Device for long-term marking of experimental animal skin part

By using low-temperature branding technology to make long-term marks on the skin of laboratory animals, the problems of non-durable marks, easy fading and allergies in existing technologies have been solved, and long-term clear skin positioning has been achieved, improving the accuracy and safety of experiments.

CN223640888UActive Publication Date: 2025-12-09VKAN CERTIFICATION & TESTING
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Patent Information

Application Number
CN202422559948.2
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-10-23
Publication Date
2025-12-09
Estimated Expiration
2034-10-23

AI Technical Summary

Technical Problem

Existing skin tagging technologies have problems in laboratory animals, such as insufficient tag persistence, difficulty in long-term tracking, potential allergic reactions, and interference with animal behavior, making it difficult to meet the requirements for long-term, safe, and clear skin localization.

Method used

Using low-temperature branding technology, the marking components are immersed in liquid nitrogen and cooled before being applied to the animal's skin. This low-temperature branding technology enables long-term, clear skin positioning. A base, drawer, and rubber partition are used to maintain the low temperature of the liquid nitrogen, ensuring the long-term stability and accuracy of the marking.

Benefits of technology

It achieves long-term, clear skin localization, reduces interference with animals, improves the accuracy and reliability of experiments, avoids marker fading and allergic reactions, and is suitable for marker recognition on dark skin.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses a device for marking the skin part of an experimental animal for a long time, and relates to the technical field of experimental animal positioning. Comprising a base, a drawer used for storing liquid nitrogen is slidably connected into the base, a rubber interlayer is slidably connected to the top face of the drawer, the rubber interlayer is fixedly connected with the top in the base, a plurality of grooves are formed in the top face of the base, and the grooves are detachably connected with marking assemblies used for marking animal skin. According to the animal skin marking device, the marking assembly is installed in the groove in the base, the marking assembly can be immersed in liquid nitrogen to be cooled, after cooling is completed, the marking assembly is taken out of the groove, and marking and positioning can be conducted on the skin of an animal through the marking assembly; through the low-temperature branding technology, positioning marks can exist clearly for a long time, and the accuracy of skin positioning can be guaranteed.
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Description

Technical Field

[0001] This utility model relates to the field of laboratory animal positioning technology, and in particular to a device for long-term marking of laboratory animal skin sites. Background Technology

[0002] Skin marker technology is mainly used for long-term identification of laboratory animals. However, with the development of medical aesthetic products, the requirements for skin marker technology in animal experimental studies are becoming increasingly stringent. For example, hyaluronic acid, collagen, and botulinum toxin products require long-term and repeated observation of changes in the skin at the injection site after implantation. However, these products often degrade and are absorbed within a short period of time after implantation / injection, leaving no visible abnormalities on the skin. When the experimental period is long, it is necessary to use long-term, effective, and clear markers to locate the experimental skin area so that the skin in that area can be accurately located and detected during the experimental process.

[0003] Currently, special dyes or inks are commonly used to mark animals directly on their skin, such as tattoos or special medical marking pens, which is a common temporary marking method. First, prepare marking tools, such as brushes, cotton swabs, or specialized marking equipment, and ensure the operating environment is clean and hygienic to avoid infection. Properly and safely restrain the animal to ensure it will not move or be injured during the marking process; sedate or anesthetize if necessary. Gently and evenly apply the dye or ink to the designated area of ​​the animal's skin, ensuring the mark is clearly identifiable, avoiding applying too much or too little. After the mark is completely dry, check whether the mark is clear, durable, and easily identifiable. If necessary, the mark can be reapplied to enhance its visibility.

[0004] Chemical dyes such as markers, picric acid (yellow), or neutral red (red) can generally last for 1-3 days after outlining and positioning, and then the marks gradually fade. Tattooing, on the other hand, involves using tattoo tweezers and tattoo paste to mark the animal's skin. This method is permanent and involves anesthetizing and sedating the animal before tattooing the skin.

[0005] However, the above methods have the following drawbacks: 1. The markings are not durable enough and may become ineffective due to hair growth, wear, or fading, requiring regular inspection and remarking; 2. Tattoos may be difficult to identify on animals with dark skin, and may fade over time; 3. Some animals may have allergic or rejection reactions to the ink or dye components, leading to skin irritation and affecting the observation of the skin during the experiment; 4. It is difficult to conduct long-term tracking without interfering with the animal's normal behavior. For example, regular and repeated shaving may irritate the animal's skin and affect the experimental results.

[0006] Therefore, there is an urgent need for a device for long-term marking of experimental animal skin sites that can effectively, safely, and animal welfare-friendly mark the skin, maintain the marking for a long time, reduce disturbance to the animals, and be easy to identify and track. Utility Model Content

[0007] The purpose of this invention is to provide a device for long-term marking of skin areas in laboratory animals, in order to solve the problems existing in the prior art.

