Low-temperature concentration and evaporation device

Abstract

The utility model discloses a low-temperature concentration and evaporation device which comprises an evaporation kettle filled with materials, the evaporation kettle is communicated with a heater, and the materials are evaporated in the evaporation kettle after being heated by the heater, so that an organic solvent in the materials is evaporated; the condensation assembly comprises a first-stage condenser, the first-stage condenser is communicated with the evaporation kettle and a condensate collecting tank, the condensate collecting tank is further communicated with a second-stage condenser, a vaporous organic solvent enters the first-stage condenser from the evaporation kettle and enters the condensate collecting tank after being condensed by the first-stage condenser, and the vaporous organic solvent enters the second-stage condenser after being condensed by the second-stage condenser. And the residual vaporous organic solvent in the condensate collecting tank enters the secondary condenser to be condensed. According to the low-temperature concentration and evaporation device disclosed by the utility model, the material concentration requirement is met by circularly evaporating materials, and the recovery rate of acetonitrile is improved through multi-stage condensation.

Description

TECHNICAL FIELD

[0001] The utility model relates to low temperature concentration technical field especially relates to a low temperature concentration evaporation device suitable for polypeptide purification intermediate acetonitrile. BACKGROUND

[0002] Polypeptide generally refers to the compound that less than one hundred amino acids are connected by peptide bond, it has the advantages such as strong activity, good specificity, strong penetration as drug, has remarkable curative effect in treating tumor, diabetes, cardiovascular disease, immune disease and antiviral, antibacterial etc. Along with the maturation of polypeptide synthesis technology, more and more polypeptide drugs begin to invest actual production. The demand of high-purity acetonitrile as the purification solvent of polypeptide product is also more and more big, and the acetonitrile mother liquor produced is separated, refined to obtain high-purity acetonitrile with high quality index, and then recycled as the purification solvent, which can significantly reduce the production cost of finished product and environmental protection. In the production process, acetonitrile inevitably mixes with water and other impurities together, and a large amount of acetonitrile waste liquid is produced.

[0003] Therefore, it is necessary to provide a device that can separate acetonitrile from the material and recycle acetonitrile. UTILITY MODEL CONTENT

[0004] The utility model solves the technical problems: the utility model provides a low temperature concentration evaporation device, through the circulation evaporation of material, satisfies the concentration demand of material, improves the recovery rate of acetonitrile through multistage condensation.

[0005] The utility model solves the technical problems and adopts the technical scheme: a low temperature concentration evaporation device, it includes: the evaporation kettle of being equipped with material, the evaporation kettle is connected with heater, and the organic solvent in the evaporation material is evaporated after the heating of material through heater in the evaporation kettle, condensing component, the condensing component includes primary condenser, the primary condenser is connected with evaporation kettle and condensate collection tank, the condensate collection tank is also connected with secondary condenser, and the organic solvent of gaseous state enters primary condenser from evaporation kettle, enters condensate collection tank after condensing through primary condenser, and the residual organic solvent of gaseous state in the condensate collection tank enters secondary condenser and condenses.

[0006] Further, in order to improve the evaporation efficiency of the material, a circulating pump is connected between the evaporation kettle and the heater, and the circulating pump pumps the material to circulate between the evaporation kettle and the heater.

[0007] Further, in order to realize the input of the material and the output of the concentrated material, a conveying pipeline for feeding and discharging is connected between the circulating pump and the evaporation kettle.

[0008] Further, in order to guarantee the evaporation and condensation effect, the secondary condenser is connected with an external vacuum system, which evacuates the condensation assembly and the evaporation kettle.

[0009] Further, in order to recycle the condensed organic solvent, a discharge pump is connected to the condensate collecting tank, which discharges the liquid organic solvent in the condensate collecting tank.

[0010] Further, in order to observe the material state in the evaporation kettle and the organic solvent state in the condensate collecting tank, the evaporation kettle and the condensate collecting tank are both provided with a liquid level meter.

[0011] Compared with the prior art, the low-temperature concentration evaporation device has the following beneficial effects:

[0012] 1. The low-temperature concentration evaporation device circulates the material in the evaporation kettle and the heater to evaporate the material, so that the material meets the concentration requirement, and the gaseous organic solvent is automatically condensed and recycled in the condensation assembly while the material is evaporated, thereby realizing the separation of the material and the organic solvent.

[0013] 2. The low-temperature concentration evaporation device condenses the organic solvent through two stages, the primary condenser changes most of the organic solvent into liquid organic solvent, and the residual gaseous organic solvent is condensed by the secondary condenser, thereby improving the recovery amount of the organic solvent. BRIEF DESCRIPTION OF DRAWINGS

[0014] The low-temperature concentration evaporation device will be further described below in combination with the drawings and embodiments.

[0015] Figure 1 The low-temperature concentration evaporation device is a schematic diagram of the principle of the low-temperature concentration evaporation device.

[0016] In the figure: 1, evaporation kettle, 2, heater, 3, circulating pump, 4, conveying pipeline, 5, primary condenser, 6, secondary condenser, 7, condensate collecting tank, 8, discharge pump. DETAILED DESCRIPTION

[0017] The low-temperature concentration evaporation device will be further described below in combination with the drawings and embodiments.

