Zirconium oxide barrier membrane for guiding bone tissue regeneration

Abstract

The utility model relates to a zirconia barrier membrane for guiding bone tissue regeneration, which comprises a barrier membrane main body formed by 3D printing, the barrier membrane main body is provided with a screw hole, a micropore, a groove and a surface lamellar structure generated by 3D layer-by-layer printing; the micropores penetrate through the inner surface and the outer surface of the barrier film main body; the inner surface and the outer surface of the barrier film body are each provided with a plurality of grooves, and the grooves are regularly arranged in parallel. The cells can be quickly migrated to the upper end of the defect area from the basal part, so that the barrier membrane has certain biological activity, and the curing effect is improved. The micropores with specific diameters can enable blood vessels and growth factors in the upper periosteum and the soft tissue to enter the regeneration area, and meanwhile, the blocking effect of the barrier membrane on invasion of connective tissue into the regeneration area is not influenced.

Description

TECHNICAL FIELD

[0001] The utility model relates to a kind of zirconium oxide barrier membranes for guiding bone tissue regeneration. BACKGROUND

[0002] Oral and maxillofacial bone tissue defects affect the function and appearance of patients. Guided bone tissue regeneration is to place a barrier membrane between the soft tissue and the bone defect, thereby preventing connective tissue cells and epithelial cells from entering the bone defect area and interfering with bone formation, while maintaining the osteogenesis space to provide a stable regeneration environment for the defect area. Currently, titanium mesh stents combined with absorbable collagen membranes are commonly used as barrier membranes, but there is a high risk of exposure during the healing process, and the defect bone tissue regeneration effect is poor.

[0003] Studies have shown that a regular and orderly surface microstructure can promote cell proliferation, migration and differentiation, and a specific diameter of micropores can allow blood vessels and growth factors in the overlying periosteum and soft tissue to enter the regeneration area, while not affecting the barrier effect of the barrier membrane on the invasion of connective tissue into the regeneration area. This surface structure combined with a regular and orderly surface microstructure can give the barrier membrane certain biological properties. Based on this, the present patent designs a zirconium oxide barrier membrane for guiding bone tissue regeneration that has both rigidity and biological activity to solve the problems of high exposure risk and poor defect bone tissue regeneration effect in the prior art. SUMMARY

[0004] In view of the shortcomings of the prior art, the technical problem to be solved by the present utility model is to provide a zirconium oxide barrier membrane for guiding bone tissue regeneration.

[0005] To solve the above technical problems, the technical solution of the present utility model is as follows: a zirconium oxide barrier membrane for guiding bone tissue regeneration, comprising a barrier membrane body 3D printed, the barrier membrane body is provided with screw holes, micropores, grooves, and a surface sheet structure generated by 3D layer-by-layer printing;

[0006] The micropores have several and pass through the inner and outer surfaces of the barrier membrane body;

[0007] The grooves have several on the inner and outer surfaces of the barrier membrane body, and the several grooves are regularly and parallelly arranged.

[0008] Preferably, the screw holes are countersunk holes.

[0009] Preferably, the 3D printing plane of the barrier membrane body is perpendicular to the plane of the base of the defect area, so that the plane in which the long axis direction of the surface sheet structure generated by 3D layer-by-layer printing is located is perpendicular to the plane of the base of the defect area.

[0010] Preferably, the long axis direction of the groove is parallel to the 3D printing plane of the barrier membrane body, so that the long axis direction of the surface sheet structure generated by the 3D layer-by-layer printing is parallel to the long axis direction of the groove.

[0011] Preferably, the width and depth of the groove are 50-100 μm.

[0012] Preferably, the diameter of the micropore is 50-150 μm.

[0013] Preferably, the material of the barrier membrane body is zirconium oxide.

[0014] Compared with the prior art, the present application has the following beneficial effects: compared with the prior art, the present application saves cost and simplifies the treatment process. The long axis direction of the surface sheet structure generated by the 3D layer-by-layer printing is perpendicular to the base plane of the defect area and parallel to the long axis direction of the groove, which can make the cells migrate faster from the base to the upper end of the defect area, so that the barrier membrane has certain biological activity and improves the cure effect. The micropore with a specific diameter can make the blood vessels and growth factors in the upper periosteum and soft tissue enter the regeneration area, and at the same time, does not affect the blocking effect of the barrier membrane on the connective tissue invading the regeneration area.

[0015] The present application will be further described below in combination with the drawings and specific embodiments. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 The figure is a schematic view of the structure of the embodiment of the present application.

[0017] Figure 2 The figure is a schematic view of the structure of the embodiment of the present application.

[0018] Figure 3 The figure is a schematic view of the structure of the embodiment of the present application.

[0019] Figure 4 The figure is a schematic view of the structure of the embodiment of the present application. DETAILED DESCRIPTION

[0020] The present application will be further described below in combination with the drawings and specific embodiments.

[0021] It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as generally understood by those skilled in the art to which the present application belongs.

[0022] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0023] like Figures 1-4 As shown, this embodiment provides a zirconia barrier membrane for guiding bone tissue regeneration, including a 3D-printed barrier membrane body 1, which has screw holes 2, micropores 3, grooves 4, and surface sheet structures 5 generated by 3D layer-by-layer printing; the zirconia material has sufficient rigidity and exhibits better soft tissue integration effect.

