Decoloring and drying device for caspofungin processing

Abstract

The utility model discloses a decoloring and drying device for caspofungin processing, which comprises a drying tower, a gas heating system and a feeding system, both the gas heating system and the feeding system are communicated with the inside of the drying tower, and a discharge pipe communicated with the inside of the drying tower is fixedly mounted at the bottom end of the drying tower. And the bottom end of the discharging pipe is detachably connected with a collecting tank, a control valve is installed on the discharging pipe, the gas heating system comprises a heating box, and the heating box is located on the left side of the drying tower. According to the utility model, the electric heating wire in the gas heating system is matched with the continuously bent heat exchange tube and the temperature stop valve, so that uniform heating and accurate temperature control of inert gas are realized, the temperature control effect is good, the feeding system uniformly sprays caspofungin solution on the top of the drying tower through the infusion pump, the shunt ring and the atomizing nozzles in the annular array, and the drying effect is good. The mist solution is in full contact with the high-temperature inert gas moving upwards from the bottom, spraying is uniform, and the drying effect is good.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of caspofungin medicine preparation processing technology, more specifically, it relates to a decoloring and drying device for caspofungin processing. BACKGROUND

[0002] Caspofungin is a semi-synthetic lipopeptide (echinocandin) compound synthesized by Glarea Lozoyensis fermentation product. Caspofungin can inhibit the synthesis of a basic component of the cell wall of many filamentous fungi and yeast, β(1,3)-D-glucan, thereby exerting an antifungal effect. In the production process of caspofungin, it needs to be prepared from solution to powder to ensure that it does not denature during transportation and maintains good properties.

[0003] Patent application number CN202121742024.6 discloses a decoloring and drying device for caspofungin processing, which comprises a drying tower, an air inlet system, an air outlet system, an atomization system, a storage barrel and a receiving barrel. The air inlet system output end is communicated with the drying tower, the air outlet system input end is communicated with the drying tower, the storage barrel is arranged on the atomization system, the atomization system output end is communicated with the drying tower, the drying tower bottom is provided with a discharge pipe, and a control valve is arranged on the discharge pipe, the receiving barrel is detachably arranged at the bottom end of the discharge pipe, and a supporting frame is arranged on the drying tower.

[0004] The structure uses water flow to warm the inert gas during use. This method has poor heat exchange efficiency and it is difficult to control the temperature, which affects the drying quality of caspofungin. In addition, the top feeding structure sprays into the drying tower and diffuses unevenly, which leads to insufficient contact with the inert gas and affects the drying efficiency and quality. SUMMARY

[0005] In view of the problems in the prior art, the utility model aims to provide a decoloring and drying device for caspofungin processing to improve the drying efficiency and production quality.

[0006] To solve the problems in the background art, the utility model adopts the following technical scheme.

[0007] The decoloring and drying device for caspofungin processing comprises a drying tower, a gas heating system and a feeding system. The gas heating system and the feeding system are both communicated with the inside of the drying tower. The bottom end of the drying tower is fixedly installed with a discharge pipe communicated with the inside thereof. The bottom end of the discharge pipe is detachably connected with a collecting tank. A control valve is installed on the discharge pipe.

[0008] The gas heating system comprises a heating box, which is located at the left side of the drying tower, and a heat exchange pipe is arranged in the heating box, the left end of the heat exchange pipe penetrates through and extends to the left side of the heating box, the right end of the heat exchange pipe penetrates through the heating box and extends to the inside of the drying tower, two baffles are fixedly installed on the inner wall of the heating box, and uniformly distributed electric heating wires are fixedly installed on the opposite sides of the two baffles, and the electric heating wires are sleeved on the heat exchange pipe.

[0009] The feeding system comprises a storage tank, which is located at the left side of the drying tower, a feeding pipe is fixedly installed at the bottom end of the storage tank, a liquid pump is fixedly installed on the feeding pipe, a shunt ring is fixedly installed on the outer side of the drying tower, the liquid pump is connected with the inside of the shunt ring in a pipeline manner, and an annular array of atomizing nozzles is fixedly installed on the inner wall of the shunt ring and penetrates through and extends to the inside of the drying tower.

[0010] As a further description of the above technical scheme, a three-way valve is fixedly installed on the inner wall of the feeding pipe and located at the left side of the liquid pump, and a flushing pipe is fixedly installed on the three-way valve.

[0011] As a further description of the above technical scheme, the part of the heat exchange pipe in the heating box is in a continuous bending state.

[0012] As a further description of the above technical scheme, a temperature cut-off valve is fixedly installed on the heat exchange pipe and located at the right side of the heating box.

