Detection and sample preparation device of nuclear magnetic resonance spectrometer

Abstract

The utility model discloses a detection and sample preparation device of a nuclear magnetic resonance spectrometer, and relates to the field of nuclear magnetic resonance spectrometers. A nuclear magnetic resonance spectrometer detection sample preparation device comprises a nuclear magnetic resonance spectrometer machine and further comprises a drawing box sliding on the inner wall of the nuclear magnetic resonance spectrometer machine, the interior of the drawing box is rotationally connected with a rotating shaft, and the surface of the rotating shaft is fixedly connected with a placement detection disc; according to the nuclear magnetic tube clamping device, under the cooperation of the control mechanism, the rotating disc, the arc-shaped groove and the moving rod, the multiple clamping plates can be synchronously driven to be close to or away from the surface of a nuclear magnetic tube, and through the arrangement of the mode, the multiple nuclear magnetic tubes are synchronously clamped or detached; therefore, capillary bubbles in a plurality of nuclear magnetic tubes are synchronously thrown to the liquid level through centrifugal rotation, so that a nuclear magnetic justice spectrometer can test a sample conveniently, and the problems that the nuclear magnetic tube is easy to fall off from the hand and break and the arms of sample preparation personnel are easy to disengage due to the fact that the nuclear magnetic tube needs to be thrown manually are solved; and the sample preparation working efficiency of the nuclear magnetic resonance spectrometer is further improved.

Description

Technical Field

[0001] This utility model belongs to the field of nuclear magnetic resonance spectrometer technology, specifically, it relates to a sample preparation device for nuclear magnetic resonance spectrometer detection. Background Technology

[0002] Nuclear magnetic resonance (NMR) spectroscopy is a technique used to study the absorption of radio frequency radiation by atomic nuclei. It is one of the most powerful tools for qualitative analysis of the composition and structure of various organic and inorganic substances, and sometimes for quantitative analysis. Its working principle is based on the fact that in a strong magnetic field, atomic nuclei undergo energy level splitting. When they absorb external electromagnetic radiation, nuclear energy level transitions occur, producing the so-called NMR phenomenon. The energy of the radio frequency field can only be effectively absorbed by the nucleus when the frequency of the applied radio frequency field matches the frequency of the atomic nucleus's spin precession, thus facilitating the energy level transition. Therefore, a specific atomic nucleus, in a given applied magnetic field, only absorbs energy from a specific frequency radio frequency field, thus forming a nuclear magnetic resonance signal. NMR studies the absorption of radio frequency radiation by atomic nuclei in a strong magnetic field. There are two main types of NMR spectrometers: high-resolution NMR spectrometers and broadband NMR spectrometers. The former can only detect liquid samples and is mainly used for organic analysis. The latter can directly measure solid samples and is more commonly used in physics. Based on their operating mode, spectrometers can be divided into continuous wave nuclear magnetic resonance spectrometers (ordinary spectrometers) and Fourier transform nuclear magnetic resonance spectrometers.

[0003] For liquid samples, a deuterated reagent is required for field locking. When performing carbon NMR analysis on nylon samples, hexafluoroisopropanol is used to dissolve the sample. However, hexafluoroisopropanol is too polar and does not contain a deuterated reagent. Therefore, a capillary containing heavy water (D20, i.e., a deuterated reagent) is placed inside the NMR tube containing the sample for field locking.

[0004] In the existing sample testing methods, air bubbles may appear in the capillary tube during transport, remaining below the sample surface and preventing normal detection by the NMR spectrometer. When multiple samples are being tested, the NMR tube must be manually shaken multiple times, which is prone to breaking the tube and causing arm dislocation for the sample preparation personnel, resulting in low work efficiency. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the shortcomings of the prior art and provide a nuclear magnetic resonance spectrometer detection sample preparation device that can overcome the above problems or at least partially solve the above problems.

[0006] To solve the above-mentioned technical problems, the basic concept of the technical solution adopted by this utility model is as follows: a sample preparation device for nuclear magnetic resonance spectrometer detection, including a nuclear magnetic resonance spectrometer, and further including: a drawer box that slides on the inner wall of the nuclear magnetic resonance spectrometer, a rotating shaft is rotatably connected inside the drawer box, a detection plate is fixedly connected to the surface of the rotating shaft, a placement groove is equidistantly formed on the surface of the placement groove, a clamping plate is provided inside the placement groove, a control mechanism is rotatably connected to the surface of the rotating shaft through a bearing, the control mechanism includes a rotating disk that rotates on the surface of the rotating shaft through a bearing, an arc-shaped groove is formed on the surface of the rotating disk, a moving rod is slidably connected inside the arc-shaped groove, the moving rod is slidably connected to the inside of the placement groove, and the end of the moving rod is fixedly connected to the clamping plate, and an adjusting screw is rotatably connected to the top of the rotating disk and the placement detection plate through a hinge seat.

