Conveying device for production type polypeptide solvent

Abstract

The utility model discloses a production type polypeptide solvent conveying device which comprises a conveying pipeline used for conveying resin, the conveying pipeline is horizontally arranged, an elastic air bag is arranged on the inner wall of the bottom of the conveying pipeline in an extending mode, an extrusion ball is arranged in the elastic air bag, and the diameter of the extrusion ball is equal to the inner diameter of the conveying pipeline; the conveying pipeline is connected with an air pressure pushing mechanism, the air pressure pushing mechanism is used for pushing the extrusion balls to move leftwards or rightwards in the conveying pipeline, and the device has the advantages that the residual amount of resin in the resin conveying pipeline is reduced, the raw material mixing proportion precision is improved, and the product quality is improved.

Description

Technical Field

[0001] This application relates to the field of peptide production equipment technology, and in particular to a transport device for production peptide solvents. Background Technology

[0002] Peptides are compounds formed by α-amino acids linked together by peptide bonds. They are intermediate products of protein hydrolysis. Peptides composed of three or more amino acid molecules are called polypeptides. In solid-phase synthesis of polypeptide drugs, resin is an essential material in the polypeptide solvent, and its quality directly affects the quality of the polypeptide drug. During the synthesis process, it is necessary to strictly control the amount of resin added. Currently, when resin is added to the drying tank through a pipeline system, especially liquid resin, some residue is easily left in the pipeline, resulting in less resin added than actually added. This affects the mixing ratio of raw materials and ultimately the quality of the polypeptide product. Utility Model Content

[0003] The main objective of this application is to provide a transport device for production-grade peptide solvents, aiming to solve the technical problem that existing peptide synthesis resin transport pipelines are prone to resin residue, which affects the mixing ratio of raw materials.

[0004] To achieve the above objectives, this application provides a transport device for a production-grade polypeptide solvent, comprising a transport pipe for transporting resin, the transport pipe being horizontally arranged, an elastic air bladder extending from the bottom inner wall of the transport pipe, a squeeze ball being disposed inside the elastic air bladder, the diameter of the squeeze ball being equal to the inner diameter of the transport pipe, and a pneumatic pushing mechanism connected to the transport pipe for pushing the squeeze ball to move left or right within the transport pipe.

[0005] Optionally, the pneumatic pushing mechanism includes an air pump, the air pump's outlet end is connected to a three-way valve, the three-way valve is respectively connected to a first air pipe and a second air pipe, the first air pipe and the second air pipe are respectively connected to the top outer wall of the transmission pipeline, and the connection positions of the first air pipe and the transmission pipeline and the connection positions of the second air pipe and the transmission pipeline are respectively close to the two sides of the transmission pipeline, and the movement range of the squeeze ball is located between the first air pipe and the second air pipe.

[0006] Optionally, the two ends of the transmission pipeline are respectively connected to a feed valve and a discharge valve.

[0007] Optionally, two limiting baffles are provided inside the transmission pipeline, each of which has multiple through holes for resin to pass through, and the extrusion ball is located between the two limiting baffles.

[0008] Optionally, multiple transmission pipelines are provided, and multiple transmission pipelines are simultaneously connected to a distributor through a corresponding feed valve. The distributor is connected to a feed pipe for conveying resin, and a feed pump is provided on the feed pipe. The other end of the feed pipe is connected to a reaction vessel.

[0009] Optionally, a flow meter is installed on the transmission pipeline, and the flow meter is located near the feed valve.

[0010] Optionally, the flow meter is electrically connected to a controller, and the feed pump, inlet valve, and outlet valve are all electrically connected to the controller.

[0011] Optionally, it also includes a recycle mechanism for recovering resin from the drying tank into the reactor.

[0012] Optionally, the return mechanism includes a return pipe, with a first return valve and a second return valve connected to both ends of the return pipe, the first return valve being used to connect to the inlet of the reactor, the second return valve being used to connect to the outlet of the drying tank, and a return pump being installed on the return pipe.

[0013] Optionally, the return pump, the first return valve, and the second return valve are all electrically connected to the controller.

