Purification device for liquid medical intermediate
By installing a detachable adsorption cylinder and a protective mesh cylinder on the reactor, and controlling the temperature with a heat exchange jacket, the problem of cumbersome adsorbent replacement in existing devices is solved, achieving high efficiency in adsorbent replacement and improved purification effect.
Patent Information
- Application Number
- CN202423255428.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-28
- Publication Date
- 2025-12-19
- Estimated Expiration
- 2034-12-28
AI Technical Summary
Existing pharmaceutical intermediate purification devices are cumbersome to operate when changing adsorbents, resulting in low replacement efficiency.
A purification device for liquid pharmaceutical intermediates is designed. By setting mounting holes and a detachable adsorption cylinder on the reaction vessel, adsorbent particles are loaded into the adsorption cylinder and fixed by threaded connection, simplifying the adsorbent replacement process. A protective mesh cylinder is set on the outside of the adsorption cylinder to prevent impurities from entering. A heat exchange jacket is set on the outer periphery of the reaction vessel to control the temperature.
It simplifies and improves the efficiency of adsorbent replacement, avoids the introduction of impurities, ensures the purity and temperature control of the purification process, and improves operational efficiency and purification effect.
Smart Images
Figure CN223683538U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model belongs to the technical field of medical intermediates production, specifically is a kind of purification device for liquid medical intermediate. BACKGROUND
[0002] The purification device for medical intermediates is usually designed to effectively purify and clean the gaseous or liquid medical intermediates generated during the production process to ensure that the purity meets the high standards of pharmaceutical grade and meets the quality requirements of subsequent synthetic drugs.
[0003] The existing adsorption purification device for medical intermediates adds liquid medical intermediates into the reaction kettle, uses adsorbent to adsorb impurities in the raw material solution to purify the medical intermediates. However, the adsorbent is usually placed inside the reaction kettle. When the adsorbent needs to be replaced, the top cover of the reaction kettle needs to be opened, the old adsorbent in the adsorbent container needs to be removed, and then new adsorbent needs to be added. The reaction kettle needs to be resealed for replacement. The operation is troublesome, time-consuming and inefficient. Therefore, a purification device for liquid medical intermediates with easy-to-replace adsorbent is needed. SUMMARY
[0004] To solve the above technical problems, the utility model provides a purification device for liquid medical intermediates with easy-to-replace adsorbent to solve the problems of existing purification device, such as troublesome operation and low replacement efficiency.
[0005] To solve the above technical problems, the utility model provides a purification device for liquid medical intermediates with easy-to-replace adsorbent to solve the problems of existing purification device, such as troublesome operation and low replacement efficiency.
[0006] Further, the stirring mechanism includes a stirring motor and a stirring paddle. The stirring motor is fixedly connected to the top of the reaction kettle. The output end of the stirring motor extends downward into the reaction kettle and is fixedly connected to the upper end of the stirring paddle.
[0007] Further, a protective mesh cylinder is arranged outside the adsorption cylinder in the reaction kettle. The upper end of the protective mesh cylinder is fixedly connected to the inner top wall of the reaction kettle. The mesh aperture of the protective mesh cylinder is smaller than the through-hole aperture of the adsorption cylinder.
[0008] Further, the reaction kettle is externally provided with a heat exchange jacket, the lower side of the heat exchange jacket is fixedly connected with a heat medium inlet, and the upper side is fixedly connected with a heat medium outlet.
[0009] Further, the reaction kettle is externally provided with a heat exchange jacket, the lower side of the heat exchange jacket is fixedly connected with a heat medium inlet, and the upper side is fixedly connected with a heat medium outlet.
[0010] The utility model has the following advantages compared with prior art:
[0011] 1. The utility model discloses a mounting hole, an adsorption cylinder is set up, and adsorbent particles are loaded into the adsorption cylinder, then the adsorption cylinder is inserted into the reaction kettle through the mounting hole and is fixed through screw connection, whenever adsorbent particles need to be replaced, only need to replace the adsorbent particles in the adsorption cylinder after rethreading and taking down the adsorption cylinder, and then reassembling to the mounting hole, the replacement of adsorbent particles can be completed, the utility model discloses simple operation reduces the operation step, and the work efficiency of adsorbent replacement is improved.
[0012] 2. The utility model discloses a protective net cylinder is arranged on the adsorption cylinder cover, avoids the adsorbent particles in the adsorption cylinder from leaking out of the adsorption cylinder and becoming impurities mixed into the pharmaceutical intermediates through the through -hole, prevents the introduction of new impurities in the purification process, the heat exchange jacket is arranged on the periphery of the reaction kettle, and heat medium is passed in the heat exchange jacket, so that the temperature environment required when the pharmaceutical intermediates are purified is guaranteed, and the applicability of the utility model is improved. DRAWINGS
[0013] Fig. 1 It is the structure schematic diagram of the utility model.
[0014] Fig. 2 It is the adsorption cylinder and sealing cover connecting structure schematic diagram of the utility model.
[0015] In the drawing: 1, reaction kettle, 2, stirring mechanism, 21, stirring motor, 22, stirring paddle, 3, discharge pipe, 4, mounting hole, 5, adsorption cylinder, 6, sealing mouth, 7, sealing cover, 8, protective net cylinder, 9, heat exchange jacket, 10, support leg. DETAILED DESCRIPTION
[0016] The utility model will be further described in connection with the drawings.