[0024] The micropores have a plurality of holes and penetrate the inner and outer surfaces of the barrier membrane body;

[0025] The grooves are present on both the inner and outer surfaces of the barrier membrane body, and the grooves are arranged in a regular parallel pattern.

[0026] The barrier membrane body is designed in a personalized manner based on a digital model of the ideal three-dimensional shape of the bone to be regenerated by the patient, so that the barrier membrane fits better into the regeneration area and the regenerated bone tissue morphology is more ideal.

[0027] This barrier membrane combines rigidity and biological activity to promote the regeneration and healing of damaged bone tissue.

[0028] All components of the barrier membrane are integrally printed using 3D printing technology, making it easy to manufacture.

[0029] In this embodiment of the invention, the surface layer structure produced by the 3D layer-by-layer printing is an uneven (rough) printing texture generated on the printing plane along the direction of print head movement.

[0030] In this embodiment of the invention, the screw hole is a countersunk hole, which is used to fix the barrier membrane. The countersunk hole ensures that the surface is smooth after the screw is connected, and prevents the membrane from cracking due to the protruding screw head.

[0031] The screw hole positions are individually set according to the specific conditions of the defect areas of different patients.

[0032] In this embodiment of the invention, the 3D printing plane 6 of the barrier membrane body is perpendicular to the base plane 7 of the defect area, so that the plane containing the long axis direction 8 of the surface sheet structure generated by 3D layer-by-layer printing is perpendicular to the base plane of the defect area. This allows cells to migrate more quickly from the base to the upper part of the defect area.

[0033] In the embodiment of the utility model, the plane where the long axis direction of the groove is located is parallel to the 3D printing plane of the barrier membrane body, so that the plane where the long axis direction of the surface sheet structure generated by 3D layer-by-layer printing is located is parallel to the plane where the long axis direction of the groove is located, and the biological performance of the barrier membrane is increased.

[0034] In the embodiment of the utility model, the width and depth of the groove are 50-100 mu m.

[0035] In the embodiment of the utility model, the diameter of the micropore is 50-150 mu m. The micropore can provide a channel for blood vessels and growth factors in the periosteum and soft tissue above the regeneration area into the regeneration area without affecting the barrier effect of the barrier membrane on the connective tissue growing into the regeneration area.

[0036] In the embodiment of the utility model, the material of the barrier membrane body is zirconium oxide.

[0037] In the embodiment of the utility model, compared with the prior art of the titanium mesh support combined with the double-material technical scheme of the absorbable collagen membrane, the utility model saves cost and simplifies the treatment process. The plane where the long axis direction of the surface sheet structure generated by 3D layer-by-layer printing is located is perpendicular to the plane of the base of the defect area and parallel to the plane where the long axis direction of the groove is located, so that cells can be migrated from the base to the upper end of the defect area 9 more quickly, the barrier membrane has certain biological activity, and the cure effect is improved. The micropore with a specific diameter can make blood vessels and growth factors in the periosteum and soft tissue above enter the regeneration area, and does not affect the barrier effect of the barrier membrane on the connective tissue invading the regeneration area.

[0038] The above is only the preferred embodiment of the utility model, and is not intended to limit the utility model in other forms. Any skilled person in the art can modify or change the above disclosed technical content into equivalent embodiments. However, any simple modification, equivalent change and modification made according to the technical essence of the utility model to the above embodiments still belong to the protection scope of the technical scheme of the utility model.

Claims

1. A zirconia barrier membrane for guided bone tissue regeneration comprising a 3D printed barrier membrane body, characterized in that: The barrier membrane body is provided with screw holes, micropores, grooves and surface sheet layer structures generated by 3D layer-by-layer printing. The micropores are several and pass through the inner and outer surfaces of the barrier membrane body. The grooves are several on the inner and outer surfaces of the barrier membrane body and are regularly arranged in parallel.

2. The zirconia barrier membrane for guided bone tissue regeneration according to claim 1, characterized in that: The screw holes are countersunk holes.

3. The zirconia barrier membrane for guided bone regeneration according to claim 1, characterized in that: The 3D printing plane of the barrier membrane body is perpendicular to the plane of the base of the defect area, so that the plane in which the long axis direction of the surface sheet layer structure generated by 3D layer-by-layer printing is located is perpendicular to the plane of the base of the defect area.

4. The zirconia barrier membrane for guided bone regeneration according to claim 3, characterized in that: The plane in which the long axis direction of the groove is located is parallel to the 3D printing plane of the barrier membrane body, so that the plane in which the long axis direction of the surface sheet layer structure generated by 3D layer-by-layer printing is located is parallel to the plane in which the long axis direction of the groove is located.

5. The zirconia barrier membrane for guided bone tissue regeneration according to claim 1, wherein: The width and depth of the groove are 50-100 μm.

6. The zirconia barrier membrane for guided bone tissue regeneration according to claim 1, wherein: The diameter of the micropore is 50-150 μm.

7. The zirconia barrier membrane for guided bone tissue regeneration according to claim 1, wherein: The material of the barrier membrane body is zirconium oxide.

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