Cell separation device

Abstract

The utility model provides a cell separation device. The cell separation device comprises a centrifugal assembly, a centrifugal driving part, a rack, a transmission assembly and a rotating platform, wherein the transmission assembly and the rotating platform are both mounted on the rack; the centrifugal driving part is connected with the rotating platform through the transmission assembly so as to drive the rotating platform to rotate around a preset rotating shaft relative to the rack through the transmission assembly. The centrifugal assembly comprises a plurality of conical centrifugal containers which are mounted on the rotating platform around the preset rotating shaft, the conical centrifugal containers and the preset rotating shaft are arranged at intervals, and the central axes of the conical centrifugal containers intersect with the preset rotating shaft at a preset inclination angle; and the conical vertex angle of the conical centrifugal container is arranged at one end far away from the preset rotating shaft. The cell separation device is simple in structure, cells can be automatically separated without being damaged, and the maximum cell treatment flux and the cell treatment efficiency are improved.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the field of biomedical technology, especially a kind of cell separation device. BACKGROUND

[0002] At present, the production equipment of autologous or allogeneic cell therapy has gradually begun to be applied, and in the use process of production equipment, there will be the processing condition of separating certain specific target cells from the cell liquid of composite components through centrifugal cup etc. The process of separating by centrifugal cup in the prior art often has the problems of limited processing efficiency, low maximum cell processing flux (generally not more than 250mL / min) etc., therefore cannot meet the needs of most treatment pipelines;And some equipment with high-flux cell concentration function is often large in size, so it needs to exert larger centrifugal force to realize centrifugation, and larger centrifugal force will damage cells, so it is not conducive to realize PBMC separation function. SUMMARY

[0003] The utility model provides a cell separation device for the technical problems of low efficiency and low flux when separating cells in prior art centrifugal cup.

[0004] In view of the above technical problems, the utility model embodiment provides a cell separation device, which comprises a centrifugal component, a centrifugal driving part, a rack, a transmission component and a rotating platform which are all installed on the rack;The centrifugal driving part is connected to the rotating platform through the transmission component, so as to drive the rotating platform to rotate around the preset rotating shaft relative to the rack through the transmission component.

[0005] The centrifugal component comprises a plurality of conical centrifugal containers installed on the rotating platform around the preset rotating shaft, the conical centrifugal containers are arranged at intervals with the preset rotating shaft, and the central axis of the conical centrifugal container intersects with the preset rotating shaft at a preset inclination angle;The conical top angle of the conical centrifugal container is arranged at one end away from the preset rotating shaft.

[0006] Optionally, the centrifugal component further comprises a cylindrical centrifugal container installed on the rotating platform, and the central axis of the cylindrical centrifugal container coincides with the preset rotating shaft.

[0007] Optionally, the preset inclination angle is 60°-120°;And / or

[0008] The conical top angle of the conical centrifugal container is 50°-70°;And / or

[0009] The radius of the conical bottom surface of the conical centrifugal container is greater than or equal to 16.5mm.

[0010] Optionally, the transmission assembly comprises a first bevel gear, a second bevel gear and a third bevel gear, which are all rotatably mounted on the frame; the first bevel gear is connected to the drive shaft of the centrifugal driving member; the second bevel gear is meshingly connected between the first bevel gear and the third bevel gear, and the third bevel gear is fixedly connected to the rotating platform.

[0011] Optionally, the central shafts of the first bevel gear and the third bevel gear are both coincident with the preset rotation axis; and the central shaft of the second bevel gear is perpendicular to the central shaft of the first bevel gear.

[0012] Optionally, the frame comprises a base provided with a first mounting space, and a mounting seat connected to the base; the centrifugal driving member is mounted in the first mounting space;

[0013] The mounting seat and the base are provided with a second mounting space in communication with the first mounting space, the first bevel gear is mounted in the second mounting space and connected to the drive shaft of the centrifugal driving member extending from the first mounting space;

[0014] The top surface of the mounting seat and the rotating platform are provided with a third mounting space for mounting the third bevel gear; and the mounting seat is further provided with a mounting groove in communication between the second mounting space and the third mounting space and for mounting the second bevel gear.

[0015] Optionally, the cell separation device further comprises a consumable pipeline in communication with the centrifugal assembly.

[0016] Optionally, the cell separation device further comprises a pipeline clamping member mounted on the frame, and the pipeline clamping member is provided with a mounting hole for bundling the consumable pipeline.

