Continuous flow multi-section reactor

Abstract

The utility model provides a continuous flow multi-section tubular reaction device, which comprises a support and a plurality of reactor components fixedly mounted on the support, each reactor component comprises a reaction tube, a liquid inlet and a liquid outlet are respectively arranged at two ends of the reaction tube, a liquid supplementing port is further arranged at one end of the liquid inlet of the reaction tube, and the liquid supplementing port is communicated with the liquid supplementing port. The liquid inlet is used for supplementing reaction materials or used as a standby liquid inlet, and a turbulent flow part is arranged in the reaction tube and used for improving the mixing effect of the reaction materials entering the reaction tube. According to the continuous flow multi-section tubular reaction device, an additional material mixing device is not needed, reaction materials to be supplemented are directly input into the reaction tube from the liquid supplementing opening and are rapidly and uniformly mixed with original reaction liquid in the reaction tube, and the operation is convenient.

Description

Technical Field

[0001] This utility model belongs to the field of continuous flow reactor technology, specifically, it relates to a continuous flow multi-stage tubular reaction device. Background Technology

[0002] In recent years, continuous production technology has been increasingly used in pharmaceutical production to improve the level of automation in pharmaceutical manufacturing. Among them, continuous flow reactors are the equipment that realizes continuous reaction processes.

[0003] Existing continuous flow tubular reactors typically only have inlet and outlet ports in their reaction tubes, with multiple tubes connected through them, and the interior of each tube is merely a passageway. During operation, the liquid reactants are pre-mixed externally before being introduced into the reactor for reaction. The mixer and reactor are relatively independent. While using a mixer for pre-mixing the reactants provides better mixing, the overall volume of the mixer is generally small, resulting in poor mixing efficiency. Furthermore, the separate mixing and reaction processes prevent integrated operation. Especially when additional reactants are needed during the reaction, adding them directly to the reactor leads to poor mixing between the added reactants and the original reaction liquid, affecting product purity and yield.

[0004] In addition, each reaction tube of a traditional continuous flow tubular reactor is usually equipped with an inlet and an outlet. If the inlet is damaged or blocked during use, it will be impossible to add or discharge the reactants to the reactor in a timely manner.

[0005] Therefore, there is a need in the art for a continuous flow tubular reactor that is simple to operate, easy to use, and produces good reaction results. Utility Model Content

[0006] To address the problems existing in current continuous flow tubular reactors, the purpose of this invention is to provide a novel continuous flow multi-stage tubular reaction device. When using this continuous flow tubular reaction device for material reactions, there is no need to pre-mix the reactants using a mixer; the reactants can be rapidly and uniformly mixed within the reaction device after being added. Furthermore, when additional reactants are needed during the reaction, they are added directly through the feed inlet, and the added reactants quickly and uniformly mix with the original reaction liquid upon entering the reaction device. To achieve the objectives of this invention, the following technical solution is adopted:

[0007] A continuous flow multi-segment tubular reaction device includes a support frame comprising several crossbeams; several reactor components fixedly mounted on the crossbeams, each reactor component including a reaction tube, with an inlet and an outlet at each end of the reaction tube, a replenishment port at one end of the inlet for replenishing reactants, and a flow-turbulence-inducing component inside the reaction tube to improve the mixing effect of the reactants entering the reaction tube.

[0008] In another preferred embodiment, the turbulence-disrupting component extends throughout the interior of the entire reaction tube and is in a single-helix or double-helix shape.

[0009] In another preferred embodiment, the reaction tube is further provided with a spare outlet at one end of the outlet.

[0010] In another preferred embodiment, the inlet and the replenishment port are located at one end of the reaction tube, and the outlet is located at the other end of the reaction tube.

[0011] In another preferred embodiment, a first connecting flange and a second connecting flange are respectively provided at both ends of the reaction tube, and the first connecting flange and the second connecting flange are respectively connected to the first end cap and the second end cap.

[0012] In another preferred embodiment, the inlet and the replenishment port are located on the first end cap, and the outlet is located on the second end cap.

[0013] In another preferred embodiment, the spare outlet is located on the second end cap.

[0014] In another preferred embodiment, a heat exchange tube is provided outside the reaction tube, and the heat exchange tube is provided with a sealing flange, the end face of which is connected to the end face of the reaction tube.

[0015] In another preferred embodiment, a third connecting flange is provided at each end of the heat exchange tube, the third connecting flange being used for interconnection between the heat exchange tube and the heat exchange equipment or another heat exchange tube.

[0016] In another preferred embodiment, the bracket is formed by splicing several profiles to form a cuboid, and the crossbeam is disposed inside the bracket.

