Portable biochemical blood coagulation analysis device

Abstract

The utility model discloses a portable biochemical blood coagulation analysis device which comprises a shell, a power supply, a control module and a detection module, the detection module is composed of a lamp source, a support, a detection chamber, a spectrograph, an in-out cabin and a chip, a direct-current brushless motor is fixed to the in-out cabin, a chip fixing seat is fixed to the upper end of the direct-current brushless motor, a circle of teeth are arranged on the chip fixing seat, the teeth are meshed with teeth on the chip through the teeth, and the chip is fixed to the detection chamber through the detection chamber. The circumferential locking of the chip is realized; an NFC chip is attached to the chip, and an NFC detection module is arranged at the upper end of the detection chamber. According to the utility model, the diluent is arranged in the chip, the diluent does not need to be additionally added during detection, the chip and the chip fixing seat are attracted by a magnet and locked by tooth meshing, the structure is simpler, chip information is stored on one NFC chip, the chip automatically reads the information when entering a constant-temperature cabin, and the action of scanning a code to read the chip information is reduced.

Description

Technical Field

[0001] This utility model relates to the field of biochemical detection technology, specifically a portable biochemical coagulation analysis device. Background Technology

[0002] In the early 1990s, Manz and Widmer proposed the concept of a microfluidic chip laboratory, also known as a Miniaturized Total Analysis System (uTAS). Microfluidic chips can concentrate chemical or biological laboratories onto a chip of just a few square centimeters, enabling sample pretreatment, separation, and detection. Through the high integration and miniaturization of chemical equipment, the functions of the analytical laboratory are transferred to portable devices to the greatest extent possible. Currently, they are widely used in many fields such as biology, drug diagnostics, gene analysis, and environmental monitoring. Simultaneously, due to their small size, portability, and convenience, microfluidic chips have also shown outstanding advantages in the field of clinical medicine, enabling "point-of-care" (POC) detection, which is of great significance to global public health.

[0003] The rapid development of microfluidic chips has brought new opportunities for on-site real-time detection, but it has also placed higher demands on detection devices.

[0004] Currently, prior art JP-2006-110491 discloses a microchip rotation device, which centrifuges a microchip into which blood of the test subject is introduced, and mixes the centrifuged plasma and reagents evenly as the test liquid, which is then introduced into the microchip centrifugation separation device of the spectrophotometric measurement section. However, it requires the chip to be removed after centrifugation before spectrophotometric analysis, which cannot achieve integrated and timely detection, thus affecting detection efficiency. Prior art CN200710126374.8 discloses a microchip inspection device that can be used for blood analysis and can integrate centrifugation and detection steps into a single chip. However, the chip placement part of this inspection device is only suitable for single-channel chip detection of a specific shape, and the chip is arranged around both sides of the rotor shaft, which increases the size of the detection device and is not suitable for multi-channel rapid detection. The prior art CN104833812A discloses a portable automatic biochemical analysis device. The detection stage is mounted on a centrifuge motor, and the detection stage and the chip are fixed together by a slot. The chip is driven to perform centrifugal motion, which can realize multi-channel detection. However, before detection, the device requires manual addition of diluent to the chip, which is inconvenient to operate and easy to confuse the diluent with the test sample. Utility Model Content

[0005] The purpose of this invention is to provide a portable biochemical coagulation analysis device to solve the problem mentioned in the background art where the detection stage is installed on a centrifuge motor, the detection stage and the chip are fixed together by a slot, and the chip is driven to perform centrifugal motion, which can realize multi-channel detection. However, this device requires manual addition of diluent to the chip before detection, which is inconvenient to operate and easily leads to confusion between diluent and test sample.

[0006] To achieve the above objectives, the present invention provides the following technical solution: including a housing, a power supply, a control module and a detection module, wherein an NFC detection board for reading information from an NFC chip is fixedly installed in the middle of the NFC detection module, and when the cabin is in the retracted state, the NFC detection board and the NFC chip are on the same vertical line.

[0007] The detection module consists of a light source, a bracket, a detection chamber, a spectrometer, an entry / exit chamber, and a chip. A DC brushless motor is fixed on the entry / exit chamber, and a chip holder is fixed on the upper end of the DC brushless motor. A ring of teeth is formed on the chip holder, so that the ring teeth mesh with the teeth on the chip to achieve circumferential locking of the chip.

