Separation and purification device for protein A filler production

Abstract

The utility model discloses a separation and purification device for protein A filler production, and particularly relates to the technical field of protein A filler production. The separation and purification device comprises a supporting frame, and a separation and purification treatment device for protein A filler production is arranged at the upper end of the supporting frame; the separation and purification treatment device for protein A filler production comprises a protein A filler separation and purification auxiliary assembly and a feeding cleaning assembly. Compared with the prior art, the separation and purification device for protein A filler production has the advantages that when the feeding cleaning assembly needs to be cleaned, the feeding cleaning assembly can be rotated to the other side of the upper end of the protein A filler separation and purification auxiliary assembly for cleaning; the protein A filler separation and purification auxiliary assembly and the feeding cleaning assembly can perform detachable separation and cleaning work, so that the cleaning difficulty of the whole device is greatly reduced, and the use convenience of the whole device is further improved.

Description

Technical Field

[0001] This utility model relates to the field of protein A packing material production technology, and more specifically, to a separation and purification device for producing protein A packing material. Background Technology

[0002] Protein A packing material uses spherical, narrowly dispersed, and highly cross-linked agarose gel as the matrix. Through Saifen Technology's proprietary technology, the agarose matrix is ​​bonded to the alkali-resistant recombinant PROTEINA ligand, which is specifically used for the separation and purification of antibodies and recombinant protein biomolecules containing FC fragments.

[0003] In the production process of existing protein A packing materials, purification and separation equipment is required. Most of the existing purification and separation equipment is an integrated purification device. When the internal parts of the purification device need to be cleaned, there are problems such as high cleaning difficulty and low convenience of disassembly and cleaning. Utility Model Content

[0004] In order to overcome the above-mentioned defects of the prior art, the embodiments of this utility model provide a separation and purification device for the production of protein A filler, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a separation and purification device for producing protein A packing material, comprising a support frame, wherein a separation and purification processing device for producing protein A packing material is provided at the upper end of the support frame, the separation and purification processing device for producing protein A packing material comprises: a protein A packing material separation and purification auxiliary component and a feeding and cleaning component, wherein the feeding and cleaning component is provided at the upper end of the protein A packing material separation and purification auxiliary component.

[0006] In a preferred embodiment, the protein A packing material separation and purification auxiliary component includes: a separation and purification processor body, an upper cleaning pipe interface, and a discharge pipe, wherein the upper end of the discharge pipe is disposed at the lower end of the separation and purification processor body, and the lower end of the discharge pipe is installed at the upper end of the separation and purification processor body.

[0007] In a preferred embodiment, the feeding and cleaning assembly includes: a feeding auxiliary body, a cleaning pipe, a separation feeder, a control valve, an upper transmission pipe, a lower transmission pipe, an assembly sealing sleeve, a telescopic placement extension pipe, an electric lifting support body, and a rotating adjustment shaft. A positioning plate is installed at the lower end of the rotating adjustment shaft, and the front end of the positioning plate is installed on the outer side wall of the separation and purification processor body.

[0008] In a preferred embodiment, the upper end of the rotation adjustment shaft is installed at the lower end of the electric lifting support body, and the feeding auxiliary body and the separating feeder side are installed on the front side of the upper end of the electric lifting support body.

[0009] In a preferred embodiment, the upper end of the separating feeder is installed at the lower end of the feeding pure auxiliary device body, and the upper end of the feeding pure auxiliary device body is installed at the lower end of the cleaning pipe.

[0010] In a preferred embodiment, the control valve is located at the lower end of the separator feeder, the lower end of the separator feeder is installed at the upper end of the upper transmission pipe, the lower end of the upper transmission pipe is installed at the upper end of the telescopic extension pipe, and the lower end of the telescopic extension pipe is detachably connected to the inside of the lower transmission pipe.

[0011] In a preferred embodiment, the lower end of the upper transmission pipe is connected to the upper end of the lower transmission pipe, and the assembly sealing sleeve is detachably installed on the outer walls of the upper and lower transmission pipes. Both the upper and lower transmission pipes are provided with threaded assembly protrusions, and the inner wall of the assembly sealing sleeve is provided with threaded assembly grooves.

[0012] The technical effects and advantages of this utility model are as follows:

[0013] A separation and purification device for producing protein A packing material has an advantage over existing technologies. When the feeding and cleaning component needs cleaning, it can be rotated to the other side of the upper end of the protein A packing material separation and purification auxiliary component for cleaning. The detachable separation and cleaning of the protein A packing material separation and purification auxiliary component and the feeding and cleaning component greatly reduces the cleaning difficulty of the entire device and further improves the ease of use of the entire device. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0015] Figure 2 This is a schematic diagram of the separation and purification device for the production of protein A filler of this utility model.

[0016] Figure 3 This is a schematic diagram of the auxiliary component for protein A separation and purification using the present invention.

