Efficient diosmin separation equipment

Abstract

The utility model discloses high-efficiency diosmin separation equipment which comprises a solution blending tank, a mobile phase blending tank, a chromatographic separation box and a stirring assembly, the solution blending tank and the mobile phase blending tank are the same in structure and each comprise a tank body and an assembly cover connected to the top of the tank body in a sealed mode. The top of the assembling cover is provided with two sets of concentrically-arranged annular pipes, and the annular pipes communicate with the inner side of the assembling cover through connecting pipes. The stirring assembly comprises a mounting shaft and upper and lower layer stirring blades fixedly connected to the mounting shaft, and the mounting shaft is located at the axis of the tank body and the assembling cover and is connected with the stirring assembly through a driving assembly. A box cover is arranged at the top of the chromatographic separation box, a liquid separation pipe is arranged on the inner side of the box cover, and the solution blending tank and the mobile phase blending tank are connected with the liquid separation pipe through a liquid supply pipe group. A liquid collecting tank is arranged at the bottom of the chromatographic separation box and is connected with the chromatographic separation box through a liquid discharging pipe group. According to the equipment, the diosmin separation efficiency is remarkably improved, the operation process is simplified, the separation precision and reliability are improved, and the equipment has a wide application prospect.

Description

TECHNICAL FIELD

[0001] The utility model relates to solution separation technical field, specifically a kind of high-efficiency orlistat separation equipment. BACKGROUND

[0002] As an important pharmaceutical ingredient, orlistat is widely used in the treatment of various diseases. However, the existing orlistat separation equipment is not designed specifically for its characteristics, resulting in many deficiencies in practical application. The current liquid chromatography separation process of orlistat usually requires orlistat solution and prepared mobile phase to be passed into the stationary phase one by one. Such separation process is not only complex, but also requires precise control of each step, increasing the possibility of manual intervention, and thus affecting the overall separation efficiency.

[0003] In traditional equipment, orlistat solution and mobile phase are usually configured independently, causing cumbersome operation process. This independent configuration method leads to a decrease in separation processing efficiency, increasing sample processing time and cost.

[0004] In addition, the separation equipment in the prior art is mostly general-purpose, which cannot be optimized and adjusted according to the physical and chemical properties of orlistat, and lacks dedicated separation and mixing equipment. This not only leads to low separation processing efficiency, but also affects the accuracy of subsequent analysis results to some extent. In order to improve the separation efficiency of orlistat, an efficient special separation equipment is urgently needed to realize rapid and uniform mixing of solution and mobile phase, and to simplify the operation process, thereby improving the efficiency and reliability of the overall separation process.

[0005] Therefore, the development of an integrated high-efficiency orlistat separation equipment can effectively solve the deficiencies of existing equipment and improve the efficiency of drug separation and analysis, which will have important practical significance and application prospect. SUMMARY

[0006] In view of the above deficiencies in the prior art, the utility model aims to provide a high-efficiency orlistat separation equipment, which has significant technical advantages in improving orlistat separation efficiency, simplifying operation process, improving separation precision and reliability, and has wide application prospect.

[0007] The utility model employs the technical scheme of: a high-efficiency orlistat separation equipment, comprising a solution preparation tank, a mobile phase preparation tank, a chromatography separation box, and a stirring assembly installed in the solution preparation tank and the mobile phase preparation tank.

[0008] The solution preparation tank and the mobile phase preparation tank are identical in structure and each comprises a tank body and an assembly cover which is sealingly connected to the top of the tank body, and two sets of annular pipes arranged concentrically are arranged on the top of the assembly cover and communicate with the inner side of the assembly cover through connecting pipes.

[0009] The stirring assembly comprises a mounting shaft and upper and lower stirring blades fixed to the mounting shaft, and the mounting shaft is rotatably mounted at the center of the tank body and the assembly cover.

[0010] The driving assembly is power-connected with the mounting shafts of the two sets of stirring assemblies.

