Manual pressurization anti-overflow adapter and solid-phase extraction device
By designing a manual pressure anti-overflow adapter, the problems of sample overflow and backflow in the solid phase extraction device were solved, achieving stable sample outflow and accurate test results.
Patent Information
- Application Number
- CN202423301359.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-31
- Publication Date
- 2025-12-26
- Estimated Expiration
- 2034-12-31
AI Technical Summary
Existing solid phase extraction devices are prone to problems such as difficulty in sample filtration and uneven liquid outflow leading to overflow or backflow under normal pressure, which affect the accuracy of test results.
A manual pressurization anti-overflow adapter was designed, including an anti-backflow unit, an isolation unit, and an adapter unit. The adapter uses a flexible plug to pressurize the solid phase extraction column, and includes an isolation disc and an anti-backflow frustum column to prevent sample overflow and backflow. It is compatible with solid phase extraction columns of different specifications.
It effectively prevents sample splashing, overflow, and backflow, ensuring a stable flow of the sample and improving the accuracy and reliability of test results.
Smart Images
Figure CN223716439U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model belongs to the separation technical field, concretely relates to the structure of exchange column, especially relates to a kind of manual pressurization anti-overflow adapter and solid phase extraction device. BACKGROUND
[0002] Solid phase extraction utilizes solid adsorbent to adsorb target compounds in liquid sample, separates from the matrix and interfering compounds of sample, and then elutes with eluent, to achieve the purpose of rapid separation, purification and concentration. During solid phase extraction operation, due to the presence of impurities in sample, high concentration or polarity and viscosity of solvent and other factors, it is difficult to filter the sample through the solid phase extraction column filler under normal pressure.
[0003] Common solid phase extraction devices can be divided into two categories: negative pressure type and positive pressure type. The negative pressure type uses vacuum negative pressure as the power source to make the liquid loaded into the solid phase extraction column pass through the filler of the solid phase extraction column at a certain rate. Since the vacuum efficiency is difficult to control stably and accurately, the liquid flow rate in different solid phase extraction columns in batch processing differs greatly. The positive pressure type uses nitrogen or air as the power source for the liquid to flow out of the solid phase extraction column. In actual application, it is found that for some special sample solutions of certain matrix, the liquid does not flow smoothly during pressure application with the ear bulb, and the high pressure in the column can cause the sample solution to overflow or suck back into the ear bulb, resulting in sample loss, sample contamination and other problems, which ultimately affects the accuracy of test results.
[0004] Therefore, it is urgent to develop a new manual pressurization anti-overflow adapter and solid phase extraction device to solve the technical problem of preventing the sample solution in the column from overflowing or sucking back due to the direct connection of the ear bulb with the solid phase extraction column.
[0005] It should be noted that the above information disclosed in the background section of the present application is only for understanding the background of the present application, and therefore, the above description is not considered as information of prior art. UTILITY MODEL CONTENT
[0006] The present disclosure provides at least a manual pressurization anti-overflow adapter and solid phase extraction device.
[0007] In the first aspect, the present disclosure provides a manual pressurization anti-overflow adapter, which comprises an anti-suckback unit, an isolation unit and an adapter unit. The anti-suckback unit, the isolation unit and the adapter unit are arranged in sequence from top to bottom, and the anti-suckback unit is in communication with the adapter unit. The adapter unit is adapted to be in interference fit with a solid phase extraction column, and the anti-suckback unit is adapted to be connected to an ear bulb to separate the solid phase extraction column from the ear bulb by the isolation unit. When the ear bulb is connected to the anti-suckback unit and the adapter unit to input positive pressure into the solid phase extraction column, the anti-suckback unit prevents the solution in the solid phase extraction column from overflowing in reverse.
[0008] In an alternative embodiment, the adapter unit comprises at least one flexible plug; the flexible plug is provided with a first flow channel; when the flexible plug is in interference fit with the SPE cartridge, the positive pressure is filled into the SPE cartridge through the first flow channel.
[0009] In an alternative embodiment, at least two flexible plugs are provided; each of the flexible plugs is arranged in a stack from top to bottom, and the outer diameter of each of the flexible plugs decreases in turn.
[0010] In an alternative embodiment, two flexible plugs are provided, and the outer diameter of one of the flexible plugs is 7-9 mm, and the outer diameter of the other of the flexible plugs is 12-14 mm.