[0017] The beneficial effects of this utility model are:

[0018] 1. The continuous flow multi-segment tubular reaction apparatus of this invention has a replenishment port at one end of the inlet of its reaction tube, and a flow-turbulence component is provided inside the reaction tube. When adding reactants to the apparatus, the reactants do not need to be pre-mixed using a mixer; the reactants entering the reaction tube can be quickly and uniformly mixed under the turbulence of the flow-turbulence component. When it is necessary to add reactants during the reaction, the reactants can be added to the reaction tube through the replenishment port, which can quickly achieve rapid mixing of the added reactants with the original reaction liquid. The replenishment port can also be used as a backup inlet pipe; if the inlet pipe becomes blocked during the reaction, it can be quickly replaced to ensure the smooth progress of the reaction.

[0019] 2. Each reaction tube of the continuous flow multi-segment tubular reaction device of this utility model is also equipped with a spare outlet at one end of its outlet. If the outlet tube becomes blocked during the reaction, it can be quickly replaced to ensure the smooth progress of the reaction. Attached Figure Description

[0020] To more clearly illustrate the specific embodiments of this utility model, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0021] Figure 1 This is a perspective view of a preferred embodiment of a continuous flow multi-section tubular reactor according to a preferred embodiment of the present invention;

[0022] Figure 2 yes Figure 1 A cross-sectional view of the reaction assembly of a continuous flow multi-stage tubular reactor without any turbulence-inducing components;

[0023] Figure 3 yes Figure 1 A cross-sectional view of a reaction tube with a double-helix turbulence-inducing component inside a continuous flow multi-segment tubular reactor.

[0024] Figure 4 yes Figure 1 A cross-sectional view of a reaction tube with a single helical turbulence component installed inside a continuous flow multi-segment tubular reactor.

[0025] Figure 5 This is a schematic diagram of the structure of the double-helix turbulence-disrupting component.

[0026] Figures 1 to 5In the diagram, 1—support, 11—beam, 2—reaction assembly, 21—reaction tube; 211—inlet; 212—outlet, 213—replenishment port, 212'—outlet, 214-1—first end cap, 214-2—second end cap, 215-1—first connecting flange, 215-2—second connecting flange, 216—heat exchange tube; 2161—sealing flange; 217—turbulence structure, 218—third connecting flange. Detailed Implementation

[0027] In the description of the embodiments of this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0028] In the description of the embodiments of this utility model, the term "several" can refer to 2 to 10 or more, depending on actual production needs.

[0029] The reaction types suitable for the continuous flow multi-segment tubular reaction apparatus of this invention are preferably reactions carried out in a liquid medium. For example, the solvent is liquid, and the reactants are either liquid themselves or dissolved in a solvent before being added to the reaction tube of the reaction apparatus.

[0030] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0031] like Figure 1 and Figure 2 As shown in the figure, the continuous flow multi-segment tubular reactor includes a support 1 with several crossbeams 11 supporting the reaction components 2. The reaction components 2 are fixed to the side walls 11 of the crossbeams. Each reaction component 2 includes several reaction tubes 21, with an inlet 211 and an outlet 212 at each end. A replenishment port 213 is also provided at one end of the inlet 211, for adding reactants to the reaction tube and serving as a backup inlet. A backup outlet 212' is also provided at one end of the outlet 212.

[0032] The reaction tube 21 is equipped with a turbulence-inducing structure 217 (see [reference]). Figure 3 The function of the turbulence structure 217 is to ensure that the reactants added to the reaction tube 21 can be rapidly and uniformly mixed within it. Furthermore, when additional reactants are needed during the reaction, the added reactants can be quickly and uniformly mixed with the original reaction solution in the reaction tube 21, improving the mixing effect and avoiding the problem of low reaction yield caused by prolonged uneven mixing. The turbulence structure 217 extends through the entire length of the reaction tube 21. The turbulence structure 217 can be a double helix shape formed by two thin sheets of material (e.g., Figure 3 As shown), it can also be a single helical shape formed from a single sheet of material (such as...). Figure 4 (As shown). The material of the turbulence structure 217 is a non-reactive material. For example, stainless steel, or stainless steel with a surface coated with polytetrafluoroethylene.