[0011] The top of the chromatographic separation tank is fixedly connected with a tank cover, a distribution pipe is arranged in the inner side of the tank cover, the solution preparation tank and the mobile phase preparation tank are connected with the distribution pipe through a liquid supply pipe group, the chromatographic separation tank is filled with chromatographic column filler, a liquid collecting tank is arranged at the bottom of the chromatographic separation tank, and a liquid discharge pipe group is connected to the bottom of the liquid collecting tank.

[0012] In some embodiments, in order to ensure that the solution preparation tank, the mobile phase preparation tank, the chromatographic separation tank and the driving assembly can be combined and installed as a whole and the compactness of the equipment is ensured, the following technical solutions are provided.

[0013] The cabinet is further provided with a cabinet compartment, and the chromatographic separation tank and the tank bodies of the solution preparation tank and the mobile phase preparation tank are fixedly installed in the cabinet compartment, and the driving assembly, the liquid supply pipe group and the liquid discharge pipe group are arranged in the cabinet compartment.

[0014] The top wall and the side wall of the cabinet are provided with cabinet doors, and supporting legs are fixedly installed at the bottom of the cabinet.

[0015] In some embodiments, in order to ensure that the dioxyrimycin initial solution, deionized water and organic solvent can be stably delivered into the corresponding annular pipes and the prepared solution of the solution preparation tank and the mobile phase preparation tank can be stably delivered into the distribution pipe through the formula tank group, the following technical solutions are provided.

[0016] Each set of annular pipes is connected with a feed pipe which extends to the outside of the cabinet.

[0017] The bottom of the tank body is provided with an annular collecting groove which is high in the center and low at the edge, and the bottom of the annular collecting groove is connected with a discharge interface.

[0018] The liquid supply pipe group comprises liquid supply branch pipes, a liquid supply main pipe and a pressurizing pump, one set of liquid supply branch pipes is connected to the discharge interface at the bottom of each tank body, a switch valve A is arranged on each liquid supply branch pipe, each liquid supply branch pipe is connected to the liquid supply main pipe, the pressurizing pump is arranged on the liquid supply main pipe, and the liquid supply main pipe communicates with the distribution pipe.

[0019] In some implementations, to ensure that the separated dioxydim and impurities can be discharged through the drain pipe group respectively, the following technical solutions are provided.

[0020] The drain pipe group includes a tee pipe and two groups of drain branch pipes, each port of the tee pipe is in communication with the liquid collecting tank and the two groups of drain branch pipes, and the drain branch pipes are provided with on-off valves B and extend to the outside of the cabinet.

[0021] In some implementations, to ensure that the driving assembly can be stably installed in the cabinet and ensure that the driving assembly can drive the two groups of stirring assemblies to operate synchronously, the following technical solutions are provided.

[0022] The driving assembly includes a driving motor and a driving shaft, the driving motor is fixedly installed in the cabinet, the driving shaft is rotatably installed in the cabinet and fixedly connected with the output shaft of the driving motor, two groups of driving bevel gears are fixedly connected to the driving shaft, the top end of the mounting shaft of each of the two groups of stirring assemblies is fixedly connected with a transmission bevel gear, and the transmission bevel gear is in engagement with the driving bevel gear on the corresponding side.

[0023] The beneficial effects of the utility model are as follows:

[0024] The device integrates the solution preparation tank and the mobile phase preparation tank, is provided with the stirring assembly, and can synchronously and efficiently mix and prepare the dioxydim solution and the mobile phase, avoids the complicated operation of independently configuring the solution and the mobile phase in the traditional device, and greatly simplifies the entire separation processing process.

[0025] The device realizes synchronous driving of the stirring assembly through the driving assembly, ensures sufficient mixing of the solution and the mobile phase in the tank body, has uniform mixing and efficient transmission mechanism, and avoids the problem of reduced separation efficiency caused by insufficient mixing.

[0026] The device has compact structure, all key components are integrated in the cabinet, operation and maintenance are facilitated, the cabinet door is designed to be convenient to disassemble, overhaul, and the support legs enhance the stability of the device.