[0011] In an alternative embodiment, the isolation unit comprises an isolation disc; the isolation disc is located between the anti-suckback unit and the adapter unit to separate the SPE cartridge and the ear bulb.
[0012] In an alternative embodiment, the isolation disc is provided with a second flow channel, and the second flow channel is in communication with the anti-suckback unit and the adapter unit.
[0013] In an alternative embodiment, the isolation disc has an outer diameter of 20-24 mm.
[0014] In an alternative embodiment, the anti-suckback unit comprises an anti-suckback truncated cone; the anti-suckback truncated cone is provided with a third flow channel, the small side of the anti-suckback truncated cone is connected with the isolation unit; the large side of the anti-suckback truncated cone is adapted to access the ear bulb, so that the ear bulb extends into the third flow channel to output the positive pressure.
[0015] In an alternative embodiment, the large side of the anti-suckback truncated cone has an outer diameter of 9-11 mm, the small side of the anti-suckback truncated cone has an outer diameter of 7-9 mm, and the height of the anti-suckback truncated cone is 15-17 mm.
[0016] In a second aspect, the embodiments of the present disclosure further provide a solid phase extraction device, comprising: the manual pressure anti-overflow adapter as described above, a solid phase extraction cartridge, and an ear bulb; wherein the manual pressure anti-overflow adapter is adapted to be in interference fit with the solid phase extraction cartridge, the manual pressure anti-overflow adapter is adapted to access the ear bulb; the ear bulb accesses the positive pressure from the manual pressure anti-overflow adapter to the solid phase extraction cartridge.
[0017] In an alternative embodiment, the solid phase extraction column is provided with a filler and a sample solution; the sample solution is located between the filler and the manual pressure anti-overflow adapter, and the ear suction ball introduces positive pressure from the manual pressure anti-overflow adapter to the solid phase extraction column, so that the sample solution is filtered through the filler and then separated.
[0018] The beneficial effects of the present application are that the anti-suction unit and the adapter unit are connected with the ear suction ball and the solid phase extraction column respectively, and the isolation unit is arranged between the anti-suction unit and the adapter unit, which can adapt to solid phase extraction columns of different specifications on the one hand, and the positive pressure guided through the anti-suction unit, the isolation unit and the adapter unit can prevent abnormal conditions such as sample liquid splashing, overflowing and suction on the other hand.
[0019] Other features and advantages of the present application will be described in the following description, and some will become apparent from the description, or will be understood from the description, or will be understood by practicing the present application. The purpose and other advantages of the present application are achieved and obtained by the structure specifically pointed out in the description and the drawings.
[0020] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the preferred embodiments are described in detail below, and the detailed description is made below with the help of the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS
[0021] In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the following will briefly introduce the drawings needed to be used in the specific embodiments or the prior art description. Obviously, the drawings described below are some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained without creative labor on the basis of these drawings.
[0022] Figure 1 A structural diagram of a manual pressure anti-overflow adapter provided by the embodiment of the present disclosure is provided.
[0023] Figure 2 A sectional view of a manual pressure anti-overflow adapter provided by the embodiment of the present disclosure is provided.
[0024] Figure 3 A structural diagram of a solid phase extraction device provided by the embodiment of the present disclosure is provided.
[0025] In the drawings:
[0026] 1, anti-suction unit; 11, anti-suction circular column; 111, third flow channel; 112, small face side; 113, large face side;
[0027] 2, isolation unit; 21, isolation disc; 211, second flow channel;
[0028] 3. Adapter unit; 31. Flexible plug; 311. First flow channel;
[0029] 4. Solid-phase extraction column; 41. Packing material; 42. Sample solution;
[0030] 5. Ear bulbs. Detailed Implementation
[0031] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.
[0032] In this document, when it is mentioned that a first component is located on a second component, this can mean that the first component can be directly formed on the second component, or that a third component can be inserted between the first and second components. Furthermore, in the accompanying drawings, the thickness of the components may be exaggerated or reduced for the purpose of effectively describing the technical content.
[0033] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.
[0034] The following detailed description, with reference to the accompanying drawings, describes some embodiments of the present invention. Unless otherwise specified, the following embodiments and features can be combined with each other.
