Sample injector for particle size analyzer
By designing the feed tube and homogenizing section of the sampler, drug particles fall along the side wall of the feed tube to form a cylindrical particle curtain, which solves the problem of uneven distribution of drug particles and improves the accuracy of particle size analysis.
Patent Information
- Application Number
- CN202421315339.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-11
- Publication Date
- 2025-12-23
- Estimated Expiration
- 2034-06-11
AI Technical Summary
The sampler of existing particle size analyzers causes uneven distribution of drug particles in the test area, affecting the accuracy of particle size analysis.
A sampler was designed, including a feed hopper, a discharge tube, and a homogenizing section. The output of drug particles is controlled by a discharge valve, and the spherical homogenizing section is used to make the drug particles fall along the side wall of the discharge tube to form a cylindrical particle curtain, ensuring uniform distribution.
This improves the accuracy of drug particle size testing results, ensures uniform distribution of drug particles within the testing area, and enhances the reliability of analytical results.
Smart Images
Figure CN223711624U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to the technical field of particle size analyzer, specifically relates to a sample feeder for particle size analyzer. BACKGROUND
[0002] Most of the raw materials, excipients, pharmaceutical intermediates and part of the preparation (such as powder injection, powder, powder spray, capsule, liposome, etc.) are powdery or granular. The particle size of the drug directly affects its solubility and in-vivo dissolution, release and absorption, and the producibility (such as flowability, mixing uniformity, compressibility) and stability. Therefore, in order to ensure the quality of the drug, laser particle size analyzer is usually used for particle size analysis of drug powder.
[0003] In the prior art, the laser particle size analyzer comprises a sample feeder and a laser test window, the sample feeder is used to send the drug particles into the test area of the test window, a high-speed camera is used to acquire and analyze the image of the drug particles in the test area, so that the particle size and distribution of the drug particles are obtained. However, the sample feeder adapted to the existing particle size analyzer is mostly free-fall sampling, and the drug particles are difficult to be uniformly distributed in the test area, resulting in low accuracy of drug particle size analysis. SUMMARY
[0004] In view of the technical problem of uneven distribution of the sample feeder of the existing particle size analyzer, the utility model provides a sample feeder for particle size analyzer, which can make the drug particles fall along the side wall of the discharge pipe into the test area, ensure that the drug particles are uniformly distributed in the test area during the falling process, and is beneficial to improve the accuracy of the drug particle size test result.
[0005] The utility model realizes the following technical scheme:
[0006] The utility model provides a sample feeder for particle size analyzer, including the feeding hopper, the feeding hopper discharge end is connected with the discharge pipe, the discharge pipe middle part is connected with the discharge valve in series, the discharge pipe is provided with the material equalizing portion, the material equalizing portion is located in the discharge end of the discharge valve, and the one end of the material equalizing portion opposite to the discharge valve is spherical arch shape, the material equalizing portion is coaxial with the discharge pipe, and the side wall of the material equalizing portion is spaced apart with the side wall of the discharge pipe.
[0007] The utility model provides a sampling device for particle size analyzer, and the feeding hopper is connected with the discharging pipe at the discharging end, and the discharging valve is connected in series at the middle part of the discharging pipe, so that the output of the medicine particles in the feeding hopper is controlled by the discharging valve; the discharging pipe is provided with the material equalizing part, the material equalizing part is located at the discharging end of the discharging valve, the end opposite to the discharging valve is in the shape of a spherical arch, and is coaxially and separately arranged with the discharging pipe, so that the medicine particles output by the discharging valve fall on the material equalizing part and roll from the material equalizing part to the side wall of the discharging pipe, so that the medicine particles fall along the side wall of the discharging pipe, thereby forming a cylindrical medicine powder particle curtain in the test area, ensuring that the medicine particles are evenly distributed in the test area during the falling process, and the accuracy of the medicine particle size test result is improved.