[0027] In summary, the device provided by the scheme has significant technical advantages in improving the dioxydim separation efficiency, simplifying the operation process, improving the separation precision and reliability, and has wide application prospect. BRIEF DESCRIPTION OF DRAWINGS

[0028] Figure 1 The utility model discloses a structure schematic diagram.

[0029] Figure 2 is a structural schematic view of the cabinet after the cabinet compartment is removed according to the present application;

[0030] Figure 3 is Figure 2 is a structural schematic view from another perspective;

[0031] Figure 4 is a structural schematic view of the internal structure of the solution preparation tank or the mobile phase preparation tank;

[0032] Figure 5 is a structural schematic view of the combination of the stirring assembly and the driving assembly;

[0033] Figure 6 is a structural schematic view of the internal structure of the chromatographic separation tank and the structure of the liquid discharge pipe group and the liquid supply pipe group.

[0034] In the figure: 101 solution preparation tank, 102 mobile phase preparation tank, 11 tank body, 111 annular collection groove, 112 discharge interface, 12 assembly cover, 121 annular pipe, 122 connecting pipe, 123 feeding pipe, 2 chromatographic separation tank, 21 tank cover, 211 liquid separation pipe, 22 chromatographic column filler, 23 liquid collection groove, 24 liquid discharge pipe group, 241 three-way pipe, 242 liquid discharge branch pipe, 243 switch valve B, 3 stirring assembly, 31 mounting shaft, 311 transmission bevel gear, 32 upper layer stirring blade, 33 lower layer stirring blade, 4 driving assembly, 41 driving motor, 42 driving shaft, 421 driving bevel gear, 5 liquid supply pipe group, 51 liquid supply branch pipe, 511 switch valve A, 52 liquid supply main pipe, 53 pressure pump, 6 cabinet compartment, 61 compartment door, 62 supporting leg. DETAILED DESCRIPTION

[0035] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0036] Please refer to Figures 1-6 , the efficient orlistat separation device comprises a solution preparation tank 101, a mobile phase preparation tank 102, a chromatographic separation tank 2 and a stirring assembly 3 assembled in the solution preparation tank 101 and the mobile phase preparation tank 102.

[0037] The solution preparation tank 101 and the mobile phase preparation tank 102 are identical in structure and each comprises a tank body 11 and an assembly cover 12 which is sealingly connected to the top of the tank body 11, and two sets of annular pipes 121 which are concentrically arranged on the top of the assembly cover 12 and are in communication with the inner side of the assembly cover 12 through connecting pipes 122.

[0038] The stirring assembly 3 comprises a mounting shaft 31 and upper and lower stirring blades 32 and 33 which are fixed to the mounting shaft 31, and the mounting shaft 31 is rotationally mounted at the center of the tank body 11 and the assembly cover 12.

[0039] The driving assembly 4 is in power connection with the mounting shafts 31 of the two sets of stirring assemblies 3.

[0040] The top of the chromatographic separation tank 2 is fixedly connected with a tank cover 21, and a liquid distribution pipe 211 is assembled on the inner side of the tank cover 21, and the solution preparation tank 101 and the mobile phase preparation tank 102 are connected with the liquid distribution pipe 211 through the liquid supply pipe group 5, and the chromatographic separation tank 2 is filled with chromatographic column filler 22, and the bottom of the chromatographic separation tank 2 is provided with a liquid collecting groove 23, and the bottom of the liquid collecting groove 23 is connected with a liquid discharge pipe group 24.

[0041] The tank body 11 and the assembly cover 12 are fixedly combined by screwing, the solution preparation tank 101 is used for fully mixing and concentration preparation of the orlistat solution and water, the mobile phase preparation tank 102 is used for fully mixing and concentration preparation of the organic solvent and who, both of which are driven by the stirring assembly 3 to fully and efficiently mix the components, and the driving assembly 4 can drive the two sets of stirring assemblies 3 to synchronously operate.

[0042] For the solution preparation tank 101, the two sets of annular pipes 121 on it are respectively connected with the orlistat initial solution and deionized water, and are uniformly input into the tank body 11 through the connecting pipes 122, and are fully mixed by the corresponding stirring assembly 3.