[0017] Optionally, the cell separation device further comprises a pipeline driving member; the consumable pipeline is rotatably mounted in the mounting hole, and one end of the consumable pipeline away from the centrifugal assembly is connected to the pipeline driving member, and the pipeline driving member is used to drive the consumable pipeline to rotate relative to the pipeline clamping member and the centrifugal assembly.

[0018] Optionally, the cell separation device further comprises a pipeline driving member; the consumable pipeline is clamped in the mounting hole, and the pipeline clamping member is mounted on the frame through the pipeline driving member, and the pipeline driving member is used to drive the pipeline clamping member and the consumable pipeline to rotate relative to the centrifugal assembly.

[0019] The utility model discloses a cell separation device, which comprises a centrifugal assembly, a centrifugal driving element, a rack and a transmission assembly and a rotating platform which are all installed on the rack.

[0020] In the cell separation device, the driving element drives the rotating platform to rotate through the transmission assembly, and then drives the conical centrifugal container to rotate around the preset rotating shaft. At this time, under the action of centrifugal force, the cell liquid in the conical centrifugal container can be stratified in a direction perpendicular to the preset rotating shaft. The cell separation device has a simple structure, a small size, and can realize cell separation without a large centrifugal force, so it can automatically realize cell separation without damaging the cells. In addition, the rotating platform is provided with a plurality of conical centrifugal containers at intervals. Therefore, one or more conical centrifugal containers can be selected for cell separation processing according to the actual cell liquid processing capacity. For example, when the cell liquid processing capacity is large, a plurality of conical centrifugal containers can be used for cell separation processing at the same time, that is, the maximum cell processing throughput is improved through a plurality of cell processing channels, and the cell processing efficiency is improved. When the cell liquid processing capacity is small, the separation precision can also be improved by using part of the conical centrifugal containers for centrifugal processing. Therefore, the cell separation device has wide applicability, can improve the processing efficiency while ensuring the separation precision. BRIEF DESCRIPTION OF DRAWINGS

[0021] The utility model will be further described below in combination with the drawings and examples.

[0022] Figure 1 is the explosion structure schematic diagram of cell separation device provided by an embodiment of the utility model;

[0023] Figure 2 is the assembly structure schematic diagram of cell separation device provided by an embodiment of the utility model;

[0024] Figure 3 is the partial structure schematic diagram of cell separation device provided by an embodiment of the utility model.

[0025] The reference signs in the specification are as follows:

[0026] 1, centrifugal assembly; 11, conical centrifugal container; 111, conical top corner; 112, conical bottom surface; 12, cylindrical centrifugal container; 2, centrifugal driving piece; 3, rack; 31, base; 32, mounting seat; 33, first mounting space; 34, second mounting space; 35, third mounting space; 36, mounting groove; 4, transmission assembly; 41, first bevel gear; 42, second bevel gear; 43, third bevel gear; 5, rotating platform; 6, consumable pipeline; 7, pipeline clamping piece; 71, mounting hole. DETAILED DESCRIPTION

[0027] In order to make the technical problems, technical schemes and beneficial effects solved by the utility model clearer and more apparent, the utility model will be further described in detail below in combination with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the utility model, and are not used to limit the utility model.

[0028] In the description of the utility model, it should be understood that the orientation or position relationship indicated by the terms "longitudinal", "radial", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like is based on the orientation or position relationship shown in the drawings, and is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the utility model. In the description of the utility model, unless otherwise specified, the meaning of "a plurality of" is two or more.

[0029] In the description of the utility model, it should be pointed out that, unless otherwise specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication inside two elements. For ordinary skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0030] As Figures 1 to 2As shown, the utility model provides cell separation device, including centrifugal component 1, centrifugal drive part 2, frame 3 and the transmission assembly 4 and rotation platform 5 of being installed on the frame 3, the centrifugal drive part 2 is connected the rotation platform 5 through the transmission assembly 4, to drive the rotation platform 5 relative to the frame 3 around the preset rotation axis rotation through the transmission assembly 4, the centrifugal component 1 includes the multiple conical centrifuge container 11 of being installed on the rotation platform 5 around the preset rotation axis, the conical centrifuge container 11 is spaced apart with the preset rotation axis, and the central axis of conical centrifuge container 11 is with the preset rotation axis is preset and meets the angle of inclination, the conical centrifuge container 11's conical vertex angle 111 is set in the end away from the preset rotation axis.

