Heating device and nucleic acid extractor
By designing a matching structure between the heating seat and the heating container, as well as a ceramic heating plate, in the nucleic acid extractor, the problems of uneven heating and difficult disassembly were solved, achieving both uniform heating and convenience.
Patent Information
- Application Number
- CN202422540394.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-21
- Publication Date
- 2025-10-31
- Estimated Expiration
- 2034-10-21
AI Technical Summary
The heating device of existing nucleic acid extractors has a relatively simple heating surface, resulting in low and uneven heating efficiency. Furthermore, the heating module is difficult to disassemble, and the assembly is time-consuming and the accuracy is difficult to guarantee, leading to the risk of magnetic beads sticking to the wall.
A heating mechanism including a heating base, a heating element and a base was designed. The conformal part matches the heating container, and the ceramic heating element and temperature sensor are combined to improve the heating uniformity. The modular design facilitates disassembly and cleaning.
This improved the uniformity of the heating device, reduced the risk of magnetic beads sticking to the wall, and enhanced assembly efficiency and ease of use.
Smart Images
Figure CN223496453U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of nucleic acid extraction equipment technology, and in particular to heating devices and nucleic acid extractors. Background Technology
[0002] In related technologies, the heating device of nucleic acid extractors has a relatively limited heating surface for the reagent kit, resulting in lower heating efficiency and uneven heating. Furthermore, the heating device cannot be easily disassembled, hindering its practicality. Additionally, the heating modules are typically in a loose, disassembled state, making assembly time-consuming and requiring precise tooling. Failure to meet assembly accuracy standards poses a risk of debugging failure, directly leading to magnetic bead adhesion to the instrument walls. Utility Model Content
[0003] This application aims to address at least one of the technical problems existing in the prior art. To this end, this application proposes a heating device and a nucleic acid extractor that can effectively improve heating uniformity.
[0004] One embodiment of this application provides a heating device, including:
[0005] The heating mechanism includes a heating base, a heating element, and a base stacked sequentially, wherein the heating element is used to heat the heating base; and
[0006] A heating container is disposed on the heating base.
[0007] Furthermore, a contoured part is provided on the side of the heating base near the heating container, and the contoured part matches the bottom of the heating container.
[0008] Furthermore, the contoured portion includes spaced grooves, the contour of which is hemispherical.
[0009] Furthermore, the heating element includes a ceramic heating element.
[0010] Furthermore, the heating mechanism also includes a temperature sensor, which is disposed at the bottom of the heating base.
[0011] Furthermore, it also includes a base plate, on which the base is disposed; or,
[0012] It also includes a circuit board and a base plate, wherein the base plate is disposed on the base plate, and the circuit board is disposed on the side of the base plate away from the heating mechanism, and the circuit board is electrically connected to the heating mechanism; or,
[0013] It also includes a base plate, a circuit board, and a protective cover. The base is disposed on the base plate, the circuit board is disposed on the side of the base plate away from the heating mechanism, the circuit board is electrically connected to the heating mechanism, the protective cover is connected to the base plate, the protective cover and the base plate enclose a receiving cavity, and the circuit board is located in the receiving cavity.
[0014] Furthermore, the base is made of plastic.
[0015] Furthermore, it also includes a limiting block, which is mounted on the base plate and is used to limit the position of the base.
[0016] Furthermore, the heating container is a perforated plate, and the perforated plate has a plurality of spaced placement holes.
[0017] Furthermore, the bottom of the heating base is provided with a first positioning protrusion, and the base is provided with a first limiting groove corresponding to the position of the first positioning protrusion, and the first positioning protrusion and the first limiting groove are connected in cooperation.
[0018] Another embodiment of the nucleic acid extractor of this application includes the heating device as described above.