[0017] Figure 4 This is a schematic diagram of the feeding and cleaning component of this utility model.

[0018] The attached figures are labeled as follows: 1. Support frame; 2. Separation and purification treatment device for protein A packing production; 21. Auxiliary component for protein A packing separation and purification; 211. Separation and purification processor body; 212. Discharge pipe; 213. Upper cleaning pipe interface; 22. Feeding and cleaning component; 221. Separation feeder; 222. Feeding and purification auxiliary device body; 223. Cleaning pipe; 224. Upper transmission pipe; 225. Control valve; 226. Telescopic placement extension pipe; 228. Assembled sealing sleeve; 229. Lower transmission pipe; 220. Electric lifting support body; 2201. Rotation adjustment shaft; 2202. Positioning plate. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0020] As attached Figure 1-4 As shown, this utility model provides a separation and purification device for the production of protein A packing material, including a support frame 1. A separation and purification processing device 2 for the production of protein A packing material is provided on the upper end of the support frame 1. The separation and purification processing device 2 for the production of protein A packing material includes a protein A packing material separation and purification auxiliary component 21 and a feeding and cleaning component 22. The feeding and cleaning component 22 is provided on the upper end of the protein A packing material separation and purification auxiliary component 21.

[0021] The protein A packing material separation and purification auxiliary component 21 includes: a separation and purification processor body 211, an upper cleaning pipe interface 213, and a discharge pipe 212. The upper end of the discharge pipe 212 is located at the lower end of the separation and purification processor body 211, and the lower end of the discharge pipe 212 is installed at the upper end of the separation and purification processor body 211.

[0022] The feeding and cleaning assembly 22 includes: a feeding auxiliary unit body 222, a cleaning pipe 223, a separator feeder 221, a control valve 225, an upper transmission pipe 224, a lower transmission pipe 229, an assembly sealing sleeve 228, a telescopic placement extension pipe 226, an electric lifting support body 220, and a rotation adjustment shaft 2201. A positioning plate 2202 is installed at the lower end of the rotation adjustment shaft 2201, and the front end of the positioning plate 2202 is installed on the outer side wall of the separation and purification processor body 211. The upper end of the rotation adjustment shaft 2201 is installed at the lower end of the electric lifting support body 220. The feeding auxiliary unit 222 and the separator feeder 221 are installed on the upper front side of the electric lifting support body 220. The upper end of the separator feeder 221 is installed on... The lower end of the feeding pure auxiliary device body 222 is installed at the lower end of the cleaning pipe 223. The control valve 225 is located at the lower end of the separating feeder 221. The lower end of the separating feeder 221 is installed at the upper end of the upper transmission pipe 224. The lower end of the upper transmission pipe 224 is installed at the upper end of the telescopic placement extension pipe 226. The lower end of the telescopic placement extension pipe 226 is detachably connected to the inside of the lower transmission pipe 229. The lower end of the upper transmission pipe 224 is connected to the upper end of the lower transmission pipe 229. The assembly sealing sleeve 228 is detachably installed on the outer wall of the upper transmission pipe 224 and the lower transmission pipe 229. Both the upper transmission pipe 224 and the lower transmission pipe 229 are provided with threaded assembly protrusions. The inner wall of the assembly sealing sleeve 228 is provided with threaded assembly grooves.

[0023] The specific implementation method is as follows: When using this utility model, the feeding and cleaning component 22 to be used is rotated and installed. The feeding and cleaning component 22 needs to be assembled before use. When the feeding and cleaning component 22 is used, the electric lifting support body 220 needs to be activated. The electric lifting support body 220 is activated to raise the height and position of the feeding pure auxiliary body 222 and the separating feeder 221. After the position of the feeding pure auxiliary body 222 and the separating feeder 221 is raised and adjusted, the rotating adjustment shaft 2201 is rotated. After the rotating adjustment shaft 2201 is rotated, the upper transmission pipe 224 set at the lower end is connected to the upper end of the lower transmission pipe 229. When the lower end of the lower transmission pipe 229 and the lower end of the upper transmission pipe 224 are connected, the telescopic extension pipe 226 set at the lower end of the upper transmission pipe 224 can be stretched. Pipe 226 is placed inside the lower transmission pipe 229. Then, the upper transmission pipe 224 is lowered by starting the electric lifting support body 220. After the lower end of the upper transmission pipe 224 is placed on the upper end of the lower transmission pipe 229, the assembly sealing sleeve 228 is rotated to install and seal the upper transmission pipe 224 and the lower transmission pipe 229. After the upper transmission pipe 224 and the lower transmission pipe 229 are assembled, they can be used with the equipment for transmission and separation. When the feeding cleaning component 22 needs to be cleaned, it can be rotated to the other side of the upper end of the protein A packing separation and purification auxiliary component 21 for cleaning. The protein A packing separation and purification auxiliary component 21 and the feeding cleaning component 22 can be detached for separation and cleaning, which greatly reduces the cleaning difficulty of the entire device and further improves the ease of use of the entire device.

