Separating device

Abstract

The utility model discloses a separating device which comprises a base, a first driving motor is fixedly mounted on the base, a supporting plate is fixedly connected to a rotating shaft of the first driving motor, a mounting disc is detachably connected to the supporting plate, a plurality of test tube barrels are mounted on the mounting disc, and a locking component is mounted on the mounting disc; a mounting vertical plate is fixedly mounted at one end of the base, a second driving motor is fixedly mounted on the mounting vertical plate, an output shaft of the second driving motor is detachably connected with one end of a mounting disc through a first connecting part, and a mounting stand column is fixedly mounted at the other end of the base; the mounting stand column is detachably connected with one end of the mounting disc through a second connecting part, so that the shaking efficiency of the ovarian cancer circulating tumor cell exosome is improved, the stability of the test tube in the shaking and centrifugal separation process is improved, the test tube is prevented from falling off, and the safety is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical instrument technical field, concretely is a separation device. BACKGROUND

[0002] At present, the traditional method of exosome separation is differential ultracentrifugation and density gradient ultracentrifugation, and the density gradient ultracentrifugation needs to ultracentrifuge the sample and gradient material together, and different components in the sample are settled in the respective isodensity region.

[0003] The patent with the patent announcement number CN215365735U and the publication date of 20211231 discloses an ovarian cancer circulating tumor cell exosome separation device, which comprises a bottom plate, a shaking device arranged above the bottom plate, and a containing device arranged above the shaking device.

[0004] The above-mentioned patent can solve the corresponding technical problems, replace manual shaking operation and improve work efficiency, but the above-mentioned ovarian cancer circulating tumor cell exosome separation device still has disadvantages in use:

[0005] The above-mentioned ovarian cancer circulating tumor cell exosome separation device can tilt and shake the test tube within a certain angle, which can be shaken evenly, but the shaking amplitude of the test tube is small, resulting in low shaking efficiency of the ovarian cancer circulating tumor cell exosome in the test tube, and the test tube in the above-mentioned patent is directly inserted into the placement disc, which is easy to be thrown during shaking, and the safety is low, which needs to be improved. UTILITY MODEL CONTENT

[0006] The utility model discloses a separation device through first drive motor, locking part, first connecting screw rod, third connecting screw rod, first connecting part, second connecting part and second drive motor, solve the separation device of prior art can be to test tube and be inclined to shake in certain angle, although can carry out shake even processing, but the shaking amplitude of test tube is small, leading to the ovarian cancer circulating tumor cell exosome in test tube shake even efficiency is lower, in addition, the test tube in above -mentioned patent is directly inserted on the placing tray, and the test tube is easy to be thrown in the shaking process, and the safety is lower, and the problem of waiting for improvement.

[0007] In order to achieve the above object, the utility model adopts the main technical scheme includes: a separation device, it includes: base, first drive motor is fixedly installed on the base, the pivot of first drive motor is fixedly connected with support plate, and the support plate is detachably connected with mounting disc, a plurality of test tube barrels are installed on the mounting disc, the test tube barrel is placed with the test tube for storing ovarian cancer circulating tumor cell exosome inside, and locking part for limiting and fixing the test tube is installed on the mounting disc, one end of the base is fixedly installed with mounting vertical plate, second drive motor is fixedly installed on the mounting vertical plate, and the output shaft of second drive motor is detachably connected with one end of the mounting disc through first connecting part, and the other end of the base is fixedly installed with mounting stand, and one end of the mounting disc is detachably connected with the mounting stand through second connecting part, and the first connecting part and the second connecting part are used in cooperation.

[0008] Further, the first connecting screw rod is fixedly installed on the support plate, the third connecting screw rod is fixedly installed on the bottom of the mounting disc, and the first connecting nut is threadedly installed between the third connecting screw rod and the first connecting screw rod.

[0009] Further, the sliding slot is formed in the base, the sliding block is slidably installed in the sliding slot, the connecting rod is fixedly connected to the upper end of the sliding block, and the upper end of the connecting rod is fixedly connected to the bottom of the support plate.

