Micro-needle patch based on micro-fluidic chip
Patent Information
- Application Number
- CN202422492208.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-15
- Publication Date
- 2025-12-26
- Estimated Expiration
- 2034-10-15
Smart Images
Figure CN223727691U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to food detection technical field, concretely relates to micro-needle patch based on microfluidic chip. BACKGROUND
[0002] With the rapid development of cold chain logistics industry, people pay more and more attention to the quality and safety of frozen food. In order to ensure the quality and safety of frozen and refrigerated food, various modern information technologies are applied to the monitoring and control, sensing and detection of frozen food. There are three traditional methods for testing the freshness of pork-physical, chemical and microbial detection method. The physical detection method is to judge the freshness of pork by professional personnel through smell, touch, smell, etc. Our country generally adopts the national standard GBT22210-2008 to standardize the sensory evaluation standard of meat and meat products. This method is one of the most basic and fastest methods recognized and regulated by the state for meat safety inspection. However, this method is easily affected by the subjective influence of the inspector, lacks scientificity, and is only suitable for one kind of meat, which has great limitations. The chemical test method is to evaluate the freshness of pork by detecting the chemical composition of pork during storage and transportation. Although the national standard GB5009.228-2016 stipulates the method for determining meat TVB-N, the detection of chemical indicators requires pretreatment of the sample, which has complicated operation steps and is destructive, and is not suitable for on-site operation. The microbial test method is an important method for evaluating the freshness of meat. Although the national standard GBT4789.17-2003 stipulates the method for microbial testing of meat and meat products, this method is destructive, requires more experimental steps and longer testing time, and cannot quickly and real-time detect freshness. CONTENT OF THE UTILITY MODEL
[0003] The utility model aims at solving the above-mentioned problems, and proposes a micro-needle patch based on microfluidic chip.
[0004] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: the utility model discloses a micro-needle patch based on microfluidic chip, which comprises a base and a plurality of needle bodies, the plurality of needle bodies are arranged on one side surface of the base, the base is a multi-hole mesh structure, the needle body is provided with a hollow pipe downward vertically along the top to the bottom, the hollow pipe corresponds to at least one hole mesh opening of the base, and the other side of the base is also provided with a detection chip.
[0005] Preferably, the detection chip comprises a plurality of input ports, a microfluidic channel and a color developing part, the input ports are arranged on one side of the detection chip close to the base, each input port is connected to the color developing part through a microfluidic channel, and the color developing part is provided with a color developing reagent.
[0006] Preferably, the color developing reagent is a fluorescent group and a quencher.
[0007] Preferably, the needle body gradually decreases in cross-sectional area from one end proximal to the base to one end distal to the base.
[0008] Preferably, the needle body is made of PVA.
[0009] Preferably, the base is cylindrical.
[0010] In summary, due to the adoption of the above technical solutions, the present application has the following beneficial effects:
[0011] The visual indicator combines a microfluidic chip and a microneedle, can rapidly detect the freshness of pork on site, can improve the efficiency of pork freshness detection, reduce the cost of pork freshness detection, realize rapid on-site detection, and makes the detection of pork freshness convenient, thereby providing protection for the safety and quality of pork. BRIEF DESCRIPTION OF DRAWINGS
[0012] Figure 1 A perspective view is shown according to an embodiment of the present application.
[0013] Figure 2 A top view is shown according to an embodiment of the present application.
[0014] Figure 3 A bottom view is shown according to an embodiment of the present application.
[0015] Figure 4 A cross-sectional view at A-A is shown. Figure 2
[0016] LEGEND
[0017] 1, needle body; 2, base; 3, detection chip; 31, input part; 32, microfluidic channel; 33, color developing part; 4, hollow pipeline. DETAILED DESCRIPTION
[0018] In order to make the purpose, technical scheme and advantages of the present application clearer, the technical scheme of the present application embodiments will be described clearly and completely in the following with reference to the drawings of the present application embodiments. The same reference signs in the drawings represent the same parts. It should be noted that the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the described embodiments of the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.
[0019] Embodiment one
[0020] As Figures 1-3 An embodiment shown provides a micro-needle patch based on a micro-fluidic chip, comprising a base 2 and a plurality of needle bodies 1, the plurality of needle bodies 1 are arranged on one side surface of the base 2, as shown in Figure 4 As shown, the base 2 is a multi-hole mesh structure, having a plurality of holes communicating between two sides, the needle body 1 is vertically arranged with a hollow pipe 4 from the top to the bottom, the hollow pipe 4 corresponds to at least one mesh hole of the base 2, and the other side of the base 2 is further provided with a detection chip 3.
