaped filter membrane is provided on the support plate, the U-shaped filter membrane passes through the longitudinal scraper plate, the primary filter outlet is connected to the membrane filter through a pipe, and the connection point is located below the longitudinal scraper plate.
[0012] The upper end of the U-shaped filter membrane is open and the lower end is closed, and the upper end of the U-shaped filter membrane is connected to the support plate.
[0013] The membrane filter is equipped with a flushing water hose. A lower pressure plate is located above the support plate, connected to a lower pressure plate cylinder. A longitudinal scraper plate is also connected to a longitudinal scraper cylinder. Flushing water in the flushing water hose enters the U-shaped filter membrane. The lower pressure plate applies pressure to the liquid phase, forcing it to reverse into the U-shaped filter membrane and remove impurities from its surface. The longitudinal scraper plate, driven up and down by the longitudinal scraper cylinder, scrapes impurities from the U-shaped filter membrane. The lower pressure plate is also driven up and down by the lower pressure plate cylinder.
[0014] A membrane filter discharge port is provided on the vertical wall of the membrane filter, and the membrane filter discharge port is located above the supporting plate.
[0015] An impurity liquid discharge pipe is connected to the bottom of the membrane filter, and the impurity liquid discharge pipe is connected to the primary filter through a return pipe. The connection between the return pipe and the primary filter is located above the filter plate.
[0016] The working principle of this utility model is:
[0017] After the fermentation tank begins operation, the agitator starts and the fermentation liquid is sampled through the sampling port. After sampling is completed, the sampling port is sterilized by high-temperature steam in the high-temperature steam pipe. After the fermentation is qualified, the fermentation liquid enters the primary filter and the rotating scraper begins to work. After the primary filter is processed, the fermentation liquid enters the membrane filter and is filtered through the U-shaped filter membrane. The filtered product enters the next device through the membrane filter outlet. When the efficiency of the membrane filter decreases, flushing water enters the membrane filter through the flushing water hose. The longitudinal scraper cylinder pushes the longitudinal scraper to start moving, removing impurities on the U-shaped filter membrane. The flushing water is then pressurized by the lower pressure plate to accelerate the removal of impurities on the U-shaped filter membrane. When the efficiency of the primary filter decreases, it is backwashed through the return pipe. The flushing water in the flushing water hose can enter the U-shaped filter membrane, and the lower pressure plate can apply pressure to the liquid phase, causing it to reverse into the U-shaped filter membrane and remove impurities on its surface. The longitudinal scraper plate moves up and down by the longitudinal scraper plate cylinder to scrape impurities on the surface of the U-shaped filter membrane, and the lower pressure plate moves up and down by the lower pressure plate cylinder.
[0018] Compared with the prior art, the beneficial effects of the present invention are:
[0019] By adopting the hyaluronic acid continuous production system of the present invention, a primary filter and a return pipe are set up, and a primary filter is added upstream of the membrane filter to remove impurities in the fermentation liquid in advance, which greatly reduces the blockage rate of the membrane filter, and the primary filter is backwashed through the return pipe, which greatly improves the overall filtration efficiency; by setting up a high-temperature steam pipe, after sampling is completed, the sampling port is sterilized by high-temperature steam, which greatly reduces the possibility of contamination of the fermentation tank. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] Figure 1 This is a schematic structural diagram of the hyaluronic acid continuous production system of the utility model;
[0021] In the figure: 1. Fermentation tank; 2. Primary filter; 3. Membrane filter; 4. Agitator; 5. Obtuse-angle discharger; 6. Sampling port; 7. High-temperature steam pipe; 8. Filter plate; 9. Rotating scraper; 10. Primary filter inlet pipe; 11. Primary filter outlet; 12. U-shaped filter membrane; 13. Lower pressure plate; 14. Support plate; 15. Longitudinal scraper; 16. Longitudinal scraper cylinder; 17. Flushing water hose; 18. Lower pressure plate cylinder; 19. Impurity liquid discharge pipe; 20. Return pipe; 21. Membrane filter outlet. DETAILED DESCRIPTION
[0022] In order to make the purpose and technical solution of the present invention more clear, the present invention is further described in detail below with reference to the accompanying drawings.