[0031] Understandably, the conical centrifuge container 11 can be detachably mounted on the rotation platform 5, and the rotation platform 5 is provided with a first fixing mechanism for detachably mounting the conical centrifuge container 11. In some embodiments, the plurality of conical centrifuge containers 11 are uniformly spaced on the rotation platform 5, that is, the spacing distance between the plurality of conical centrifuge containers 11 is equal. Further, the center points of the plurality of conical centrifuge containers 11 can be located on the same circle, at which time, the distance between each conical centrifuge container 11 and the preset rotation axis is equal, which can make the rotation of the rotation platform 5 more balanced, facilitate the uniform distribution of centrifugal force, and further make the centrifugal rate more consistent, thereby improving the cell separation efficiency. Understandably, in the utility model, the plurality of conical centrifuge containers 11 can be arranged to be not uniformly distributed according to the requirements, and the distance between the plurality of conical centrifuge containers 11 and the preset rotation axis can also not be equal.

[0032] The conical centrifuge container 11 can rotate around the preset rotation axis, and the conical vertex angle 111 of the conical centrifuge container 11 is located on the side of the conical centrifuge container 11 away from the preset rotation axis. Therefore, when the conical centrifuge container 11 rotates around the preset rotation axis, the cell liquid enters from the conical vertex angle 111, the sedimentation speed generated by the centrifugal force is balanced with the counterflow speed of the cell liquid entering the conical centrifuge container 11, thereby forming a fluidized bed of cells and suspending the cells inside the centrifuge cup. When the conical centrifuge container 11 rotates at high speed around the preset rotation axis, the cell liquid can be shaken to the side close to the conical vertex angle 111 of the conical centrifuge container 11, and the heavier part (the part with a density greater than water) in the cell liquid will be shaken to the conical vertex angle 111 of the conical centrifuge container 11 under the action of the centrifugal force, and the lighter substance in the cell liquid will be located on the side of the cell liquid close to the preset rotation axis, that is, at the gas-liquid interface position of the cell liquid in the conical centrifuge container 11, thereby realizing the stratification of the cell liquid under the density gradient centrifugation treatment, and then collecting the stratified cells to realize cell separation.

[0033] The preset rotation axis only needs to be arranged on the side of the conical centrifugal container 11 away from the conical top corner 111, so as to realize the above-mentioned cell layering process. The relative position relationship between the preset rotation axis and the conical centrifugal container 11 can be set according to specific requirements. In an embodiment, the preset inclination angle is 60°-120°; as a preferred, the preset inclination angle is 90°, at this time, the central axis of the conical centrifugal container 11 is perpendicular to the preset rotation axis and located on the same plane. In this way, when the conical centrifugal container 11 rotates around the preset rotation axis, the cell liquid in the conical centrifugal container 11 can be symmetrically distributed with the central axis as the symmetry axis, so as to make the distribution of the cell liquid in the conical centrifugal container 11 more uniform, and facilitate the cell processing process. As a preferred, the distance between the conical bottom surface 112 of the conical centrifugal container 11 and the preset rotation axis is 133mm-200mm, so as to ensure better centrifugal effect.

[0034] Understandably, the conical centrifugal container 11 is not limited to be a circular cone, but can also be arranged in a spliced shape of a circular cone and other shapes, or an approximate conical shape, for example, the conical top corner 111 can be arranged in a circular cone shape, and the conical tail end can be arranged in other shapes, such as a cylindrical shape; the entire conical centrifugal container 11 can also be arranged in a circular table shape, and the small diameter end of the circular table is the conical top corner 111; the conical centrifugal container 11 can also be arranged in a pyramid, etc., which is not limited here; as long as the above-mentioned cell layering effect can be realized. In an embodiment, the conical top corner 111 of the conical centrifugal container is 50°-70°; in this way, the separation effect of the conical centrifugal assembly 1 can be ensured to be good. Further, the radius of the conical bottom surface 112 of the conical centrifugal container 11 is greater than or equal to 16.5mm; the volume of each conical centrifugal container 11 can be set according to requirements, such as being designed to be 10ml-100ml, in this way, the cell separation can be realized without too much centrifugal force to avoid cell damage, and the maximum cell processing throughput can be improved by multiple conical centrifugal containers 11 for cell separation. In the present application, cell damage is avoided during cell separation, the operation is simple, and high recovery rate and high purity of separation can be ensured.