[0010] Further, the mounting groove is formed in the mounting disc, the lap plate is integrally formed on the upper portion of the test tube barrel, the lap plate is clamped and connected in the mounting groove, and the lap plate is fixedly connected to the mounting disc through the screw.

[0011] Further, the locking part includes the pressing plate, the pressing plate is pressed on the top of the plurality of test tubes at the same time, and the pressing plate is pressed on the mounting disc through the handle bolt.

[0012] Further, the first connecting part comprises a second connecting screw rod and a fifth connecting screw rod, one end of the second connecting screw rod is fixedly installed on the mounting disc, one end of the fifth connecting screw rod is fixedly connected with the output shaft of the second driving motor, and a second connecting screw sleeve is threadedly installed between the second connecting screw rod and the fifth connecting screw rod;

[0013] The second connecting part comprises a fourth connecting screw rod threadedly installed on the mounting column and a rotating shaft fixedly installed on one end of the mounting disc, one end of the fourth connecting screw rod is fixedly installed with a first bearing, a plug rod is fixedly installed in the inner ring of the first bearing, and one end of the rotating shaft is provided with a plug slot, and the plug rod is rotationally inserted into the plug slot.

[0014] Further, a fixed plate is fixedly installed on the second connecting screw sleeve, and a handle screw rod is threadedly installed on the fixed plate.

[0015] One end of the handle screw rod is embeddedly inserted into the limiting slot.

[0016] Further, a mounting frame is fixedly installed on the mounting column, a second bearing is fixedly installed on the mounting frame, and the output shaft of the second driving motor is fixedly installed in the inner ring of the second bearing.

[0017] Further, a twisting ring is fixedly installed at one end of the fourth connecting screw rod.

[0018] Further, the test tube barrel is in a hollow structure.

[0019] The utility model at least has the following beneficial effects:

[0020] The utility model provides a kind of separating device, and the cooperation of first connecting part and second connecting part is used to connect and fix mounting disc, and the second driving motor can drive mounting disc to quickly turn back and forth, can be substantially shaken operation to the ovarian cancer circulating tumor cell exosome in test tube, improve the shaking efficiency of ovarian cancer circulating tumor cell exosome;

[0021] The locking part is used to press and fix the test tube, which increases the stability of the test tube during shaking and centrifugal separation, avoids the test tube from falling off, and increases the safety;

[0022] The first connecting screw sleeve is used to connect the third connecting screw rod and the first connecting screw rod, so that the mounting disc is fixedly installed on the supporting plate, and the first driving motor drives the mounting disc to rotate, completes the centrifugal separation operation of the ovarian cancer circulating tumor cell exosome in the test tube, can realize the centrifugal separation of the ovarian cancer circulating tumor cell exosome after shaking, and is convenient to operate, saves time and effort. BRIEF DESCRIPTION OF DRAWINGS

[0023] The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiments of the application and together with the description serve to explain the application. In the drawings:

[0024] Figure 1 It is a perspective view of the separation device of the utility model;

[0025] Figure 2 It is a front view of the separation device of the utility model;

[0026] Figure 3 It is a top view of the separation device of the utility model;

[0027] Figure 4 It is a perspective view of the separation device of the utility model Figure 3 It is a structure enlarged schematic view of A part of the utility model;

[0028] Figure 5 It is a partial structure explosion schematic view of the separation device of the utility model;

[0029] Figure 6 It is a test tube cylinder structure schematic view of the separation device of the utility model;

[0030] Figure 7 It is an insertion rod installation structure schematic view of the separation device of the utility model.