[0008] In an optional embodiment, the middle part of the discharging pipe is provided with a connecting horizontal rod, the connecting horizontal rod is located between the discharging valve and the material equalizing part, the connecting horizontal rod extends along the radial direction of the discharging pipe, and the two ends of the connecting horizontal rod are fixedly connected with the corresponding side walls of the discharging pipe, respectively; a connecting vertical rod is arranged between the material equalizing part and the connecting horizontal rod, one end of the connecting vertical rod is fixedly connected with the middle part of the connecting horizontal rod, and the other end is fixedly connected with the middle part of the arch top of the material equalizing part, so as to fix the material equalizing part in the middle part of the discharging pipe and minimize the disturbance to the falling of the medicine particles.
[0009] In an optional embodiment, the connecting horizontal rod is in the shape of a sheet, and the width direction of the connecting horizontal rod is parallel to the axial direction of the discharging pipe, so as to reduce the influence of the connecting horizontal rod on the falling of the medicine particles.
[0010] In an optional embodiment, the discharging valve comprises a valve ball, and a cylindrical material passing hole is coaxially arranged in the middle part of the valve ball; when the discharging valve is in the fully open state, the material passing hole is coaxial with the discharging pipe, so as to ensure that the medicine particles falling from the feeding hopper fall from the middle part of the discharging pipe to the middle part of the material equalizing part, and further ensure the uniformity of the distribution of the medicine particles in the test area.
[0011] In an optional embodiment, the valve ball is made of stainless steel, so as to avoid the attachment of a large amount of medicine powder on the valve ball.
[0012] In an optional embodiment, the lower end of the feeding hopper is provided with a mounting hole, and the upper end of the discharging pipe is sealingly inserted into the mounting hole, so as to connect the discharging end of the feeding hopper with the discharging pipe.
[0013] In an optional embodiment, a flexible sealing ring is sleeved on the upper end of the discharging pipe, the flexible sealing ring is used to seal the gap between the side wall of the discharging pipe and the side wall of the mounting hole, so as to ensure the sealing performance of the connection between the feeding hopper and the discharging pipe.
[0014] In an optional embodiment, the feeding hopper is made of stainless steel.
[0015] In an optional embodiment, the feeding hopper is fitted with a vibrator to shake the feeding hopper sidewall by the vibrator to avoid the formation of arch in the feeding hopper, so that the medicine particles in the feeding hopper can be discharged through the discharge valve.
[0016] In an optional embodiment, the vibrator is an eccentric vibrator.
[0017] Compared with the prior art, the utility model has the following advantages and beneficial effects:
[0018] The feeding hopper is connected with a discharge pipe, a discharge valve is connected in the middle of the discharge pipe, the output of the medicine particles in the feeding hopper is controlled through the discharge valve, a material uniformizing part is arranged in the discharge pipe, the material uniformizing part is arranged at the discharge end of the discharge valve, one end of the material uniformizing part opposite to the discharge valve is in a spherical arch shape and is coaxially and separately arranged with the discharge pipe, so that the medicine particles output by the discharge valve fall on the material uniformizing part and roll from the material uniformizing part to the sidewall of the discharge pipe, the medicine particles fall along the sidewall of the discharge pipe, a cylindrical medicine powder particle curtain is formed in the test area, the medicine particles are evenly distributed in the test area during the falling process, and the accuracy of the medicine particle size test result is improved. BRIEF DESCRIPTION OF DRAWINGS
[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiments, and it should be understood that the following drawings only show some embodiments of the present application, and therefore should not be regarded as a limitation on the scope, and for those skilled in the art, other related drawings can also be obtained without creative labor.
[0020] In the drawings:
[0021] Figure 1 The utility model discloses a structure schematic view for the feeding device of particle size analyzer.
[0022] Markings in the drawings and corresponding names of parts:
[0023] 1-feeding hopper, 2-discharge pipe, 3-discharge valve, 4-material uniformizing part, 5-connection cross bar, 6-connection vertical bar, 7-feeding hole, 8-flexible sealing ring, 9-vibrator. DETAILED DESCRIPTION
[0024] In order to make the purpose, technical scheme and advantages of the embodiments of the present application more clear, the technical scheme in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application, and obviously, the described embodiments are some embodiments of the present application, not all embodiments.