[0008] An NFC chip 9 is attached to the chip, and an NFC detection module is installed at the top of the detection chamber.

[0009] Preferably, the power supply provides power to the control module and the detection module, and the control module provides signal support for the operation of the detection module.

[0010] Preferably, the entry / exit cabin is fixed on a support, and the cabin body of the entry / exit cabin is driven to extend and retract through the cooperation of gears and racks.

[0011] Preferably, the chip holder is equipped with a magnet, and an iron plate is embedded in the bottom of the magnet, so that the chip and the chip holder are attracted together.

[0012] Preferably, heating films are provided above and below the detection chamber.

[0013] Preferably, a temperature sensor is installed next to the testing chamber so that the temperature inside the testing chamber can be controlled by the temperature sensor.

[0014] Compared with the prior art, the beneficial effects of this utility model are:

[0015] During testing, the chamber of this invention extends outwards, facilitating the placement of the chip on the chip holder by the operator. The chip holder is equipped with a magnet, with an iron plate embedded at the bottom of the magnet, causing the chip to adhere to the chip holder. During this adhesion, the dilution cup membrane inside the chip is automatically torn open, allowing the diluent to flow into the chip. The chip holder has a ring of teeth that mesh with the teeth on the chip, achieving circumferential locking of the chip. This ensures the diluent is internally contained within the chip, eliminating the need for additional diluent during testing. The combination of magnetic attraction and toothed locking between the chip and the chip holder results in a simpler structure.

[0016] This invention also features a chip that enters the testing chamber along with the retracted chamber body. Heating films are installed above and below the testing chamber, and a temperature sensor is located next to the chamber to control the internal temperature. An NFC chip is attached to the chip, and an NFC detection module is located at the top of the testing chamber. An NFC detection board for reading information from the NFC chip is fixedly installed in the middle of the NFC detection module. When the chamber body is retracted, the NFC detection board and the NFC chip are on the same vertical line, allowing the NFC detection module's identification system to read information from the NFC chip in conjunction with the NFC detection board. After reading, a DC brushless motor drives the chip to centrifuge (this action can also be accomplished using a built-in scanner). After centrifugation, the sample and diluent flow into the detection holes around the chip, reacting with the freeze-dried bulbs inside. Illumination is achieved by a light source passing through the detection holes, and a spectrometer collects and analyzes the light beam to obtain the results. The chip information is stored on an NFC chip, and the information is automatically read when the chip enters the constant temperature chamber, reducing the need for scanning. The chip's identification information can detect biochemical reagent trays and coagulation reagent trays, offering a wider range of testing types and packages. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the shell structure of a portable biochemical coagulation analysis device according to the present invention;

[0018] Figure 2 This is a schematic diagram of the detection module of the present invention in the blood coagulation inlet / outlet chamber retraction state;

[0019] Figure 3 This is a schematic diagram of the detection module of the present invention in the extended state of the coagulation inlet / outlet chamber;

[0020] Figure 4 This is a cross-sectional schematic diagram of the overall structure of a portable biochemical coagulation analysis device according to the present invention;

[0021] Figure 5 This is a partial structural diagram of a portable biochemical coagulation analysis device according to the present invention.

[0022] Figure 6 This is a schematic diagram of the chip in the present invention in the state of being attracted and locked.

[0023] In the diagram: 1. Housing; 2. NFC detection module; 3. Light source; 4. Detection chamber; 5. Spectrometer; 6. Entry / exit chamber; 7. Chip; 8. DC brushless motor; 9. NFC chip; 10. NFC detection board. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Please see Figure 1-6 This utility model provides a technical solution for a portable biochemical coagulation analysis device: including a housing 1, a power supply, a control module and a detection module, so that the housing 1 protects the internal control module and detection module, the power supply provides power support for the control module and detection module, and the control module provides signal support for the operation of the detection module;

[0026] The detection module consists of a lamp source 3, a bracket, a detection chamber 4, a spectrometer 5, an inlet / outlet chamber 6, and a chip 7. The inlet / outlet chamber 6 is fixed on the bracket. The chamber body of the inlet / outlet chamber 6 is driven to extend and retract through the cooperation of gears and racks. A DC brushless motor 8 is fixed on the inlet / outlet chamber 6. This motor has a centrifugal function (this motor is also called a centrifugal motor). A chip mounting bracket is fixed on the upper end of the DC brushless motor 8.