[0007] Preferably, the control mechanism further includes an adjusting rod that slides inside the placement slot, with a clamping plate fixedly connected to the end of the adjusting rod. A hidden slot is provided inside the placement detection plate, and the adjusting rod is slidably connected to the inside of the hidden slot. An adjusting spring is fixedly connected to the end of the adjusting rod, and the adjusting spring is fixedly connected to the inside of the hidden slot.

[0008] Preferably, a connecting cover is installed on the top of the detection plate, and the connecting cover extends through the surface of the rotating shaft.

[0009] Preferably, the placement groove is provided with a sponge pad, and the number of sponge pads is equal to the number of spaces in the placement groove.

[0010] Preferably, a servo motor is fixedly connected to the bottom of the rotating shaft, and the servo motor is fixedly connected to the inner bottom wall of the drawer.

[0011] Preferably, a limiting rod is fixedly connected to the bottom of the detection tray, and a limiting groove is formed in the inner bottom wall of the drawer, with the limiting rod slidably connected to the inside of the limiting groove.

[0012] Preferably, the adjusting screw includes a threaded cylinder that rotates on top of the detection disc via a hinge seat, the threaded cylinder having a threaded rod internally connected to it, and the threaded rod being rotatably connected to the top of the threaded cylinder via the hinge seat.

[0013] Preferably, an adjuster is fixedly connected to the front of the drawer, and the adjuster is electrically connected to the output end of the servo motor.

[0014] After adopting the above technical solution, the present invention has the following beneficial effects compared with the prior art: the present invention.

[0015] This NMR spectrometer sample preparation device, through the coordination of a control mechanism, a rotating disk, an arc-shaped groove, and a moving rod, can simultaneously move multiple clamping plates closer to or further away from the surface of the NMR tubes. This design enables the simultaneous clamping or disassembly of multiple NMR tubes, thereby simultaneously throwing capillary bubbles inside the tubes onto the liquid surface via centrifugal rotation. This facilitates NMR spectrometer testing of the samples, avoiding the risks of manually shaking the NMR tubes, which could easily result in breakage or dislocation of the sample preparation personnel. This further improves the efficiency of NMR spectrometer sample preparation. Attached Figure Description

[0016] In the attached diagram:

[0017] Figure 1 This is a schematic diagram of the sample preparation device for nuclear magnetic resonance spectrometer proposed in this utility model;

[0018] Figure 2 This is a schematic diagram of the structure of the sample preparation device for nuclear magnetic resonance spectrometer proposed in this utility model, showing the placement of the detection tray.

[0019] Figure 3 This is a schematic diagram of the control mechanism of a sample preparation device for nuclear magnetic resonance spectrometer proposed in this utility model;

[0020] Figure 4 This utility model proposes a sample preparation device for nuclear magnetic resonance spectrometer detection. Figure 3 Schematic diagram of the structure at point A;

[0021] Figure 5 This is a cross-sectional view of the sample preparation device for nuclear magnetic resonance spectrometer proposed in this utility model.

[0022] Figure 6 This is a schematic diagram of the adjusting screw structure of a nuclear magnetic resonance spectrometer sample preparation device proposed in this utility model.

[0023] In the diagram: 1. Nuclear magnetic resonance spectrometer; 2. Drawer box; 3. Rotating shaft; 31. Servo motor; 4. Placement detection plate; 41. Limiting rod; 42. Limiting slide; 5. Placement slot; 6. Clamping plate; 7. Control mechanism; 71. Rotating disk; 72. Arc groove; 73. Moving rod; 74. Adjusting screw; 741. Threaded cylinder; 742. Threaded rod; 75. Adjusting rod; 76. Hidden slot; 77. Adjusting spring; 8. Connecting cover; 9. Sponge pad. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions in the embodiments will be clearly and completely described below with reference to the accompanying drawings. The following embodiments are used to illustrate this utility model, but are not intended to limit the scope of this utility model.