[0035] like Figures 1 to 3 As shown, at least one embodiment provides a manual pressurized anti-overflow adapter, which includes: an anti-backflow unit 1, an isolation unit 2, and an adapter unit 3; wherein the anti-backflow unit 1, the isolation unit 2, and the adapter unit 3 are arranged sequentially from top to bottom, and the anti-backflow unit 1 is connected to the adapter unit 3; the adapter unit 3 is adapted to be interference-fitted with the solid-phase extraction column 4, and the anti-backflow unit 1 is adapted to be connected to the suction bulb 5 so that the isolation unit 2 separates the solid-phase extraction column 4 from the suction bulb 5; when positive pressure is introduced into the solid-phase extraction column 4 from the anti-backflow unit 1 and the adapter unit 3 through the suction bulb 5, the anti-backflow unit 1 prevents the solution in the solid-phase extraction column 4 from overflowing in the reverse direction.
[0036] In at least one embodiment, the anti-suckback unit 1, the adapter unit 3 are connected with the ear suction ball 5, the solid phase extraction column 4 respectively, and the isolation unit 2 is arranged between the anti-suckback unit 1 and the adapter unit 3, which can adapt to solid phase extraction columns 4 of different specifications on the one hand, and can prevent abnormal conditions such as sample liquid splashing, overflowing, and suckback on the other hand.
[0037] In at least one embodiment, referring to Figure 1 , Figure 2 , the adapter unit 3 comprises at least one flexible plug head 31; a first flow channel 311 is arranged in the flexible plug head 31; when the flexible plug head 31 is in interference fit with the solid phase extraction column 4, the positive pressure is filled into the solid phase extraction column 4 through the first flow channel 311.
[0038] Specifically, the flexible plug head 31 can be squeezed into the solid phase extraction column 4 to realize interference fit between the flexible plug head 31 and the solid phase extraction column 4.
[0039] Specifically, the first flow channel 311 functions to connect the isolation unit 2 and the solid phase extraction column 4.
[0040] Specifically, the first flow channel 311 can also guide the positive pressure flow to the solid phase extraction column 4.
[0041] Specifically, the first flow channel 311 can also prevent abnormal conditions such as sample liquid splashing, overflowing, and suckback in the solid phase extraction column 4.
[0042] In at least one embodiment, referring to Figure 1 , Figure 2 at least two flexible plug heads 31 are arranged; each flexible plug head 31 is arranged in a stacked manner from top to bottom, and the outer diameter of each flexible plug head 31 decreases in turn.
[0043] Specifically, two or more flexible plug heads 31 can match solid phase extraction columns 4 of different specifications.
[0044] In at least one embodiment, referring to Figure 1 , Figure 2 two flexible plug heads 31 are arranged, and the outer diameter of one flexible plug head 31 is 7-9mm, and the outer diameter of the other flexible plug head 31 is 12-14mm.
[0045] Specifically, the outer diameter of one flexible plug head 31 is preferably 8mm, which can adapt to a 3mL specification SPE column.
[0046] Specifically, the outer diameter of the other flexible plug head 31 is preferably 13mm, which can adapt to a 6mL specification SPE column.
[0047] Specifically, the flexible plug 31 can be made of rubber, resin, fiber, etc.
[0048] In at least one embodiment, the isolation unit 2 comprises an isolation disc 21, which is located between the anti-suckback unit 1 and the adapter unit 3 to separate the solid phase extraction column 4 and the ear sucker 5.
[0049] Specifically, the isolation disc 21 functions to block the solid phase extraction column 4, so that the sample solution in the solid phase extraction column 4 can not overflow after the flexible plug 31 is inserted into the solid phase extraction column 4.
[0050] In at least one embodiment, referring to Figure 1 , Figure 2 , the isolation disc 21 is provided with a second flow channel 211, which is in communication with the anti-suckback unit 1 and the adapter unit 3.
[0051] Specifically, the second flow channel 211 functions to communicate the anti-suckback unit 1 and the first flow channel 311.
[0052] In at least one embodiment, referring to Figure 1 , Figure 2 , the isolation disc 21 has an outer diameter of 20-24 mm.
[0053] Specifically, the isolation disc 21 has an outer diameter of 22 mm, which can separate the anti-suckback unit 1 and the adapter unit 3.