[0014] The beneficial effects that this application can achieve are as follows:

[0015] This application includes a transfer pipe for conveying resin. The transfer pipe is horizontally arranged, and an elastic air bladder extends from the inner wall of its bottom. A squeezing ball is placed inside the elastic air bladder, with a diameter equal to the inner diameter of the transfer pipe. The transfer pipe is connected to a pneumatic pushing mechanism, which pushes the squeezing ball to move left or right within the transfer pipe. Based on this structure, after resin is conveyed through the transfer pipe, the elastic air bladder can be manually pressed upwards to allow the squeezing ball inside to enter the transfer pipe. Then, the pneumatic pushing mechanism generates air pressure inside the transfer pipe in the direction of resin delivery, thereby pushing the squeezing ball to expel residual resin from the transfer pipe's outlet. The air pressure direction can then be changed to move the squeezing ball back to the elastic air bladder. The squeezing ball can then be reinstalled in the elastic air bladder for future use. Therefore, this application, through the ingenious design of the squeezing ball, can effectively expel residual resin, thereby improving the accuracy of the raw material mixing ratio and ensuring the quality of the peptide product. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the specific embodiments of this application or the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0017] Figure 1 This is a schematic diagram of the structure of a transport device for a production-grade polypeptide solvent in an embodiment of this application;

[0018] Figure 2This is a schematic diagram of the structure of a delivery device for a production-grade polypeptide solvent in an embodiment of this application, showing the movement of a squeeze ball.

[0019] Figure 3 This is a schematic diagram (top view) of the connection structure between the splitter and multiple transmission pipes in an embodiment of this application.

[0020] Figure label:

[0021] 110-Transmission pipe, 120-Elastic airbag, 130-Extrusion ball, 140-Pneumatic pushing mechanism, 141-Air pump, 142-Three-way valve, 143-First air pipe, 144-Second air pipe, 150-Feed valve, 160-Discharge valve, 170-Limit baffle, 180-Diverter, 190-Feeding pipe, 210-Feeding pump, 220-Reaction vessel, 230-Flow meter, 240-Controller, 250-Return mechanism, 251-Return pipe, 252-First return valve, 253-Second return valve, 254-Return pump, 260-Drying tank, 270-Control valve.

[0022] The realization of the purpose, functional features and advantages of this application will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0023] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0024] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of this application are only used to explain the relative positional relationship and movement of each component in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0025] In this application, unless otherwise expressly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral part; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0026] Furthermore, if the embodiments of this application involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the meaning of "and / or" throughout the text includes three parallel solutions; for example, "A and / or B" includes solution A, solution B, or a solution where both A and B are satisfied simultaneously. Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed in this application.

[0027] Example

[0028] Reference Figures 1-3 This embodiment provides a transport device for a production-grade polypeptide solvent, including a transport pipe 110 for transporting resin. The transport pipe 110 is arranged horizontally, and an elastic air bladder 120 is extended from the bottom inner wall of the transport pipe 110. A squeeze ball 130 is disposed inside the elastic air bladder 120. The diameter of the squeeze ball 130 is equal to the inner diameter of the transport pipe 110. The transport pipe 110 is connected to a pneumatic pushing mechanism 140, which is used to push the squeeze ball 130 to move left or right within the transport pipe 110.

[0029] In this embodiment, after the resin is transported through the transmission pipe 110, the elastic airbag 120 can be manually pressed upwards to allow the extrusion ball 130 inside the elastic airbag 120 to enter the transmission pipe 110. At this time, the air pressure pushing mechanism 140 generates air pressure inside the transmission pipe 110 in the direction of resin transport, thereby pushing the extrusion ball 130 to move and squeeze the residual resin in the transmission pipe 110 out of its outlet. Then, the air pressure direction is changed so that the extrusion ball 130 moves in the opposite direction to the elastic airbag 120. The extrusion ball 130 can then be installed back into the elastic airbag 120 for future use. Therefore, through the ingenious design of the extrusion ball 130, this embodiment can effectively squeeze out residual resin, thereby improving the accuracy of the raw material mixing ratio and ensuring the quality of the peptide product.

[0030] It should be noted that the elastic airbag 120 can be made of rubber. There is an opening between the elastic airbag 120 and the transmission pipe 110 for the extrusion ball 130 to pass through. When there is no extrusion ball 130, the elastic airbag 120 is in a deflated bag shape. When it is necessary to put the extrusion ball 130 into the elastic airbag 120, part of the extrusion ball 130 can slide into the elastic airbag 120 under its own weight. Then, squeeze the extrusion ball 130 to make it move down, thereby causing the elastic airbag 120 to expand and tightly wrap the extrusion ball 130. The operation is convenient and quick.

