Ultrasonic 3D printing device

Abstract

The utility model provides an ultrasonic 3D printing device. The ultrasonic 3D printing device comprises a forming cabin (1), a forming module, a transmitting module, a moving module, an auxiliary function module and a central power supply (17), the forming module is arranged in the forming cabin (1) and comprises a bio-ink container (2) and bio-ink (3); the transmitting module comprises a focused ultrasonic transducer group (4) which is arranged on a sliding block (6) of a three-dimensional motion guide rail in the motion module through a connecting piece; the motion module comprises a guide rail with a three-dimensional motion bearing function and a displacement control unit (10); the auxiliary function module comprises a high-definition camera (11), a high-definition display screen (12), a sterilization device (13) and a temperature control device (15); the central power source (17) is used for providing electric power needed by the ultrasonic 3D printing device. According to the ultrasonic 3D printing device, the precision and the biological safety of ultrasonic biological 3D printing are improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological 3D printing technical field especially, relate to a kind of ultrasonic 3D printing device. BACKGROUND

[0002] 3D printing technology is currently a kind of many rapid prototyping technologies, also called additive manufacturing, is a kind of advanced technology based on digital model file, using metal powder, plastic or high polymer solution and other materials, by layer printing to construct object. At present, a part of biological implant is constructed by 3D printing technology. However, the existing biological 3D printing technology is generally constructed by using inkjet, laser direct writing, extrusion, light curing and other 3D printing methods in vitro to obtain biological material, and the following problems may occur during implantation process: (1) soft biological material such as hydrogel may be damaged artificially; (2) open operation in a large range increases the risk of infection; (3) biological material and tissue interface mismatch reduces its biological function.

[0003] The front biological 3D printing technology tends to construct biological active material / device directly in vivo. Near-infrared light (NIR) as an effective stimulation control medium has been reported to be used for non-invasive in vivo 3D biological printing of tissue structure. However, since NIR can only penetrate biological tissue with a depth of less than 5mm, it is still challenging to use NIR to penetrate optical scattering medium (such as biological tissue) and perform subsequent 3D printing operation. In addition, the light attenuation of photosensitive ink itself, the biological toxicity of photoinitiator and other factors limit the material selection and construction size of light curing biological 3D printing.

[0004] Ultrasound has stronger penetration performance, which can reach centimeter level, enough to penetrate various tissues in vivo. At the same time, ultrasound can also be focused by focused ultrasound (FUS) transducer in a certain "focus point", which can effectively avoid energy absorption of non-target tissue and protect healthy tissue outside the implanted material. In addition, since FUS transducer can generate positive and negative pressure at megahertz frequency alternately and propagate along the depth direction, the technology can continuously and accurately deliver acoustic energy to the focus area. However, the current focused ultrasound biological 3D printing equipment still has problems such as low precision (millimeter level), high acoustic pressure (peak value reaching more than 35MPa), single function and complex device, which still has a distance for realizing high-precision ultrasonic biological 3D printing, tissue repair and other clinical applications. UTILITY MODEL CONTENT

[0005] Therefore, the utility model provides an ultrasonic 3D printing device to solve the above problems.

[0006] The utility model provides a kind of ultrasonic 3D printing device, comprising: forming cabin (1), forming module, emission module, movement module, auxiliary function module, central power supply (17);The forming module is arranged in the forming cabin (1), including biological ink container (2) and biological ink (3), the biological ink container (2) is used to hold the biological ink (3) and print initial product, the biological ink (3) realizes thermal curing based on ultrasonic effect;The emission module includes focused ultrasonic transducer group (4), the focused ultrasonic transducer group (4) is used to accurately solidify printing to biological ink of different spatial positions, is installed on the slider (6) of three-dimensional movement guide rail in the movement module by connecting piece;The movement module includes guide rail and displacement control unit (10) with bearing three-dimensional movement function, the displacement control unit (10) cuts the preset three-dimensional model, exports with path instruction, controls the slider (6) installed on the guide rail and carries out displacement, drives the focused ultrasonic transducer (4) and accurately solidifies biological ink of spatial position;The auxiliary function module includes high-definition camera (11), high-definition display screen (12), sterilization device (13), temperature control device (15), the high-definition camera (11) carries out real-time recording to the scene in focused ultrasonic printing range, and picture is transmitted to the high-definition display screen (12) connected, to feed back real-time printing state, for adjusting printing parameter;The sterilization device (13) is used to kill microorganism in printing environment;The temperature control device (15) is used to maintain the constancy of temperature in printing environment;The central power supply (17) is used to provide the power required by ultrasonic 3D printing device.