[0043] For the mobile phase preparation tank 102, the two sets of annular pipes 121 on it are respectively connected with deionized water and organic solvents (such as acetonitrile or methanol), and the proportion of the fully mixed organic solvents is gradually increased with the progress of the elution stage by the corresponding stirring assembly 3.

[0044] After the solution of Diosmin to be separated is prepared in the solution preparation tank 101, it is transported to the distribution pipe 211 by the liquid supply pipe group 5, and the Diosmin solution is uniformly dropped into the C18 reverse phase chromatographic column filler 22 below, which can effectively improve the separation efficiency of Diosmin. When the Diosmin solution passes through the chromatographic column filler 22, the Diosmin affected by polarity can be adsorbed by the chromatographic column filler 22, while other impurities in the solution can pass normally and be discharged from the bottom of the chromatographic separation box 2 to realize efficient separation of Diosmin and impurities.

[0045] After the separated Diosmin is eluted, the mobile phase prepared by the mobile phase preparation tank 102 is uniformly transported into the chromatographic separation box 2 by the liquid supply pipe group 5 and the distribution pipe 211. According to the continuous elution process, the proportion of organic solvent gradually increases to ensure that the Diosmin attached to the chromatographic column filler 22 is completely eluted, and the eluted Diosmin is also discharged from the bottom of the chromatographic separation box 2.

[0046] To ensure that the solution preparation tank 101, the mobile phase preparation tank 102, the chromatographic separation box 2 and the driving assembly 4 can be combined and installed to ensure the compactness of the whole device, the following technical solutions are provided.

[0047] The cabinet 6 is also provided, and the chromatographic separation box 2 and the tank bodies 11 of the solution preparation tank 101 and the mobile phase preparation tank 102 are fixedly installed in the cabinet 6, and the driving assembly 4, the liquid supply pipe group 5 and the liquid discharge pipe group 24 are assembled in the cabinet 6.

[0048] The cabinet 6 is also provided, and the chromatographic separation box 2 and the tank bodies 11 of the solution preparation tank 101 and the mobile phase preparation tank 102 are fixedly installed in the cabinet 6, and the driving assembly 4, the liquid supply pipe group 5 and the liquid discharge pipe group 24 are assembled in the cabinet 6.

[0049] The cabinet 6 is also provided, and the chromatographic separation box 2 and the tank bodies 11 of the solution preparation tank 101 and the mobile phase preparation tank 102 are fixedly installed in the cabinet 6, and the driving assembly 4, the liquid supply pipe group 5 and the liquid discharge pipe group 24 are assembled in the cabinet 6.

[0050] To ensure that the Diosmin initial solution, deionized water and organic solvent can be stably transported into the corresponding annular pipes 121, and the solutions prepared in the solution preparation tank 101 and the mobile phase preparation tank 102 can be stably transported to the distribution pipe 211 by the formula tank group, the following technical solutions are provided.

[0051] Each group of annular pipes 121 is connected with a feed pipe 123, and the feed pipe 123 extends to the outside of the cabinet 6.

[0052] The bottom of the tank body 11 is provided with a center-high and edge-low annular collecting groove 111, and the bottom of the annular collecting groove 111 is connected with a discharge interface 112.

[0053] The liquid supply pipe group 5 includes liquid supply branch pipes 51, a liquid supply main pipe 52, and a pressurizing pump 53. Each of the two groups of discharge interfaces 112 at the bottom of the tank body 11 is connected with a group of liquid supply branch pipes 51, each of the liquid supply branch pipes 51 is equipped with an on-off valve A511, each of the liquid supply branch pipes 51 is connected to the liquid supply main pipe 52, and the pressurizing pump 53 is equipped on the liquid supply main pipe 52, and the liquid supply main pipe 52 is in communication with the distribution pipe 211.

[0054] The arrangement of the feed pipe 123 can ensure that the initial solution of diosmin, deionized water, and organic solvent can be stably delivered to the corresponding annular pipe 121, and then delivered to the corresponding tank body 11 through the connecting pipe 122.