[0031] As an optional implementation, the pneumatic pushing mechanism 140 includes an air pump 141. The air outlet of the air pump 141 is connected to a three-way valve 142. The three-way valve 142 is connected to a first air pipe 143 and a second air pipe 144. The first air pipe 143 and the second air pipe 144 are respectively connected to the top outer wall of the transmission pipe 110. The connection positions of the first air pipe 143 and the transmission pipe 110 and the connection positions of the second air pipe 144 and the transmission pipe 110 are respectively close to the two sides of the transmission pipe 110. The movement range of the squeeze ball 130 is located between the first air pipe 143 and the second air pipe 144.

[0032] In this embodiment, the air pump 141 can generate compressed gas with air pressure. When it is necessary to push the extrusion ball 130 to extrude residual resin, the first air pipe 143 is connected only through the three-way valve 142, and the second air pipe 144 is closed. The compressed gas enters the side of the transmission pipeline 110 near the feed end from the first air pipe 143, thereby pushing the extrusion ball 130 to move in the resin conveying direction. After extrusion is completed, the second air pipe 144 is connected only through the three-way valve 142, and the first air pipe 143 is closed. The compressed gas enters the side of the transmission pipeline 110 near the discharge end from the second air pipe 144, thereby pushing the extrusion ball 130 to move in the opposite direction to reset. This realizes the use of air pressure in different directions to push the extrusion ball 130 to move left or right, which is convenient and quick to operate.

[0033] As an optional implementation, the two ends of the transmission pipeline 110 are respectively connected to a feed valve 150 and a discharge valve 160. The discharge valve 160 is used to connect to the drying tank 260 through the pipeline, and the conveyed resin enters the drying tank 260.

[0034] In this embodiment, when conveying resin, both the feed valve 150 and the discharge valve 160 are open. When it is necessary to push the extrusion ball 130 to move in the resin conveying direction, the feed valve 150 is closed and the discharge valve 160 is opened, so that the compressed gas in the transmission pipeline 110 flows towards the discharge valve 160 to push the extrusion ball 130. When it is necessary to push the extrusion ball 130 to move in the opposite direction for resetting, the feed valve 150 is opened and the discharge valve 160 is closed, so that the compressed gas flows towards the feed valve 150 to push the extrusion ball 130 to move in the same direction.

[0035] As an optional implementation, two limiting baffles 170 are provided in the transmission pipe 110. Each limiting baffle 170 has multiple through holes for resin to pass through, and the extrusion ball 130 is located between the two limiting baffles 170.

[0036] In this embodiment, two limiting baffles 170 are used to limit the movement limit position of the extrusion ball 130, and the limiting baffles 170 are a certain distance away from the two ends of the transmission pipe 110, which can prevent the extrusion ball 130 from being blocked at the two ends of the transmission pipe 110, thereby ensuring that the extrusion ball 130 can move smoothly under air pressure, and the through hole design on the limiting baffles 170 does not affect the flow of resin.

[0037] As an optional implementation, multiple transmission pipes 110 are provided, and multiple transmission pipes 110 are simultaneously connected to a distributor 180 through a corresponding feed valve 150. The distributor 180 is connected to a feed pipe 190 for conveying resin. A feed pump 210 is provided on the feed pipe 190, and the other end of the feed pipe 190 is connected to a reaction vessel 220.

[0038] In this embodiment, the resin in the reactor 220 enters the distributor 180 under the action of the feed pump 210. By setting multiple transmission pipes 110, multiple drying tanks 260 can be connected as needed. The required transmission pipes 110 can be connected through the feed valve 150, which can meet the production needs of high efficiency and high output.

[0039] It should be noted that the feed pipe 190 is connected to the reactor 220 via the control valve 270, and the control valve 270 is only opened when needed.

[0040] As an optional implementation, a flow meter 230 is installed on the transmission pipe 110, and the flow meter 230 is close to the feed valve 150. The flow meter 230 can monitor the resin flow rate through the corresponding transmission pipe 110, thereby allowing precise control of the resin flow rate in each transmission pipe 110. When the corresponding flow rate is reached, the corresponding feed valve 150 can be closed. This method is flexible, can meet more application needs, and improves versatility.

