Particle size detection sampler for bulk drugs

Abstract

The utility model provides a particle size detection sampler for raw material medicines, which belongs to the technical field of sampling equipment and comprises a storage shell, the sampling assembly is arranged on the inner wall of the storage shell, the sampling assembly comprises a conveying pipe, a screw rod, a driving assembly, a conical barrel, a sampling pipe, a clamping barrel, a supporting spring and an extrusion plug, and the conveying pipe is embedded in the inner wall of the storage shell. According to the sampling assembly, firstly, a sampling pipe is embedded into a storage shell through a mounting opening, a supporting spring is used for driving an extrusion plug to extrude the sampling pipe, so that one end of the sampling pipe is arranged on the outer wall of a conical barrel in a sleeving manner, and then a micro motor is started, so that a driving gear drives a driven gear to rotate; the raw material medicine is conveyed into the mounting barrel through the screw rod, then the raw material medicine is conveyed into the sampling pipe through the conical barrel, the raw material medicine is rapidly sampled with high efficiency, and the pollution problem caused by the fact that the raw material medicine makes contact with the external environment is avoided.

Description

Technical Field

[0001] This utility model belongs to the field of sampling equipment technology, specifically relating to a sampler for particle size detection of pharmaceutical raw materials. Background Technology

[0002] The particle size of a drug refers to the size of particles in a pharmaceutical formulation. It has a direct impact on the quality and efficacy of the drug. Particle size control is crucial for the consistency and stability of the drug. In the drug research and development and production process, particle size analysis and control are essential steps. There are many methods for particle size testing, including sieving, microscopy, and laser particle size analysis. For some drugs, especially poorly soluble ones, particle size can affect the drug's dissolution and bioavailability, thus requiring particle size control. For example, the "Basic Technical Guidelines for Research on Chemical Drug Formulations" and the "Technical Guidelines for Research on Generic Chemical Drugs for Topical Use (Trial)" both mention the impact of particle size on formulation quality and related properties, requiring analysis and testing in pharmaceutical evaluation. In short, the particle size of a drug has a significant impact on its quality and efficacy, necessitating appropriate control and analysis.

[0003] Existing methods for particle size analysis of active pharmaceutical ingredients (APIs) require frequent sampling of the APIs. Frequent use of the sampling spoon may cause API leakage. Frequent contact with the external environment during sampling can easily cause air pollution, often leading to errors in subsequent testing processes. Furthermore, sampling is quite difficult. Utility Model Content

[0004] The purpose of this invention is to provide a sampler for particle size detection of pharmaceutical raw materials, aiming to solve the problems raised in the background art.

[0005] A sampler for particle size analysis of pharmaceutical raw materials, comprising:

[0006] Storage case;

[0007] A sampling assembly is located on the inner wall of the storage shell, comprising: a delivery pipe, a screw, a drive assembly, a conical cylinder, a sampling tube, a clamping cylinder, a support spring, and a compression plug. The delivery pipe is embedded in the inner wall of the storage shell, the screw is rotatably embedded in the inner wall of the delivery pipe, the conical cylinder is interconnected with the delivery pipe, the sampling tube is embedded in the outer wall of the conical cylinder, the clamping cylinder is embedded in the inner wall of the storage shell, one end of the support spring is fixedly located on the inner wall of the clamping cylinder, one side of the outer wall of the compression plug is fixedly located at the other end of the support spring, and the other side of the outer wall of the compression plug is attached to the outer wall of the sampling tube. The drive assembly is located on the inner wall of the storage shell.

[0008] Furthermore, the drive assembly includes a protective shell, a sealing ring, a driven gear, a driving gear, and a micro motor.

[0009] Furthermore, the sealing ring is fitted onto the outer wall of the conveying pipe, the driven gear is fitted onto the outer wall of the screw, and the protective shell and the storage shell are matched with each other.

[0010] Furthermore, the driving gear is embedded in the inner wall of the protective shell, and the driven gear meshes with the outer wall of the driving gear for transmission.

[0011] Furthermore, the output end of the micro motor is fixedly located at the center of the outer wall of the drive gear.

[0012] Furthermore, an installation cylinder is fixedly provided on the outer wall of one end of the storage shell, and the installation cylinder is sleeved on the outer wall of the delivery pipe. An installation port is opened on one side of the outer wall of the storage shell, and the installation port matches the sampling tube. A handle is fixedly provided on one side of the outer wall of the storage shell.