[0007] In another implementation mode of the utility model, the focused ultrasonic transducer group (4) integrates multiple focused ultrasonic transducers of different frequencies.

[0008] In another implementation mode of the utility model, the focused ultrasonic transducer group (4) is regulated by focused ultrasonic control unit (5), for generating ultrasonic focusing effect of different power density.

[0009] In another implementation mode of the utility model, the frequency range of the focused ultrasonic transducer group (4) is 20kHz-50 MHz.

[0010] In another implementation mode of the utility model, the guide rail with bearing three-dimensional movement function includes x shaft screw guide rail (7), y shaft screw guide rail (8), z shaft screw guide rail (9);The displacement of the slider (6) in x, y, z axle direction drives the focused ultrasonic transducer group (4) and carries out focused printing to biological ink of different spatial positions.

[0011] In another implementation mode of the utility model, the sterilization device (13) includes ozone generator, ultraviolet lamp and timing switch element.

[0012] In another implementation mode of the utility model, the temperature control device (15) includes temperature sensitive sensor, cooling element, temperature rising element and temperature control processor (16), the temperature sensitive sensor is fed back to temperature control processor (16) with the real-time temperature information in printing container, and the temperature control processor outputs control signal, and starts temperature rising element or cooling element.

[0013] The utility model discloses an ultrasonic 3D printing device, adopts integrated ultrasonic transducer emission module, can switch different frequency ultrasonic transducer for different categories or structure demand biological ink fast, adopts the slider of three -dimensional direction motion, has micron -level positioning accuracy, improves the precision of ultrasonic biological 3D printing, and the modular degree is higher, can change component fast for different scene demand, is also favorable to the maintenance of later period, through the regulation and control ultrasonic frequency, intensity, can reduce ultrasonic sound pressure, through the adjustment biological ink or control temperature of forming cabin, can regulate and control material forming temperature, makes it have biological safety. BRIEF DESCRIPTION OF DRAWINGS

[0014] In order to more clearly illustrate the utility model embodiments or prior art technical scheme, the following will be briefly introduced the drawings needed to be used in embodiment or prior art description, through reading the detailed description of the embodiment, the advantages and benefits in the scheme become clear and obvious to the person skilled in the art. The drawings are only for the purpose of showing the preferred embodiment, and are not considered as limiting the utility model. In the drawings,

[0015] Figure 1 It is the ultrasonic 3D printing device schematic diagram of an embodiment of the utility model. BRIEF DESCRIPTION OF DRAWINGS

[0017] 1-forming cabin, 2-biological ink container, 3-biological ink, 4-focusing ultrasonic transducer group, 5-focusing ultrasonic control unit, 6-slider, 7-x axis screw guide rail, 8-y axis screw guide rail, 9-z axis screw guide rail, 10-displacement control unit, 11-high definition camera, 12-high definition display screen, 13-sterilization device, 14-timing switch, 15-temperature control device, 16-temperature control processor, 17-central power supply. DETAILED DESCRIPTION

[0018] In order to make the personnel in the art better understand the technical solutions in the embodiments of the present application, the technical solutions in the embodiments of the present application will be clearly and detailedly described below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the embodiments of the present application, all other embodiments obtained by the person skilled in the art should belong to the protection scope of the embodiments of the present application.

[0019] Figure 1 A schematic diagram of an ultrasonic 3D printing device provided by the embodiments of the present application is shown in the drawings, and the embodiments mainly include: Figure 1

[0020] A forming cabin (1), a forming module, a transmitting module, a moving module, an auxiliary function module, and a central power supply (17).

[0021] The forming module is arranged in the forming cabin (1) and includes a biological ink container (2) and biological ink (3). The biological ink container (2) is used for containing the biological ink (3) and a printing initial product. The biological ink (3) is based on ultrasonic action to realize thermal curing.

[0022] Exemplarily, the forming module further includes a material forming platform. The material forming platform can be used for quickly setting the printing biological ink material on the platform, and placing different biological ink containers (2). The biological ink container (2) can be used as a biological ink carrier vessel to directly and quickly form a high-precision adjustable and stable three-dimensional structure during printing, so that the fine three-dimensional structure of the active material can be safely and effectively constructed in vivo.