[0035] The cell separation device of the above-embodiment of the utility model, drive piece drives rotating platform 5 to rotate through transmission assembly 4, and then drive conical centrifugal container 11 to rotate around preset rotation axis, at this moment, under the action of centrifugal force, cell liquid in conical centrifugal container 11 can realize stratification in the direction perpendicular to preset rotation axis, the structure of the cell separation device of the utility model is simple, and the volume is small, and cell separation can be realized without large centrifugal force, so that cell separation can be automatically realized without damaging cells;And, a plurality of conical centrifugal containers 11 are arranged at intervals on rotating platform 5, so that one or more conical centrifugal containers 11 can be selected for cell separation treatment according to the actual cell liquid processing capacity, for example, when the cell liquid processing capacity is large, a plurality of conical centrifugal containers 11 can be used for cell separation treatment at the same time, that is, the maximum cell processing flux is improved through a plurality of cell processing channels, and the cell processing efficiency is further improved;And when the cell processing capacity is small, part of the conical centrifugal containers 11 are used for centrifugal treatment, and the separation precision can also be improved;Therefore, the cell separation device of the utility model has wide applicability, and the processing efficiency can be improved while ensuring the separation precision.

[0036] In an embodiment, as shown in Figures 1 to 2 The centrifugal assembly 1 further comprises a cylindrical centrifugal container 12 mounted on the rotating platform 5, and the central axis of the cylindrical centrifugal container 12 coincides with the preset rotation axis. Understandably, the cylindrical centrifugal container 12 can be detachably mounted on the rotating platform 5, and the rotating platform 5 is provided with a second fixing mechanism for detachably mounting the cylindrical centrifugal container 12. The cylindrical centrifugal container 12 and the conical centrifugal container 11 rotate around the preset rotation axis with the rotation of the rotating platform 5, that is, the angular velocity of rotation of the conical centrifugal container 11 and the cylindrical centrifugal container 12 is the same as the angular velocity of rotation of the rotating platform 5. In the utility model, the cylindrical centrifugal container 12 can be a hollow annular cup, and the inlet and outlet of the cylindrical centrifugal container 12 are at least two, for example, flow channel openings can be arranged on the upper and lower planes of the cylindrical centrifugal container 12 respectively. When the cylindrical centrifugal container 12 rotates at high speed around the preset rotation axis, under the action of centrifugal force, the cell liquid will gradually stratify in the radial direction of the preset rotation axis, and then the position of the flow channel opening can be set to correspond to the layer where the target cells (cells that need to be collected) are located, and the target cells can be extracted.

[0037] In the utility model, the conical centrifugal container 11 can be used for separating mononuclear cells, and the cylindrical centrifugal container 12 can be used for separating T cells. The minimum distance between the conical centrifugal container 11 and the preset rotation axis is greater than the radius of the cylindrical centrifugal container 12, that is, the conical centrifugal container 11 is located on the periphery of the cylindrical centrifugal container 12 on the rotating platform 5, thereby avoiding mutual interference between the two.

[0038] In an embodiment, as shown inFigures 1 to 3 As shown in the figure, the transmission assembly 4 comprises a first bevel gear 41, a second bevel gear 42 and a third bevel gear 43, which are all rotatably installed on the frame 3; the first bevel gear 41 is connected with the driving shaft of the centrifugal driving member 2; the second bevel gear 42 is engagedly connected between the first bevel gear 41 and the third bevel gear 43, and the third bevel gear 43 is fixedly connected with the rotating platform 5. Understandably, the frame 3 is provided with positioning grooves at positions corresponding to the rotating shafts of the three bevel gears respectively, so that the rotating shafts of the three bevel gears are respectively inserted into the corresponding positioning grooves and can rotate in the positioning grooves. In this embodiment, the transmission assembly 4 comprises three bevel gears (the first bevel gear 41, the second bevel gear 42 and the third bevel gear 43), which are engagedly connected with each other to transmit the driving force of the driving member to the rotating platform 5, thereby driving the rotating platform 5 to rotate and finally driving the centrifugal assembly 1 to rotate to realize cell separation.

[0039] Further, as shown in the figures, Figure 1 and Figure 3 the central shafts of the first bevel gear 41 and the third bevel gear 43 are both coincident with the preset rotating shaft; and the central shaft of the second bevel gear 42 is perpendicular to the central shaft of the first bevel gear 41. That is, in this embodiment, the central shafts of the first bevel gear 41 and the third bevel gear 43 are both perpendicular to the central shaft of the second bevel gear 42, and the central shafts of the first bevel gear 41, the second bevel gear 42 and the third bevel gear 43 are all located on the same plane, so that the linkage between the three bevel gears can be better realized, thereby efficiently transmitting the driving force.