[0033] Figure 2 , Figure 3 and Figure 4 In the continuous flow multi-segment tubular reactor shown, the replenishment port 213 can also be used as a backup inlet during operation. The inlet 211 and the replenishment port 213 are located at both ends of the reaction tube 21. Figure 2 , Figure 3 and Figure 4 The reaction tube 21 of the continuous flow multi-segment tubular reactor shown has a first flange 215-1 and a second flange 215-2 at both ends, which are connected to a first end cap 214-1 and a second end cap 214-2, respectively. An inlet 211 and a replenishment port 213 are located on the top wall of the first end cap 214-1. An outlet 212 and a spare outlet 212' are located on the top wall of the second end cap 214-2. This structure facilitates the manufacture of the reaction tube 21. Alternatively, the inlet 211, replenishment port 213, outlet 212, and spare outlet 212' can be directly located on the end wall of the reaction tube 21.

[0034] exist Figure 1 and Figure 2 In the continuous flow multi-stage tubular reactor shown, a heat exchange tube 216 is also installed outside the reaction tube 2 to control (lower or higher) the temperature of the reaction liquid inside the reaction tube 21. Sealing flanges 2161 are installed at both ends of the heat exchange tube 216. The end face of the sealing flange 2161 is connected to the end face of the reaction tube 21. Connecting flanges 218 are also installed at both ends of the heat exchange tube 216 for interconnection with heat exchange equipment or other heat exchange tubes.

[0035] In use, the reaction tubes 21 of the continuous flow multi-segment tubular reactor are connected sequentially, and the temperature of the heat exchange tubes 216 is set as needed. Then, the reactants are fed into the reaction tubes 21 through the liquid inlet 211. The reactants can be added sequentially to the reaction tubes 21, and under the turbulence of the turbulence structure 217, the various reactants are rapidly and uniformly mixed. Therefore, no additional mixing device is needed to mix the various reactants before feeding them into the reaction tubes 21. During the reaction, when it is necessary to add reactants, they are added to the reaction tubes 21 through the liquid replenishment port 213. After entering the reaction tubes 21, the added material is rapidly and uniformly mixed with the original reaction liquid under the turbulence of the turbulence structure 217.

[0036] In summary, the continuous flow multi-segment tubular reaction device of this invention can achieve uniform mixing of reactants during the material addition process, is easy to operate, and has good reaction effect.

Claims

1. A continuous flow multi-stage tubular reaction apparatus, characterized in that, Includes a support (1), which includes several crossbeams (11), and Several reactor assemblies (2) are fixedly installed on the crossbeam (11), each reactor assembly (2) including a reaction tube (21). The reaction tube (21) is provided with an inlet (211) and an outlet (212) at both ends, and a replenishment port (213) is also provided at one end of the inlet (211) for adding reactants or as a backup inlet. The reaction tube (21) is equipped with a flow-turbulence component (217) to improve the mixing effect of the reactants entering the reaction tube (21).

2. The continuous flow multi-stage tubular reactor according to claim 1, characterized in that, The turbulence-inducing component (217) extends through the entire interior of the reaction tube (21) and is in the shape of a single helix or a double helix.

3. The continuous flow multi-stage tubular reactor according to claim 1 or 2, characterized in that, The reaction tube (21) is also provided with a spare outlet (212') at one end of the outlet (212).

4. The continuous flow multi-stage tubular reactor according to claim 1 or 2, characterized in that, The inlet (211) and the replenishment port (213) are located at one end of the reaction tube (21), and the outlet (212) is located at the other end of the reaction tube (21).

5. The continuous flow multi-stage tubular reactor according to claim 3, characterized in that, The reaction tube (21) is provided with a first connecting flange (215-1) and a second connecting flange (215-2) at both ends, and the first connecting flange (215-1) and the second connecting flange (215-2) are respectively connected to the first end cap (214-1) and the second end cap (214-2).

6. The continuous flow multi-stage tubular reactor according to claim 5, characterized in that, The inlet (211) and the replenishment port (213) are located on the first end cap (214-1), and the outlet (212) is located on the second end cap (214-2).

7. The continuous flow multi-stage tubular reactor according to claim 5, characterized in that, The spare liquid outlet (212') is located on the second end cap (214-2).

8. The continuous flow multi-stage tubular reactor according to claim 1 or 2, characterized in that, A heat exchange tube (216) is provided outside the reaction tube (21), and a sealing flange (2161) is provided on the heat exchange tube (216). The end face of the sealing flange (2161) is connected to the end face of the reaction tube (21).

9. The continuous flow multi-stage tubular reactor according to claim 8, characterized in that, The heat exchange tube (216) is provided with a third connecting flange (218) at both ends. The third connecting flange (218) is used for the mutual connection between the heat exchange tube (216) and the heat exchange equipment or another heat exchange tube.

10. The continuous flow multi-stage tubular reactor according to claim 1, characterized in that, The bracket (1) is formed by splicing several profiles to form a cuboid, and the crossbeam (11) is set inside the bracket (1).

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