Small-dose filtering injector
By designing a small-dose filtration syringe with a spiral structure and pressurization components, the problem of pressure bursting caused by loose connections in plastic microporous filter membrane syringes was solved, achieving a more efficient and safer buffer filtration process.
Patent Information
- Application Number
- CN202423132667.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-18
- Publication Date
- 2025-12-26
- Estimated Expiration
- 2034-12-18
AI Technical Summary
Existing plastic microporous membrane injectors have loose connections during use, which can cause the joints to burst open when the pressure is too high, affecting the efficiency of buffer impurity removal and posing a safety hazard.
A small-dose filtration syringe was designed, which uses a spiral structure to connect the syringe and the replacement head, and is equipped with a pressurization component. Uniform pressurization is achieved by rotating the pressurization rod, avoiding pressure concentration and reducing leakage and splashing.
It achieves more efficient buffer filtering, simplifies operation, reduces buffer waste and safety risks, and improves the safety and reproducibility of experiments.
Smart Images
Figure CN223717182U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model belongs to the field of biological experiment equipment, concretely relates to a small dose filter syringe. BACKGROUND
[0002] In protein experiment, the in-vitro buffer of protein is essential, and the buffer is the condition for the survival of protein in vitro, and without suitable buffer, the protein will be easily degraded or denatured in vitro. And the impurities in the buffer will also affect the protein, affecting the properties of the protein. At the same time, the buffer containing a large amount of impurities will cause the blocking of the purification column when the protein is subjected to affinity chromatography and molecular exclusion chromatography, which greatly affects the repeatability of the experiment and the experimental efficiency. Therefore, the effective removal of impurities from the buffer is an extremely important step in the protein expression and purification process.
[0003] At present, the devices for removing buffer impurities in the laboratory mainly include two types: (1) vacuum filtration instrument, which is mainly used for removing impurities from a large amount of buffer, and the buffer is filtered out from the filter membrane by applying pressure difference through a vacuum pump. (2) plastic microporous membrane syringe, which is mainly used for removing impurities from a small amount of buffer, and the plastic microporous membrane is mounted at the front end of the syringe needle, and the buffer is filtered out from the plastic microporous membrane by artificially pressurizing the syringe.
[0004] However, the existing plastic microporous membrane syringe still has some shortcomings, because the plastic microporous membrane is not tightly connected with the syringe, and the combination port is often broken due to the high pressure in the syringe, which not only affects the efficiency of removing impurities from the buffer, but also the buffer is easily splashed to the eyes and other parts of the experimental personnel, causing serious safety hazards to the experimental personnel.
[0005] Therefore, a new type of syringe is needed to remove impurities from a small amount of buffer. UTILITY MODEL CONTENTS
[0006] The utility model aims at overcoming the defects of the prior art, and provides a small dose filter syringe
[0007] A small dose filter syringe, comprising a needle cylinder, a replacement head and a pressurizing assembly, a push rod is arranged in the needle cylinder, and a piston is arranged at the front end of the push rod; an external thread is arranged at the front end of the outer surface of the needle cylinder; the replacement head comprises a sleeve, an internal thread matched with the external thread is arranged in the sleeve; and a filter membrane is fixedly arranged at the front end of the sleeve.
[0008] The pressurizing assembly is detachably arranged at the rear end of the needle cylinder.
[0009] Further, the pressurizing assembly comprises a pressurizing cylinder and a pressurizing rod, the pressurizing cylinder is rotationally connected with the pressurizing rod, and the pressurizing assembly realizes pressurizing when the pressurizing rod is rotated.
[0010] Further, the lower end of the pressurizing cylinder is provided with a bayonet, and the pressurizing assembly is detachably connected with the needle cylinder through the bayonet.
[0011] Further, the filter membrane adopts a nylon filter membrane.
[0012] Further, the pore size of the filter membrane is 0.45um or 0.22um, and the thickness is 0.1mm.
[0013] Further, the needle cylinder is externally provided with a scale line.
[0014] Further, the front end of the replacement head is provided with a needle.
[0015] Compared with the prior art, the beneficial effects of the present application are:
[0016] The utility model discloses a transformation to the connecting place, and the connecting place of syringe needle cylinder and replacement head (filter membrane) is designed as spiral structure, makes the pressure that entire syringe wall uniformly shares buffer extrusion produces, lets the filtration of small amount buffer be more convenient, and operation is more simple and convenient, need not embedding plastic microporous filter membrane on syringe with force, also reduces the leakage condition of buffer at the connecting port, and the loss of buffer reduces.
[0017] Meanwhile, the utility model discloses a pressurizing assembly, solves the problem that it is difficult for people to complete filtration due to too much impurity or too much bacteria in part of buffer or bacteria liquid in the filtration process, and the utility model discloses the pressurizing of the mode of rotation, greatly reduces the loss of human force. BRIEF DESCRIPTION OF DRAWINGS
[0018] Figure 1 It is the whole structure schematic diagram of the utility model.