[0040] In an embodiment, as shown in the figures, Figures 1 to 3As shown, the rack 3 comprises a base 31 provided with a first mounting space 33, and a mounting seat 32 connected to the base 31; the centrifugal driving member 2 is mounted in the first mounting space 33; the second mounting space 34 communicating with the first mounting space 33 is arranged between the mounting seat 32 and the base 31, the first bevel gear 41 is mounted in the second mounting space 34 and connected with the driving shaft of the centrifugal driving member 2 extending from the first mounting space 33; the third mounting space 35 for mounting the third bevel gear 43 is arranged between the top surface of the mounting seat 32 and the rotating platform 5; the mounting groove 36 for mounting the second bevel gear 42 is further arranged on the mounting seat 32 and communicates between the second mounting space 34 and the third mounting space 35. That is, the base 31 is provided with a first mounting space 33 for fixing the centrifugal driving member 2 (such as a motor), and the centrifugal driving member 2 can be fixed on the base 31 through a threaded hole, and the fixing position of the centrifugal driving member 2 can be thickened to avoid the vibration of the centrifugal driving member 2 affecting the deviation of the preset rotating shaft. The first mounting space 33, the second mounting space 34, the mounting groove 36 and the third mounting space 35 are sequentially communicated, thereby ensuring the sequential connection between the centrifugal driving member 2, the first bevel gear 41, the second bevel gear 42 and the third bevel gear 43, and thereby realizing the transmission of driving force.

[0041] In an embodiment, as shown in Figures 1 to 3 As shown, the cell separation device further comprises a consumable pipeline 6 communicating with the centrifugal assembly 1. In this embodiment, all centrifugal containers in the centrifugal assembly 1, whether conical centrifugal containers 11 or cylindrical centrifugal containers 12, are separately arranged, and the corresponding consumable pipeline 6 of each centrifugal container is separate and does not interfere with each other. The consumable pipeline 6 is separate from the rotating platform 5 and does not interfere with each other. In this embodiment, the consumable pipeline 6 can be rotationally connected with the centrifugal assembly 1, for example, the consumable pipeline 6 can be rotationally connected with the centrifugal assembly 1 through a shaft seal structure, while realizing the sealing of the connection position between the consumable pipeline 6 and the centrifugal assembly 1; the consumable pipeline 6 is rotationally mounted on the centrifugal assembly 1, and when the centrifugal assembly 1 rotates around the preset rotating shaft, the rotation of the consumable pipeline 6 relative to the centrifugal assembly 1 can avoid the winding of the consumable pipeline 6. Understandably, the consumable pipeline 6 can also be fixedly connected with the centrifugal assembly, at this time, the consumable pipeline 6 needs to be driven to rotate by a pipeline driving member or the like to avoid winding of the consumable pipeline 6.

[0042] In an embodiment, as shown in Figures 1 to 3As shown, the cell separation device further comprises a pipeline clamp 7 mounted on the rack 3, and the pipeline clamp 7 is provided with a mounting hole 71 for collecting the consumable pipeline 6. In this embodiment, the pipeline clamp 7 can be used to arrange and store the consumable pipeline 6 in the mounting hole 71, so as to avoid the scattering of the consumable pipeline 6 and affect the cell separation process. In an embodiment, the mounting holes 71 are arranged at intervals above the rotating platform 5. Further, the mounting holes 71 are coaxially arranged with the preset rotating shaft. In this way, the collection of the consumable pipeline 6 on the entire rotating platform 5 can be facilitated.

[0043] In an embodiment, the consumable pipeline 6 is clamped in the mounting hole 71, the pipeline clamp 7 is mounted on the rack 3 through the pipeline driving member, and the pipeline driving member is used to drive the pipeline clamp 7 and the consumable pipeline 6 to rotate relative to the centrifugal assembly 1. In this embodiment, the pipeline driving member is connected with the pipeline clamp 7, the mounting hole 71 of the pipeline clamp 7 clamps and fixes the consumable pipeline 6, the pipeline driving member can drive the pipeline clamp 7 and the consumable pipeline 6 to rotate together, so as to realize self-rotation while ensuring that the consumable pipeline 6 is not scattered, thereby avoiding the winding of the consumable pipeline 6. Understandably, the pipeline driving member can be a motor or the like, and the pipeline driving member can drive the consumable pipeline 6 to rotate at 1 / 2 times the angular velocity of the rotating platform 5, thereby avoiding pipeline knotting. Understandably, the pipeline driving member can be a gear or the like transmission member connected with the transmission assembly 4, or can be a motor or the like separately arranged on the rack 3.