[0031] BRIEF DESCRIPTION OF DRAWINGS

[0032] 1, base; 11, sliding groove; 12, sliding block; 13, connecting rod; 2, first drive motor; 3, support plate; 4, first connecting screw; 41, first connecting screw sleeve; 5, mounting disc; 51, test tube cylinder; 511, lap plate; 52, mounting groove; 53, screw; 54, pressing plate; 55, handle bolt; 56, rotating shaft; 561, insertion slot; 57, second connecting screw; 58, limiting groove; 59, third connecting screw; 6, mounting stand; 7, fourth connecting screw; 71, twisting ring; 72, first bearing; 73, insertion rod; 8, mounting stand plate; 9, second drive motor; 91, fifth connecting screw; 92, second connecting screw sleeve; 921, fixed plate; 922, handle screw; 93, mounting frame; 931, second bearing; 10, test tube. DETAILED DESCRIPTION

[0033] The embodiments of the present application will be described in detail hereinafter with reference to the drawings and embodiments, so that the realization process of how to apply technical means to solve technical problems and achieve technical effects of the present application can be fully understood and implemented.

[0034] EMBODIMENT

[0035] Referring to Figures 1 to 7 The utility model discloses an embodiment provides a kind of separating device, comprising: base 1, first drive motor 2 is fixedly installed on base 1, the rotating shaft of first drive motor 2 is fixedly connected with support plate 3, support plate 3 is detachably connected with mounting disc 5, a plurality of test tube barrels 51 are installed on mounting disc 5, test tube 10 for storing ovarian cancer circulating tumor cell exosome is placed in test tube barrel 51, locking component for limiting and fixing test tube 10 is installed on mounting disc 5;Mounting vertical plate 8 is fixedly installed on one end of base 1, second drive motor 9 is fixedly installed on mounting vertical plate 8, the output shaft of second drive motor 9 is detachably connected with one end of mounting disc 5 by first connecting component, mounting stand 6 is fixedly installed on the other end of base 1, and one end of mounting disc 5 is detachably connected with mounting stand 6 by second connecting component, first connecting component and second connecting component are used in cooperation, can be substantially uniform operation to ovarian cancer circulating tumor cell exosome in the inside of test tube 10, improve the uniformity efficiency of ovarian cancer circulating tumor cell exosome, test tube 10 is fixed by locking component and is pressed, increase the stability of test tube 10 in the process of uniformity and centrifugal separation, avoid test tube 10 to drop off, increase security, can realize that ovarian cancer circulating tumor cell exosome is first shaken and then centrifugal separation, and it is easy to operate, save time and effort.

[0036] Among them, first connecting screw rod 4 is fixedly installed on support plate 3, third connecting screw rod 59 is fixedly installed on the bottom of mounting disc 5, and first connecting nut 41 is threadedly installed between third connecting screw rod 59 and first connecting screw rod 4, when first connecting nut 41 is connected to third connecting screw rod 59 and first connecting screw rod 4, mounting disc 5 is fixedly installed on support plate 3, and mounting disc 5 is installed in horizontal state, test tube 10 on mounting disc 5 is in vertical state, and centrifugal separation operation can be carried out on ovarian cancer circulating tumor cell exosome in the inside of test tube 10.

[0037] Among them, chute 11 is formed in base 1, sliding block 12 is slidably installed in the inside of chute 11, the upper end of sliding block 12 is fixedly connected with connecting rod 13, the upper end of connecting rod 13 is fixedly connected with the bottom of support plate 3, support plate 3 is supported by connecting rod 13, the stability of the output of first drive motor 2 is increased, so that mounting disc 5 rotates more stably, and the centrifugal separation efficiency of ovarian cancer circulating tumor cell exosome is improved.

[0038] Among them, mounting groove 52 is formed in mounting disc 5, and lap plate 511 is integrally formed on the upper portion of test tube barrel 51, lap plate 511 is embedded and clamped in the inside of mounting groove 52, and lap plate 511 is fixedly connected with mounting disc 5 by screw 53, through the detachable installation mode of test tube barrel 51, it is convenient to disassemble and overhaul test tube barrel 51, and it is convenient to replace test tube barrel 51.

[0039] The locking component comprises a pressing plate 54, which simultaneously presses against the top of the plurality of test tubes 10, and the pressing plate 54 is pressed against the mounting disc 5 through a handle bolt 55, so that the plurality of test tubes 10 can be simultaneously fixed and pressed through the pressing plate 54, the stability of the test tubes 10 during uniform shaking and centrifugal separation is increased, the test tubes 10 are prevented from falling off, and the pressing plate 54 is fixed through the handle bolt 55, so that the pressing plate 54 is convenient to disassemble and assemble and convenient to operate.