[0025] Example 1: Refer to Figures 1-6 A sample preparation device for nuclear magnetic resonance (NMR) spectrometer detection includes an NMR spectrometer 1 and a drawer 2 that slides on the inner wall of the NMR spectrometer 1. A rotating shaft 3 is rotatably connected inside the drawer 2. A detection plate 4 is fixedly connected to the surface of the rotating shaft 3. Placement slots 5 are evenly spaced on the surface of the detection plate 4. A clamping plate 6 is disposed inside the placement slots 5. A control mechanism 7 is rotatably connected to the surface of the rotating shaft 3 via bearings. The control mechanism 7 includes a rotating disk 71 that rotates on the surface of the rotating shaft 3 via bearings. An arc-shaped groove 72 is formed on the surface of the rotating disk 71. A moving rod 73 is slidably connected inside the arc-shaped groove 72. The rod 73 is slidably connected to the inside of the placement groove 5, and the end of the moving rod 73 is fixedly connected to the clamping plate 6. The rotating disk 71 and the top of the placement detection disk 4 are rotatably connected by an adjusting screw 74 through a hinge seat. The top of the placement detection disk 4 is equipped with a connecting cover 8, which extends through to the surface of the rotating shaft 3. The inside of the placement groove 5 is provided with a sponge pad 9, and the number of sponge pads 9 is equal to that inside the placement groove 5. The adjusting screw 74 includes a threaded cylinder 741 that rotates on the top of the placement detection disk 4 through a hinge seat. The inside of the threaded cylinder 741 is threadedly connected to a threaded rod 742, and the threaded rod 742 and the top of the threaded cylinder 741 are rotatably connected by a hinge seat.

[0026] In this invention, during use, the drawer 2 on the inner wall of the nuclear magnetic resonance spectrometer 1 is first expanded outward. Then, with multiple placement slots 5 on the surface of the placement detection disk 4 fixed by the rotating shaft 3, multiple NMR tubes can be sequentially placed into the placement slots 5. The clamping plates 6 then clamp and fix the NMR tubes in the placement slots 5. Through the control mechanism 7, the clamping plates 6 can be synchronously moved, allowing for rapid installation and removal of the NMR tubes. The clockwise rotation of the rotating disk 71 causes the arc-shaped groove 72 on its surface to shift at an angle. This angular shift in the arc-shaped groove 72 causes the moving rod 73 to move backward. During the backward movement of the moving rod 73, the clamping plates 6 in the placement slots 5 are simultaneously displaced, increasing the distance between the clamping plates 6, thus facilitating better placement of the NMR tubes into the placement slots 5. Then, by rotating the rotating disk 71 counterclockwise, the moving rod 73 on the surface of the arc-shaped groove 72 moves closer to the center of the placement groove 5, which can simultaneously clamp and limit the NMR tubes in multiple placement grooves 5. Then, the connecting cover 8 is installed on the top of the placement detection disk 4 to protect the top of multiple NMR tubes. Then, the rotating shaft 3 drives the placement detection disk 4 to rotate, thereby using centrifugal force to throw the capillary bubbles inside multiple NMR tubes to the liquid surface, thereby eliminating the bubbles inside the capillaries, so that the NMR spectrometer can test the samples. By adjusting the screw 74, the operator can manually rotate the threaded cylinder 741 clockwise, which can control the threaded rod 742 to move outward, thereby driving the rotating disk 71 to rotate clockwise. When the threaded rod 742 rotates counterclockwise, it can control the threaded rod 742 to move inward, thereby driving the rotating disk 71 to rotate counterclockwise.

[0027] In addition, the number of clamping plates 6 is symmetrically arranged, and the surface of the clamping plates 6 is made of rubber, so that when clamping the surface of the NMR tube, the anti-slip effect is better and the surface of the NMR tube will not be damaged.

[0028] Example 2: Refer to Figure 4 and Figure 5 Similar to Embodiment 1, but further: the control mechanism 7 also includes an adjusting rod 75 that slides inside the placement slot 5. The end of the adjusting rod 75 is fixedly connected to the clamping plate 6. The interior of the placement detection plate 4 is provided with a hidden slot 76. The adjusting rod 75 is slidably connected to the interior of the hidden slot 76. The end of the adjusting rod 75 is fixedly connected to an adjusting spring 77. The adjusting spring 77 is fixedly connected to the interior of the hidden slot 76. The bottom of the rotating shaft 3 is fixedly connected to a servo motor 31. The servo motor 31 is fixedly connected to the inner bottom wall of the drawer 2. The bottom of the placement detection plate 4 is fixedly connected to a limiting rod 41. The inner bottom wall of the drawer 2 is provided with a limiting groove 42. The limiting rod 41 is slidably connected to the interior of the limiting groove 42. The front of the drawer 2 is fixedly connected to an adjuster. The adjuster is electrically connected to the output end of the servo motor 31.