[0008] To achieve the above objectives, the present invention provides the following solution: The present invention provides a device for long-term marking of experimental animal skin, including a base, a drawer for storing liquid nitrogen slidably connected inside the base, a rubber partition slidably connected to the top surface of the drawer, the rubber partition being fixedly connected to the top of the base, and a plurality of grooves provided on the top surface of the base, the grooves being detachably connected to marking components for marking animal skin.

[0009] Preferably, the groove is symmetrically provided with slots, which are formed on the rubber partition.

[0010] Preferably, the top surface of the drawer abuts against the rubber partition.

[0011] Preferably, the marking component includes a stamp handle, a movable block is slidably connected inside the stamp handle, a connecting post is fixedly connected to the top surface of the movable block, and an adjustment button is fixedly connected to one end of the connecting post extending beyond the top surface of the stamp handle.

[0012] Preferably, the bottom of the stamp handle is fixedly connected to a base plate that is detachably connected to the groove, and the base plate is symmetrically provided with limiting grooves, which correspond one-to-one with the slot.

[0013] Preferably, the base plate is adapted to the groove.

[0014] Preferably, the movable block is symmetrically provided with a marking metal at one end away from the connecting column, one end of the marking metal is fixedly connected to the movable block, and the other end of the marking metal extends into the limiting groove and is slidably connected to the limiting groove.

[0015] Preferably, the marking metal extends into the drawer through the limiting groove and the card slot in sequence.

[0016] The present invention discloses the following technical effects:

[0017] This invention involves installing the imprinting component into a groove on the base, allowing the component to be immersed in liquid nitrogen for cooling. Once cooled, the imprinting component is removed from the groove, enabling it to be used to mark and locate an animal's skin. This invention utilizes low-temperature branding technology, ensuring that the positioning mark remains clear and long-term, guaranteeing the accuracy of skin positioning. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the frontal perspective structure of this utility model;

[0020] Figure 2 This is a top view of the structure of this utility model;

[0021] Figure 3 This is a perspective view of the base structure of this utility model;

[0022] Figure 4 This is a front view structural diagram of the marking component of this utility model;

[0023] Figure 5 This is a bottom view of the marking component of this utility model;

[0024] The components include: 1. base; 2. drawer; 3. groove; 4. slot; 5. connecting column; 6. rubber partition; 7. stamp handle; 8. adjustment button; 9. marking metal; 10. base plate; 11. liquid nitrogen; and 12. movable block. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0027] Reference Figures 1-5This utility model discloses a device for long-term marking of experimental animal skin, including a base 1, a drawer 2 for storing liquid nitrogen 11 slidably connected inside the base 1, a rubber partition 6 slidably connected to the top surface of the drawer 2, the rubber partition 6 being fixedly connected to the top inside the base 1, and a plurality of grooves 3 being provided on the top surface of the base 1, the grooves 3 being detachably connected to marking components for marking animal skin.

[0028] Drawer 2 has heat insulation and heat preservation properties, which can effectively reduce the evaporation of liquid nitrogen 11 and maintain its low temperature. In order to prevent drawer 2 from falling out of the base 1, drawer 2 can only be pulled out to one-fifth of its total length.

[0029] This invention involves installing the imprinting component into the groove 3 on the base 1, allowing the imprinting component to be immersed in liquid nitrogen 11 for cooling. After cooling, the imprinting component is removed from the groove 3, enabling marking and positioning on the animal's skin. This invention utilizes low-temperature branding technology, ensuring that the positioning mark remains clear for a long time and guaranteeing the accuracy of skin positioning.

[0030] Further optimizing the design, grooves 4 are symmetrically arranged within the groove 3, and the grooves 4 are formed on the rubber partition 6. The grooves 4 on the rubber partition 6 not only facilitate the insertion of the marking component into the liquid nitrogen 11 inside the drawer 2, but also, due to the elasticity of the rubber partition 6, when the marking component is removed from the groove 4, the groove 4 remains sealed, effectively reducing the evaporation of liquid nitrogen 11 and creating a relatively sealed environment. Simultaneously, the grooves 4 can also remove excess liquid nitrogen 11 from the marking component.

[0031] Meanwhile, the rubber diaphragm 6 can effectively prevent the marking component from being immersed in liquid nitrogen during the cooling process. This prevents liquid nitrogen 11 from splashing out when the handle is pulled out or inserted, ensuring the safety of the operator.

[0032] The design is further optimized so that the top surface of drawer 2 abuts against the rubber partition 6. The tight contact between drawer 2 and rubber partition 6 not only facilitates the pulling out of drawer 2, but also ensures that drawer 2 is in a sealed environment when it is inside base 1, effectively reducing the volatilization of liquid nitrogen 11 stored in drawer 2.

[0033] The design is further optimized so that the stamping component includes a stamp handle 7, a movable block 12 is slidably connected inside the stamp handle 7, a connecting post 5 is fixedly connected to the top surface of the movable block 12, and an adjustment button 8 is fixedly connected to one end of the connecting post 5 that extends beyond the top surface of the stamp handle 7. The adjustment button 8 can control the raising and lowering of the movable block 12 within the stamp handle 7.

