Special mixer for combined use of NK and thymosin

Abstract

The utility model relates to the technical field of NK (Natural Killer) cells, and provides a special mixer for combined use of NK and thymosin, which comprises a mixing tube, a feeding cover arranged at the upper end of the mixing tube, a driving and stirring component arranged inside the mixing tube, and a conveying and discharging component arranged inside the mixing tube, the driving and stirring assembly comprises an output motor, the output motor is arranged on the side wall of the mixing pipe, the output end of the output motor is inserted into the mixing pipe, the output end of the output motor is connected with a driving shaft, the driving shaft is fixedly sleeved with a stabilizing sleeve, a swing arm is arranged on the side wall of the stabilizing sleeve, and an inclined stirring piece is arranged on the inner side wall of the swing arm. According to the technical scheme, the problems that in the prior art, when a mixer is used for feeding, the pushing phenomenon is likely to happen, feeding is difficult, NK cells need to be discharged after sufficient mixing and stirring are conducted, and the phenomenon that the NK cells adhere to the wall can happen to a common mixer, and discharging is difficult are solved.

Description

TECHNICAL FIELD

[0001] The utility model relates to NK cell technical field, specifically, relate to a special mixer that NK and thymic peptide are used in combination. BACKGROUND

[0002] NK cell is the important immune cell of organism, not only with antitumor, antiviral infection and immunoregulation are related, and participate in hypersensitivity and the occurrence of autoimmune disease in certain circumstances, can identify target cell, killing medium, derive from bone marrow lymphoid stem cell, its differentiation, development depend on bone marrow and thymic microenvironment, mainly distribute in bone marrow, peripheral blood, liver, spleen, lung and lymph node. NK cell is different from T, B cell, is a kind of lymphocyte that can non-specifically kill tumor cell and virus infection cell without prior sensitization.

[0003] NK cell expansion process will use reaction kettle to carry out efficient stirring to NK cell, and the following problems exist in the stirring process: 1, the phenomenon of push and shove occurs when the mixer feeds, so that its feeding is difficult;2, after mixing and stirring sufficiently, NK cells need to be discharged, and the commonly used mixer will produce sticky wall-hanging phenomenon, so that its discharge is difficult, in view of this, a special mixer for NK and thymic peptide is used in combination. UTILITY MODEL CONTENT

[0004] The utility model provides a special mixer that NK and thymic peptide are used in combination, solve the phenomenon of push and shove in the mixer feeding in related art, so that its feeding is difficult, after mixing and stirring sufficiently, NK cells need to be discharged, and the commonly used mixer will produce sticky wall-hanging phenomenon, so that its discharge is difficult.

[0005] The technical scheme of the utility model is as follows: including

[0006] Mixing pipe, the upper end of the mixing pipe is provided with a feeding cover;

[0007] Drive stirring assembly, the drive stirring assembly is arranged in the inside of the mixing pipe;

[0008] Conveying and discharging assembly, the conveying and discharging assembly is arranged in the inside of the mixing pipe;

[0009] The drive stirring assembly includes output motor, the output motor is arranged in the side wall of the mixing pipe, the output end of the output motor is inserted into the mixing pipe, the output end of the output motor is connected with drive shaft, the drive shaft is fixedly sleeved with stabilizing sleeve, the side wall of the stabilizing sleeve is provided with swing arm, the inner side wall of the swing arm is provided with inclined stirring blade.

[0010] As a further technical scheme, the number of the stabilizing sleeves is 2, 3 swing arms are arranged on the two stabilizing sleeves, and the outer wall of the inclined stirring blade is attached to the inner side wall of the mixing pipe.

[0011] As a further technical scheme, the conveying and discharging assembly comprises a hinge shaft, the hinge shaft is fixedly connected with the driving shaft, hinge plates are arranged on the hinge shaft, the hinge plates are located in the mixing pipe, and a discharging opening is arranged at the bottom of the mixing pipe.

[0012] As a further technical scheme, the discharging opening is connected with two closing covers through shafts, and the two closing covers are connected to seal the discharging opening.

[0013] As a further technical scheme, the closing cover is provided with a sealing pad at the edge.

[0014] As a further technical scheme, the inner side wall of the mixing pipe is provided with an expansion cavity, and a part of the inclined stirring blade is located in the expansion cavity.

[0015] As a further technical scheme, the bottom of the output motor is provided with a motor base, and bolt holes are arranged on the motor base.

[0016] As a further technical scheme, the upper end of the feeding cover is provided with a wide-mouth collecting cover, and the wide-mouth collecting cover is connected with the feeding cover.

[0017] As a further technical scheme, the inner cavity of the mixing pipe is in a circular structure, and the outer side wall of the hinge plate is attached to the inside of the mixing pipe.