[0021] Working principle and use process of the embodiment:
[0022] The needle body 1 is inserted into the pork, and the tissue fluid in the pork is absorbed by the micro-needle due to capillary action in a short time, and the absorbed tissue fluid is transmitted to the base 2 through the hollow pipe 4, and the tissue fluid falls into the detection chip 3 through the mesh hole of the base 2 due to the multi-hole mesh structure of the base 2, and the detection chip 3 detects the freshness of the tissue fluid of the pork to realize rapid detection of the pork.
[0023] Embodiment two
[0024] As shown in Figure 3 The embodiment is based on the above-mentioned embodiment and is developed to solve the problem of how to detect the freshness of the tissue fluid in the pork, specifically, the detection chip 3 comprises a plurality of input ports 31, a micro-fluidic channel 32 and a color developing part 33, the input port 31 is arranged on one side of the detection chip 3 close to the base 2, each input port 31 is connected to the color developing part 33 through the micro-fluidic channel 32, and the color developing reagent is arranged in the color developing part 33, after the pork tissue fluid is transmitted to the detection chip 3, a plurality of input ports 31 are arranged on the detection chip 3, the pork tissue fluid flows into the input port 31, and then enters the color developing part 33 from the micro-fluidic channel 32, and the color developing reagent in the color developing part 33 occurs color developing reaction, and the staff can judge the freshness of the pork by the color of the final color developing reaction.
[0025] Further, the color developing reagent is a fluorophore and a quencher, and the fluorophore and the quencher are combined to inhibit the color development of the fluorophore when the biological amine in the pork tissue fluid does not appear. When the biological amine appears, the biological amine combines with the fluorophore to form a complex, destroys the fluorophore-quencher, and thus makes the fluorophore develop color. The fluorophore can react with the biological amine, and when the fluorophore recognizes the analyte, a covalent bond is formed, thereby changing the fluorescence intensity and absorbance of the dye. According to the difference in fluorescence intensity, the biological amine in the specific pork tissue fluid can be quantitatively analyzed. Then, the freshness of the pork is judged according to the analyzed biological amine index (BAI), and when the BAI is less than or equal to 20 mg / kg, the meat is in an acceptable consumption range; when the BAI is between 20 and 50 mg / kg, the meat is low-quality meat; and when the BAI is greater than or equal to 50 mg / kg, the meat is spoiled meat.
[0026] Embodiment three
[0027] As shown in Figures 1-2 , Figure 4 , the embodiment is developed on the basis of the above-mentioned embodiments to solve the problem of how the microneedle absorbs the tissue fluid in the pork, and specifically, the cross-sectional area of the needle body 1 gradually decreases from the end adjacent to the base 2 to the end away from the base 2. This arrangement makes the tip of the microneedle have a sharp end, which facilitates the penetration into the pork tissue.
[0028] Embodiment four
[0029] As shown in Figures 1-4 , the embodiment is developed on the basis of the above-mentioned embodiments to solve the problem of not affecting the quality of the pork, and specifically, the material of the needle body 1 is PVA. PVA is biodegradable and harmless to the human body, and has good mechanical properties and adsorption properties, which facilitates the absorption of the pork tissue fluid by the needle body 1 and avoids affecting the quality of the pork.
[0030] Embodiment five
[0031] As shown in Figures 1-4 , the embodiment is developed on the basis of the above-mentioned embodiments, and specifically, the base 2 is in a cylindrical shape, which facilitates the user to hold it.
[0032] The above description of the embodiments enables a person skilled in the art to implement or use the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application should not be limited to the embodiments shown herein, but should be consistent with the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A microneedle patch based on a microfluidic chip, comprising a base (2) and a plurality of needle bodies (1), the plurality of needle bodies (1) are arranged on one side surface of the base (2), characterized in that: The base (2) is a multi-hole mesh structure, the needle body (1) is vertically provided with a hollow pipe (4) from the top to the bottom, the hollow pipe (4) corresponds to at least one hole mesh opening of the base (2), and the other side of the base (2) is further provided with a detection chip (3).
2. The microfluidic chip-based microneedle patch of claim 1, wherein: The detection chip (3) comprises a plurality of input ports (31), microfluidic channels (32) and chromogenic parts (33), the input ports (31) are arranged on the side of the detection chip (3) close to the base (2), each input port (31) is connected to the chromogenic part (33) through a microfluidic channel (32), and the chromogenic part (33) is provided with a chromogenic reagent.
3. The microfluidic chip-based microneedle patch of claim 1, wherein: The cross-sectional area of the needle body (1) gradually decreases from one end close to the base (2) to the other end away from the base (2).
4. The microfluidic chip-based microneedle patch of claim 1, wherein: The material of the needle body (1) is PVA.
5. The microfluidic chip-based microneedle patch of claim 1, wherein: The base (2) is a cylindrical shape.