[0024] The working principle of this utility model is as follows: When using this utility model, the feeding and cleaning component 22 is rotated and installed. The feeding and cleaning component 22 needs to be assembled before use. When the feeding and cleaning component 22 is used, the electric lifting support body 220 is activated. The electric lifting support body 220 raises the height and position of the feeding auxiliary body 222 and the separating feeder 221. After the height adjustment of the feeding auxiliary body 222 and the separating feeder 221 is completed, the rotating adjustment shaft 2201 is rotated. After the rotating adjustment shaft 2201 is completed, the upper transmission pipe 224 at the lower end is connected to the upper end of the lower transmission pipe 229. When the lower transmission pipe 229 and the lower end of the upper transmission pipe 224 are connected, Extend the telescopic placement extension pipe 226 at the lower end of the upper transmission pipe 224 and place it inside the lower transmission pipe 229. Then, move the upper transmission pipe 224 down by activating the electric lifting support body 220. After the lower end of the upper transmission pipe 224 is placed on the upper end of the lower transmission pipe 229, rotate the assembly sealing sleeve 228 to install and seal the upper transmission pipe 224 and the lower transmission pipe 229. After the upper transmission pipe 224 and the lower transmission pipe 229 are assembled, they can be used with the equipment for transmission and separation. When the feeding cleaning component 22 needs to be cleaned, it can be rotated to the other side of the upper end of the protein A packing separation and purification auxiliary component 21 for cleaning.

[0025] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change.

[0026] Secondly: The accompanying drawings of the embodiments disclosed in this utility model only involve the structures involved in the embodiments disclosed in this utility model. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this utility model can be combined with each other.

[0027] Finally: The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A separation and purification apparatus for producing protein A packing material, comprising a support frame (1), characterized in that: The upper end of the support frame (1) is provided with a separation and purification treatment device (2) for the production of protein A filler; The separation and purification device (2) for producing protein A packing material includes: a protein A packing material separation and purification auxiliary component (21) and a feeding and cleaning component (22), wherein the feeding and cleaning component (22) is located at the upper end of the protein A packing material separation and purification auxiliary component (21).

2. The separation and purification apparatus for producing protein A packing material according to claim 1, characterized in that: The protein A packing material separation and purification auxiliary component (21) includes: a separation and purification processor body (211), an upper cleaning pipe interface (213), and a discharge pipe (212). The upper end of the discharge pipe (212) is located at the lower end of the separation and purification processor body (211), and the lower end of the discharge pipe (212) is installed at the upper end of the separation and purification processor body (211).

3. The separation and purification apparatus for producing protein A packing material according to claim 2, characterized in that: The feeding and cleaning assembly (22) includes: a feeding and purification auxiliary device body (222), a cleaning pipe (223), a separation feeder (221), a control valve (225), an upper transmission pipe (224), a lower transmission pipe (229), an assembly sealing sleeve (228), a telescopic placement extension pipe (226), an electric lifting support body (220), and a rotation adjustment shaft (2201). The lower end of the rotation adjustment shaft (2201) is equipped with a positioning plate (2202), and the front end of the positioning plate (2202) is installed on the outer side wall of the separation and purification processor body (211).

4. The separation and purification apparatus for producing protein A packing material according to claim 3, characterized in that: The upper end of the rotating adjustment shaft (2201) is installed at the lower end of the electric lifting support body (220), and the side of the feeding pure auxiliary body (222) and the separating feeder (221) are installed on the front side of the upper end of the electric lifting support body (220).

5. The separation and purification apparatus for producing protein A packing material according to claim 3, characterized in that: The upper end of the separating feeder (221) is installed at the lower end of the feeding pure auxiliary device body (222), and the upper end of the feeding pure auxiliary device body (222) is installed at the lower end of the cleaning pipe (223).

6. The separation and purification apparatus for producing protein A packing material according to claim 3, characterized in that: The control valve (225) is located at the lower end of the separator feeder (221). The lower end of the separator feeder (221) is installed at the upper end of the upper transmission pipe (224). The lower end of the upper transmission pipe (224) is installed at the upper end of the telescopic placement extension pipe (226). The lower end of the telescopic placement extension pipe (226) is detachably connected to the inside of the lower transmission pipe (229).

7. The separation and purification apparatus for producing protein A packing material according to claim 3, characterized in that: The lower end of the upper transmission pipe (224) is connected to the upper end of the lower transmission pipe (229). The assembly sealing sleeve (228) is detachably installed on the outer wall of the upper transmission pipe (224) and the lower transmission pipe (229). Both the upper transmission pipe (224) and the lower transmission pipe (229) are provided with threaded assembly protrusions. The inner wall of the assembly sealing sleeve (228) is provided with threaded assembly grooves.

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