[0019] Figure 2 It is the needle cylinder part structure schematic diagram of the utility model.
[0020] Figure 3 It is the replacement head part structure schematic diagram of the utility model.
[0021] Figure 4 It is the pressurizing assembly part structure schematic diagram of the utility model.
[0022] Marked in the figure: 1, needle cylinder; 1-1, push rod; 1-2, piston; 2, replacement head; 2-1, needle; 2-2, sleeve; 2-3, filter membrane; 3, pressurizing assembly; 3-1, pressurizing cylinder; 3-2, pressurizing rod. DETAILED DESCRIPTION
[0023] The application is further illustrated below with reference to the drawings.
[0024] As Figure 1 shown, the utility model provides a small dose filter syringe, including needle cylinder 1, replacement head 2 and pressurizing assembly 3, as Figure 2 shown, the needle cylinder 1 is equipped with push rod 1-1, and the front end of push rod 1-1 is equipped with piston 1-2; the outer surface front end of needle cylinder 1 is equipped with external thread; as Figure 3 shown, the replacement head 2 includes sleeve 2-2 and needle 2-1, and the inside of sleeve 2-2 is equipped with internal thread matched with external thread; the front end of sleeve 2-2 is fixedly provided with filter membrane 2-3; as Figure 4 shown, the pressurizing assembly 3 includes pressurizing cylinder 3-1 and pressurizing rod 3-2, and pressurizing cylinder 3-1 is rotationally connected with pressurizing rod 3-2, when rotating pressurizing rod 3-2, pressurizing assembly 3 realizes pressurizing, and the lower end of pressurizing cylinder 3-1 is equipped with bayonet, and pressurizing assembly 3 is detachably arranged at the rear end of needle cylinder 1 through the bayonet.
[0025] Specifically, the filter membrane 2-3 adopts nylon filter membrane 2-3, the pore size is 0.45um or 0.22um, and the thickness is 0.1. The capacity of the whole precision filter syringe is in the range of 1~100mL, the inner diameter of the needle cylinder 1 is 15~34mm, the cylinder length is 60~150mm, the full length of the syringe is 88~190mm, and the inner diameter of the replacement head 2 is 4mm.
[0026] In a preferred embodiment of the utility model, the needle cylinder 1 is optionally provided with scale lines on the outside.
[0027] The utility model discloses a filter head for syringe, including syringe 1, piston 1-2, push rod 1-1, sleeve 2-2, filter membrane 2-3 and pressurizing assembly 3, syringe 1 is provided with piston 1-2, piston 1-2 is provided with push rod 1-1, push rod 1-1 is provided with sleeve 2-2, sleeve 2-2 is provided with filter membrane 2-3, filter membrane 2-3 is provided with pressurizing assembly 3, the utility model discloses a filter head for syringe, can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter the buffer of different concentration, and the filter head for syringe can be used to filter
Claims
1. A low-dose filtering syringe, comprising a syringe (1), a replacement head (2), and a pressurization assembly (3), characterized in that, The syringe (1) is provided with a push rod (1-1) inside, and a piston (1-2) is provided at the front end of the push rod (1-1); the front end of the outer surface of the syringe (1) is provided with an external thread; the replacement head (2) includes a sleeve (2-2), and the sleeve (2-2) is provided with an internal thread that mates with the external thread; a filter membrane (2-3) is fixedly provided at the front end of the sleeve (2-2); The pressurizing component (3) is detachably mounted at the rear end of the syringe (1).
2. The low-dose filtering syringe according to claim 1, characterized in that, The pressurizing assembly (3) includes a pressurizing cylinder (3-1) and a pressurizing rod (3-2). The pressurizing cylinder (3-1) is rotatably connected to the pressurizing rod (3-2). When the pressurizing rod (3-2) is rotated, the pressurizing assembly (3) applies pressure.
3. The low-dose filtering syringe according to claim 2, characterized in that, The lower end of the pressure cylinder (3-1) is provided with a bayonet, and the pressure assembly (3) is detachably connected to the syringe (1) through the bayonet.
4. The low-dose filtering syringe according to claim 1, characterized in that, The filter membrane (2-3) is a nylon filter membrane (2-3).
5. The low-dose filtering syringe according to claim 1, characterized in that, The filter membrane (2-3) has a pore size of 0.45 μm or 0.22 μm and a thickness of 0.1 mm.
6. The low-dose filtering syringe according to claim 1, characterized in that, The syringe (1) has scale lines on its outside.
7. The low-dose filtering syringe according to claim 1, characterized in that, The replacement head (2) has a needle (2-1) at its front end.