[0055] The arrangement of the annular collecting groove 111 at the bottom of the tank body 11 can ensure that the solution in the tank body 11 is collected and delivered to the corresponding liquid supply branch pipe 51 through the discharge interface 112. By controlling the on-off state of the on-off valve A511 on the corresponding liquid supply branch pipe 51, the corresponding solution can be delivered to the liquid supply main pipe 52, and the solution can be stably delivered to the distribution pipe 211 by the pressurizing pump 53.

[0056] The arrangement of the solution preparation tank 101 and the mobile phase preparation tank 102 can effectively improve the separation efficiency of diosmin. During the process of delivering the diosmin in the solution preparation tank 101 to the chromatographic separation tank 2, the mobile phase preparation tank 102 mixes and prepares the organic solvent and deionized water. After the separation process is completed, the on-off valve A511 connected to the solution preparation tank 101 is closed, and the on-off valve A511 connected to the mobile phase preparation tank 102 is opened, so that the mobile phase is delivered to the chromatographic separation tank 2 for elution treatment. During the elution process, the proportion of organic solvent is controlled to be continuously added and uniformly mixed by the stirring assembly 3, so as to improve the proportion of organic solvent in the mobile phase. During the elution process, the next batch of diosmin can be input into the solution preparation tank 101 for re-preparation.

[0057] In this process, the preparation of diosmin solution and the preparation of mobile phase are carried out at the same time, so as to effectively improve the separation efficiency of diosmin.

[0058] In order to ensure that the separated diosmin and impurities can be respectively discharged outside through the liquid discharge pipe group 24, the following technical solutions are provided.

[0059] The liquid discharge pipe group 24 includes a three-way pipe 241 and two groups of liquid discharge branch pipes 242. Each port of the three-way pipe 241 is in communication with the liquid collecting tank 23 and the two groups of liquid discharge branch pipes 242. The liquid discharge branch pipe 242 is equipped with an on-off valve B243, and the liquid discharge branch pipe 242 extends to the outside of the cabinet 6.

[0060] When the impurities and the dioxatim are to be discharged, the corresponding switch valves B243 are opened to enable the impurities and the dioxatim to be discharged through the three-way pipe 241 and the corresponding discharge branch pipe 242.

[0061] To ensure that the driving assembly 4 can be stably installed in the cabinet 6 and ensure that the driving assembly 4 can drive the two groups of stirring assemblies 3 to operate synchronously, the following technical solutions are provided.

[0062] The driving assembly 4 comprises a driving motor 41 and a driving shaft 42, the driving motor 41 is fixedly installed in the cabinet 6, the driving shaft 42 is rotatably installed in the cabinet 6 and fixedly connected with the output shaft of the driving motor 41, two groups of driving bevel gears 421 are fixedly connected on the driving shaft 42, the top end of the mounting shaft 31 of each of the two groups of stirring assemblies 3 is fixedly connected with a transmission bevel gear 311, and the transmission bevel gear 311 is in meshing connection with the driving bevel gear 421 on the corresponding side.

[0063] When the driving motor 41 drives the driving shaft 42 and the driving bevel gears 421 thereon to operate, the mounting shaft 31 and the upper stirring blades 32 and the lower stirring blades 33 assembled on the mounting shaft 31 can be stably driven by the transmission bevel gear 311 to operate, so as to achieve sufficient stirring and mixing of the solutions.

[0064] It is apparent for those skilled in the art that the present application is not limited to the details of the above exemplary embodiments, but can be implemented in other concrete forms without departing from the spirit or essential characteristics of the present application. Therefore, the embodiments should be considered as exemplary and non-limiting, and the scope of the present application is defined by the appended claims rather than the above description, and all changes falling within the meaning and range of equivalents of the essential elements of the claims are intended to be embraced therein. Any reference signs in the claims should not be considered as limiting the claims involved.

[0065] In addition, it should be understood that, although the present specification is described in terms of embodiments, not every embodiment contains only one independent technical solution, and the description of the specification is only for the sake of clarity, and those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can be properly combined to form other embodiments that those skilled in the art can understand.