[0023] Example 1
[0024] like Figure 1 As shown, a continuous hyaluronic acid production system includes a fermentor 1 connected to a membrane filter 3 via a primary filter 2. A sampling port 6 is provided below the fermentor 1, connected to a high-temperature steam pipe 7. A filter plate 8 is provided inside the primary filter 2, and a rotating scraper 9 is provided below the filter plate 8. A U-shaped filter membrane 12 is provided inside the membrane filter 3. The upper edge of the rotating scraper 9 is tangent to the lower edge of the filter plate 8. Supports are provided on both sides of the U-shaped filter membrane 12 to prevent deformation due to changes in water pressure. An agitator 4 is provided inside the fermentor 1. An obtuse-angled discharger 5 is provided below the fermentor 1, connected to the primary filter 2 via a primary filter inlet pipe 10. The sampling port 6 is positioned obliquely downward and has a valve. The connection between the high-temperature steam pipe 7 and the sampling port 6 is located below the valve. A primary filter outlet 11 is provided on the wall of the primary filter 2. The primary filter outlet 11 is located above the filter plate 8, and the connection between the primary filter inlet pipe 10 and the primary filter 2 is located below the filter plate 8. The membrane filter 3 is equipped with a support plate 14 within. A longitudinal scraper plate 15 is located below the support plate 14. A U-shaped filter membrane 12 is mounted on the support plate 14 and extends through the longitudinal scraper plate 15. The primary filter outlet 11 is connected to the membrane filter 3 via a pipe, with the connection located below the longitudinal scraper plate 15. A flushing water hose 17 is provided on the membrane filter 3. A lower pressure plate 13 is located above the support plate 14. A lower pressure plate cylinder 18 is connected to the lower pressure plate 13, while a longitudinal scraper cylinder 16 is connected to the longitudinal scraper plate 15. A membrane filter outlet 21 is provided on the vertical wall of the membrane filter 3 and is located above the support plate 14. An impurity liquid discharge pipe 19 is connected below the membrane filter 3. This impurity liquid discharge pipe 19 is connected to the primary filter 2 via a return pipe 20. The connection between the return pipe 20 and the primary filter 2 is located above the filter plate 8.
[0025] The above-mentioned hyaluronic acid continuous production system, when in operation, comprises the following steps:
[0026] (1) After the fermentation tank 1 starts working, the agitator 4 is started and the fermentation liquid is sampled through the sampling port 6. After the sampling is completed, the sampling port 6 is sterilized by high-temperature steam in the high-temperature steam pipe 7. After the fermentation is qualified, the fermentation liquid enters the primary filter 2 and the rotating scraper 9 starts working; (2) After the primary filter 2 is processed, the fermentation liquid enters the membrane filter 3 and is filtered by the U-shaped filter membrane 12. The filtered product enters the next device through the membrane filter outlet 21; (3) When the efficiency of the membrane filter 3 decreases, the flushing water enters the membrane filter 3 through the flushing water hose 17, and the longitudinal scraper cylinder 16 pushes the longitudinal scraper 15 to start moving, removing impurities on the U-shaped filter membrane 12. Then, the flushing water is pressurized by the lower pressure plate 13 to accelerate the removal of impurities on the U-shaped filter membrane 12. When the efficiency of the primary filter 2 decreases, it is backwashed through the return pipe 20.
Claims
1. A continuous production system for hyaluronic acid, characterized in that: The invention comprises a fermentation tank (1), wherein the fermentation tank (1) is connected to a membrane filter (3) via a primary filter (2), a sampling port (6) is provided below the fermentation tank (1), a high-temperature steam pipe (7) is connected to the sampling port (6), a filter plate (8) is provided inside the primary filter (2), a rotating scraper plate (9) is provided below the filter plate (8), and a U-shaped filter membrane (12) is provided inside the membrane filter (3).
2. The hyaluronic acid continuous production system according to claim 1, characterized in that: The fermentation tank (1) is provided with a stirrer (4) inside, and an obtuse-angled discharger (5) is provided below the fermentation tank (1). The obtuse-angled discharger (5) is connected to the primary filter (2) through a primary filter inlet pipe (10).
3. The hyaluronic acid continuous production system according to claim 1, characterized in that: The sampling port (6) is arranged obliquely downward, a valve is provided on the sampling port (6), and the connection between the high-temperature steam pipe (7) and the sampling port (6) is located below the valve.
4. The hyaluronic acid continuous production system according to claim 2, characterized in that: A primary filter outlet (11) is provided on the vertical wall of the primary filter (2), and the primary filter outlet (11) is located above the filter plate (8). The connection between the primary filter inlet pipe (10) and the primary filter (2) is located below the filter plate (8).
5. The hyaluronic acid continuous production system according to claim 4, characterized in that: The membrane filter (3) is provided with a support plate (14) inside, a longitudinal scraper plate (15) is provided below the support plate (14), a U-shaped filter membrane (12) is provided on the support plate (14), and the U-shaped filter membrane (12) passes through the longitudinal scraper plate (15). The primary filter outlet (11) is connected to the membrane filter (3) through a pipeline, and the connection point is located below the longitudinal scraper plate (15).
6. The hyaluronic acid continuous production system according to claim 5, characterized in that: The membrane filter (3) is provided with a flushing water hose (17), a lower pressure plate (13) is provided above the support plate (14), a lower pressure plate cylinder (18) is connected to the lower pressure plate (13), and a longitudinal scraper cylinder (16) is connected to the longitudinal scraper plate (15).
7. The hyaluronic acid continuous production system according to claim 5, characterized in that: A membrane filter discharge port (21) is provided on the vertical wall of the membrane filter (3), and the membrane filter discharge port (21) is located above the support plate (14).
8. The hyaluronic acid continuous production system according to claim 1, characterized in that: An impurity liquid discharge pipe (19) is connected below the membrane filter (3), and the impurity liquid discharge pipe (19) is connected to the primary filter (2) through a return pipe (20). The connection between the return pipe (20) and the primary filter (2) is located above the filter plate (8).