[0054] In at least one embodiment, referring to Figure 1 , Figure 2 , the anti-suckback unit 1 comprises an anti-suckback disc column 11, which is provided with a third flow channel 111, and the small side 112 of the anti-suckback disc column 11 is connected with the isolation unit 2, and the large side 113 of the anti-suckback disc column 11 is adapted to be connected with the ear sucker 5, so that the ear sucker 5 extends into the third flow channel 111 to output positive pressure.
[0055] Specifically, the third flow channel 111 functions to communicate the ear sucker 5 and the second flow channel 211.
[0056] Specifically, the large side 113 extends into the ear sucker 5, and the small side 112 is connected with the isolation disc 21, which can prevent the sample solution from flowing downward, and is also conducive to guiding the positive pressure from the anti-suckback disc column 11 to the solid phase extraction column 4 through the isolation disc 21 and the flexible plug 31.
[0057] In at least one embodiment, referring to Figure 1 , Figure 2The outer diameter of the large surface side 113 of the anti-suction frustum column 11 is 9-11mm, the outer diameter of the small surface side 112 of the anti-suction frustum column 11 is 7-9mm, and the height of the anti-suction frustum column 11 is 15-17mm.
[0058] Specifically, the outer diameter of the large surface side 113 of the anti-suction frustum column 11 is preferably 10mm, the outer diameter of the small surface side 112 of the anti-suction frustum column 11 is preferably 8mm, and the height of the anti-suction frustum column 11 is preferably 16mm.
[0059] Based on the same concept, as shown in Figure 1 At least one embodiment also provides a solid phase extraction device, which comprises: a manual pressure anti-overflow adapter, a solid phase extraction column 4 and an ear sucker 5 as described above; wherein the manual pressure anti-overflow adapter is adapted to be interference-fitted with the solid phase extraction column 4, the manual pressure anti-overflow adapter is adapted to be connected to the ear sucker 5; and the ear sucker 5 introduces positive pressure from the manual pressure anti-overflow adapter to the solid phase extraction column 4.
[0060] In at least one embodiment, referring to Figure 2 Figures 1 to 3 Figure 3 The solid phase extraction column 4 is provided with filler 41 and sample solution 42; the sample solution 42 is located between the filler 41 and the manual pressure anti-overflow adapter, and the ear sucker 5 introduces positive pressure from the manual pressure anti-overflow adapter to the solid phase extraction column 4, so that the sample solution 42 is filtered through the filler 41 and then separated.
[0061] In summary, the anti-suction unit and the adapter unit are connected with the ear sucker and the solid phase extraction column respectively, and the isolation unit is arranged between the anti-suction unit and the adapter unit, which can adapt to solid phase extraction columns of different specifications on the one hand, and the positive pressure guided through the anti-suction unit, the isolation unit and the adapter unit can prevent abnormal conditions such as splashing, overflowing and suction of sample liquid on the other hand.
[0062] In the description of the embodiments of the utility model, unless otherwise explicitly specified and limited, the terms "mounting", "connection" and "connection" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium, or it can be the communication inside two elements. For ordinary skilled in the art, the specific meaning of the above-mentioned terms in the utility model can be understood according to specific circumstances.
[0063] In the description of the utility model, it is necessary to explain, the term "center", "upper", "lower", "left", "right", "vertical", "horizontal", "internal", "external" and so on indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawing, only for the convenience of describing the utility model and simplifying the description, and not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, therefore, it cannot be understood as a limitation on the utility model. In addition, terms such as "first", "second" and other numerical terms are used in this text, and do not imply order or sequence unless the text is explicitly indicated. Therefore, the above-discussed first element, component, area, layer or section can be referred to as the second element, component, area, layer or section without departing from the teachings of the example embodiments.
[0064] Spatially relative terms, such as "internal", "external", "lower", "under", "bottom", "top", "above", and the like, can be used herein for ease of description to describe one element or feature's relationship to another element(s) or feature(s) as illustrated in the figures. The spatially relative terms can be intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" the other elements or features. Thus, the example term "below" can encompass both an orientation of above and below. The device can be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
[0065] In the above discussion, unless otherwise stated, the terms "about", "approximately", "substantially" and the like, when used in describing a numerical value, mean a variation of + / - 10% of the value.