[0019] As can be seen from the above technical solutions, the embodiments of this application have at least the following beneficial effects:
[0020] In the heating device and nucleic acid extractor provided in this application embodiment, the heating container is used to place the items to be heated. By using the heating body to heat the heating seat, and then using the heating seat to heat the heating container placed on the heating seat, the heating uniformity of the heating device can be effectively improved. Attached Figure Description
[0021] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0022] Figure 1 This is an exploded structural diagram of a heating device provided in one embodiment of this application;
[0023] Figure 2 This is a schematic diagram of the heating mechanism in a heating device provided in one embodiment of this application;
[0024] Figure 3 This is a schematic diagram of the heating mechanism and the base plate in a heating device provided in one embodiment of this application.
[0025] Figure label:
[0026] 100. Heating mechanism; 110. Heating base; 111. Groove; 112. First positioning protrusion; 120. Heating element; 130. Base; 131. Receiving groove; 132. First limiting groove; 140. Temperature sensor;
[0027] 200. Heating container; 210. Placement hole;
[0028] 300. Base plate; 310. Limiting block; 320. Push handle;
[0029] 400. Circuit board; 410. Connecting post;
[0030] 500. Protective cover. Detailed Implementation
[0031] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0032] Nucleic acid extractors are analytical instruments in the field of biology, and are widely used in biological extraction and biochemical analysis. Nucleic acid extractors are high-tech instruments composed of various structures, including a heating device. Since nucleic acid extracts are prone to crystallization at low temperatures, a heating device is needed to provide the necessary working temperature for the nucleic acid extracts.
[0033] Existing nucleic acid extractors are usually equipped with heating devices. During nucleic acid extraction, the sample kit is placed in the sample compartment of the nucleic acid extractor, and the heating device heats the lysis buffer and elution buffer contained in the kit.
[0034] See Figures 1 to 3 As shown, one embodiment of this application discloses a heating device, including a heating mechanism 100 and a heating container 200.
[0035] Specifically, the heating mechanism 100 includes a heating seat 110, a heating element 120, and a base 130 arranged in sequence. The heating element 120 is used to heat the heating seat 110; and a heating container 200 is disposed on the heating seat 110. The heating container 200 is used to hold the item to be heated. During heating, the heating element 120 heats the heating seat 110, and the heating seat 110 transfers heat to the heating container 200, thereby heating the item to be heated in the heating container 200.
[0036] In the heating device and nucleic acid extractor provided in this application embodiment, the heating container 200 is used to place the items to be heated. The heating body 120 is used to heat the heating seat 110, and then the heating seat 110 is used to heat the heating container 200 placed on the heating seat 110. In this way, the heating uniformity of the heating device can be effectively improved.
[0037] See Figure 1 and Figure 3 As shown, in some embodiments of this application, the heating container 200 is an orifice plate with a plurality of spaced placement holes 210. Each placement hole 210 is separated from the others, and each placement hole 210 can be used to place the reagent to be heated.
[0038] It is worth understanding that the heating container 200 can also be a container structure with an open or closed receiving cavity, which can be used to place items such as solutions or solids to be heated.
[0039] In this embodiment, the heating element 120 is used to heat the heating base 110, and the heating base 110 is used to transfer heat to the heating container 200 to heat the items inside the heating container 200, which can also effectively improve the uniformity of heating.
[0040] See Figures 1 to 3 As shown, in some embodiments of this application, the heating base 110 is provided with a contoured portion on the side near the heating container 200, and the contoured portion matches the bottom of the heating container 200. In this way, the part of the heating base 110 that contacts the heating container 200 can fit snugly against the bottom of the heating container 200, which helps to increase the heat transfer area, thereby improving the uniformity of heat transfer and thus improving the heating uniformity of the heating device.
[0041] In one possible implementation, please continue to see Figures 1 to 3 The contoured part includes spaced grooves 111, the outline of which is hemispherical. Specifically, in the end face where the heating seat 110 abuts against the bottom of the heating container 200, the position corresponding to the groove 111 is a depression away from the bottom of the heating container 200, while the position not corresponding to the groove 111 is a protrusion extending toward the side of the heating container 200.