[0023] Specifically, the biological ink (3) includes a polymer material, a bioactive ingredient, and a sound-sensitive agent. The polymer material includes one or more of an unsaturated polymer, agar, and poly (N-isopropyl acrylamide). The bioactive ingredient includes one or more of cells, polypeptides, proteins, nucleic acids, metal oxide particles, or metal elements. The sound-sensitive agent is a metal oxide particle or an ultrasonic sensitive molecular compound. Further, various materials for 3D printing can be prepared into ultrasonic response biological ink according to requirements in a certain ratio and placed in the biological ink container.

[0024] The transmitting module includes a focused ultrasonic transducer group (4). The focused ultrasonic transducer group (4) is used for accurately curing and printing the biological ink at different spatial positions and is installed on the slider (6) of the three-dimensional motion guide rail in the moving module through a connecting piece.

[0025] ​The motion module comprises a guide rail with a bearing three-dimensional motion function and a displacement control unit (10), the displacement control unit (10) cuts a preset three-dimensional model to output path instructions, controls a slider (6) installed on the guide rail to displace, and drives the focused ultrasonic transducer (4) to accurately solidify biological ink at a spatial position.

[0026] Exemplarily, a product model is designed by computer aided design (CAD) technology, and is digitally cut and divided according to a required scheme, and then instructions are output to control displacement of a slider, and further drive the ultrasonic transducer to focus biological ink at different spatial positions to solidify for 3D printing.

[0027] The auxiliary function module comprises a high-definition camera (11), a high-definition display screen (12), a sterilization device (13) and a temperature control device (15), the high-definition camera (11) records a scene in a focused ultrasonic printing range in real time, and transmits a picture to the connected high-definition display screen (12) to feed back a real-time printing state for adjusting printing parameters, the sterilization device (13) is used for killing microorganisms in a printing environment, and the temperature control device (15) is used for maintaining constant temperature in the printing environment, the auxiliary function comprises real-time high-definition monitoring, sterilization and temperature control functions, and the functions can be selectively turned on according to actual application requirements.

[0028] The central power supply (17) is used for providing power required by the ultrasonic 3D printing device.

[0029] The ultrasonic 3D printing device of the utility model adopts integrated ultrasonic transducer emission module, can quickly switch different frequency ultrasonic transducers for biological ink of different categories or structure requirements, adopts slider with three-dimensional direction motion, has micron-level positioning precision, improves the precision of ultrasonic biological 3D printing, has higher modular degree, can quickly replace components for different scene requirements, is also favorable for later maintenance, can reduce ultrasonic sound pressure by regulating and controlling ultrasonic frequency and intensity, can regulate and control material forming temperature by adjusting biological ink or controlling temperature of a forming cabin, and has biological safety.

[0030] In another implementation mode of the utility model, a plurality of focused ultrasonic transducers with adjustable frequency and power are integrated in the focused ultrasonic transducer group (4), different frequency ultrasonic waves can be quickly switched for biological ink of different categories or different structure requirements, in addition, focused ultrasonic waves can realize three-dimensional solidification forming for heat-cured materials.

[0031] In another implementation mode of the utility model, the focused ultrasonic transducer group (4) is regulated by the focused ultrasonic control unit (5), and is used for generating ultrasonic focusing effect of different power density, and the ultrasonic transducer is used for curing printing of biological ink in focus point position by emitting specific focused ultrasonic wave.

[0032] In another implementation mode of the utility model, the frequency range of the focused ultrasonic transducer group (4) is 20 kHz-50 MHz.

[0033] Exemplarily, the selection of focused ultrasonic frequency and intensity is through the corresponding relationship between focused ultrasonic frequency / power and ink forming effect established by prior test or experiment, and the frequency and intensity with high precision, low sound pressure and low sound heat are screened out and the corresponding ultrasonic transducer is developed for 3D printing equipment, preferably 20 kHz, 100 kHz, 1 MHz, 3 MHz, 6 MHz and 10 MHz, and the ultrasonic frequency and intensity with the best forming effect are selected according to the preferred relationship to print.

[0034] In another implementation mode of the utility model, the guide rail with three-dimensional movement function includes x shaft screw guide rail (7), y shaft screw guide rail (8) and z shaft screw guide rail (9), and the displacement of the sliding block (6) in x, y and z axis directions drives the focused ultrasonic transducer group (4) to focus printing of biological ink in different space positions.

[0035] In another implementation mode of the utility model, the sterilization device (13) includes ozone generator, ultraviolet lamp and timing switch element.