[0040] The first connecting component comprises a second connecting screw rod 57 and a fifth connecting screw rod 91, the second connecting screw rod 57 is fixedly installed at one end of the mounting disc 5, one end of the fifth connecting screw rod 91 is fixedly connected with the output shaft of the second driving motor 9, and the second connecting screw rod 57 and the fifth connecting screw rod 91 are threadedly provided with a second connecting screw sleeve 92; the second connecting component comprises a fourth connecting screw rod 7 which is threadedly installed on the mounting stand 6 and a rotating shaft 56 which is fixedly installed at one end of the mounting disc 5, one end of the fourth connecting screw rod 7 is fixedly installed with a first bearing 72, the inner ring of the first bearing 72 is fixedly installed with a plug rod 73, one end of the rotating shaft 56 is provided with a plug groove 561, and the plug rod 73 is rotatably inserted into the inside of the plug groove 561; when the second connecting screw sleeve 92 connects the second connecting screw rod 57 and the fifth connecting screw rod 91, one end of the plug rod 73 is also simultaneously inserted into the inside of the plug groove 561, and the mounting disc 5 can be quickly and back and forth flipped by the second driving motor 9, so that the ovarian cancer circulating tumor cell exosomes in the test tubes 10 can be uniformly shaken.

[0041] The second connecting screw sleeve 92 is fixedly installed with a fixed plate 921, and the fixed plate 921 is threadedly installed with a handle screw rod 922; one end of the handle screw rod 922 is embedded and inserted into the inside of the limiting groove 58 of the mounting disc 5, so as to limit the second connecting screw sleeve 92, and prevent the second connecting screw sleeve 92 from rotating during the flipping and uniform shaking of the mounting disc 5.

[0042] The mounting stand 8 is fixedly installed with a mounting frame 93, the mounting frame 93 is fixedly installed with a second bearing 931, and the output shaft of the second driving motor 9 is fixedly installed in the inner ring of the second bearing 931, so as to increase the stability of the output of the second driving motor 9 and facilitate the use of the device.

[0043] One end of the fourth connecting screw rod 7 is fixedly installed with a twisting ring 71, so as to facilitate manual twisting of the fourth connecting screw rod 7 to rotate and facilitate operation.

[0044] The test tube barrel 51 has a hollow structure, so that the uniform shaking and centrifugal separation of the ovarian cancer circulating tumor cell exosomes in the test tubes 10 can be directly observed.

[0045] As known to those skilled in the art, the working principle and wiring method of the first driving motor 2 and the second driving motor 9 are common, which belong to conventional means or common general knowledge, and will not be described here again, and those skilled in the art can select any model according to their needs or convenience.

[0046] Working principle: in use, first, the test tube 10 containing ovarian cancer circulating tumor cell exosomes is inserted into the inside of the test tube cylinder 51, and the test tube 10 is tightly fixed by the pressing plate 54, then the second connecting screw rod 57 and the fifth connecting screw rod 91 are connected and fixed by the second connecting sleeve 92, at the same time, the fourth connecting screw rod 7 is rotated to drive one end of the plug rod 73 to be inserted into the plug slot 561, then the mounting disc 5 can be driven to quickly flip back and forth by the second driving motor 9, so that the ovarian cancer circulating tumor cell exosomes in the test tube 10 can be shaken evenly, when the ovarian cancer circulating tumor cell exosomes in the test tube 10 are shaken evenly, the rotating shaft 56 and the second connecting screw rod 57 at the left and right ends of the mounting disc 5 are separated from their corresponding structures respectively, the third connecting screw rod 59 and the first connecting screw rod 4 are connected by the first connecting sleeve 41, so that the mounting disc 5 is fixedly installed on the support plate 3, and the mounting disc 5 is rotated by the first driving motor 2, so as to realize the centrifugal separation operation of the ovarian cancer circulating tumor cell exosomes in the test tube 10.