[0025] In the description of the embodiments of the present application, the indicated orientation or positional relationship is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship commonly used when the product of the application is used, or the orientation or positional relationship commonly understood by those skilled in the art, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.
[0026] At the same time, the terms "provided", "opened", "mounted", "connected", "connected" should be broadly understood, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be directly connected, or indirectly connected through an intermediate medium, or it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.
[0027] Embodiments
[0028] In combination Figure 1 The present embodiment provides a feeder for a particle size analyzer, which comprises a feeding hopper 1 connected with a discharging pipe 2 at the discharge end, and a discharging valve 3 connected in series in the middle of the discharging pipe 2; a material uniformizing part 4 is arranged in the discharging pipe 2, the material uniformizing part 4 is located at the discharge end of the discharging valve 3, and the end of the material uniformizing part 4 opposite to the discharging valve 3 is in a spherical arch shape; the material uniformizing part 4 is coaxially arranged with the discharging pipe 2, and the side wall of the material uniformizing part 4 is arranged in a spaced manner with the side wall of the discharging pipe 2.
[0029] Generally, the feeding hopper 1 is made of stainless steel, i.e. the feeding hopper 1 is made of medical stainless steel (316 stainless steel). At the same time, the feeding hopper 1 is adapted with a vibrator 9 to drive the side wall of the feeding hopper 1 to vibrate through the vibrator 9, so that the drug particles in the feeding hopper 1 can be uniformly discharged through the discharging valve 3.
[0030] Preferably, the vibrator 9 is an eccentric vibrator 9. The eccentric vibrator 9 has the characteristics of simple structure, convenient maintenance and low cost.
[0031] In addition, the feeding hopper 1 is provided with a mounting hole at the lower end, and the upper end of the discharging pipe 2 is sealingly inserted into the mounting hole, so as to connect the discharging pipe 2 with the discharge end of the feeding hopper 1.
[0032] It can be understood that the upper end of the discharge pipe 2 is sleeved with a flexible sealing ring 8, which is used to seal the gap between the side wall of the discharge pipe 2 and the side wall of the mounting hole, so as to ensure the sealing of the connection between the feed hopper 1 and the discharge pipe 2. At the same time, the flexible sealing ring 8 can absorb the vibration of the feed hopper 1, avoiding the vibration of the discharge pipe 2 with the feed hopper 1.
[0033] The discharge valve 3 only needs to be able to control whether the medicine particles in the feed hopper 1 flow or not, which can be a gate valve or a ball valve. In this embodiment, a ball valve is used as the discharge valve 3. That is, the discharge valve 3 includes a valve ball, and a cylindrical material hole 7 is coaxially arranged in the middle of the valve ball; wherein, when the discharge valve 3 is in a fully open state, the material hole 7 is coaxial with the discharge pipe 2, so as to ensure that the medicine particles falling from the feed hopper 1 fall from the middle of the discharge pipe 2 to the middle of the material distribution part 4, further ensuring the uniformity of the distribution of the medicine particles in the test area.
[0034] Similarly, the valve ball is made of stainless steel (316 stainless steel) to avoid the attachment of a large amount of medicine powder on the valve ball.
[0035] For the setting of the material distribution part 4, it should avoid affecting the flow of medicine particles passing through the material distribution part 4, and in this embodiment, the following structure is used for installation:
[0036] The middle of the discharge pipe 2 is provided with a connecting cross bar 5, which is located between the discharge valve 3 and the material distribution part 4; the connecting cross bar 5 extends along the radial direction of the discharge pipe 2, and the two ends of the connecting cross bar 5 are fixedly connected with the corresponding side walls of the discharge pipe 2; a connecting vertical bar 6 is arranged between the material distribution part 4 and the connecting cross bar 5, one end of the connecting vertical bar 6 is fixedly connected with the middle of the connecting cross bar 5, and the other end is fixedly connected with the middle of the vault of the material distribution part 4, so as to fix the material distribution part 4 in the middle of the discharge pipe 2, and as far as possible to reduce the disturbance to the falling of medicine particles.