[0018] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "transverse," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential," etc., indicating the orientation or positional relationship shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, features defined with "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0019] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0020] like Figure 1 As shown, a low-temperature concentration and evaporation apparatus includes an evaporator 1 and a condenser assembly. The evaporator 1 is equipped with a level gauge to detect the concentration state of the material.

[0021] Evaporator 1 is connected to heater 2. The material is heated by heater 2 and then evaporated in evaporator 1, thereby evaporating the organic solvent in the material. A circulation pump 3 is connected between evaporator 1 and heater 2, pumping the material to circulate between evaporator 1 and heater 2. A conveying pipeline 4 for feeding and discharging is connected between circulation pump 3 and evaporator 1. The material is fed into evaporator 1 through conveying pipeline 4 by circulation pump 3, then enters heater 2 for heating, and then enters evaporator 1 for evaporation. The material can be circulated and evaporated multiple times as needed. During the evaporation process, the material (peptide) is concentrated, and the low-boiling-point organic solvent (acetonitrile) becomes gaseous and enters the condenser, achieving separation of the material and the organic solvent. Finally, the evaporated material is discharged again through conveying pipeline 4.

[0022] The condensing assembly comprises a primary condenser 5 and a secondary condenser 6, and the primary condenser 5 and the secondary condenser 6 are communicated with a condensate collecting tank 7; the gaseous organic solvent from the evaporation kettle 1 enters the primary condenser 5, and after being condensed by the primary condenser 5, enters the condensate collecting tank 7; the gaseous organic solvent remaining in the condensate collecting tank 7 enters the secondary condenser 6 to be condensed. The condensate collecting tank 7 is connected with a discharge pump 8, and the discharge pump 8 discharges the liquid organic solvent in the condensate collecting tank 7. The condensate collecting tank 7 is provided with a liquid level meter, and when the organic solution reaches the liquid level, the condensed liquid organic solvent is finally discharged through the discharge pump 8, so that the organic solvent is recycled.

[0023] The secondary condenser 6 is connected with an external vacuum system, and the vacuum system vacuums the condensing assembly and the evaporation kettle 1. The evaporation kettle 1, the primary condenser 5, the secondary condenser 6 and the condensate collecting tank 7 are in a specific vacuum state, which meets the process requirements.

[0024] The working principle of the utility model is: the material enters through the conveying pipeline 4, is sent into the heater 2 through the circulating pump 3, is heated in the heater 2, enters the evaporation kettle 1, and the acetonitrile in the evaporation kettle 1 is flashed into low-temperature steam, and the polypeptide is retained in the evaporation kettle 1; after multiple cycle evaporation, the concentrated product in the evaporation kettle 1 is collected. The low-temperature steam automatically enters the primary condenser 5, most of the low-temperature steam is changed into liquid through the primary condenser 5 and is retained in the condensate collecting tank 7, and a small amount of low-temperature steam enters the secondary condenser 6, is condensed into liquid through the secondary condenser 6 and is returned to the condensate collecting tank 7, so that the separation of acetonitrile and polypeptide and the recovery of acetonitrile are realized.

[0025] In summary, the low-temperature concentration evaporation device meets the concentration requirement of the material through cycle evaporation of the material, and improves the recovery rate of acetonitrile through multistage condensation.

[0026] According to the ideal embodiment of the utility model, the related personnel can make various changes and modifications without deviating from the technical idea of the utility model. The technical scope of the utility model is not limited to the content in the specification, and must be determined by the scope of claims.

Claims

1. A low temperature concentration evaporation apparatus, characterized by, The application relates to a device for evaporating organic solvent from material, comprising: an evaporation kettle (1) containing material, which is communicated with a heater (2), and the material is evaporated in the evaporation kettle (1) after being heated by the heater (2), so that the organic solvent in the material is evaporated; a condensing assembly, which comprises a primary condenser (5), the primary condenser (5) being communicated with the evaporation kettle (1) and a condensate collecting tank (7), the condensate collecting tank (7) being further communicated with a secondary condenser (6), the gaseous organic solvent from the evaporation kettle (1) enters the primary condenser (5), is condensed in the primary condenser (5) and then enters the condensate collecting tank (7), and the gaseous organic solvent remaining in the condensate collecting tank (7) enters the secondary condenser (6) to be condensed.

2. The cryo-concentrating evaporation device of claim 1, wherein, A circulating pump (3) is connected between the evaporation kettle (1) and the heater (2), and the circulating pump (3) pumps the material to flow between the evaporation kettle (1) and the heater (2).

3. The cryo-concentrating evaporation device of claim 2, wherein, A conveying pipeline (4) for feeding and discharging is connected between the circulating pump (3) and the evaporation kettle (1).

4. The cryo-concentrating evaporation device of claim 1, wherein, The secondary condenser (6) is connected with an external vacuum system, and the vacuum system evacuates the condensing assembly and the evaporation kettle (1).

5. The cryoconcentrating evaporation device of claim 1, wherein, A discharging pump (8) is connected to the condensate collecting tank (7), and the discharging pump (8) discharges the liquid organic solvent in the condensate collecting tank (7).

6. The cryo-concentrating evaporation device of claim 1, wherein, Both the evaporation kettle (1) and the condensate collecting tank (7) are provided with liquid level meters.

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