[0041] As an optional implementation, the flow meter 230 is electrically connected to the controller 240. The feed pump 210, the feed valve 150 and the discharge valve 160 are all electrically connected to the controller 240. The controller 240 can control the opening or closing of the feed pump 210, the feed valve 150 and the discharge valve 160 respectively, which facilitates intelligent control. Here, the controller 240 can be a PLC controller of model S7-200.

[0042] As an optional implementation, a return mechanism 250 is also included, which is used to recover the resin in the drying tank 260 into the reactor 220. The return mechanism 250 includes a return pipe 251, with a first return valve 252 and a second return valve 253 connected to its two ends, respectively. The first return valve 252 is used to connect to the inlet of the reactor 220, and the second return valve 253 is used to connect to the outlet of the drying tank 260. A return pump 254 is provided on the return pipe 251.

[0043] In this embodiment, when the drying tank 260 produces excess resin, the first return valve 252 and the second return valve 253 can be opened, and the return pump 254 can be started, so as to recover the excess resin into the reactor 220 for reuse and reduce raw material waste.

[0044] As an optional implementation, the return pump 254, the first return valve 252, and the second return valve 253 are all electrically connected to the controller 240, so that they can be controlled separately.

[0045] The above are merely preferred embodiments of this application and do not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A transport device for production-grade polypeptide solvents, characterized in that, It includes a transfer pipe for conveying resin, the transfer pipe is arranged horizontally, and an elastic air bladder is extended from the bottom inner wall of the transfer pipe. A squeeze ball is installed inside the elastic air bladder. The diameter of the squeeze ball is equal to the inner diameter of the transfer pipe. The transfer pipe is connected to a pneumatic pushing mechanism, which is used to push the squeeze ball to move left or right inside the transfer pipe.

2. The transport device for production-grade polypeptide solvents as described in claim 1, characterized in that, The pneumatic pushing mechanism includes an air pump, the air pump outlet is connected to a three-way valve, the three-way valve is connected to a first air pipe and a second air pipe respectively, the first air pipe and the second air pipe are respectively connected to the top outer wall of the transmission pipeline, and the connection positions of the first air pipe and the transmission pipeline and the connection positions of the second air pipe and the transmission pipeline are respectively close to the two sides of the transmission pipeline, and the movement range of the squeeze ball is located between the first air pipe and the second air pipe.

3. The transport device for production-grade polypeptide solvents as described in claim 2, characterized in that, The two ends of the transmission pipeline are connected to a feed valve and a discharge valve, respectively.

4. The transport device for production-grade polypeptide solvents as described in claim 3, characterized in that, Two limiting baffles are installed inside the transmission pipeline. Each limiting baffle has multiple through holes for resin to pass through, and the extrusion ball is located between the two limiting baffles.

5. The transport device for production-grade polypeptide solvents as described in claim 3, characterized in that, Multiple transmission pipelines are provided, and each transmission pipeline is simultaneously connected to a distributor through a corresponding feed valve. The distributor is connected to a feed pipe for conveying resin, and a feed pump is installed on the feed pipe. The other end of the feed pipe is connected to a reaction vessel.

6. The transport device for a production-grade polypeptide solvent as described in claim 5, characterized in that, A flow meter is installed on the transmission pipeline, and the flow meter is close to the feed valve.

7. The transport device for a production-grade polypeptide solvent as described in claim 6, characterized in that, The flow meter is electrically connected to a controller, and the feed pump, inlet valve, and outlet valve are all electrically connected to the controller.

8. The transport device for a production-grade polypeptide solvent as described in claim 7, characterized in that, It also includes a recycle mechanism, which is used to recover the resin in the drying tank into the reactor.

9. The transport device for a production-grade polypeptide solvent as described in claim 8, characterized in that, The return mechanism includes a return pipe, with a first return valve and a second return valve connected to both ends of the return pipe. The first return valve is used to connect to the inlet of the reactor, and the second return valve is used to connect to the outlet of the drying tank. A return pump is installed on the return pipe.

10. The transport device for a production-grade polypeptide solvent as described in claim 9, characterized in that, The return pump, the first return valve, and the second return valve are all electrically connected to the controller.

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