[0037] Preferably, the connecting cross bar 5 is a sheet structure, and the width direction of the connecting cross bar 5 is parallel to the axial direction of the discharge pipe 2, so as to reduce the influence of the connecting cross bar 5 on the falling of medicine particles.
[0038] It should be noted that the sample feeder for the particle size analyzer provided in the embodiment is connected with the test window cavity of the particle size analyzer in use, and then the medicine particles are put into the feeding hopper 1, and the feeding valve 3 and the vibrator 9 are opened during the test, so that the medicine particles fall through the material holes 7 to the middle position on the top of the material uniformizing part 4, and roll from the material uniformizing part 4 to the side wall of the feeding pipe 2, so that the medicine particles fall along the side wall of the feeding pipe 2, thereby forming a cylindrical medicine particle curtain in the test area, and ensuring that the medicine particles are uniformly distributed in the test area during the falling process, which is beneficial to improve the accuracy of the particle size test result of the medicine particles.
[0039] The above specific embodiments further illustrate the purpose, technical scheme and beneficial effects of the present application, and it should be understood that the above description is only a specific embodiment of the present application and is not used to limit the protection scope of the present application, and any modification, equivalent replacement, improvement, etc. within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims
1. A sample injector for a particle size analyzer, characterized by, Including the feeding hopper (1), the feeding hopper (1) is connected with the discharge pipe (2) in the discharge end, the discharge pipe (2) is connected with the discharge valve (3) in the middle part; The discharge pipe (2) is provided with the even material part (4), the even material part (4) is located in the discharge end of the discharge valve (3), and the even material part (4) is opposite to the one end of the discharge valve (3) and is spherical arch shape; The even material part (4) is coaxially arranged with the discharge pipe (2), and the side wall of the even material part (4) is spaced apart from the side wall of the discharge pipe (2).
2. A sample injector for a particle size analyzer according to claim 1, wherein, The discharge pipe (2) is provided with the connecting cross bar (5), the connecting cross bar (5) is located between the discharge valve (3) and the even material part (4); The connecting cross bar (5) extends along the radial direction of the discharge pipe (2), and the two ends of the connecting cross bar (5) are fixedly connected with the corresponding side wall of the discharge pipe (2); The connecting vertical bar (6) is arranged between the even material part (4) and the connecting cross bar (5), one end of the connecting vertical bar (6) is fixedly connected with the middle part of the connecting cross bar (5), and the other end is fixedly connected with the middle part of the arch top of the even material part (4).
3. A sample injector for a particle size analyzer according to claim 2, wherein, The connecting cross bar (5) is a sheet structure, and the width direction of the connecting cross bar (5) is parallel to the axial direction of the discharge pipe (2).
4. The sample injector for a particle size analyzer of claim 1, wherein, The discharge valve (3) comprises a valve ball, a cylindrical material passing hole (7) is coaxially arranged in the middle part of the valve ball; Wherein, when the discharge valve (3) is in the fully open state, the material passing hole (7) is coaxial with the discharge pipe (2).
5. A sample injector for a particle size analyzer according to claim 4, wherein, The valve ball is made of stainless steel.
6. The sample injector for a particle size analyzer of claim 1, wherein, The lower end of the feeding hopper (1) is provided with a mounting hole, and the upper end of the discharge pipe (2) is sealingly inserted into the mounting hole.
7. A sample injector for a particle size analyzer according to claim 6, wherein, The upper end of the discharge pipe (2) is provided with a flexible sealing ring (8), which is used for sealing the gap between the side wall of the discharge pipe (2) and the side wall of the mounting hole.
8. The sample injector for a particle size analyzer of claim 1, wherein, The feeding hopper (1) is made of stainless steel.
9. The sample injector for a particle size analyzer according to any one of claims 1 to 8, wherein The feeding hopper (1) is provided with a vibrator (9).
10. A sample injector for a particle size analyzer according to claim 9, wherein, The vibrator (9) is an eccentric wheel vibrator.