[0036] In another implementation mode of the utility model, the temperature control device (15) includes temperature sensitive sensor, cooling element, temperature rising element and temperature control processor (16), the real-time temperature information in the printing container is fed back to the temperature control processor (16) through the temperature sensitive sensor, the temperature control processor outputs control signal, and the temperature rising element or the temperature reducing element is started.

[0037] In another aspect of the utility model, an ultrasonic 3D printing method is provided, and the printing method includes selection and preparation of ultrasonic response ink, digital cutting and division of product model for printing, selection and application of focused ultrasonic frequency and intensity, and debugging and opening of auxiliary function, and the specific steps include:

[0038] First, the material for printing is made into liquid or fluid, and the sound sensitive agent is added and uniformly dispersed, that is, biological ink is obtained, and the ink is delivered to the biological ink tank of the forming module or the position to be filled of the biological body.

[0039] Subsequently, the model is designed by the printer control unit, and the product model is digitally cut according to the requirements of the printed product, so as to set the printing path.

[0040] Then, the ultrasonic frequency / strength required for 3D printing is set by the focused ultrasonic control unit, and the ultrasonic frequency and strength with the best forming effect are selected through pre-experiment, so that the ink at the focal point is quickly solidified, and then the corresponding focused ultrasound is selected for 3D printing.

[0041] Finally, the three-dimensional motion of the slider in the motion module drives the transducer to continuously change the focal point, so as to continuously construct the three-dimensional structure based on ultrasonic 3D printing.

[0042] During the period, the printing process is monitored by the camera in the auxiliary function module, and the related printing parameters are adjusted in real time according to the printing state, so as to ensure the smooth progress of printing; the sterilization device can also be opened according to the requirements of the printed product, so as to ensure the sterile state of the printing process and protect the product; the temperature control device is used to maintain the constant temperature in the forming cabin, so as to ensure the continuous and stable progress of printing and reduce the forming effect difference caused by temperature change.

[0043] Thus, specific embodiments of the present application have been described. Other embodiments are within the scope of the following claims. In some cases, the actions recited in the claims can be performed in a different order and still achieve desirable results. In addition, the processes depicted in the figures do not necessarily require the particular order shown, or sequential order, to achieve desirable results. In certain implementations, multitasking and parallel processing can be advantageous.

[0044] It should be noted that all directional indications (such as up, down, left, right, rear, etc.) in the embodiments of the present application are only used to explain the relative positional relationship, movement condition, etc. between components in a certain posture (as shown in the drawings), and if the certain posture changes, the directional indications also change accordingly.

[0045] In the description of the present application, the terms "first", "second" are only used for the convenience of describing different components or names, and cannot be understood as indicating or implying the order relationship, relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features limited by "first", "second" can be explicitly or implicitly included at least one feature.

[0046] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the present application belongs. The terms used in the specification of the present application are only for the purpose of describing specific embodiments and are not intended to limit the present application.

[0047] It should be noted that, although the specific embodiments of the utility model are described in detail in combination with the drawings, it should not be understood as the limitation of the protection scope of the utility model. Various modifications and changes made by the skilled in the art within the scope described in the claims still belong to the protection scope of the utility model without creative labor.

[0048] The examples of the embodiments of the utility model are intended to simply explain the technical features of the embodiments of the utility model, so that the skilled in the art can intuitively understand the technical features of the embodiments of the utility model, and not as improper limitation of the embodiments of the utility model.

[0049] Finally, it should be pointed out that: the above examples are only used to illustrate the technical scheme of the utility model, and not to limit it; although the utility model has been described in detail with reference to the foregoing embodiments, the skilled in the art should understand that: it can still modify the technical scheme recorded in the foregoing embodiments, or make equivalent replacement for part of the technical features; and these modifications or replacements do not make the essence of the corresponding technical scheme deviate from the spirit and scope of the technical scheme of the embodiments of the utility model.

Claims

1. An ultrasonic 3D printing device, characterized by, The application relates to a 3D printing device. The application relates to a 3D printing device. The application relates to a 3D printing device. The application relates to a 3D printing device. The application relates to a 3D printing device. The application relates to a 3D printing device. The application relates to a 3D printing device.

2. The apparatus of claim 1, wherein, The application relates to a 3D printing device.

3. The apparatus of claim 2, wherein, The application relates to a 3D printing device.

4. The apparatus of claim 3, wherein, The application relates to a 3D printing device.

5. The apparatus of claim 1, wherein, The application relates to a 3D printing device. The application relates to a 3D printing device.

6. The apparatus of claim 1, wherein, The application relates to a 3D printing device.

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