[0013] Compared with the prior art, the beneficial effects of this utility model are:

[0014] In this solution, the sampling tube is first embedded into the housing using the mounting port via the sampling assembly. A support spring drives the compression plug to compress the sampling tube, causing one end of the tube to fit onto the outer wall of the conical cylinder. Then, a micro motor is activated, causing the drive gear to rotate and the screw to transport the raw material into the housing. Subsequently, the raw material is transported through the conical cylinder into the sampling tube, allowing for rapid sampling of the raw material with high efficiency and avoiding contamination caused by the raw material coming into contact with the external environment. Attached Figure Description

[0015] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0016] Figure 1 This is a perspective view of the present utility model;

[0017] Figure 2 This is a partial half-sectional perspective view of the present invention;

[0018] Figure 3 This is a perspective view of the handle of this utility model.

[0019] In the diagram: 1. Storage shell; 2. Handle; 3. Protective shell; 4. Mounting cylinder; 5. Delivery pipe; 6. Screw; 7. Sealing ring; 8. Driven gear; 9. Driven gear; 10. Micro motor; 11. Conical cylinder; 12. Sampling tube; 13. Clamping cylinder; 14. Support spring; 15. Squeezing plug; 101. Mounting port. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] In the description of this utility model, it should be noted that the terms "upper," "lower," "inner," "outer," "top / bottom," etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0022] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," "sleeved / connected," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0023] Please see Figure 1-3 The technical solution provided in this embodiment is as follows:

[0024] A sampler for particle size analysis of pharmaceutical raw materials, comprising:

[0025] Storage case 1;

[0026] The sampling assembly is located on the inner wall of the storage shell 1. The sampling assembly includes a delivery pipe 5, a screw 6, a drive assembly, a conical cylinder 11, a sampling tube 12, a clamping cylinder 13, a support spring 14, and a squeeze plug 15. The delivery pipe 5 is embedded in the inner wall of the storage shell 1. The screw 6 is rotatably embedded in the inner wall of the delivery pipe 5. The conical cylinder 11 and the delivery pipe 5 are interconnected. The sampling tube 12 is embedded in the outer wall of the conical cylinder 11. The clamping cylinder 13 is embedded in the inner wall of the storage shell 1. One end of the support spring 14 is fixedly set in the inner wall of the clamping cylinder 13. One side of the outer wall of the squeeze plug 15 is fixedly set in the other end of the support spring 14. The other side of the outer wall of the squeeze plug 15 is attached to the outer wall of the sampling tube 12. The drive assembly is located on the inner wall of the storage shell 1.

[0027] In this application, "screw" refers to a spiral conveying component (also known in the industry as a spiral conveyor rod / auger) used to rotate inside a conveying pipe and propel powder / granular materials axially. It is driven by a micro motor to rotate inside the conveying pipe via active / driven gears, and works with a conical cylinder to directionally introduce the raw material into the sampling tube to achieve closed and rapid sampling.

[0028] In a specific embodiment of this utility model, the sampling assembly first embeds the sampling tube 12 into the housing shell 1 using the mounting port 101. The support spring 14 drives the compression plug 15 to compress the sampling tube 12, so that one end of the sampling tube 12 is fitted onto the outer wall of the conical cylinder 11. Then, the micro motor 10 is started, causing the drive gear 9 to drive the driven gear 8 to rotate. The screw 6 transports the raw material to the inside of the mounting cylinder 4. Subsequently, the raw material is transported through the conical cylinder 11 to the inside of the sampling tube 12, thus quickly sampling the raw material with high efficiency and avoiding contamination problems caused by the raw material coming into contact with the external environment.

[0029] Specifically, the drive assembly includes a protective shell 3, a sealing ring 7, a driven gear 8, a driving gear 9, and a micro motor 10.

[0030] In a specific embodiment of this utility model, a stable screw 6 drive can be achieved through the drive component.

[0031] Specifically, the sealing ring 7 is fitted onto the outer wall of the conveying pipe 5, the driven gear 8 is fitted onto the outer wall of the screw 6, and the protective shell 3 and the storage shell 1 are matched with each other.

[0032] In a specific embodiment of this utility model, a stable seal can be achieved for the driven gear 8 by fitting a sealing ring 7 onto the outer wall of the conveying pipe 5.