[0047] The above description shows and describes several preferred embodiments of the present application, but as mentioned above, it should be understood that the present application is not limited to the forms disclosed herein, and should not be considered as excluding other embodiments, but can be used in various other combinations, modifications and environments, and can be modified within the scope of the application conceived herein by the above teachings or related art or knowledge. Any modification and change made by those skilled in the art without departing from the spirit and scope of the present application shall be within the protection scope of the appended claims of the present application.

Claims

1. A separation device, characterized in that, include: A base (1) is fixedly mounted on the base (1), and a support plate (3) is fixedly connected to the shaft of the first drive motor (2). A mounting plate (5) is detachably connected to the support plate (3). A plurality of test tube tubes (51) are mounted on the mounting plate (5). A test tube (10) for storing ovarian cancer circulating tumor cell exosomes is placed inside the test tube tube (51). A locking component for limiting and fixing the test tube (10) is installed on the mounting plate (5). A mounting plate (8) is fixedly installed on one end of the base (1), and a second drive motor (9) is fixedly installed on the mounting plate (8). The output shaft of the second drive motor (9) is detachably connected to one end of the mounting plate (5) through a first connecting component. A mounting column (6) is fixedly installed on the other end of the base (1), and a second connecting component is detachably connected to one end of the mounting plate (5). The first connecting component and the second connecting component are used in conjunction.

2. The separation device according to claim 1, characterized in that: A first connecting screw (4) is fixedly installed on the support plate (3), and a third connecting screw (59) is fixedly installed on the bottom of the mounting plate (5). A first connecting sleeve (41) is threaded between the third connecting screw (59) and the first connecting screw (4).

3. The separation device according to claim 2, characterized in that: The base (1) has a sliding groove (11), and a slider (12) is slidably installed inside the sliding groove (11). A connecting rod (13) is fixedly connected to the upper end of the slider (12), and the upper end of the connecting rod (13) is fixedly connected to the bottom of the support plate (3).

4. The separation device according to claim 1, characterized in that: The mounting plate (5) has a mounting groove (52), and the upper part of the test tube tube (51) is integrally formed with a lap plate (511). The lap plate (511) is fitted and snapped into the inside of the mounting groove (52), and the lap plate (511) is fixedly connected to the mounting plate (5) by screws (53).

5. A separation device according to claim 4, characterized in that: The locking component includes a pressure plate (54) that simultaneously presses against the top of the plurality of test tubes (10), and the pressure plate (54) is pressed onto the mounting plate (5) by a handle bolt (55).

6. The separation device according to claim 1, characterized in that: The first connecting component includes a second connecting screw (57) and a fifth connecting screw (91). The second connecting screw (57) is fixedly installed at one end of the mounting plate (5), and one end of the fifth connecting screw (91) is fixedly connected to the output shaft of the second drive motor (9). A second connecting sleeve (92) is threaded between the second connecting screw (57) and the fifth connecting screw (91). The second connecting component includes a fourth connecting screw (7) threaded onto the mounting column (6) and a rotating shaft (56) fixedly mounted on one end of the mounting plate (5). A first bearing (72) is fixedly mounted on one end of the fourth connecting screw (7), and a plug rod (73) is fixedly mounted in the inner ring of the first bearing (72). A slot (561) is provided on one end of the rotating shaft (56), and the plug rod (73) is rotatably inserted into the slot (561).

7. A separation device according to claim 6, characterized in that: A fixing plate (921) is fixedly installed on the second connecting screw sleeve (92), and a handle screw (922) is threadedly installed on the fixing plate (921); One end of the mounting plate (5) has a limiting groove (58), and one end of the handle screw (922) is fitted into the inside of the limiting groove (58).

8. A separation device according to claim 6, characterized in that: A mounting bracket (93) is fixedly installed on the mounting plate (8), and a second bearing (931) is fixedly installed on the mounting bracket (93). The output shaft of the second drive motor (9) is fixedly installed in the inner ring of the second bearing (931).

9. A separation device according to claim 6, characterized in that: A screw ring (71) is fixedly installed at one end of the fourth connecting screw (7).

10. A separation device according to claim 6, characterized in that: The test tube (51) has a hollow structure.

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