[0029] By sliding the adjusting rod 75 on the inner wall of the hidden groove 76, the clamping plates 6 in the placement groove 5 can move away from or closer to each other, thereby clamping and fixing the NMR tube in the placement groove 5. By adjusting the spring force of the adjusting spring 77, the adjusting rod 75 can be controlled to make a certain range of compensation, so that fine adjustments can be made when clamping different NMR tubes. Under the spring force of the adjusting spring 77, the servo motor 31 can drive the rotating shaft 3 to fix the placement detection disk 4 to rotate quickly. With the help of the adjuster, the speed of the servo motor 31 can be controlled, so as to meet the requirements of different NMR tubes and capillary bubbles. The bottom limiting rod 41 of the placement detection disk 4 slides in the limiting groove 42, which can ensure the stability of the placement detection disk 4 during rotation.

[0030] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Although the present utility model has been disclosed above with reference to a preferred embodiment, it is not intended to limit the present utility model. Any person skilled in the art can make some modifications or alterations to the above-described technical content to create equivalent embodiments without departing from the scope of the present utility model. Any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present utility model without departing from the scope of the present utility model shall still fall within the scope of the present utility model.

Claims

1. A sample preparation device for nuclear magnetic resonance (NMR) spectrometer detection, comprising an NMR spectrometer (1), characterized in that, Also includes: A drawer (2) slides on the inner wall of the nuclear magnetic resonance spectrometer (1). A rotating shaft (3) is rotatably connected inside the drawer (2). A detection plate (4) is fixedly connected to the surface of the rotating shaft (3). Placement slots (5) are evenly spaced on the surface of the detection plate (4). A clamping plate (6) is provided inside the placement slot (5). A control mechanism (7) is rotatably connected to the surface of the rotating shaft (3) via a bearing. The control mechanism (7) includes a rotating disk (71) that rotates on the surface of the rotating shaft (3) via a bearing. An arc-shaped groove (72) is provided on the surface of the rotating disk (71). A moving rod (73) is slidably connected inside the arc-shaped groove (72). The moving rod (73) is slidably connected to the inside of the placement slot (5), and the end of the moving rod (73) is fixedly connected to the clamping plate (6). An adjusting screw (74) is rotatably connected to the top of the rotating disk (71) and the detection plate (4) via a hinge seat.

2. The nuclear magnetic resonance spectrometer sample preparation device according to claim 1, characterized in that, The control mechanism (7) further includes an adjusting rod (75) that slides inside the placement slot (5). The end of the adjusting rod (75) is fixedly connected to a clamping plate (6). The placement detection plate (4) has a hidden slot (76) inside. The adjusting rod (75) is slidably connected to the inside of the hidden slot (76). The end of the adjusting rod (75) is fixedly connected to an adjusting spring (77), which is fixedly connected to the inside of the hidden slot (76).

3. The nuclear magnetic resonance spectrometer sample preparation device according to claim 2, characterized in that, A connecting cover (8) is installed on the top of the placement detection plate (4), and the connecting cover (8) extends through the surface of the rotating shaft (3).

4. The nuclear magnetic resonance spectrometer sample preparation device according to claim 3, characterized in that, The placement groove (5) is provided with a sponge pad (9), and the number of sponge pads (9) is equal to the number of the placement groove (5).

5. The nuclear magnetic resonance spectrometer sample preparation device according to claim 4, characterized in that, A servo motor (31) is fixedly connected to the bottom of the rotating shaft (3), and the servo motor (31) is fixedly connected to the inner bottom wall of the drawer (2).

6. The nuclear magnetic resonance spectrometer sample preparation device according to claim 1, characterized in that, The bottom of the placement detection plate (4) is fixedly connected to a limiting rod (41), and the inner bottom wall of the drawer (2) is provided with a limiting groove (42). The limiting rod (41) is slidably connected to the inside of the limiting groove (42).

7. The nuclear magnetic resonance spectrometer sample preparation device according to claim 1, characterized in that, The adjusting screw (74) includes a threaded cylinder (741) that rotates on top of the detection disk (4) via a hinge seat. The threaded cylinder (741) is internally threaded with a threaded rod (742), and the threaded rod (742) is rotatably connected to the top of the threaded cylinder (741) via a hinge seat.

8. The nuclear magnetic resonance spectrometer sample preparation device according to claim 1, characterized in that, An adjuster is fixedly connected to the front of the drawer (2), and the adjuster is electrically connected to the output end of the servo motor (31).

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