[0044] In another embodiment, the cell separation device further comprises a pipeline driving member (not shown in the figure); the consumable pipeline 6 is rotatably mounted in the mounting hole 71, and the end of the consumable pipeline 6 away from the centrifugal assembly 1 is connected with the pipeline driving member, and the pipeline driving member is used to drive the consumable pipeline 6 to rotate relative to the pipeline clamp 7 and the centrifugal assembly 1. In this embodiment, the pipeline driving member is directly connected with the consumable pipeline 6 and drives the consumable pipeline 6 to rotate, and although the consumable pipeline 6 is collected in the mounting hole 71, it can rotate in the mounting hole 71. Therefore, this scheme can ensure that the consumable pipeline 6 rotates while being not scattered, thereby avoiding the winding of the consumable pipeline 6.

[0045] The above is only an embodiment of the cell separation device of the present application, and does not limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A cell separation device, characterized by, The centrifugal assembly, a centrifugal driving element, a rack, a transmission assembly and a rotating platform all mounted on the rack; The centrifugal driving element is connected with the rotating platform through the transmission assembly to drive the rotating platform to rotate around a preset rotating shaft relative to the rack through the transmission assembly; The centrifugal assembly comprises a plurality of conical centrifugal containers mounted on the rotating platform around the preset rotating shaft, the conical centrifugal containers are spaced apart from the preset rotating shaft, and the central axis of the conical centrifugal containers intersects with the preset rotating shaft at a preset oblique angle; the conical top angle of the conical centrifugal container is arranged at one end away from the preset rotating shaft; The centrifugal assembly further comprises a cylindrical centrifugal container mounted on the rotating platform, and the central axis of the cylindrical centrifugal container coincides with the preset rotating shaft; The preset oblique angle is 60°-120°; and / or The conical top angle of the conical centrifugal container is 50°-70°; and / or The radius of the conical bottom surface of the conical centrifugal container is greater than or equal to 16mm.

2. The cell separation device of claim 1, wherein, The transmission assembly comprises a first bevel gear, a second bevel gear and a third bevel gear all rotatably mounted on the rack; the first bevel gear is connected with the driving shaft of the centrifugal driving element; the second bevel gear is meshingly connected between the first bevel gear and the third bevel gear, and the third bevel gear is fixedly connected with the rotating platform.

3. The cell separation device of claim 2, wherein, The central axes of the first bevel gear and the third bevel gear all coincide with the preset rotating shaft; and the central axis of the second bevel gear intersects perpendicularly with the central axis of the first bevel gear.

4. The cell separation device of claim 2, wherein, The rack comprises a base provided with a first mounting space, and a mounting seat connected with the base; the centrifugal driving element is mounted in the first mounting space; A second mounting space is provided between the mounting seat and the base and communicates with the first mounting space, the first bevel gear is mounted in the second mounting space and connected with the driving shaft of the centrifugal driving element extending from the first mounting space; A third mounting space for mounting the third bevel gear is provided between the top surface of the mounting seat and the rotating platform; and a mounting groove for mounting the second bevel gear is further provided on the mounting seat and communicates between the second mounting space and the third mounting space.

5. The cell separation device of claim 1, wherein, The cell separation device further comprises a consumable pipeline communicating with the centrifugal assembly.

6. The cell separation device of claim 5, wherein, The cell separation device further comprises a pipeline clamping element mounted on the rack, and the pipeline clamping element is provided with a mounting hole for bundling the consumable pipeline.

7. The cell separation device of claim 6, wherein, The cell separation device further comprises a pipeline driving element; the consumable pipeline is clamped in the mounting hole, the pipeline clamping element is mounted on the rack through the pipeline driving element, and the pipeline driving element is used to drive the pipeline clamping element and the consumable pipeline to rotate relative to the centrifugal assembly.

8. The cell separation device of claim 6, wherein, The cell separation device further comprises a pipeline driving element; the consumable pipeline is rotatably mounted in the mounting hole, one end of the consumable pipeline away from the centrifugal assembly is connected with the pipeline driving element, and the pipeline driving element is used to drive the consumable pipeline to rotate relative to the pipeline clamping element and the centrifugal assembly.

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