[0018] As a further technical scheme, the two closing covers are connected to form a semicircular structure.

[0019] The working principle and beneficial effects of the utility model are as follows:

[0020] The utility model realizes the following effects: 1. After stirring is completed, the discharging can be carried out by opening the closing cover, so that the adhesion in the mixing pipe is prevented; 2. The output motor drives the driving shaft to rotate, the stabilizing sleeve drives the swing arm to swing, and the NK cells are stirred by the inclined stirring blade, so that the stirring effect is realized, and the NK cells or the pancreatic peptide can be conveyed through the hinge plate. DRAWINGS

[0021] The utility model will be further explained in detail in combination with the drawings and specific embodiments.

[0022] Fig. 1 The utility model is a structural schematic view.

[0023] Fig. 2 It is the cross section view of the mixing pipe of the utility model;

[0024] Fig. 3 It is the cross section view of the discharge port of the utility model;

[0025] Fig. 4 It is the side view of the swing arm shaft of the utility model;

[0026] In the drawing: 1, mixing pipe; 2, feed cover; 3, drive stirring assembly; 3-1, output motor; 3-2, drive shaft; 3-3, stabilizing sleeve; 3-4, swing arm; 3-5, inclined stirring blade; 4, conveying and discharging assembly; 4-1, hinge shaft; 4-2, hinge blade; 4-3, discharge port; 4-4, closing cover; 4-5, sealing and fitting pad; 5, expansion cavity; 6, motor base; 7, wide-mouth collecting cover. DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the utility model will be clearly and completely described below in conjunction with the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor are involved in the protection scope of the utility model.

[0028] As shown in Figs. 1-4 the embodiment, the utility model discloses a special mixer for NK and thymic peptide combination, including

[0029] Mixing pipe 1, the upper end of mixing pipe 1 is provided with feed cover 2;

[0030] Drive stirring assembly 3, drive stirring assembly 3 is arranged in the inside of mixing pipe 1;

[0031] Conveying and discharging assembly 4, conveying and discharging assembly 4 is arranged in the inside of mixing pipe 1;

[0032] Drive stirring assembly 3 includes output motor 3-1, output motor 3-1 is arranged in the side wall of mixing pipe 1, the output end of output motor 3-1 is inserted into mixing pipe 1, the output end of output motor 3-1 is connected with drive shaft 3-2, drive shaft 3-2 is fixedly sleeved with stabilizing sleeve 3-3, the side wall of stabilizing sleeve 3-3 is provided with swing arm 3-4, the inner side wall of swing arm 3-4 is provided with inclined stirring blade 3-5, the number of stabilizing sleeve 3-3 is 2, 3 swing arms 3-4 are arranged on the two stabilizing sleeves 3-3, and the outer wall of inclined stirring blade 3-5 is attached to the inner side wall of mixing pipe 1.

[0033] In this embodiment, the output motor 3-1 drives the driving shaft 3-2 to rotate, the stabilizing sleeve 3-3 drives the swing arm 3-4 to swing, and the NK cells are stirred by the inclined stirring blade 3-5, thereby realizing the stirring effect.

[0034] Specifically, the conveying and discharging assembly 4 includes a hinge shaft 4-1, which is fixedly connected between the driving shaft 3-2, and a hinge plate 4-2 arranged on the hinge shaft 4-1. The hinge plate 4-2 is located inside the mixing pipe 1, and the bottom of the mixing pipe 1 is provided with a discharge port 4-3.

[0035] In this embodiment, the hinge shaft 4-1 rotates with the driving shaft 3-2, and when the feeding cover 2 is filled with NK cells, the hinge plate 4-2 is driven by the hinge shaft 4-1, so that the hinge plate 4-2 drives the NK cells in the mixing pipe 1 to be conveyed to the inclined stirring blade 3-5.

[0036] Further, the discharge port 4-3 is connected with a closing cover 4-4 through a shaft, the number of the closing cover 4-4 is two, and the two closing covers 4-4 are spliced to seal the discharge port 4-3.

[0037] In this embodiment, the closing cover 4-4 is used for closing the discharge port 4-3, and after the stirring is completed, the discharging can be performed by opening the closing cover 4-4.

[0038] Further, the edge of the closing cover 4-4 is provided with a sealing and fitting pad 4-5, the inner side wall of the mixing pipe 1 is provided with an expansion cavity 5, a part of the inclined stirring blade 3-5 is located inside the expansion cavity 5, the bottom of the output motor 3-1 is provided with a motor base 6, and the motor base 6 is provided with a bolt hole.