[0042] The bottom of the heating container 200 matches the contoured part; that is, the bottom of the heating container 200 has a protrusion corresponding to the groove 110 at the same position as the groove 111, and the bottom of the heating container 200 has another matching groove 111 corresponding to the protrusion. This allows the heat from the heating base 110 to be directly transferred to the interior of the heating container 200, improving the uniformity of heat transfer. Simultaneously, because the heat from the heating base 110 is directly transferred to the interior of the heating container 200, and the spaced grooves 111 increase the contact area between the heating container 200 and the heating base 110, heat transfer efficiency is improved, thereby achieving rapid heating and increasing heating efficiency.
[0043] It should be noted that the contoured part may also be presented as a wavy, stepped or other shape end face, which is not limited here.
[0044] See Figures 1 to 3 As shown, in some embodiments of this application, the heating element 120 includes a ceramic heating element. Specifically, the ceramic heating element is disposed at the bottom of the heating base 110. When heating, the ceramic heating element is energized and generates heat. The heat generated by the ceramic heating element is transferred to the heating container 200 through the heating base 110 to heat the item to be heated in the heating container 200.
[0045] In some other possible implementations, the heating element 120 may also be a heating structure composed of a heating wire or a heating film.
[0046] In some embodiments of this application, see Figure 1 and Figure 2 As shown, the base 130 has a receiving groove 131 corresponding to the position of the heating element 120. The heating element 120 is disposed in the aforementioned receiving groove 131, which can limit the position of the heating element 120. The heating element 120 is clamped between the heating seat 110 and the base 130, and the heating element 120 can be fixed by the limiting function of the receiving groove 131.
[0047] Further, see Figure 1 and Figure 2 The depth of the receiving groove 131 is equal to the thickness of the heating element 120. When the bottom of the heating seat 110 abuts against the upper surface of the base 130, the bottom of the heating seat 110 can simultaneously abut against the heating element 120. In this way, the heat loss of the heating element 120 can be reduced, which helps to improve the heating efficiency.
[0048] In some embodiments of this application, see Figure 2 and Figure 3 The heating mechanism 100 also includes a temperature sensor 140, which is located at the bottom of the heating base 110. The temperature sensor 140 can detect the temperature of the heating base 110, which is beneficial for accurate control of the heating temperature.
[0049] In one possible implementation, the temperature sensor 140 includes a temperature control probe, which is embedded in a groove 111 at the bottom of the heating base 110. Meanwhile, a ceramic heating element is attached to the bottom of the heating base 110 using thermally conductive adhesive. The temperature control probe is located between the heating base 110 and the ceramic heating element, and is fixed to the heating base 110 by the ceramic heating element.
[0050] In some embodiments of this application, see Figures 1 to 3 The heating device also includes a base plate 300, on which a base 130 is disposed. In some embodiments of this application, the heating mechanism 100 is detachably connected to the base plate 300. That is, the heating mechanism 100 can be removed from the base plate 300, which facilitates cleaning of the surface of the heating seat 110 and improves the practicality and ease of use of the heating device in this embodiment.
[0051] In one possible implementation, the heating device further includes a limiting block 310, which is mounted on the base plate 300 and serves to limit the position of the base 130. Specifically, the limiting block 310 is located on the side of the base plate 300 near the heating mechanism 100, and protrudes from the surface of the base plate 300. After assembly, the limiting block 310 abuts against the side of the base 130. This effectively improves assembly efficiency.
[0052] Furthermore, the limiting block 310 has a strip-shaped structure, and the limiting block 310 is spaced apart on the base plate 300, with each limiting block 310 enclosing a mounting cavity for placing the heating mechanism 100. During assembly, the heating mechanism 100 can be directly placed into the mounting cavity to complete the positioning and installation of the heating mechanism 100, which helps to improve assembly efficiency.