[0034] To further optimize the design, the bottom of the stamp handle 7 is fixedly connected to a base plate 10 that is detachably connected to the groove 3. The base plate 10 has symmetrical limit grooves, and the limit grooves and the card slots 4 are set one-to-one.

[0035] The design was further optimized so that the base plate 10 fits into the groove 3, allowing the base plate 10 to be effectively placed within the groove 3.

[0036] In a further optimized design, the movable block 12 is symmetrically equipped with marking metal 9 at one end opposite to the connecting column 5. One end of the marking metal 9 is fixedly connected to the movable block 12, and the other end of the marking metal 9 extends into the limiting groove and is slidably connected to the limiting groove. The two marking metal 9 are raised and lowered by the movable block 12.

[0037] To facilitate the adjustment of the length of the marker metal 9 by the button 8, a rubber ring is provided between the movable block 12 and the inner wall of the stamp handle 7. The rubber ring is embedded in the movable block 12, which increases the friction and allows the movable block 12 to be stably positioned in the designated position.

[0038] The design was further optimized so that the marked metal 9 passes through the limiting groove and the card slot 4 in sequence and extends into the drawer 2.

[0039] By setting the limit groove and the card slot 4 in a one-to-one correspondence, the marking metal 9 can be raised and lowered stably.

[0040] To protect operators, the marking metal 9 is made of a metal with good thermal conductivity, the stamp handle 7 and the adjustment button 8 are made of durable and skin-friendly materials, and the connecting column 5, the base plate 10 and the movable block 12 are made of cold-resistant and wear-resistant materials.

[0041] Working process: Pull out drawer 2 and pour liquid nitrogen 11 into drawer 2, filling it to three-quarters of its volume. Then push drawer 2 back into base 1. At this point, the rubber partition 6 tightly abuts against drawer 2, creating a sealed environment for the liquid nitrogen 11 inside. Then, place base plate 10 into groove 3, ensuring the limiting groove aligns with the card slot 4. Press adjustment button 8, allowing the marking metal 9 to pass through the limiting groove and be submerged in liquid nitrogen 11. After cooling, pull up adjustment button 8 to reset it, remove stamp handle 7, and then adjust the exposed length of marking metal 9 again using adjustment button 8, based on the raised areas on the animal's skin, to mark and position the area. This allows the marking to accurately position the skin test area for a long period without affecting the observation of the skin during the experiment, thus improving the accuracy and reliability of skin testing experiments.

[0042] In the description of this utility model, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0043] The embodiments described above are merely preferred embodiments of the present utility model and are not intended to limit the scope of the present utility model. Various modifications and improvements made to the technical solutions of the present utility model by those skilled in the art without departing from the spirit of the present utility model should fall within the protection scope defined by the claims of the present utility model.

Claims

1. A device for long-term marking of skin sites in laboratory animals, characterized in that: Includes a base (1), in which a drawer (2) for storing liquid nitrogen (11) is slidably connected, and a rubber partition (6) is slidably connected to the top surface of the drawer (2). The rubber partition (6) is fixedly connected to the top of the base (1). Several grooves (3) are provided on the top surface of the base (1). The grooves (3) are detachably connected to marking components for marking animal skin.

2. The device for long-term marking of experimental animal skin sites according to claim 1, characterized in that: The groove (3) is symmetrically provided with slots (4), which are formed on the rubber partition (6).

3. The device for long-term marking of experimental animal skin sites according to claim 1, characterized in that: The top surface of the drawer (2) abuts against the rubber partition (6).

4. The device for long-term marking of experimental animal skin sites according to claim 2, characterized in that: The marking assembly includes a stamp handle (7), a movable block (12) is slidably connected inside the stamp handle (7), a connecting post (5) is fixedly connected to the top surface of the movable block (12), and an adjustment button (8) is fixedly connected to one end of the connecting post (5) that extends out of the top surface of the stamp handle (7).

5. The device for long-term marking of experimental animal skin sites according to claim 4, characterized in that: The bottom of the stamp handle (7) is fixedly connected to a base plate (10) that is detachably connected to the groove (3). The base plate (10) has symmetrically opened limit grooves, and the limit grooves are set one-to-one with the card slot (4).

6. The device for long-term marking of experimental animal skin sites according to claim 5, characterized in that: The base plate (10) is adapted to the groove (3).

7. The device for long-term marking of experimental animal skin sites according to claim 5, characterized in that: The movable block (12) is symmetrically provided with a marking metal (9) at one end away from the connecting column (5). One end of the marking metal (9) is fixedly connected to the movable block (12), and the other end of the marking metal (9) extends into the limiting groove and is slidably connected to the limiting groove.

8. The device for long-term marking of experimental animal skin sites according to claim 7, characterized in that: The marking metal (9) passes through the limiting groove and the card slot (4) in sequence and extends into the drawer (2).