[0033] Specifically, the driving gear 9 is embedded in the inner wall of the protective shell 3, and the driven gear 8 meshes with the outer wall of the driving gear 9 for transmission.

[0034] In a specific embodiment of this utility model, the driving gear 8 and the driving gear 9 are meshed and connected by transmission, which can ensure the stability of power transmission.

[0035] Specifically, the output end of the micro motor 10 is fixedly located at the center of the outer wall of the drive gear 9.

[0036] In a specific embodiment of this utility model, the output end of the micro motor 10 is fixedly disposed at the center of the outer wall of the drive gear 9, which can ensure stable power.

[0037] Specifically, an installation cylinder 4 is fixedly installed on the outer wall of one end of the storage shell 1, and the installation cylinder 4 is sleeved on the outer wall of the delivery pipe 5. An installation port 101 is opened on one side of the outer wall of the storage shell 1, and the installation port 101 matches the sampling pipe 12. A handle 2 is fixedly installed on one side of the outer wall of the storage shell 1.

[0038] In a specific embodiment of this utility model, a handle 2 is fixedly provided on one side of the outer wall of the storage shell 1 to ensure stable gripping.

[0039] The working process of the sampler for particle size detection of pharmaceutical raw materials provided by this utility model is as follows:

[0040] Using the sampling assembly, the sampling tube 12 is first embedded into the housing 1 through the mounting port 101. The support spring 14 drives the compression plug 15 to compress the sampling tube 12, so that one end of the sampling tube 12 is fitted onto the outer wall of the conical cylinder 11. Then, the micro motor 10 is started, so that the driving gear 9 drives the driven gear 8 to rotate. The screw 6 transports the raw material to the inside of the mounting cylinder 4. Then, the raw material is transported through the conical cylinder 11 to the inside of the sampling tube 12. The raw material is sampled quickly with high efficiency, avoiding the pollution problem caused by the raw material coming into contact with the external environment.

[0041] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A sampler for particle size detection of pharmaceutical raw materials, characterized in that, include, Storage shell (1); A sampling assembly is located on the inner wall of the housing (1), wherein: the sampling assembly includes a delivery pipe (5), a screw (6), a drive assembly, a conical cylinder (11), a sampling tube (12), a clamping cylinder (13), a support spring (14), and a squeeze plug (15). The delivery pipe (5) is embedded in the inner wall of the housing (1), and the screw (6) is rotatably embedded in the inner wall of the delivery pipe (5). The screw (6) is used to push the raw material drug axially within the delivery pipe (5); the conical cylinder (11) The sampling tube (12) is embedded in the outer wall of the conical cylinder (11) and the clamping cylinder (13) is embedded in the inner wall of the storage shell (1). One end of the support spring (14) is fixedly set in the inner wall of the clamping cylinder (13). One side of the outer wall of the squeeze plug (15) is fixedly set in the other end of the support spring (14). The other side of the outer wall of the squeeze plug (15) is attached to the outer wall of the sampling tube (12). The driving assembly is set in the inner wall of the storage shell (1).

2. The sampler for particle size detection of pharmaceutical raw materials according to claim 1, characterized in that, The drive assembly includes a protective shell (3), a sealing ring (7), a driven gear (8), a driving gear (9), and a micro motor (10).

3. A sampler for particle size detection of pharmaceutical raw materials according to claim 2, characterized in that, The sealing ring (7) is fitted on the outer wall of the conveying pipe (5), the driven gear (8) is fitted on the outer wall of the screw (6), and the protective shell (3) and the storage shell (1) are matched with each other.

4. A sampler for particle size detection of pharmaceutical raw materials according to claim 3, characterized in that, The driving gear (9) is embedded in the inner wall of the protective shell (3), and the driven gear (8) meshes with the outer wall of the driving gear (9) for transmission.

5. A sampler for particle size detection of pharmaceutical raw materials according to claim 4, characterized in that, The output end of the micro motor (10) is fixedly located at the center of the outer wall of the drive gear (9).

6. A sampler for particle size detection of pharmaceutical raw materials according to claim 5, characterized in that, An installation cylinder (4) is fixedly provided on the outer wall of one end of the storage shell (1), and the installation cylinder (4) is sleeved on the outer wall of the conveying pipe (5). An installation port (101) is opened on one side of the outer wall of the storage shell (1), and the installation port (101) matches the sampling tube (12). A handle (2) is fixedly provided on one side of the outer wall of the storage shell (1).

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