[0053] Furthermore, the limiting block 310 protrudes from the surface of the base plate 300 and can abut against the side of the heating container 200, thereby providing a limit for the heating container 200.
[0054] In this embodiment, see Figures 1 to 3 The base plate 300 has a recessed portion, and the heating mechanism 100 is disposed in the recessed portion. The upper surface of the heating seat 110 is flush with the upper surface of the base plate 300, and the limiting block 310 provides limiting for both the heating seat 110 and the heating container 200.
[0055] In some embodiments of this application, the heating device further includes a circuit board 400, which is disposed on the side of the base plate 300 away from the heating mechanism 100, and is electrically connected to the heating mechanism 100. Specifically, the circuit board 400 has a connecting post 410 extending toward the heating mechanism 100 to enable the circuit board 400 to be electrically connected to the heating mechanism 100.
[0056] In some embodiments of this application, the base 130 is made of plastic. The plastic base 130 can serve as heat insulation, reducing the heat generated by the heating mechanism 100 during heating and thus effectively preventing damage to the circuit board 400.
[0057] In one possible implementation, the circuit board 400 is electrically connected to the heating element 120 and the temperature sensor 140. The circuit board 400 controls the operation of the heating element 120 to control the heating mechanism 100.
[0058] In some embodiments of this application, see Figure 1 The heating device also includes a protective cover 500, which is connected to the base plate 300. The protective cover 500 and the base plate 300 enclose a receiving cavity, within which the circuit board 400 is located. Specifically, the circuit board 400 is located within the aforementioned receiving cavity. The protective cover 500 and the base plate 300 enclose the sealed receiving cavity, which provides protection for the circuit board 400 and reduces the possibility of damage to the circuit board 400.
[0059] In some embodiments of this application, see Figure 2 The heating base 110 has a first positioning protrusion 112 at its bottom, and the base 130 has a first limiting groove 132 at the position corresponding to the first positioning protrusion 112. The first positioning protrusion 112 and the first limiting groove 132 are connected to each other to achieve the alignment of the heating base 110 and the base 130.
[0060] In some embodiments of this application, see Figure 2 The bottom of the base 130 is provided with a second positioning protrusion, and the base plate 300 is provided with a second limiting groove at the position corresponding to the second positioning protrusion. The second positioning protrusion and the second limiting groove are connected to achieve the positioning and installation of the base 130.
[0061] In one embodiment of this application, see [link to embodiment]. Figure 1 and Figure 3 As shown, the heating device also includes a pusher 320, which is mounted on the base plate 300 to facilitate the movement of the base plate 300.
[0062] The heating device of this application embodiment is described in detail below with reference to a specific embodiment. It should be noted that the following embodiment is only an exemplary description and should not be construed as a limitation on the heating device of this application embodiment.
[0063] See Figures 1 to 3 The heating device includes a protective cover 500, a circuit board 400, a connecting column 410, a base plate 300, a pusher 320, a limit block 310, a heating mechanism 100, and a deep hole plate.
[0064] The heating mechanism 100 includes a heating base 110, a temperature control probe, a ceramic heating element, and a base 130.
[0065] The heating device in this embodiment uses modular assembly. The temperature control probe is embedded in the groove designed at the bottom of the heating base 110. At the same time, the ceramic heating element is attached to the bottom of the heating base 110 with thermally conductive adhesive, and the temperature control probe is fixed and limited. Then, the groove of the base 130 and the protrusion at the bottom of the heating base 110 are connected to form the heating mechanism 100, which is then installed on the base plate 300. At the same time, the base plate 300 is equipped with limit blocks 310 on both sides, which are used to limit the deep hole plate. The circuit board 400 is installed on the bottom surface of the base plate 300 through the connecting post 410 and is connected to the heating mechanism 100 installed on the base plate 300 to form the circuit control of the heating mechanism 100. The pusher 320 is installed on the top of the base plate 300.