Claims

1. A high efficiency Oxsilan separation apparatus characterized by: Including solution preparation tank (101), mobile phase preparation tank (102), chromatographic separation box (2) and stirring assembly (3) assembled in solution preparation tank (101), mobile phase preparation tank (102); The structure of the solution preparation tank (101), the mobile phase preparation tank (102) is same and includes a tank body (11), an assembly cover (12), the assembly cover (12) is sealingly connected to the top of the tank body (11), and two sets of annular pipes (121) arranged concentrically are arranged on the top of the assembly cover (12), the annular pipe (121) is communicated with the inner side of the assembly cover (12) through the connecting pipe (122); The stirring assembly (3) includes a mounting shaft (31) and an upper stirring blade (32) and a lower stirring blade (33) fixed to the mounting shaft (31), and the mounting shaft (31) is rotatably installed at the shaft center of the tank body (11) and the assembly cover (12); It also includes a driving assembly (4), which is power connected with the mounting shaft (31) of the two sets of stirring assemblies (3); The top of the chromatographic separation box (2) is fixedly connected with a box cover (21), the inner side of the box cover (21) is provided with a liquid separation pipe (211), the solution preparation tank (101) and the mobile phase preparation tank (102) are connected with the liquid separation pipe (211) through a liquid supply pipe group (5), the chromatographic separation box (2) is filled with chromatographic column filler (22), and the bottom of the chromatographic separation box (2) is provided with a liquid collecting tank (23), and the bottom of the liquid collecting tank (23) is connected with a liquid discharge pipe group (24).

2. The high potency olsalazine separation apparatus of claim 1, wherein: It also includes a cabinet (6), the chromatographic separation box (2) and the tank body (11) of the solution preparation tank (101) and the mobile phase preparation tank (102) are fixedly installed in the cabinet (6), and the driving assembly (4), the liquid supply pipe group (5) and the liquid discharge pipe group (24) are assembled in the cabinet (6); The top wall and the side wall of the cabinet (6) are provided with a door (61), and the bottom of the cabinet (6) is fixedly provided with a supporting leg (62).

3. The high potency olsalazine separation apparatus of claim 2, wherein: Each set of annular pipes (121) is connected with a feed pipe (123), and the feed pipe (123) extends to the outside of the cabinet (6); The bottom of the tank body (11) is provided with an annular collecting groove (111) with a high center and a low edge, and the bottom of the annular collecting groove (111) is connected with a discharge interface (112); The liquid supply pipe group (5) includes a liquid supply branch pipe (51), a liquid supply main pipe (52) and a pressure pump (53), one set of liquid supply branch pipes (51) is connected to the discharge interface (112) at the bottom of each tank body (11), a switch valve A (511) is assembled on each liquid supply branch pipe (51), each liquid supply branch pipe (51) is connected to the liquid supply main pipe (52), the pressure pump (53) is assembled on the liquid supply main pipe (52), and the liquid supply main pipe (52) is communicated with the liquid separation pipe (211).

4. The high potency gerbera extract of claim 2, wherein: The liquid drainage pipe group (24) comprises a tee pipe (241) and two groups of liquid drainage branch pipes (242), the ports of the tee pipe (241) are in communication with the liquid collecting tank (23) and the two groups of liquid drainage branch pipes (242) respectively, the liquid drainage branch pipes (242) are provided with switch valves B (243), and the liquid drainage branch pipes (242) extend to the outside of the cabinet (6).

5. The high potency gerbera extract of claim 2, wherein: The driving assembly (4) comprises a driving motor (41) and a driving shaft (42), the driving motor (41) is fixedly installed in the cabinet (6), the driving shaft (42) is rotatably installed in the cabinet (6) and is fixedly connected with the output shaft of the driving motor (41), two groups of driving bevel gears (421) are fixedly connected to the driving shaft (42), the top ends of the mounting shafts (31) of the two groups of stirring assemblies (3) are fixedly connected with transmission bevel gears (311), and the transmission bevel gears (311) are in meshing connection with the driving bevel gears (421) on the corresponding side.

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