[0066] With the above ideal embodiments according to the utility model as the inspiration, through the above description, relevant staff can make various changes and modifications without deviating from the technical idea of the utility model. The technical scope of the utility model is not limited to the content in the specification, and the technical scope must be determined according to the scope of claims.
Claims
1. A manually pressurizable spill-resistant adapter, comprising: The application relates to a manual pressure anti-overflow adapter. The adapter comprises a backflow prevention unit (1), an isolation unit (2) and an adapter unit (3). The backflow prevention unit (1), the isolation unit (2) and the adapter unit (3) are sequentially arranged from top to bottom, and the backflow prevention unit (1) is in communication with the adapter unit (3). The adapter unit (3) is adapted to be in interference fit with a solid phase extraction column (4), and the backflow prevention unit (1) is adapted to be connected with an ear suction ball (5) so that the isolation unit (2) separates the solid phase extraction column (4) from the ear suction ball (5). When the ear suction ball (5) is connected with the backflow prevention unit (1), the adapter unit (3) and the solid phase extraction column (4) to input positive pressure, the backflow prevention unit (1) prevents the solution in the solid phase extraction column (4) from overflowing reversely.
2. The manual pressure anti-overflow adapter according to claim 1, wherein The adapter unit (3) comprises at least one flexible plug (31). A first flow channel (311) is formed in the flexible plug (31). When the flexible plug (31) is in interference fit with the solid phase extraction column (4), the positive pressure is filled into the solid phase extraction column (4) through the first flow channel (311).
3. The manual pressure anti-overflow adapter according to claim 2, wherein At least two flexible plugs (31) are arranged. The flexible plugs (31) are sequentially arranged from top to bottom, and the outer diameters of the flexible plugs (31) are sequentially reduced.
4. The manual pressure anti-overflow adapter according to claim 3, wherein Two flexible plugs (31) are arranged, and the outer diameter of one flexible plug (31) is 7-9 mm, and the outer diameter of the other flexible plug (31) is 12-14 mm.
5. The manual pressure anti-overflow adapter according to claim 1, wherein The isolation unit (2) comprises an isolation disc (21). The isolation disc (21) is arranged between the backflow prevention unit (1) and the adapter unit (3) to separate the solid phase extraction column (4) from the ear suction ball (5).
6. The manual pressure anti-overflow adapter according to claim 5, wherein A second flow channel (211) is formed in the isolation disc (21), and the second flow channel (211) is in communication with the backflow prevention unit (1) and the adapter unit (3).
7. The manual pressure anti-overflow adapter according to claim 5, wherein The outer diameter of the isolation disc (21) is 20-24 mm.
8. The manual pressure anti-overflow adapter according to claim 1, wherein The backflow prevention unit (1) comprises a backflow prevention circular truncated column (11). A third flow channel (111) is formed in the backflow prevention circular truncated column (11), and a small side (112) of the backflow prevention circular truncated column (11) is connected with the isolation unit (2). A large side (113) of the backflow prevention circular truncated column (11) is adapted to be connected with the ear suction ball (5) so that the ear suction ball (5) extends into the third flow channel (111) to output the positive pressure.
9. The manual pressure anti-overflow adapter according to claim 8, wherein The large surface side (113) of the anti-suckdown circular truncated cone column (11) has an outer diameter of 9-11 mm, the small surface side (112) of the anti-suckdown circular truncated cone column (11) has an outer diameter of 7-9 mm, and the height of the anti-suckdown circular truncated cone column (11) is 15-17 mm.
10. A solid phase extraction device, characterized by, Comprise: The manual pressure anti-overflow adapter, the solid phase extraction column (4) and the ear sucker (5) according to any one of claims 1-9; wherein The manual pressure anti-overflow adapter is adapted to be in interference fit with the solid phase extraction column (4), and the manual pressure anti-overflow adapter is adapted to be connected to the ear sucker (5); The solid phase extraction column (4) is internally provided with a filler (41) and a sample solution (42); The sample solution (42) is located between the filler (41) and the manual pressure anti-overflow adapter, and the ear sucker (5) is connected to the solid phase extraction column (4) from the manual pressure anti-overflow adapter to input a positive pressure, so that the sample solution (42) is filtered through the filler (41) and then separated out.