[0066] The working principle of the heating device in this embodiment is to use ceramic heating elements to raise the temperature of the heating base 110, thereby heating the deep hole plate placed on the heating base 110. At the same time, the temperature control probe installed at the bottom of the heating base 110 is used to monitor the real-time temperature in order to control the heating temperature. Because the heating base 110 and the bottom of the deep well plate are designed to fit in a symmetrical hemispherical shape, the deep well plate can be heated evenly and rapidly, quickly increasing the temperature of the reagent inside the deep well plate and improving heating efficiency. Meanwhile, the plastic structure of the base 130 also provides insulation against other components. The use of ceramic heating elements for heat conduction ensures a uniform temperature distribution on the heating base 110, resulting in a uniform temperature rise of the reagent inside the deep well plate. Both the heating base 110 and the base 130 are designed with mounting limiting grooves, effectively preventing incorrect assembly and improving assembly efficiency. Furthermore, the heating mechanism 100, as a small component, can be flexibly installed inside the base plate 300. Therefore, after use, the entire heating mechanism 100 can be removed, and the heating base 110 can be cleaned, effectively improving the practicality and ease of use of the heating device.
[0067] Another embodiment of this application discloses a nucleic acid extractor, which includes the heating device as described above and has all the technical effects of the aforementioned heating device, and will not be repeated here.
[0068] In the description of this application, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.
[0069] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more.
[0070] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.
[0071] In the description of this specification, specific features, structures, materials, or characteristics may be combined in any suitable manner in one or more embodiments or examples.
[0072] It should be understood that although the steps in the flowcharts of the accompanying figures are shown sequentially as indicated by the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless explicitly stated herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least some steps in the flowcharts of the accompanying figures may include multiple sub-steps or multiple stages. These sub-steps or stages are not necessarily completed at the same time, but can be executed at different times, and their execution order is not necessarily sequential, but can be performed alternately or in turn with other steps or at least some of the sub-steps or stages of other steps.
Claims
1. A heating device, characterized in that, include: A heating mechanism includes a heating seat, a heating element, and a base arranged in sequence, wherein the heating element is used to heat the heating seat; as well as A heating container is disposed on the heating base; The heating device further includes a base plate, and the base is disposed on the base plate; or... The heating device further includes a base plate and a circuit board. The base is disposed on the base plate, and the circuit board is disposed on the side of the base plate away from the heating mechanism. The circuit board is electrically connected to the heating mechanism; or, The heating device further includes a base plate, a circuit board, and a protective cover. The base is disposed on the base plate, the circuit board is disposed on the side of the base plate away from the heating mechanism, the circuit board is electrically connected to the heating mechanism, the protective cover is connected to the base plate, the protective cover and the base plate enclose a receiving cavity, and the circuit board is located in the receiving cavity.
2. The heating device according to claim 1, characterized in that, The heating base has a contoured part on the side near the heating container, and the contoured part matches the bottom of the heating container.
3. The heating device according to claim 2, characterized in that, The contoured part includes spaced grooves, the contour of which is hemispherical.
4. The heating device according to claim 1, characterized in that, The heating element includes a ceramic heating element.
5. The heating device according to any one of claims 1 to 4, characterized in that, The heating mechanism also includes a temperature sensor, which is located at the bottom of the heating base.
6. The heating device according to claim 1, characterized in that, It also includes a limiting block, which is installed on the base plate and is used to limit the position of the base.
7. The heating device according to claim 1, characterized in that, The heating container is a perforated plate, which has a plurality of spaced placement holes.
8. The heating device according to claim 1, characterized in that, The bottom of the heating base is provided with a first positioning protrusion, and the base is provided with a first limiting groove corresponding to the position of the first positioning protrusion. The first positioning protrusion and the first limiting groove are connected in cooperation.
9. A nucleic acid extractor, characterized in that, Includes the heating device as described in any one of claims 1 to 8.