[0027] During testing, the chamber of the entry / exit chamber 6 extends, allowing the operator to place the chip 7 on the chip holder. The chip holder is equipped with a magnet, and an iron plate is embedded at the bottom of the magnet, which causes the chip 7 to be attracted to the chip holder. During the process of the chip 7 being attracted to the chip holder, the dilution cup membrane inside the chip 7 is automatically torn open, and the diluent flows into the chip 7. The chip holder has a ring of teeth that can mesh with the teeth on the chip 7, which can achieve circumferential locking of the chip 7.

[0028] The chamber 6 retracts, carrying chip 7 into detection chamber 4. Heating films are installed above and below detection chamber 4, and a temperature sensor is installed next to detection chamber 4 to control the temperature inside. NFC chip 9 is attached to chip 7. NFC detection module 2 is installed at the top of detection chamber 4. NFC detection board 10 for reading information from NFC chip 9 is fixedly installed in the middle of NFC detection module 2. When the chamber 6 is retracted, NFC detection board 10 and NFC chip 9 are on the same vertical line, allowing the identification system of NFC detection module 2 to read information from NFC chip 9 in conjunction with NFC detection board 10. After reading the information, DC brushless motor 8 drives chip 7 to centrifuge (this action can also be accomplished by a built-in scanner). After centrifugation, the sample and diluent flow into the detection holes around chip 7 and react with the freeze-dried bulbs inside. Light source 3 illuminates the detection holes, and spectrometer 5 collects the light beam for analysis to obtain results.

[0029] The diluent is built into the chip 7, so no additional diluent needs to be added during testing; the chip 7 and the chip holder are locked by magnetic attraction and tooth engagement, which simplifies the structure; the information of the chip 7 is stored on an NFC chip 9, and the information is automatically read when the chip 7 enters the constant temperature chamber, reducing the need to scan the code to read the information of the chip 7.

[0030] The NFC chip identification information can be used to detect biochemical reagent trays and coagulation reagent trays, providing a wider range of detection types and packages. It should be noted that the detection module can perform both biochemical and coagulation tests; only the corresponding chip and the corresponding centrifugation motion and detection logic need to be replaced.

[0031] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0032] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A portable biochemical coagulation analysis device, characterized in that: Includes housing (1), power supply, control module and detection module; The detection module consists of a lamp source (3), a bracket, a detection chamber (4), a spectrometer (5), an entry / exit chamber (6), and a chip (7). A DC brushless motor (8) is fixed on the entry / exit chamber (6), and a chip holder is fixed on the upper end of the DC brushless motor (8). A ring of teeth is opened on the chip holder, so that the ring teeth mesh with the teeth on the chip (7) to achieve circumferential locking of the chip (7). An NFC chip (9) is attached to the chip (7). An NFC detection module (2) is provided at the upper end of the detection chamber (4). An NFC detection board (10) for reading information from the NFC chip (9) is fixedly installed in the middle of the NFC detection module (2). When the cabin of the in-and-out chamber (6) is in the retracted state, the NFC detection board (10) and the NFC chip (9) are on the same vertical line.

2. The portable biochemical coagulation analysis device according to claim 1, characterized in that: The power supply provides power to the control module and the detection module, and the control module provides signal support for the operation of the detection module.

3. A portable biochemical coagulation analysis device according to claim 2, characterized in that: The entry / exit cabin (6) is fixed on the support, and the cabin body of the entry / exit cabin (6) is driven to extend and retract through the cooperation of gears and racks.

4. A portable biochemical coagulation analysis device according to claim 3, characterized in that: The chip holder is equipped with a magnet, and an iron plate is embedded in the bottom of the magnet, so that the chip (7) is attracted to the chip holder.

5. A portable biochemical coagulation analysis device according to claim 4, characterized in that: Heating films are provided above and below the detection chamber (4).

6. A portable biochemical coagulation analysis device according to claim 5, characterized in that: A temperature sensor is installed next to the detection chamber (4) so ​​that the temperature inside the detection chamber (4) can be controlled by the temperature sensor.

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