[0013] As a further description of the above technical scheme, the top end of the drying tower is connected with an exhaust pipe, and the other end of the exhaust pipe is sequentially connected with a condensing pipe and a cyclone separator.

[0014] Compared with the prior art, the advantages of the present application are that:

[0015] In the present application, the electric heating wires in the gas heating system cooperate with the continuous bending heat exchange pipe and the temperature cut-off valve to realize uniform heating of the inert gas and accurate temperature control, and the temperature control effect is good. The feeding system uniformly sprays the caspofungin solution on the top of the drying tower through the liquid pump, the shunt ring and the annular array of atomizing nozzles, so that the misty solution fully contacts with the high-temperature inert gas moving upward from the bottom, and the spraying is uniform and the drying effect is good. BRIEF DESCRIPTION OF DRAWINGS

[0016] Fig. 1 It is a three-dimensional structure schematic diagram of the present application;

[0017] Fig. 2 It is a front view cross-sectional structure schematic diagram of the heating box of the present application;

[0018] Fig. 3This is a top view cross-sectional structural diagram of the diversion ring of this utility model.

[0019] Explanation of the labels in the diagram:

[0020] 1. Drying tower; 2. Gas heating system; 201. Heating box; 202. Heat exchange tube; 3. Feeding system; 301. Storage tank; 302. Feeding pipe; 4. Discharge pipe; 5. Collection tank; 6. Control valve; 7. Baffle plate; 8. Heating wire; 9. Liquid pump; 10. Diverter ring; 11. Atomizing nozzle; 12. Three-way valve; 13. Flushing pipe; 14. Temperature shut-off valve; 15. Exhaust pipe; 16. Condenser; 17. Cyclone separator. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model;

[0022] Please see Figs. 1-3 In this utility model, the decolorizing and drying device for processing caspofungin includes a drying tower 1, a gas heating system 2 and a feeding system 3. The gas heating system 2 and the feeding system 3 are both connected to the interior of the drying tower 1. A discharge pipe 4 connected to the interior of the drying tower 1 is fixedly installed at the bottom end of the drying tower 1. A collection tank 5 is detachably connected to the bottom end of the discharge pipe 4. A control valve 6 is installed on the discharge pipe 4.

[0023] The gas heating system 2 includes a heating box 201, which is located on the left side of the drying tower 1. A heat exchange tube 202 is installed inside the heating box 201. The left end of the heat exchange tube 202 passes through and extends to the left side of the heating box 201, and the right end of the heat exchange tube 202 passes through the heating box 201 and extends into the interior of the drying tower 1. Two partitions 7 are fixedly installed on the inner wall of the heating box 201. Evenly distributed heating wires 8 are fixedly installed on the opposite side of the two partitions 7. The heating wires 8 are sleeved on the heat exchange tube 202.

[0024] The feeding system 3 includes a storage tank 301, which is located on the left side of the drying tower 1. A feeding pipe 302 is fixedly installed at the bottom of the storage tank 301. A liquid pump 9 is fixedly installed on the feeding pipe 302. A diversion ring 10 is fixedly installed on the outside of the drying tower 1. The liquid pump 9 is connected to the inside of the diversion ring 10 through a pipe. An array of atomizing nozzles 11 is fixedly installed on the inner wall of the diversion ring 10. The atomizing nozzles 11 penetrate and extend into the interior of the drying tower 1.

[0025] A three-way valve 12 is fixedly installed on the inner wall of the feeding pipe 302. The three-way valve 12 is located on the left side of the liquid pump 9. A flushing pipe 13 is fixedly installed on the three-way valve 12.

[0026] The part of the heat exchange pipe 202 inside the heating box 201 is in a continuous bending state, and a temperature cut-off valve 14 is fixedly installed on the heat exchange pipe 202 and located at the right side of the heating box 201.

[0027] The top end of the drying tower 1 is connected with an exhaust pipe 15, and the other end of the exhaust pipe 15 is sequentially connected with a condensing pipe 16 and a cyclone separator 17.

[0028] When the decolorization and drying operation of caspofungin needs to be performed, the user first fills inert gas into the heat exchange pipe 202 of the gas heating system 2, and then starts the electric heating wire 8 in the heating box 201, so that the electric heating wire 8 generates heat, and since the electric heating wire 8 is sleeved on the heat exchange pipe 202 in a continuous bending state, the inert gas in the pipe can be fully heated, and the temperature cut-off valve 14 can monitor and control the temperature of the heated gas, so that the temperature of the gas reaches a suitable drying temperature.