[0017] As Figs. 1-2The shown one kind liquid medical intermediate purifying device, including reaction kettle 1, be provided with stirring mechanism 2 in reaction kettle 1, top is provided with feed inlet, bottom is fixedly connected with discharge pipe 3, discharge pipe 3 is installed with unloading valve, reaction kettle 1 top is provided with two mounting holes 4, the inner wall of mounting hole 4 is equipped with internal thread, adsorption cylinder 5 upper end opening, the outer wall of adsorption cylinder 5 upper end is equipped with external thread, each mounting hole 4 is all detachably connected with adsorption cylinder 5 by thread, the side and bottom of adsorption cylinder 5 are provided with a plurality of through holes, adsorption cylinder 5 is filled with adsorbent particles, the particle size of adsorbent particles is greater than the particle size of through hole, adsorption cylinder 5 upper end is fixedly connected with sealing mouth 6, sealing mouth 6 is detachably connected with sealing cover 7 by thread, sealing mouth 6 diameter is greater than the diameter of adsorption cylinder 5.
[0018] In order to stir the pharmaceutical intermediates in the reaction kettle 1, accelerate the flow, increase the contact opportunity with the adsorbent particles, and improve the adsorption efficiency, the stirring mechanism 2 includes a stirring motor 21 and a stirring paddle 22. The stirring motor 21 is fixedly connected to the top of the reaction kettle 1, and the output end of the stirring motor 21 penetrates downward into the reaction kettle 1 and is fixedly connected to the upper end of the stirring paddle 22.
[0019] In order to avoid the adsorbent particles in the adsorption cylinder 5 from leaking out of the adsorption cylinder 5 and mixing impurities into the pharmaceutical intermediates after purification, a protective mesh cylinder 8 is provided on the outside of the adsorption cylinder 5 inside the reaction kettle 1. The upper end of the protective mesh cylinder 8 is fixedly connected to the inner top wall of the reaction kettle 1, and the mesh aperture of the protective mesh cylinder 8 is smaller than the through hole aperture of the adsorption cylinder 5. When the device is periodically cleaned, the adsorbent particles that may exist in the protective mesh cylinder 8 are also cleaned simultaneously.
[0020] In order to properly heat the pharmaceutical intermediates in the reaction kettle 1 and ensure that the adsorption purification can be carried out at appropriate temperature conditions, a heat exchange jacket 9 is provided on the outside of the reaction kettle 1. The lower side of the heat exchange jacket 9 is fixedly connected with a heat medium inlet, and the upper side is fixedly connected with a heat medium outlet.
[0021] In order to support the reaction kettle 1 and improve the overall stability of the device, support legs 10 are fixedly connected to the bottom of the reaction kettle 1.
[0022] The specific working process of the utility model is as follows:
[0023] When the adsorbent particles need to be replaced, the adsorption cylinder 5 is rotated in the opposite direction, and is screwed out of the installation hole 4. The adsorption cylinder 5 is taken out, the sealing cover 7 is unscrewed, and the adsorbent particles in the sealing cover 7 are poured out. New adsorbent particles are refilled, the sealing cover 7 is re-covered and screwed, the adsorption cylinder 5 with the replaced adsorbent particles is put back into the installation hole 4 and is screwed tightly, and the replacement of the adsorbent particles is completed.
[0024] When the adsorbent particles need to be replaced, the adsorption cylinder 5 is rotated in the opposite direction, and is screwed out of the installation hole 4. The adsorption cylinder 5 is taken out, the sealing cover 7 is unscrewed, and the adsorbent particles in the sealing cover 7 are poured out. New adsorbent particles are refilled, the sealing cover 7 is re-covered and screwed, the adsorption cylinder 5 with the replaced adsorbent particles is put back into the installation hole 4 and is screwed tightly, and the replacement of the adsorbent particles is completed.
Claims
1. A purification device for liquid pharmaceutical intermediates, comprising a reaction vessel (1), wherein the reaction vessel (1) is provided with a stirring mechanism (2), has a feed inlet at the top, and a discharge pipe (3) fixedly connected to the bottom, characterized in that: The reactor (1) has two mounting holes (4) on its top. Each mounting hole (4) is detachably connected to an adsorption cylinder (5) by a thread. The adsorption cylinder (5) has several through holes on its side and bottom. The adsorption cylinder (5) is filled with adsorbent particles. The upper end of the adsorption cylinder (5) is fixedly connected to a sealing port (6). The sealing port (6) is detachably connected to a sealing cap (7) by a thread. The diameter of the sealing port (6) is larger than the diameter of the adsorption cylinder (5).
2. The purification apparatus for liquid pharmaceutical intermediates according to claim 1, characterized in that: The stirring mechanism (2) includes a stirring motor (21) and a stirring paddle (22). The stirring motor (21) is fixedly connected to the top of the reactor (1). The output end of the stirring motor (21) extends downward through the reactor (1) and is fixedly connected to the upper end of the stirring paddle (22).
3. The purification apparatus for liquid pharmaceutical intermediates according to claim 1, characterized in that: The reactor (1) is equipped with a protective mesh cylinder (8) located outside the adsorption cylinder (5). The upper end of the protective mesh cylinder (8) is fixedly connected to the inner top wall of the reactor (1). The mesh diameter of the protective mesh cylinder (8) is smaller than the through hole diameter of the adsorption cylinder (5).
4. The purification apparatus for liquid pharmaceutical intermediates according to claim 1, characterized in that: The reactor (1) is fitted with a heat exchange jacket (9), with a heat medium inlet fixedly connected to the lower side and a heat medium outlet fixedly connected to the upper side of the heat exchange jacket (9).
5. The purification apparatus for liquid pharmaceutical intermediates according to claim 1, characterized in that: The bottom of the reactor (1) is fixedly connected to a support leg (10).