[0039] In this embodiment, the sealing and fitting pad 4-5 improves the sealing property of the closing cover 4-4, the expansion cavity 5 provides space for the rotation of the inclined stirring blade 3-5, and the motor base 6 is used for fixedly mounting the output motor 3-1.

[0040] Further, the upper end of the feeding cover 2 is provided with a wide-mouth collecting cover 7, the wide-mouth collecting cover 7 is connected with the feeding cover 2 in communication, the inner cavity of the mixing pipe 1 is in a circular structure, the outer side wall of the hinge plate 4-2 is fitted to the inside of the mixing pipe 1, and the two closing covers 4-4 are spliced to form a semicircular structure.

[0041] In this embodiment, the wide-mouth collecting cover 7 is used for feeding, and after the wide-mouth collecting cover 7 is connected with the feeding cover 2 in communication, the area of feeding is increased through the wide-mouth collecting cover 7.

[0042] When the feeding needs to be carried out, the hinge shaft 4-1 rotates with the driving shaft 3-2, when the feeding cover 2 is filled with NK cells, the hinge piece 4-2 drives the hinge shaft 4-1 to drive the NK cells in the mixing pipe 1 to be transported to the inclined stirring piece 3-5, the output motor 3-1 drives the driving shaft 3-2 to rotate, the stabilizing sleeve 3-3 drives the swing arm 3-4 to swing, and the NK cells are stirred by the inclined stirring piece 3-5, so that the stirring effect is realized, the closing cover 4-4 is used for closing the discharge port 4-3, and after the stirring is completed, the discharge can be carried out by opening the closing cover 4-4.

[0043] The above is only a preferred embodiment of the present application, and is not used to limit the present application, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A dedicated mixer for the use of NK in combination with thymic peptides, characterized in that, The utility model relates to a mixing pipe, which comprises a mixing pipe (1) provided with a feeding cover (2) at the upper end thereof; a driving stirring assembly (3) arranged inside the mixing pipe (1); and a conveying discharging assembly (4) arranged inside the mixing pipe (1). The driving stirring assembly (3) comprises an output motor (3-1) arranged on the side wall of the mixing pipe (1), the output end of the output motor (3-1) being inserted into the mixing pipe (1), a driving shaft (3-2) connected to the output end of the output motor (3-1), a stabilizing sleeve (3-3) fixedly sleeved on the driving shaft (3-2), an oscillating arm (3-4) arranged on the side wall of the stabilizing sleeve (3-3), and an inclined stirring blade (3-5) arranged on the inner side wall of the oscillating arm (3-4). The stabilizing sleeve (3-3) is provided in two pieces, and three oscillating arms (3-4) are arranged on each of the two stabilizing sleeves (3-3); the outer wall of the inclined stirring blade (3-5) is attached to the inner side wall of the mixing pipe (1). The conveying discharging assembly (4) comprises a hinge shaft (4-1) fixedly connected to the driving shaft (3-2), a hinge blade (4-2) arranged on the hinge shaft (4-1), and a discharging opening (4-3) arranged at the bottom of the mixing pipe (1). The discharging opening (4-3) is connected to a closing cover (4-4) via a pin shaft, the closing cover (4-4) is provided in two pieces, and the two closing covers (4-4) are connected to each other to seal the discharging opening (4-3).

2. The special mixer for NK combined with thymic peptide according to claim 1, characterized in that, The closing cover (4-4) is provided with a sealing gasket (4-5) at the edge thereof.

3. The special mixer for NK combined with thymic peptide according to claim 1, characterized in that, The inner side wall of the mixing pipe (1) is provided with an expansion cavity (5), and a part of the inclined stirring blade (3-5) is arranged inside the expansion cavity (5).

4. The dedicated mixer for NK and thymosin peptide combination use according to claim 3, characterized in that, The bottom of the output motor (3-1) is provided with a motor base (6), and the motor base (6) is provided with bolt holes.

5. The dedicated mixer for NK and thymosin peptide combination use according to claim 4, characterized in that, The upper end of the feeding cover (2) is provided with a wide-mouth collecting cover (7) connected to the feeding cover (2).

6. The special mixer for NK combined with thymosin peptide according to claim 1, characterized in that, The inner cavity of the mixing pipe (1) has a circular structure, and the outer side wall of the hinge blade (4-2) is attached to the inside of the mixing pipe (1).

7. The special mixer for NK combined with thymosin peptide according to claim 1, characterized in that, The two closing covers (4-4) are connected to each other to form a semicircular structure.

8. The dedicated mixer for NK and thymosin peptide combination use according to claim 1, characterized in that, ​ 9. The special mixer for NK combined with thymic peptide according to claim 3, characterized in that, ​ 10. The special mixer for NK combined with thymic peptide according to claim 4, characterized in that, ​

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