[0029] Then, the liquid pumping pump 9 in the feeding system 3 is started, the caspofungin solution in the storage tank 301 is pumped into the flow dividing ring 10 through the feeding pipe 302, and is uniformly sprayed on the top of the drying tower 1 through the annular array of atomizing nozzles 11, and the solution moves downward in a mist state, and at this time, the three-way valve 12 is connected with the feeding pipe 302 and the liquid pumping pump 9.

[0030] At the same time, the heated high-temperature inert gas moves upward from the bottom of the drying tower 1 and fully contacts with the mist-shaped caspofungin solution moving downward, so that the decolorization and drying of caspofungin are realized, and in the drying process, the waste gas in the drying tower 1 is discharged through the exhaust pipe 15 and sequentially treated through the condensing pipe 16 and the cyclone separator 17.

[0031] When the drying is completed, the control valve 6 on the discharging pipe 4 is opened, and the caspofungin after decolorization and drying falls into the collecting tank 5 for collection, and if the feeding system 3 needs to be flushed, the flushing liquid can be made to enter the feeding pipe 302 from the flushing pipe 13 through the control of the three-way valve 12, so that the feeding system 3 is cleaned, and the device is clean for next use.

[0032] In the utility model, the electric heating wire 8 in the gas heating system 2 cooperates with the heat exchange pipe 202 in a continuous bending state and the temperature cut-off valve 14, so that the inert gas is uniformly heated and the temperature is accurately controlled, the temperature control effect is good, the feeding system 3 uniformly sprays the caspofungin solution on the top of the drying tower 1 through the liquid pumping pump 9, the flow dividing ring 10 and the annular array of atomizing nozzles 11, so that the mist-shaped solution fully contacts with the high-temperature inert gas moving upward from the bottom, the spraying is uniform, and the drying effect is good.

[0033] The above merely describes a preferred embodiment of the present application; the scope of protection of the present application is not limited thereto. Any skilled person in the art, according to the technical scheme and improvement concept of the present application, makes equivalent replacement or change within the technical range disclosed by the present application, which should be covered in the scope of protection of the present application.

Claims

1. A decolorizing and drying apparatus for processing caspofungin, comprising a drying tower (1), a gas heating system (2), and a feeding system (3), wherein the gas heating system (2) and the feeding system (3) are both connected to the interior of the drying tower (1), characterized in that: The bottom end of the drying tower (1) is fixedly installed with a discharge pipe (4) in communication with the inside thereof, the bottom end of the discharge pipe (4) is detachably connected with a collecting tank (5), and the discharge pipe (4) is installed with a control valve (6). The gas heating system (2) comprises a heating box (201), the heating box (201) is located on the left side of the drying tower (1), the inside of the heating box (201) is provided with a heat exchange pipe (202), the left end of the heat exchange pipe (202) penetrates and extends to the left side of the heating box (201), the right end of the heat exchange pipe (202) penetrates the heating box (201) and extends to the inside of the drying tower (1), two baffle plates (7) are fixedly installed on the inner wall of the heating box (201), and the opposite sides of the two baffle plates (7) are fixedly installed with evenly distributed electric heating wires (8), the electric heating wires (8) are sleeved on the heat exchange pipe (202); The feeding system (3) comprises a storage tank (301), the storage tank (301) is located on the left side of the drying tower (1), the bottom end of the storage tank (301) is fixedly installed with a feeding pipe (302), the feeding pipe (302) is fixedly installed with a liquid pump (9), the outer side of the drying tower (1) is fixedly installed with a shunt ring (10), the liquid pump (9) is in communication with the inside of the shunt ring (10) through a pipeline, and the inner wall of the shunt ring (10) is fixedly installed with an annular array of atomizing nozzles (11), the atomizing nozzles (11) penetrate and extend to the inside of the drying tower (1).

2. The decoloring and drying device for processing caspofungin according to claim 1, characterized in that: A three-way valve (12) is fixedly installed on the inner wall of the feeding pipe (302), the three-way valve (12) is located on the left side of the liquid pump (9), and a flushing pipe (13) is fixedly installed on the three-way valve (12).

3. The decoloring and drying device for processing caspofungin according to claim 1, characterized by: The part of the heat exchange pipe (202) in the heating box (201) is in a continuous bending state.

4. The decoloring and drying apparatus for processing caspofungin according to claim 1, characterized by: A temperature cut-off valve (14) is fixedly installed on the heat exchange pipe (202), and the temperature cut-off valve (14) is located on the right side of the heating box (201).

5. The decoloring and drying apparatus for processing caspofungin according to claim 1, characterized by: The top end of the drying tower (1) is connected with an exhaust pipe (15), and the other end of the exhaust pipe (15) is sequentially connected with a condensing pipe (16) and a cyclone separator (17).

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